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31. 发明授权

US08309561B2 Phenylalanine derivatives 有权
标题翻译：苯丙氨酸衍生物
公开(公告)号：US08309561B2
公开(公告)日：2012-11-13
申请号：US11963144
申请日：2007-12-21
申请人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
发明人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
IPC分类号： A61K31/517 , A61K31/519 , C07D239/70 , C07D239/95
CPC分类号： C07D239/70 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04
摘要： Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：特定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

32. 发明申请

US20090314573A1 Magnetostrictive Torque Sensor and Electric Steering System 有权
标题翻译：磁致伸缩转矩传感器和电动转向系统
公开(公告)号：US20090314573A1
公开(公告)日：2009-12-24
申请号：US12324024
申请日：2008-11-26
申请人： Yoshihiro ONIWA , Takashi Miyoshi , Koichi Fujita , Atsuhiko Yoneda , Yasuo Shimizu
发明人： Yoshihiro ONIWA , Takashi Miyoshi , Koichi Fujita , Atsuhiko Yoneda , Yasuo Shimizu
IPC分类号： B62D5/04 , G01L3/10
CPC分类号： G01L3/102 , B62D5/046 , B62D5/0481 , B62D5/049 , B62D6/10 , G01L3/105 , G01L5/221
摘要： A magnetostrictive torque sensor comprising: a magnetostrictive film provided on a ferromagnetic shaft; a bias magnetization device which applies a bias magnetic field to the shaft to magnetize the shaft; and a detection device which detects a change in magnetism of the magnetostrictive film, wherein: a torque acting on the shaft calculated based on the detection results of the detection device; and the bias magnetization device applies a bias magnetic field to the shaft at a predetermined timing.
摘要翻译：一种磁致伸缩扭矩传感器，包括：设在铁磁轴上的磁致伸缩膜; 偏置磁化装置，其向所述轴施加偏置磁场以使所述轴磁化; 以及检测装置，其检测所述磁致伸缩膜的磁性变化，其中：基于所述检测装置的检测结果计算的作用在所述轴上的转矩; 并且偏置磁化装置在预定的时刻向轴施加偏置磁场。

33. 发明申请

US20090170911A1 NOVEL AZOLE COMPOUND 审中-公开
标题翻译：新型AZOLE化合物
公开(公告)号：US20090170911A1
公开(公告)日：2009-07-02
申请号：US12389711
申请日：2009-02-20
申请人： Takashi YAMAMOTO , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
发明人： Takashi YAMAMOTO , Akira Chiba , Koichi Fujita , Yuka Kataba , Koji Ohsumi , Sayaka Asari , Naoyuki Fukuchi , Misato Noguchi , Itsuya Tanabe , Chiori Ijichi , Naoko Oomuta , Yuko Iida , Satoshi Iwayama
IPC分类号： A61K31/4192 , C07D261/14 , A61K31/42 , C07D275/02 , A61K31/425 , C07D271/00 , A61K31/4245 , C07D285/06 , C07D285/10
CPC分类号： A61K31/4245 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/433
摘要： Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.
摘要翻译：由式I表示的唑类化合物：其中环A是异恶唑等，R 1是取代或未取代的芳基等，R 2是氢原子等，R 3是取代或未取代的烷基等，和其药学上可接受的盐抑制溶血磷脂酸（LPA）的生理活性，并且可用于预防或治疗其中抑制LPA的生理活性用于预防或治疗其的疾病，例如涉及 LPA受体。

34. 发明申请

US20090018161A1 METHOD FOR PROMOTING GASTROINTESTINAL FUNCTION AND METHOD FOR SCREENING FOR PROMOTER OF GASTROINTESTINAL FUNCTION 审中-公开
标题翻译：促进胃肠功能的方法和筛查胃肠功能促进剂的方法
公开(公告)号：US20090018161A1
公开(公告)日：2009-01-15
申请号：US12114125
申请日：2008-05-02
申请人： Tatsuro Tanaka , Hisayuki Uneyama , Shinichi Fujita , Saori Ogawa , Yusuke Amino , Seiji Shiraishi , Koichi Fujita , Tatsuhiro Yamada , Takashi Yamamoto , Takeshi Aihara , Manabu Suzuki
发明人： Tatsuro Tanaka , Hisayuki Uneyama , Shinichi Fujita , Saori Ogawa , Yusuke Amino , Seiji Shiraishi , Koichi Fujita , Tatsuhiro Yamada , Takashi Yamamoto , Takeshi Aihara , Manabu Suzuki
IPC分类号： A61K31/47 , A61K31/16 , A61K31/164 , A61K31/343 , A61K31/4439 , G01N33/53 , A61P1/00 , C12Q1/02 , A61K31/221 , A61K31/357 , A61K31/44
CPC分类号： A61K31/36 , A23L33/10 , A61K31/165 , A61K31/166 , A61K31/343
摘要： The present invention provides a more effective gastrointestinal function promoter. The present invention also provides a method for the prophylaxis or improvement of functional gastrointestinal disorders, a method for appetite regulation and the like. The present invention also provides a method for screening for a substance capable of promoting a gastrointestinal function. The present invention provides a gastrointestinal function promoter containing a T1R agonist as an active ingredient and a method for the prophylaxis or improvement of functional gastrointestinal disorders, a method for appetite regulation and the like by administering a T1R agonist. The present invention also provides a method of screening for a substance capable of promoting a gastrointestinal function which method uses a cell expressing T1R receptor.
摘要翻译：本发明提供了更有效的胃肠功能促进剂。本发明还提供了预防或改善功能性胃肠道疾病的方法，食欲调节方法等。本发明还提供了筛选能够促进胃肠功能的物质的方法。本发明提供了含有T1R激动剂作为活性成分的胃肠功能促进剂和通过施用T1R激动剂来预防或改善功能性胃肠道疾病的方法，食欲调节方法等。本发明还提供一种筛选能够促进胃肠功能的方法，该方法使用表达T1R受体的细胞。

35. 发明申请

US20050222141A1 Novel phenylalanine derivatives 有权
标题翻译：新型苯丙氨酸衍生物
公开(公告)号：US20050222141A1
公开(公告)日：2005-10-06
申请号：US11018226
申请日：2004-12-22
申请人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
发明人： Kazuyuki Sagi , Tatsuya Okuzumi , Tatsuhiro Yamada , Shunsuke Kageyama , Yoichiro Shima , Tadakiyo Nakagawa , Munetaka Tokumasu , Masayuki Sugiki , Hajime Ito , Itsuya Tanabe , Tamotsu Suzuki , Akira Nakayama , Kazuyuki Ubukata , Kenji Shinkai , Yasuhiro Tanaka , Misato Noguchi , Ayatoshi Andou , Yoriko Yamamoto , Noriyasu Kataoka , Koichi Fujita
IPC分类号： A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/541 , C07D239/70 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/02 , C07D417/02 , C07D471/04 , C07D487/04 , C07D43/02
CPC分类号： C07D239/70 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/04 , C07D471/04 , C07D487/04
摘要： Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译：具体的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。它们被用作关于α4整联蛋白的各种疾病的治疗剂。

36. 发明申请

US20050200448A1 Platinum resistor temperature sensor 有权
标题翻译：铂电阻温度传感器
公开(公告)号：US20050200448A1
公开(公告)日：2005-09-15
申请号：US11074075
申请日：2005-03-08
申请人： Koichi Fujita , Masatoshi Ueki , Hitoshi Yokoi
发明人： Koichi Fujita , Masatoshi Ueki , Hitoshi Yokoi
IPC分类号： G01K7/18 , G01K13/02 , H01C3/04
CPC分类号： G01K7/18 , G01K13/02 , G01K2013/024 , G01K2205/04 , H01C7/006 , H01C7/008
摘要： A platinum temperature sensor incorporating an evaporation-suppressing layer containing platinum in the vicinity of the platinum thin-film resistor of the sensor. The evaporation-suppressing layer is preferably positioned between the platinum resistor and a porous layer that is formed close to the platinum resistor and in contact with the evaporation-suppressing layer.
摘要翻译：在传感器的铂薄膜电阻附近配有含有铂的蒸发抑制层的铂温度传感器。蒸发抑制层优选位于铂电阻器和靠近铂电阻器并与蒸发抑制层接触的多孔层之间。

37. 发明授权

US5451807A Metal oxide semiconductor field effect transistor 失效
标题翻译：金属氧化物半导体场效应晶体管
公开(公告)号：US5451807A
公开(公告)日：1995-09-19
申请号：US230226
申请日：1994-04-20
申请人： Koichi Fujita
发明人： Koichi Fujita
IPC分类号： H01L21/336 , H01L29/10 , H01L29/78 , H01L29/772
CPC分类号： H01L29/66659 , H01L29/1045 , H01L29/1083 , H01L29/7835
摘要： A field effect transistor includes a gate electrode disposed on a first conductivity type semiconductor substrate via an insulating film, a second conductivity type region having a first dopant impurity concentration region in the substrate at the drain side of the gate electrode contacting the insulating film, a second conductivity type region in the substrate having a higher dopant impurity concentration than the first dopant impurity concentration at the source side of the gate electrode contacting the insulating film, and a first conductivity type region in the substrate having a higher dopant impurity concentration than the substrate and surrounding the source region in the substrate. The ON-resistance of the transistor is reduced. The first conductivity type region improves the drain-source breakdown voltage, suppresses variations in the threshold voltage, and reduces the gate-source and gate-drain capacitances.
摘要翻译：场效应晶体管包括通过绝缘膜设置在第一导电类型半导体衬底上的栅电极，在与绝缘膜接触的栅电极的漏极侧的衬底中具有第一掺杂杂质浓度区域的第二导电类型区域，所述衬底中的第二导电类型区域具有比与所述绝缘膜接触的所述栅电极的源极侧的所述第一掺杂剂杂质浓度高的掺杂剂杂质浓度以及所述衬底中具有比所述衬底高的掺杂剂杂质浓度的第一导电类型区域并围绕衬底中的源极区域。晶体管的导通电阻降低。第一导电类型区域提高了漏极 - 源极击穿电压，抑制了阈值电压的变化，并且降低了栅极 - 源极和栅极 - 漏极电容。

38. 发明授权

US5135254A Vehicle air bag apparatus 失效
标题翻译：车用空气袋装置
公开(公告)号：US5135254A
公开(公告)日：1992-08-04
申请号：US686623
申请日：1991-04-18
申请人： Mitsuhiko Masegi , Akira Kondo , Masahito Mutoh , Koichi Fujita
发明人： Mitsuhiko Masegi , Akira Kondo , Masahito Mutoh , Koichi Fujita
IPC分类号： B60R21/16 , B60R21/01
CPC分类号： B60R21/017 , B60R21/0173
摘要： Air bags are located at different positions within a vehicle. Squibs serve to fire and activate the air bags respectively. An acceleration detecting device is provided in common to the squibs for detecting an acceleration of the vehicle upon a collision of the vehicle and executing a switching operation in response to the detected vehicle acceleration. Constant-current circuits supplied with an electric power from a vehicle battery feed constant electric currents for a firing operation to the squibs respectively in response to the switching operation of the acceleration detecting device. An energy storage device serves to feed a backup electric power to the constant-current circuits when the supply of the electric power from the vehicle battery is cut off. Each of the constant-current circuits includes a first transistor for feeding an electric current to the related squib, a first resistor for detecting a level of the electric current fed to the squib, a second transistor conducting an electric current with a level which depends on the electric current level detected by the first resistor, and a second resistor for generating a voltage which depends on the electric current conducted by the second transistor and for controlling the first transistor in response to the generated voltage.

39. 发明申请

US20130264648A1 PROTECTION DIODE 有权
标题翻译：保护二极管
公开(公告)号：US20130264648A1
公开(公告)日：2013-10-10
申请号：US13739042
申请日：2013-01-11
申请人： Koichi Fujita
发明人： Koichi Fujita
IPC分类号： H01L27/02
CPC分类号： H01L29/7808 , H01L27/0248 , H01L27/0255
摘要： A protection diode includes: a semiconductor substrate; a well region of a first conductivity type in the semiconductor substrate; a gate side diffusion region of a second conductivity type in the semiconductor substrate and joined to the well region; a grounding side diffusion region of the second conductivity type in the semiconductor substrate, separated from the gate side diffusion region, and joined to the well region; a gate side electrode connected between a gate of a transistor and the gate side diffusion region; and a grounding electrode connected to the grounding side diffusion region. Dopant impurity concentration in the grounding side diffusion region is lower than dopant impurity concentration in the gate side diffusion region.
摘要翻译：保护二极管包括：半导体衬底; 半导体衬底中的第一导电类型的阱区; 半导体衬底中的第二导电类型的栅极侧扩散区，并连接到阱区; 半导体衬底中的与栅极侧扩散区分离的第二导电类型的接地侧扩散区，并与阱区连接; 连接在晶体管的栅极和栅极侧扩散区之间的栅极电极; 以及与接地侧扩散区域连接的接地电极。接地侧扩散区域中的掺杂剂杂质浓度低于栅极侧扩散区域中的掺杂剂杂质浓度。

40. 发明授权

US08058432B2 Method for preparing phenylalanine derivatives having quinazoline-dione skeleton and intermediates for use in the preparation of derivatives 有权
标题翻译：制备具有喹唑啉二酮骨架的苯丙氨酸衍生物的方法和用于制备衍生物的中间体
公开(公告)号：US08058432B2
公开(公告)日：2011-11-15
申请号：US12470846
申请日：2009-05-22
申请人： Noriyasu Kataoka , Kotaro Okado , Tatsuhiro Yamada , Koichi Fujita , Tamotsu Suzuki , Tatsuya Okuzumi , Masayuki Sugiki , Akinori Tatara
发明人： Noriyasu Kataoka , Kotaro Okado , Tatsuhiro Yamada , Koichi Fujita , Tamotsu Suzuki , Tatsuya Okuzumi , Masayuki Sugiki , Akinori Tatara
IPC分类号： C07D239/96
CPC分类号： C07D239/96 , C07C233/47 , C07C233/87 , C07C237/40 , C07C237/42 , C07C265/12 , C07C271/22 , C07C271/28 , C07C275/42 , Y02P20/55
摘要： The present invention releates to a method for preparing a phenylalanine compound having a quinazoline-dione ring represented by the following formula (1) or a pharmaceutically acceptable salt thereof: where R1-R4 are defined herein. The method involves reacting a specified acyl phenylalanine compound with a carbonyl group-introducing reagent and a specified anthranilic acid compound to form a carboxy-asymmetric urea compound which is converted to a quinazoline-dione compound in the presence of a carboxyl group-activating agent.
摘要翻译：本发明涉及制备具有由下式（1）表示的喹唑啉二酮环的苯丙氨酸化合物或其药学上可接受的盐的方法：其中R1-R4如本文所定义。该方法包括使特定的酰基苯丙氨酸化合物与羰基引入试剂和特定的邻氨基苯甲酸化合物反应，形成羧基不对称脲化合物，其在羧基活化剂存在下转化为喹唑啉二酮化合物。

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