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    • 32. 发明申请
    • Method for removing horn substances from animal skin
    • 从动物皮肤去除角质物质的方法
    • US20060037148A1
    • 2006-02-23
    • US10531167
    • 2003-10-14
    • Hans-George LemaireTilman TaegerGunther PabstPhilippe LamalleMichael BreuerBurkhard KrogerThomas Subkowski
    • Hans-George LemaireTilman TaegerGunther PabstPhilippe LamalleMichael BreuerBurkhard KrogerThomas Subkowski
    • C14C1/00
    • C14C1/065
    • The invention relates to a method for removing horn substances from animal skin. Said method is characterised in that animal skins are treated in an aqueous bath containing between 0.05 and 5 wt. %—in relation to the weight of the salt—of at least one compound of general formula I or the corresponding alkali metallic salts or alkaline-earth metallic salts thereof or ammonium or phosphonium salts, the variables having the following definitions: R1 is selected from hydrogen or C1-C12 alkyl, unsubstituted or substituted by at least one S—H group or one O—H group; X1 to X4 are the same or different and selected from hydrogen, C1-C4 alkyl, O—H, S—H or N—HR2; and R2 represents hydrogen or C1-C12 alkyl or a C1-C4-alkyl-C═O group, at least one X1 to X4 representing S—H. If R1 contains neither O—H nor S—H, at least one other X1 to X4 is selected from S—H, OH or NH—R2. Said aqueous bath also comprises at least one compound which catalyses the hydrolysis of peptide compounds.
    • 本发明涉及从动物皮肤去除角质物质的方法。 所述方法的特征在于动物皮肤在含有0.05至5wt。 % - 与至少一种通式I化合物或其相应的碱金属盐或碱土金属盐或铵盐或鏻盐的盐的重量相关,所述变量具有以下定义:R 1选自 氢或C1-C12烷基,未被取代或被至少一个SH基团或一个OH基团取代; X 1〜X 4相同或不同,选自氢,C 1 -C 4烷基,O-H,S-H或N-HR 2; 并且R 2表示氢或C 1 -C 12烷基或C 1 -C 4烷基-C 0基团,至少一个表示S-H的X 1至X 4。 如果R 1既不含O-H也不包含S-H,则至少一个其它的X 1至X 4选自S-H,OH或NH-R 2。 所述水浴还包含至少一种催化肽化合物水解的化合物。
    • 34. 发明授权
    • Method for producing optically active alcohols using an Azoarcus sp. EbN1 dehydrogenase
    • 使用Azoarcus sp。制备光学活性醇的方法 EbN1脱氢酶
    • US08338146B2
    • 2012-12-25
    • US12665383
    • 2008-06-16
    • Michael BreuerRalf RabusJohann Heider
    • Michael BreuerRalf RabusJohann Heider
    • C12P7/02
    • C12P7/02
    • A process for preparing optically active alcohols of the formula Ia or Ib in which R1,R2 are alkyl, alkenyl, aryl, or alkylaryl groups which may in turn be substituted one or more times by alkyl, halogen, SH, SR2, OH, OR2, NO2, CN, CO, COOR2, NR2R3 or NR2R3R4+X, where R2, R3 and R4 are independently of one another H or a lower alkyl or lower alkoxy radical, and X−is a counter ion, with the proviso that R1 is not equal to R2, by reducing the corresponding ketone, where the reduction is carried out with a dehydrogenase having the polypeptide sequence of SEQ ID NO: 2 or NO: 4, or with a polypeptide sequence in which up to 25% of the amino acid residues are altered by comparison with SEQ ID NO: 2 or NO: 4 by deletion, insertion, substitution or a combination thereof.
    • 制备式Ia或Ib的光学活性醇的方法,其中R1,R2是烷基,烯基,芳基或烷基芳基,其又可以被烷基,卤素,SH,SR2,OH,OR2取代一次或多次 ,NO 2,CN,CO,COOR 2,NR 2 R 3或NR 2 R 3 R 4 + X,其中R 2,R 3和R 4彼此独立地为H或低级烷基或低级烷氧基,X为抗衡离子,条件是R 1为 通过还原相应的酮,其中还原是用具有SEQ ID NO:2或NO:4的多肽序列的脱氢酶,或多肽序列,其中多达25%的氨基酸 通过与SEQ ID NO:2或NO:4的比较,通过缺失,插入,取代或其组合来改变残基。