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    • 35. 发明授权
    • Preparation of terpyridines
    • 制备三联吡啶
    • US06784296B2
    • 2004-08-31
    • US10134626
    • 2002-04-30
    • Ralph LunkwitzGunther PabstGünter Scherr
    • Ralph LunkwitzGunther PabstGünter Scherr
    • C07D40102
    • C07D213/61
    • The present invention provides a process for preparing a terpyridine compound of the formula I by obtaining a C1-C4-alkyl pyridine-2-carboxylate derivative by acid hydrolysis of a 2-cyanopyridine derivative by means of an anhydrous inorganic acid or its anhydride in the presence of water and a C1-C4-alkanol, with an equimolar amount of water being added to the 2-cyanopyridine derivative prior to addition of the anhydrous inorganic acid or its anhydride, subsequently condensing the resultant C1-C4-alkyl pyridine-2-carboxylate derivative with acetone in an aprotic solvent in the presence of a base, then reacting the obtained 1,5-bis(2-pyridyl)pentane-1,3,5-trione derivative with ammonia or ammonium salts (NH4)qY with removal of the water of reaction formed by employing a C1-C4-alkanol as an entrainer, and finally chlorinating the resultant 2,6-bis(2-pyridyl)-4(1H)pyridinone derivative in the presence of phosphorus oxide chloride.
    • 本发明提供了通过在存在下通过无水无机酸或其酸酐水解2-氰基吡啶衍生物的方法获得C1-C4烷基吡啶-2-羧酸酯衍生物来制备式I的三联吡啶化合物的方法, 的水和C1-C4链烷醇,在加入无水无机酸或其酸酐之前,将等摩尔量的水加入到2-氰基吡啶衍生物中,随后将所得的C1-C4烷基吡啶-2-羧酸酯 衍生物与丙酮在非质子溶剂中在碱存在下反应,然后将所得的1,5-双(2-吡啶基)戊烷-1,3,5-三酮衍生物与氨或铵盐(NH 4)qY反应,除去 通过使用C1-C4链烷醇作为夹带剂形成的反应水,最后在磷酰氯的存在下氯化所得的2,6-双(2-吡啶基)-4(1H)吡啶酮衍生物。