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31. 发明授权

US06535762B1 Combination ICD and pacemaker system having integrated distal electrode 失效
标题翻译：组合ICD和具有集成远端电极的起搏器系统
公开(公告)号：US06535762B1
公开(公告)日：2003-03-18
申请号：US09256902
申请日：1999-02-24
申请人： Gabriel A. Mouchawar
发明人： Gabriel A. Mouchawar
IPC分类号： A61N1362
CPC分类号： A61N1/056
摘要： The implantable cardiac stimulation system is adapted to transmit both shocking and pacing signals using a single electrode lead. The single biocompatible electrode, located at the distal end of the lead, includes a coil for shocking purposes and is in electrical continuity with an end cap which engages with the body tissue in a chamber of the patient's heart. The system delivers shocking, pacing and sensing signals between the single electrode and the enclosure for the ICD. Being of the same diameter as the electrical lead, the end cap preferably has a porous outer surface with an irregular relatively large surface area and an outer diameter substantially the same as that of the electrical lead.
摘要翻译：可植入心脏刺激系统适用于使用单个电极引线传输震动和起搏信号。单个生物相容性电极位于引线的远端，包括用于令人震惊的目的的线圈，并且与端帽电连接，端盖与患者心脏的腔室中的身体组织接合。该系统在单个电极和ICD的外壳之间提供惊人的起搏和感应信号。具有与电引线相同的直径，端盖优选具有多孔外表面，具有不规则的相对大的表面积和与电引线基本上相同的外径。

32. 发明授权

US08620446B2 Systems and methods for remote monitoring of signals sensed by an implantable medical device during an MRI 有权
标题翻译：用于在MRI期间远程监测由可植入医疗装置感测的信号的系统和方法
公开(公告)号：US08620446B2
公开(公告)日：2013-12-31
申请号：US13471018
申请日：2012-05-14
申请人： Xiaoyi Min , Gabriel A. Mouchawar
发明人： Xiaoyi Min , Gabriel A. Mouchawar
IPC分类号： A61N1/08
CPC分类号： A61N1/3718 , A61B5/0031 , A61B5/02028 , A61B5/02055 , A61B5/0422 , A61B5/686 , A61B5/7203
摘要： Systems and methods are provided for allowing an implantable medical device, such as pacemaker, to properly sense electrophysiological signals and hemodynamic signals within a patient during a magnetic resonance imaging (MRI) procedure. Systems and methods are also provided for allowing the implantable medical device to transmit the sensed data to an external monitoring system during the MRI procedure so that attending medical personnel can closely monitor the health of the patient and the operation of the implantable device during the MRI. These improvements provide the attending personnel with information needed to determine whether the MRI should be suspended in response to induced tachyarrhythmias or other adverse conditions within the patient.
摘要翻译：提供了系统和方法，用于允许诸如起搏器的可植入医疗装置在磁共振成像（MRI）程序期间适当地感测患者内的电生理信号和血液动力学信号。还提供了系统和方法，以允许可植入医疗设备在MRI过程期间将感测到的数据传送到外部监视系统，使得参加医务人员可以在MRI期间密切监视患者的健康状况和可植入装置的操作。这些改进为主管人员提供了确定是否应该根据感染性快速性心律失常或患者其他不良情况暂停MRI的信息。

33. 发明授权

US08200334B1 Systems and methods for remote monitoring of signals sensed by an implantable medical device during an MRI 有权
标题翻译：用于在MRI期间远程监测由可植入医疗装置感测的信号的系统和方法
公开(公告)号：US08200334B1
公开(公告)日：2012-06-12
申请号：US11938088
申请日：2007-11-09
申请人： Xiaoyi Min , Gabriel A. Mouchawar
发明人： Xiaoyi Min , Gabriel A. Mouchawar
IPC分类号： A61N1/08
CPC分类号： A61N1/3718 , A61B5/0031 , A61B5/02028 , A61B5/02055 , A61B5/0422 , A61B5/686 , A61B5/7203
摘要： Systems and methods are provided for allowing an implantable medical device, such as pacemaker, to properly sense electrophysiological signals and hemodynamic signals within a patient during a magnetic resonance imaging (MRI) procedure. Systems and methods are also provided for allowing the implantable medical device to transmit the sensed data to an external monitoring system during the MRI procedure so that attending medical personnel can closely monitor the health of the patient and the operation of the implantable device during the MRI. These improvements provide the attending personnel with information needed to determine whether the MRI should be suspended in response to induced tachyarrhythmias or other adverse conditions within the patient.
摘要翻译：提供了系统和方法，用于允许诸如起搏器的可植入医疗装置在磁共振成像（MRI）程序期间适当地感测患者内的电生理信号和血液动力学信号。还提供了系统和方法，以允许可植入医疗设备在MRI过程期间将感测到的数据传送到外部监视系统，使得参加医务人员可以在MRI期间密切监视患者的健康状况和可植入装置的操作。这些改进为主管人员提供了确定是否应该根据感染性快速性心律失常或患者其他不良情况暂停MRI的信息。

34. 发明授权

US07139604B1 Cardiac stimulation system and method for discriminating sinus from non-sinus events 有权
标题翻译：心脏刺激系统和方法用于区分窦性与非窦性事件
公开(公告)号：US07139604B1
公开(公告)日：2006-11-21
申请号：US10113263
申请日：2002-03-28
申请人： Nabil A. Mouchawar , Elia Arambula Mouchawar , Gabriel A. Mouchawar
发明人： Nabil A. Mouchawar , Elia Arambula Mouchawar , Gabriel A. Mouchawar
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0456 , A61B5/0468 , A61B5/7203 , A61N1/3621 , A61N1/3624 , A61N1/3688
摘要： A cardiac stimulation device and method discriminates sinus events from non-sinus events and provide a uniquely prescribed response upon detection of a specific event.
摘要翻译：心脏刺激装置和方法鉴别窦性事件与非窦性事件并且在检测到特定事件时提供唯一规定的响应。

35. 发明授权

US07065403B1 System and method for measuring lead impedance in an implantable stimulation device employing pulse-train waveforms 失效
标题翻译：用于测量采用脉冲波形的可植入刺激装置中的引线阻抗的系统和方法
公开(公告)号：US07065403B1
公开(公告)日：2006-06-20
申请号：US10306502
申请日：2002-11-26
申请人： Gabriel A. Mouchawar , Jorge N. Amely-Velez , Steven W. Badelt
发明人： Gabriel A. Mouchawar , Jorge N. Amely-Velez , Steven W. Badelt
IPC分类号： A61N1/36
CPC分类号： A61N1/3931 , A61N2001/083
摘要： A leakage detection system for use in an implantable cardiac stimulation device, such as a cardioverter defibrillator. The leakage detection system includes a switch bank and a controller that regulates the switching arrangements of various switches. The leakage detection system causes pulse generators to generate a pulse-train waveform comprised of a sequence of pulses of opposite polarities, and to deliver these pulses in a preselected temporal relation. The controller detects the current leakage from the pulse generator to the tissues by sensing and analyzing the voltage or current of the pulse generator, leads, and electrodes. The pulsatility and alternating polarities of biphasic pulse-train waveforms increase the stimulation threshold of the motor or sensory nerves and excitable tissues.
摘要翻译：一种用于可植入心脏刺激装置（例如心律转复除颤器）的泄漏检测系统。泄漏检测系统包括开关组和调节各种开关的开关装置的控制器。泄漏检测系统使得脉冲发生器产生由相反极性的脉冲序列组成的脉冲串波形，并将这些脉冲递送到预选的时间关系。控制器通过感测和分析脉冲发生器，引线和电极的电压或电流来检测从脉冲发生器到组织的电流泄漏。双相脉冲串波形的脉动和交替极性增加了马达或感觉神经和可兴奋组织的刺激阈值。

36. 发明授权

US06671548B1 Implantable stimulation device and method for discrimination atrial and ventricular arrhythmias 失效
标题翻译：植入式刺激装置及鉴别心房和室性心律失常的方法
公开(公告)号：US06671548B1
公开(公告)日：2003-12-30
申请号：US09651287
申请日：2000-08-30
申请人： Gabriel A. Mouchawar , Anne M. Street , Steven W. Badelt
发明人： Gabriel A. Mouchawar , Anne M. Street , Steven W. Badelt
IPC分类号： A61N1362
CPC分类号： A61N1/3622
摘要： By redistributing the running totals for various preliminary classifications to other preliminary classifications based upon the values of the most recent cardiac events, the present invention biases the running totals (thereby biasing the duration criteria) to help overcome common discrimination problems which permits the stimulation device to make a correct and final therapy decision more quickly. To identify a patient's heart rhythm, various electrical events such as P-waves and R-waves, and their timing, relationship, and stability, are detected and a preliminary classification is made for each detected event. Running totals of the numbers of all events detected within each of the preliminary classifications are maintained, along with sliding totals covering only the most recently detected events. Then, the arrhythmia is identified based upon an analysis of both the running totals and the sliding totals. In a preferred embodiment, the arrhythmia is identified by first determining whether the sliding total of the number of detected events in any one of the preliminary classifications exceeds a corresponding sliding total threshold. If so, the running totals are then selectively redistributed based upon the sliding totals. The final decision is then made based upon whether the running total corresponding to any one of the preliminary classifications exceeds a corresponding running total threshold. Both method and apparatus embodiments are disclosed. Methods are further described for determining the preliminary classifications of the detected events.
摘要翻译：通过基于最近的心脏事件的值将用于各种初步分类的运行总计重新分配到其他初步分类，本发明偏倚运行总计（从而偏置持续时间标准）来帮助克服常见的辨别问题，其允许刺激装置更快地做出正确和最终的治疗决定。为了识别患者的心律，检测各种电气事件，例如P波和R波，及其时间，关系和稳定性，并对每个检测到的事件进行初步分类。保持在每个初步分类中检测到的所有事件的数量的总计，以及仅覆盖最近检测到的事件的滑动总计。然后，基于对总计和滑动总数的分析来确定心律失常。在优选实施例中，通过首先确定任何一个初步分类中的检测到的事件的数量的滑动总数是否超过相应的滑动总阈值来识别心律失常。如果是这样，则基于滑动总计选择性地重新分配运行总计。然后根据对应于任何一个初步分类的运行总计是否超过相应的运行总阈值来作出最终决定。公开了方法和装置实施例。进一步描述用于确定检测到的事件的初步分类的方法。

37. 发明授权

US09048541B2 Inverted E antenna with capacitance loading for use with an implantable medical device 有权
标题翻译：具有电容负载的倒置E天线，用于可植入医疗设备
公开(公告)号：US09048541B2
公开(公告)日：2015-06-02
申请号：US13538501
申请日：2012-06-29
申请人： Perry Li , Gabriel A. Mouchawar , Jorge Amely-Velez , Reza Imani
发明人： Perry Li , Gabriel A. Mouchawar , Jorge Amely-Velez , Reza Imani
IPC分类号： H01Q1/12 , H01Q1/36 , H01Q1/24 , H01Q1/27 , H01Q1/22 , H01Q9/42 , A61N1/372
CPC分类号： H01Q1/36 , A61N1/37229 , H01Q1/22 , H01Q1/24 , H01Q1/273 , H01Q9/42
摘要： The device includes radio frequency (RF) communication components installed within a case of the device and an antenna with an inverted E shape mounted within a header of the device. The antenna has three branches extending from a main horizontal arm: a capacitive branch connecting one end of the main arm to the case via a capacitive load; an RF signal feed branch connecting a middle portion of the main arm to the internal RF components of the device via a feedthrough; and an inductive branch connecting the opposing (far) end of the main arm to the case to provide a shunt to ground. The E-shaped configuration and the provision of capacitive loading allows for cancellation of inductance to bring the antenna into resonance and to provide optimal radiation efficiency as well as to provide for impedance with no reactive component.
摘要翻译：该装置包括安装在装置的壳体内的射频（RF）通信部件和安装在装置的头部内的具有倒置E形状的天线。天线具有从主水平臂延伸的三个分支：通过电容性负载将主臂的一端连接到外壳的电容分支; RF信号馈送支路，通过馈通将主臂的中间部分连接到装置的内部RF部件; 以及将主臂的相对（远）端连接到壳体以将接地分流连接的感应支路。 E形配置和电容负载的提供允许消除电感以使天线谐振并且提供最佳的辐射效率以及提供没有无功元件的阻抗。

38. 发明授权

US09008777B2 Leadless intra-cardiac medical device with reduced number of feed-thrus 有权
标题翻译：无铅心脏内心脏医疗器械，饲料数量减少
公开(公告)号：US09008777B2
公开(公告)日：2015-04-14
申请号：US13529226
申请日：2012-06-21
申请人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
发明人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
IPC分类号： A61N1/00 , A61N1/375 , A61N1/368
CPC分类号： A61N1/3756 , A61B5/042 , A61N1/362 , A61N1/368 , Y10T29/49002
摘要： A leadless implantable medical device (LIMD) includes a housing formed from a battery and an end cap. A proximal end of the end cap forms an LIMD proximal end and a distal end of the battery case forms an LIMD distal end. A non-conductive coupler mechanically secures a terminal end of the battery case to a mating end of the end cap, while maintaining the battery case and end cap electrically separated. A first electrode projects from the proximal end of the end cap. An intra-cardiac (IC) device extension projects from the distal end of the battery case. The extension includes a second electrode that is electrically connected to the battery case. The second electrode is located remote from the LIMD distal end. An electronics module is located within an internal cavity of the end cap and communicates with the first and second electrodes.
摘要翻译：无引线植入式医疗装置（LIMD）包括由电池和端盖形成的壳体。端盖的近端形成LIMD近端，并且电池壳体的远端形成LIMD远端。非导电耦合器将电池壳体的终端机械地固定到端盖的配合端，同时保持电池壳体和端盖电气分离。第一电极从端盖的近端突出。心脏内（IC）装置延伸部从电池盒的远端伸出。该延伸部包括电连接到电池壳体的第二电极。第二电极远离LIMD远端。电子模块位于端盖的内部空腔内并与第一和第二电极连通。

39. 发明授权

US08996110B2 System and method for determining cause of irregularity within physiologic data 有权
标题翻译：用于确定生理数据中不规则因素的系统和方法
公开(公告)号：US08996110B2
公开(公告)日：2015-03-31
申请号：US13537714
申请日：2012-06-29
申请人： Shiloh Sison , Gabriel A. Mouchawar
发明人： Shiloh Sison , Gabriel A. Mouchawar
IPC分类号： A61B5/11 , A61B5/00 , A61B5/0402 , A61N1/365 , A61N1/37 , A61B5/042
CPC分类号： A61B5/721 , A61B5/0006 , A61B5/0402 , A61B5/042 , A61B5/1116 , A61B5/686 , A61B5/7246 , A61B2560/0223 , A61B2562/0219 , A61N1/365 , A61N1/36535 , A61N1/36542 , A61N1/3702
摘要： A method for determining the cause of an irregularity in physiologic data collected by a medical device may include monitoring a collected physiologic characteristic of a patient through the physiologic data, detecting an irregularity in the physiologic data, monitoring position data of the patient, correlating the physiologic data with the position data, and determining the cause of the irregularity in the physiologic data based on correlation of the physiologic data with the position data.
摘要翻译：用于确定由医疗装置收集的生理数据的不规则性的原因的方法可以包括通过生理数据监测患者的收集的生理特征，检测生理数据的不规则性，监测患者的位置数据，将生理学数据与位置数据，并根据生理数据与位置数据的相关性确定生理数据不规则的原因。

40. 发明授权

US08634912B2 Dual-chamber leadless intra-cardiac medical device with intra-cardiac extension 有权
标题翻译：具有心脏扩张的双室无引导心脏内心脏医疗器械
公开(公告)号：US08634912B2
公开(公告)日：2014-01-21
申请号：US13352136
申请日：2012-01-17
申请人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
发明人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/057 , A61N1/0573 , A61N1/3622 , A61N1/368 , A61N1/3684 , A61N1/3688 , A61N1/3756
摘要： A leadless intra-cardiac medical device includes a housing that is configured to be implanted entirely within a single local chamber of the heart. A first electrode is provided on the housing at a first position such that when the housing is implanted in the local chamber, the first electrode engages the local wall tissue at a local activation site within the conduction network of the local chamber. An intra-cardiac extension is coupled to the housing and configured to extend from the local chamber into an adjacent chamber of the heart. A stabilization arm of the intra-cardiac extension engages the adjacent chamber. A second electrode on the intra-cardiac extension engages distal wall tissue at a distal activation site within the conduction network of the adjacent chamber.
摘要翻译：无引线心脏内心脏医疗设备包括被配置为完全植入心脏的单个局部腔室内的壳体。第一电极在第一位置处设置在壳体上，使得当壳体被植入局部腔室时，第一电极在局部腔室的传导网络内的局部激活位置接合局部壁组织。心脏内延伸部分耦合到壳体并且构造成从局部腔室延伸到心脏的相邻室中。心脏内延伸部的稳定臂与相邻的腔室相接合。心脏延伸部分上的第二个电极与相邻腔室的传导网络内的远端活化位点处的远端壁组织接合。

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