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31. 发明授权

US5364788A Pure culture of Bacillus subtilis FERM BP-3418 失效
标题翻译：枯草芽孢杆菌FERM BP-3418的纯培养物
公开(公告)号：US5364788A
公开(公告)日：1994-11-15
申请号：US906460
申请日：1992-06-30
申请人： Kazuhiro Kubo
发明人： Kazuhiro Kubo
IPC分类号： A01N63/00 , A23K1/00 , A23K1/18 , A01N25/00 , A01N25/34 , C12N1/20
CPC分类号： C12R1/10 , A01N63/00 , A23K10/18 , A23K50/30 , C12R1/125 , Y10S426/807 , Y10S435/822 , Y10S435/839
摘要： A bacterium belonging to Bacillus subtilis. The bacterium being identified as Bacillus subtilis FERM BP-3418. In addition the bacterium possesses the capability of decomposing aflatoxin. It is useful as an active ingredient in products such as a fungal growth inhibitor, fermentation promoter, and livestock fattening agent.
摘要翻译：属于枯草芽孢杆菌的细菌。该细菌被鉴定为枯草芽孢杆菌FERM BP-3418。此外，细菌具有分解黄曲霉毒素的能力。作为真菌生长抑制剂，发酵促进剂和家畜育肥剂等产品中的活性成分是有用的。

32. 发明授权

US5068236A Xanthine derivatives 失效
标题翻译： XANTHINE DERIVATIVES
公开(公告)号：US5068236A
公开(公告)日：1991-11-26
申请号：US486831
申请日：1990-03-01
申请人： Fumio Suzuki , Junichi Shimada , Kazuhiro Kubo , Tetsuji Ohno , Akira Karasawa , Akio Ishii , Hiromi Nonaka
发明人： Fumio Suzuki , Junichi Shimada , Kazuhiro Kubo , Tetsuji Ohno , Akira Karasawa , Akio Ishii , Hiromi Nonaka
IPC分类号： A61K31/52 , A61K31/522 , A61P7/10 , A61P9/08 , A61P9/12 , A61P13/02 , A61P15/00 , C07D473/04 , C07D473/06 , C07D473/08 , C07D473/10 , C07D473/12 , C07D473/20 , C07D473/22
CPC分类号： C07D473/04 , C07D473/06 , C07D473/22
摘要： Novel xanthine compounds represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have a diuretic action, a renal-protecting action and a vasodilative action.The compounds are useful as a diuretic, a renal-protecting agent and an antihypertensive agent.

33. 发明授权

US4962107A Agent for cerebral protection 失效
标题翻译：脑保护剂
公开(公告)号：US4962107A
公开(公告)日：1990-10-09
申请号：US321692
申请日：1989-03-10
申请人： Joji Nakamura , Kazuhiro Kubo , Shunji Ichikawa , Hajime Takahashi , Keisuke Isozumi , Toyofumi Yamada
发明人： Joji Nakamura , Kazuhiro Kubo , Shunji Ichikawa , Hajime Takahashi , Keisuke Isozumi , Toyofumi Yamada
IPC分类号： A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/54 , A61P25/28 , C07D211/16 , C07D211/22 , C07D211/46 , C07D265/30 , C07D265/32 , C07D279/12 , C07D295/18 , C07D295/185
CPC分类号： C07D265/30 , C07D211/16 , C07D211/22 , C07D279/12 , C07D295/185
摘要： Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl;R.sub.1 is hydrogen, halogen or trifluoromethyl;R.sub.2 is hydrogen methyl or hydroxymethyl;R.sub.3 is hydrogen or lower alkyl; andY is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia.The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.

34. 发明申请

US20090202619A1 POLYOXYALKYLENE CHAIN-CONTAINING LIPID DERIVATIVE AND LIPID FILM STRUCTURE CONTAINING SUCH DERIVATIVE 审中-公开
标题翻译：含有这种衍生物的聚氧乙烯链脂质衍生物和脂质膜结构
公开(公告)号：US20090202619A1
公开(公告)日：2009-08-13
申请号：US11816680
申请日：2006-02-17
申请人： Hiroshi Kiwada , Tatsuhiro Ishida , Chika Ito , Kazuhiro Kubo , Kenji Sakanoue , Hiroshi Kikuchi
发明人： Hiroshi Kiwada , Tatsuhiro Ishida , Chika Ito , Kazuhiro Kubo , Kenji Sakanoue , Hiroshi Kikuchi
IPC分类号： A61K9/127 , C07F9/02 , A61K47/18
CPC分类号： C07K7/06 , A61K9/1271 , A61K47/60 , A61K47/62 , C07K5/0806 , C07K5/1008
摘要： A polyoxyalkylene chain-containing lipid derivative, which is represented by the following formula (1): wherein L, Y, W, X1, X2, X3, OA, Z, m1, m2, m3, n1, n2 and n3 are as defined in the specification.
摘要翻译：由下式（1）表示的含有聚氧化烯链的脂质衍生物：其中L，Y，W，X1，X2，X3，OA，Z，m1，m2，m3，n1，n2和n3如上所定义在规范中。

35. 发明申请

US20070031481A1 Phospolipid derivative 有权
标题翻译：磷脂衍生物
公开(公告)号：US20070031481A1
公开(公告)日：2007-02-08
申请号：US10549630
申请日：2004-03-19
申请人： Chika Itoh , Syunsuke Ohhashi , Kazuhiro Kubo , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
发明人： Chika Itoh , Syunsuke Ohhashi , Kazuhiro Kubo , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
IPC分类号： A61K9/127 , A61K31/685 , C07F9/02
CPC分类号： A61K9/127 , C07F9/10 , C11D1/345
摘要： A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5≦m≦600, 1≦n≦45, 0≦q≦200, 10≦m+n+q≦600, 0.04≦n/(m+n+q), and q/(m+n+q)≦0.8, which can thicken the water shell of liposome surface by suppressing the spreading of the polyalkylene oxide structure on the surface and thus increase stability of the liposome.
摘要翻译：由下式（I）表示的磷脂衍生物，其中R 1 CO和R 2 CO独立地表示酰基; R 3表示氢原子或烃基; 符号“a”表示0〜4的整数，符号“b”表示0或1，条件是当a为0时，b为0; X表示氢原子，碱金属原子，铵或有机铵; A 1 O和A 3 O表示含氧化乙烯基的氧化烯基，其中A 1 O 3中的氧乙烯基与氧化烯基的比例 O和A 3 O以重量比计为0.5以上; O 2表示氧化烯基; 符号“m”和“q”表示加成的氧化烯基团的平均摩尔数; 符号“n”表示加成的氧化烯基的平均摩尔数; 条件是m，n和q满足以下条件：5 <= m <= 600,1 <= n <= 45,0 <= q <= 200,10 <= m + n + q <= 600,0.04 < = n /（m + n + q）和q /（m + n + q）<= 0.8，这可以通过抑制聚环氧烷结构在表面上的扩散而增加脂质体表面的水壳，从而增加稳定性的脂质体。

36. 发明申请

US20050220856A1 Phospholipid derivative 有权
标题翻译：磷脂衍生物
公开(公告)号：US20050220856A1
公开(公告)日：2005-10-06
申请号：US10508704
申请日：2003-03-28
申请人： Chika Itoh , Kazuhiro Kubo , Syunsuke Ohhashi , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Kurosawa , Hitoshi Yamauchi
发明人： Chika Itoh , Kazuhiro Kubo , Syunsuke Ohhashi , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Kurosawa , Hitoshi Yamauchi
IPC分类号： A61K8/14 , A61K8/55 , A61K8/86 , A61K9/127 , A61P35/00 , A61Q19/00 , C07F9/10 , C08G65/26 , C08G65/335 , C07F9/02
CPC分类号： A61K47/24 , A61K8/14 , A61K8/553 , A61K8/556 , A61K8/86 , A61K9/1271 , A61Q19/00 , C07F9/10 , C08G65/2609 , C08G65/3353
摘要： A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3≦m≦200, 9≦m×(k1+k2+k3)≦1000, 1≦k1≦2, 0≦k2≦9 and 0≦k3≦9, and 3≦k1+k2+k3≦10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.
摘要翻译：由式（1）表示的磷脂衍生物（Z表示具有3〜10个羟基的化合物的残基; AO表示碳原子数2〜4的氧化烯基，R 1，CO， SO 2表示碳原子数为8〜22的酰基，X表示氢原子，碱金属原子，铵或有机铵，“a”表示0〜4的整数，“b”表示 0或1; Q表示氢原子或甲基; m表示加入的氧化烯基的平均摩尔数; m，k1，k2和k3为满足以下条件的数：3 <= m <= 200,9 <= mx（k1 + k2 + k3）<= 1000,1 <= k1 <= 2,0 <= k2 <= 9，0 <= k3 = 9，3 <= k1 + k2 + k3 = 10 ），其对于活体是高度安全的，并且适合用于生理活性物质等的溶解和分散，或者在药物递送系统如脂质体和化妆品领域中。

37. 发明授权

US06875841B2 Polyoxyalkylene derivative and process of producing the same 有权
标题翻译：聚氧化烯衍生物及其制备方法
公开(公告)号：US06875841B2
公开(公告)日：2005-04-05
申请号：US10206955
申请日：2002-07-30
申请人： Kenji Sakanoue , Kazuhiro Kubo , Syunsuke Ohashi , Chika Itoh
发明人： Kenji Sakanoue , Kazuhiro Kubo , Syunsuke Ohashi , Chika Itoh
IPC分类号： A61K47/48 , C08G65/22 , C08G65/325 , C08G65/329 , C08G65/332 , C08G65/333 , C08G65/34
CPC分类号： C08G65/33337 , A61K47/60 , C08G65/3255 , C08G65/329 , C08G65/3324 , C08G65/33303
摘要： A polyoxyalkylene derivative is represented by formula (I): wherein Z represents a residue of a compound having 2 to 8 hydroxyl groups; AO represents an oxyalkylene group having 2 to 18 carbon atoms; n and m each represent an integer of 0 to 2000 provided that both n and m do not represent 0; a and b each represent an integer satisfying the relationships: 2≦a+b≦8 and 1≦b; R represents a hydrocarbon group having 1 to 30 carbon atoms; and X represents a divalent hydrocarbon group having 3 to 10 carbon atoms.
摘要翻译：聚氧化烯衍生物由式（I）表示：其中Z表示具有2-8个羟基的化合物的残基; AO表示碳原子数2〜18的氧化烯基， n和m各自表示0〜2000的整数，条件是n和m都不表示0; a和b各自表示满足以下关系的整数：2 <= a + b <= 8和1 <= b; R表示碳原子数1〜30的烃基; X表示碳原子数3〜10的二价烃基。

38. 发明授权

US06679822B2 Polyalkylene oxide-modified phospholipid and production method thereof 有权
标题翻译：聚环氧烷改性磷脂及其制备方法
公开(公告)号：US06679822B2
公开(公告)日：2004-01-20
申请号：US10086430
申请日：2002-03-04
申请人： Kazuhiro Kubo , Chika Itoh , Syunsuke Ohhashi , Tohru Yasukohchi
发明人： Kazuhiro Kubo , Chika Itoh , Syunsuke Ohhashi , Tohru Yasukohchi
IPC分类号： C07F902
CPC分类号： C07F9/10 , A61K8/14 , A61K8/86 , A61Q19/00 , C08G65/3356
摘要： A polyalkylene oxide-modified phospholipid represented by formula (1) defined in the specification, has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight.
摘要翻译：由说明书中定义的式（1）表示的聚环氧烷改性磷脂的单酰基磷脂含量不超过3重量％，氮原子含量不大于0.02重量％。

39. 发明授权

US5290782A Xanthine derivatives 失效
标题翻译：黄嘌呤衍生物
公开(公告)号：US5290782A
公开(公告)日：1994-03-01
申请号：US839690
申请日：1992-02-24
申请人： Fumio Suzuki , Junichi Shimada , Akio Ishii , Tetsuji Ohno , Akira Karasawa , Kazuhiro Kubo , Hiromi Nonaka
发明人： Fumio Suzuki , Junichi Shimada , Akio Ishii , Tetsuji Ohno , Akira Karasawa , Kazuhiro Kubo , Hiromi Nonaka
IPC分类号： C07D473/06 , C07D473/08 , C07D473/20 , C07D473/22 , C07D473/02 , A61K31/52
CPC分类号： C07D473/06 , C07D473/08 , C07D473/20 , C07D473/22
摘要： Novel xanthine compounds represented by the following formula: ##STR1## wherein each of X.sup.1 and X.sup.2 independently represents oxygen or sulfur; and Q represents; ##STR2## where ----- represents a single bond or a double bond; Y represents a single bond or alkylene, n represents 0 or 1, each of W.sup.1 and W.sup.2 independently represents hydrogen, lower alkyl or amino, Z represents --CH.sub.2 -, --O--, --S-- or --NH--; represents ##STR3## each of R.sup.1 and R.sup.2 independently represents hydrogen, lower alkyl, allyl or propargyl; and R.sup.3 represents hydrogen or lower alkyl, and when Q represents the groups other than ##STR4## each of R.sup.1, R.sup.2 and R.sup.3 independently represents hydrogen or lower alkyl;provided that when Q is ##STR5## then R.sup.1 R.sup.2 and R.sup.3 are notsimultaneously methyl; and pharmaceutically acceptable salts thereof have a diuretic effect, a renal-protecting effect and a bronchodilatory effect.
摘要翻译：由下式表示的新型黄嘌呤化合物：其中X1和X2各自独立地表示氧或硫; 和Q表示; 其中-----表示单键或双键; Y表示单键或亚烷基，n表示0或1，W1和W2各自独立地表示氢，低级烷基或氨基，Z表示-CH2 - ， - O - ， - S-或-NH-。 R1和R2各自表示氢，低级烷基，烯丙基或炔丙基; 且R 3表示氢或低级烷基，并且当Q表示除R1之外的基团时，R 1，R 2和R 3各自独立地表示氢或低级烷基; 条件是当Q为时，则R1 + L，R2和R3不同时为甲基; 及其药学上可接受的盐具有利尿作用，肾脏保护作用和支气管扩张作用。

40. 发明授权

US5270316A Condensed purine derivatives 失效
标题翻译：凝血嘌呤衍生物
公开(公告)号：US5270316A
公开(公告)日：1993-12-14
申请号：US599758
申请日：1990-10-19
申请人： Fumio Suzuki , Junichi Shimada , Takeshi Kuroda , Kazuhiro Kubo , Akira Karasawa , Tetsuji Ohno , Kenji Ohmori
发明人： Fumio Suzuki , Junichi Shimada , Takeshi Kuroda , Kazuhiro Kubo , Akira Karasawa , Tetsuji Ohno , Kenji Ohmori
IPC分类号： A61K31/00 , A61K31/495 , A61K31/505 , A61K31/519 , A61K31/529 , A61P7/00 , A61P7/10 , A61P9/00 , A61P9/12 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/00 , A61P13/02 , A61P13/12 , A61P15/00 , C07D471/14 , C07D487/14 , A61K31/52
CPC分类号： C07D471/14 , C07D487/14
摘要： There are disclosed condensed purine derivatives represented by formula; ##STR1## in which R.sup.3 represents hydrogen, lower alkyl or benzyl; each of X.sup.1 and X.sup.2 independently represents hydrogen, lower alkyl, aralkyl or phenyl; and n is an integer of 0 or 1; R.sup.1 represents hydrogen, lower alkyl, alicyclic alkyl, noradamantan-3-yl, dicyclopropylmethyl or styryl; and R.sup.2 represents hydrogen, lower alkyl or alicyclic alkyl; or a pharmaceutically acceptable salt thereof. The derivatives and pharmaceutically acceptable salts are useful as diuretics, renal protecting agents, antiallergic agents and hypotensives.

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