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31. 发明申请

US20080188900A1 HEART RATE REDUCTION METHOD AND SYSTEM 审中-公开
标题翻译：心率降低方法和系统
公开(公告)号：US20080188900A1
公开(公告)日：2008-08-07
申请号：US11962966
申请日：2007-12-21
申请人： Howard Levin , Mark Gelfand
发明人： Howard Levin , Mark Gelfand
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/3621
摘要： A method and apparatus to slow a heart rate with subthreshold electric stimulation of the SA node. Stimulation is applied at a specific time in the cardiac cycle and at a specific subthreshold level. To control the heart rate, the stimulating signal may be modified automatically based on physiologic feedbacks. Stimulation may be applied using an implantable pulse generator directly to the SA node of the heart.
摘要翻译：一种通过SA节点的亚阈值电刺激来减慢心率的方法和装置。在心脏周期和特定亚阈值水平的特定时间施加刺激。为了控制心率，刺激信号可以根据生理反馈自动修改。刺激可以使用可植入脉冲发生器直接应用于心脏的SA节点。

32. 发明申请

US20080045877A1 BLOOD EXCHANGE DIALYSIS METHOD AND APPARATUS 审中-公开
标题翻译：血液交换透析法和装置
公开(公告)号：US20080045877A1
公开(公告)日：2008-02-21
申请号：US11839305
申请日：2007-08-15
申请人： Howard Levin , Mark Gelfand
发明人： Howard Levin , Mark Gelfand
IPC分类号： A61M1/36
CPC分类号： A61M1/342 , A61M1/02 , A61M1/16 , A61M1/1611 , A61M1/3441 , A61M1/3458 , A61M1/36 , A61M1/3607 , A61M2205/3331 , A61M2205/3334 , A61M2205/3365 , A61M2205/3368 , A61M2205/50
摘要： A method and apparatus for replacement of renal function by periodically removing a substantial volume of patient's blood and simultaneously replacing it with the reconstituted blood. Reconstituted blood consists of the patient's own condensed blood cells and proteins diluted with the sterile physiologic solution. As a result, small molecules and excess water are periodically removed and discarded. Blood cells and proteins are safely stored to be used at the next therapy session.
摘要翻译：一种通过周期性地去除大量患者血液并同时用重构血液代替肾功能来替代肾功能的方法和装置。重建的血液由患者自己的浓缩血细胞和用无菌生理溶液稀释的蛋白质组成。结果，小分子和过量的水被周期性地去除并丢弃。血细胞和蛋白质被安全地储存在下次治疗期间使用。

33. 发明申请

US20070118183A1 System and method to modulate phrenic nerve to prevent sleep apnea 有权
标题翻译：调节膈神经的系统和方法，以防止睡眠呼吸暂停
公开(公告)号：US20070118183A1
公开(公告)日：2007-05-24
申请号：US11601150
申请日：2006-11-17
申请人： Mark Gelfand , Howard Levin , Andrew Halpert
发明人： Mark Gelfand , Howard Levin , Andrew Halpert
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36135
摘要： An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.
摘要翻译：一种用于治疗诸如中枢性睡眠呼吸暂停的呼吸障碍的可植入医疗装置，其中刺激从未通过经静脉引导系统提供给膈神经，其中在吸气之后开始刺激以延长呼吸持续时间并且将膈肌保持在收缩状态。

34. 发明申请

US20060270971A1 Patient hydration system with a redundant monitoring of hydration fluid infusion 有权
标题翻译：患者水合系统具有水化液输液的冗余监测
公开(公告)号：US20060270971A1
公开(公告)日：2006-11-30
申请号：US11408851
申请日：2006-04-21
申请人： Mark Gelfand , Howard Levin
发明人： Mark Gelfand , Howard Levin
IPC分类号： A61M31/00 , A61M1/00
CPC分类号： A61M5/1723 , A61B5/201 , A61B5/208 , A61B5/4839 , A61M5/007 , A61M5/142 , A61M5/16895 , A61M5/365 , A61M2205/18 , A61M2205/3355 , A61M2205/3393 , G01G17/04
摘要： A patient hydration system including an infusion device for administering hydration fluid to a patient, and a hydration fluid measurement device responsive to a source of hydration fluid, a patient urine output measurement device. A controller is responsive to the hydration fluid measurement device and the patient urine output measurement device. The controller operates the infusion device, in response to the patient urine output measurement device and the hydration fluid measurement device, to hydrate the patient based on the patient's urine output. The controller also monitors the operation history of the infusion device thereby providing redundancy in the measurement of the amount of hydration fluid administered to the patient.
摘要翻译：一种患者水合系统，包括用于向患者施用水合流体的输注装置，以及响应于水合流体源的水合流体测量装置，患者尿液输出测量装置。控制器响应于水合流体测量装置和患者尿液输出测量装置。控制器响应于患者尿液输出测量装置和水合流体测量装置操作输液装置，以基于患者的尿液输出水合患者。控制器还监测输注装置的操作历史，从而在测量给予患者的水合液量的量方面提供冗余。

35. 发明申请

US20060052764A1 Patient hydration system and method 有权
标题翻译：患者水合系统及方法
公开(公告)号：US20060052764A1
公开(公告)日：2006-03-09
申请号：US10936945
申请日：2004-09-09
申请人： Mark Gelfand , Howard Levin
发明人： Mark Gelfand , Howard Levin
IPC分类号： A61M31/00
CPC分类号： A61M5/142 , A61B5/201 , A61B5/208 , A61B5/4839 , A61M5/007 , A61M5/16895 , A61M5/1723 , A61M5/365 , A61M2205/18 , A61M2205/3355 , A61M2205/3393 , G01G17/04
摘要： A patient hydration system and method wherein a urine collection system is connected to the patient. An infusion system is also connected to the patient. An infusion pump is connected to a source of hydration fluid. A control subsystem is responsive to the amount of urine output by the patient and configured to automatically adjust the infusion rate of the infusion pump based on the urine output by the patient.
摘要翻译：一种患者水合系统和方法，其中将尿液收集系统连接到患者。输液系统也连接到患者身上。输液泵连接到水合液源。控制子系统响应于患者的尿量输出，并被配置为基于患者的尿液输出自动调节输液泵的输注速率。

36. 发明授权

US10219855B2 Endovascular catheters and methods for carotid body ablation 有权
公开(公告)号：US10219855B2
公开(公告)日：2019-03-05
申请号：US15677978
申请日：2017-08-15
申请人： Mark Gelfand , Howard Levin
发明人： Mark Gelfand , Howard Levin
IPC分类号： A61B18/14 , A61B18/02 , A61B18/18 , A61M25/00 , A61B18/00 , A61B90/00
摘要： Systems, devices, and methods for treating a patient having a sympathetically mediated disease associated at least in part with augmented peripheral chemoreflex or heightened sympathetic activation. The treatments include ablating one or more peripheral chemoreceptors or associated afferent nerves to reduce or remove afferent neural signals from the peripheral chemoreceptor.

37. 发明授权

US10207110B1 Devices and methods for treatment of heart failure via electrical modulation of a splanchnic nerve 有权
公开(公告)号：US10207110B1
公开(公告)日：2019-02-19
申请号：US15293021
申请日：2016-10-13
申请人： Mark Gelfand , Tamara Colette Baynham , Howard Levin
发明人： Mark Gelfand , Tamara Colette Baynham , Howard Levin
IPC分类号： A61N1/36 , A61N1/05 , A61B5/00 , A61N1/362
摘要： Disclosed herein is a device, and method for treating heart failure by electrically modulating a splanchnic nerve with an implantable device.

38. 发明授权

US08521280B2 Methods and apparatus to increase secretion of endogenous naturetic hormones 有权
标题翻译：增加内源性激素分泌的方法和装置
公开(公告)号：US08521280B2
公开(公告)日：2013-08-27
申请号：US13426068
申请日：2012-03-21
申请人： Howard Levin , Mark Gelfand
发明人： Howard Levin , Mark Gelfand
IPC分类号： A61N1/368 , A61N1/36
CPC分类号： A61M25/10181 , A61M25/10 , A61M25/1018 , A61M29/00 , A61M2025/102 , A61N1/36117 , A61N1/3627 , A61N1/368 , A61N1/37235
摘要： A method and apparatus for treatment of heart failure by increasing secretion of endogenous naturetic hormones ANP and BNP such as by stimulation of the heart atria. Heart pacing is done at an atrial contraction rate that is increased and can be higher than the ventricular contraction rate. Pacing may include mechanical distension of the right atrial appendage. An implantable device is used to periodically cyclically stretch the walls of the appendage with an implanted balloon.
摘要翻译：通过增加内源性激素ANP和BNP的分泌来治疗心力衰竭的方法和装置，例如通过刺激心脏心房。心脏起搏是以增加的心房收缩速率完成的，可以高于心室收缩率。起搏可能包括右心耳的机械扩张。使用可植入装置周期性地用植入的气球循环地拉伸附肢的壁。

39. 发明申请

US20120172680A1 METHOD FOR SYMPATHETIC REBALANCING OF PATIENT 审中-公开
标题翻译：患者症状重新平衡的方法
公开(公告)号：US20120172680A1
公开(公告)日：2012-07-05
申请号：US13338876
申请日：2011-12-28
申请人： Mark Gelfand , Howard Levin
发明人： Mark Gelfand , Howard Levin
IPC分类号： A61B18/14 , A61B18/08 , A61B18/18 , A61B5/00
CPC分类号： A61N1/3627 , A61B18/14 , A61B18/18 , A61N1/056 , A61N1/06 , A61N1/36114 , A61N1/365
摘要： A method and device for assessing, and treating patients having sympathetically mediated disease, such as cardiac, metabolic, or pulmonary disease involving chemoreceptor hyperactivity and heightened sympathetic tone by reducing chemosensor input to the nervous system.
摘要翻译：用于评估和治疗患有交感神经介导的疾病的患者的方法和装置，例如涉及化学感受器多动症的心脏，代谢或肺部疾病和通过减少化学传感器输入到神经系统的交感神经紧张度。

40. 发明申请

US20100204677A1 Patient hydration system and method 审中-公开
标题翻译：患者水合系统及方法
公开(公告)号：US20100204677A1
公开(公告)日：2010-08-12
申请号：US12798940
申请日：2010-04-13
申请人： Mark Gelfand , Howard Levin
发明人： Mark Gelfand , Howard Levin
IPC分类号： A61M5/168 , A61B5/20 , A61B6/00 , A61M25/00
CPC分类号： A61M5/142 , A61B5/201 , A61B5/208 , A61B5/4839 , A61M5/007 , A61M5/16895 , A61M5/1723 , A61M5/365 , A61M2205/18 , A61M2205/3355 , A61M2205/3393 , G01G17/04
摘要： A fluid management system for a patient includes a console for mounting on an IV pole. The console includes an input for setting a desired fluid balance for a set therapy duration. A weighing subsystem weighs the patient's urine output collected in a urine collection chamber and weighs a source of hydration fluid. An infusion pump is integrated with the console and is configured to pump hydration fluid from the source of hydration fluid into the patient. A controller in the console is responsive to the set desired fluid balance, the set therapy duration, and the weighing subsystem. The controller is configured to determine the patient's urine output based on the weight of the urine collection chamber, determine the amount of fluid infused into the patient, and control the infusion pump to inject hydration fluid into the patient based on the set desired fluid balance, the weight of the urine collection chamber, and the weight of the source of hydration fluid to achieve the desired fluid balance during the set therapy duration.
摘要翻译：用于患者的流体管理系统包括用于安装在IV极上的控制台。控制台包括用于设定所需流体平衡以用于设定治疗持续时间的输入。称重子系统称重患者在尿液收集室中收集的尿量，并称重水合液源。输液泵与控制台集成在一起，并被配置为将水合流体从水合流体源泵送到患者体内。控制台中的控制器响应于设定的所需流体平衡，设定的治疗持续时间和称重子系统。控制器被配置为基于尿液收集室的重量来确定患者的尿液输出，确定输入到患者体内的流体的量，并且基于设定的所需流体平衡控制输注泵将水合流体注入患者体内，尿液收集室的重量以及水合流体源的重量，以在设定的治疗持续时间内实现所需的液体平衡。

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