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31. 发明授权

US5629161A Use of HVP-16 E6 and E7-gene derived peptides to diagnose HPV-16-associated invasive cervical cancer 失效
标题翻译：使用HVP-16 E6和E7基因衍生的肽来诊断HPV-16相关浸润性宫颈癌
公开(公告)号：US5629161A
公开(公告)日：1997-05-13
申请号：US363586
申请日：1994-12-23
申请人： Martin Muller , Lutz Gissmann
发明人： Martin Muller , Lutz Gissmann
IPC分类号： A61K39/395 , A61K39/42 , A61K47/48 , C07K14/01 , C07K14/025 , C07K16/00 , C07K16/08 , C12N15/09 , C12N15/34 , C12P21/08 , G01N33/53 , G01N33/569 , G01N33/571 , G01N33/574 , C07K16/44
CPC分类号： C07K14/005 , C07K16/084 , C12N2710/20022
摘要： The present invention relates to the use of human paillomavirus 16 (HPV-16) E7-gene derived peptides for the diagnostic identification of HPV-16-associated invasive cervical cancer.
摘要翻译：本发明涉及人类白斑病毒16（HPV-16）E7基因衍生肽用于HPV-16相关浸润性宫颈癌的诊断鉴定的用途。

32. 发明授权

US5548961A Temperature stratification-free storage of cryogenic liquids 失效
标题翻译：低温液体无温度分层储存
公开(公告)号：US5548961A
公开(公告)日：1996-08-27
申请号：US351835
申请日：1994-12-08
申请人： Peter Luger , Franz Grafwallner , Helmuth Peller , Martin Muller , Valentin V. Malyshev , Sergey B. Galperin , Viacheslav P. Logviniouk
发明人： Peter Luger , Franz Grafwallner , Helmuth Peller , Martin Muller , Valentin V. Malyshev , Sergey B. Galperin , Viacheslav P. Logviniouk
IPC分类号： F17C13/00 , B60K15/03 , B60K15/077 , B64D37/02 , B64D37/20 , F17C13/02 , F17C13/12 , F17C5/02
CPC分类号： B60K15/077 , B60K15/03006 , B64D37/02 , F17C13/025 , F17C13/123 , F17C2205/0332 , F17C2205/0391 , F17C2221/012 , F17C2221/033 , F17C2223/0161 , F17C2223/033 , F17C2223/041 , F17C2227/0135 , F17C2227/0178 , F17C2227/0386 , F17C2260/027 , F17C2265/02 , F17C2270/0189 , Y02E60/321 , Y02T90/44
摘要： Process for the temperature stratification-free storage of a cryogenic liquid in a thermally insulated tank under gravitation conditions or under gravitation and movement conditions, which generate a liquid volume with a clearly limited, unmoving or only moderately moving liquid level as well as with a gas space located above it in the storage volume of the tank. Liquid is pumped off from the area near the bottom of the tank continuously or at time intervals, it is fed into the area of the gas space, and it is directed vertically or at an acute angle toward the liquid level there in the form of at least one high-energy jet.
摘要翻译：用于在重力条件下或在重力和运动条件下在绝热罐中温度分层地存储低温液体的方法，其产生具有明显有限的，不流动的或仅适度移动的液面以及气体的液体体积位于其上方的空间在储罐的存储容积中。液体从罐底部附近的区域被连续地或间隔地从泵送到气体空间的区域中，并且以垂直方向或以锐角方向朝向液面的方向以至少一台高能喷气机。

33. 发明授权

US5262401A Porphycene compounds for photodynamic therapy 失效
标题翻译：卟啉化合物用于光动力疗法
公开(公告)号：US5262401A
公开(公告)日：1993-11-16
申请号：US875314
申请日：1992-04-29
申请人： Emanuel Vogel , Clemens Richert , Thomas Benninghaus , Martin Muller , Alexander D. Cross
发明人： Emanuel Vogel , Clemens Richert , Thomas Benninghaus , Martin Muller , Alexander D. Cross
IPC分类号： A61K41/00 , C07D487/22 , A61K31/70 , C07H15/00
CPC分类号： C07D487/22 , A61K41/0057
摘要： A porphycene having the structure ##STR1## wherein each R.sup.1 is, independently, (a) --(CH.sub.2).sub.n --X, where n= 1-4, X is OR.sup.2 and R.sup.2 is C.sub.1-6 alkyl, aralkyl or aryl; CN; OH; OSO.sub.2 R.sup.2 ; NH.sub.2 ; NHR.sup.2 ; NR.sup.2.sub.2 ; SH; SR.sup.2 ; S(O).sub.1-2 R.sup.2 ; COOH; CO.sub.2 R.sup.2 ; C(O)NH.sub.2 ; C(O)NHR.sup.2 ; C(O)NR.sup.2.sub.2 ; halogen; or CHO;(b) --(CH.sub.2).sub.m CH.dbd.CH.sub.2 where m is 0-2; or(c) --(CH.sub.2).sub.n --O--G where G is a mono- or oligosaccharide;(d) --(CH.sub.2).sub.2n --X, where X is an amino acid, oligopeptide covalently bonded by an ether-, ester- or amine-bond or --Y--(CH.sub.2).sub.n -porphycene.sup.2 (porphycene.sup.2 being a compound of the same structure and Y is a direct bond; --O--; or --CH.dbd.CH.sub.2); or(e) where one, two or three of the substituents R.sup.1 are C.sub.1-6 alkyl or aryl and the remaining substituents are as above under (a)-(d), and salts and metal complexes thereof. The porphycene compounds and pharmaceutical compositions containing the compounds are useful in photodynamic therapy treatment of tumors and psoriasis.
摘要翻译：具有结构的卟菲烯，其中每个R 1独立地为（a） - （CH 2）n -X，其中n = 1-4，X为OR 2，R 2为C 1-6烷基，芳烷基或芳基; CN; 哦; OSO2R2; NH2; NHR2; NR22; SH; SR2; S（O）1-2R2; COOH; CO2R2; C（O）NH 2; C（O）NHR 2; C（O）NR22; 卤素; 或CHO; （b） - （CH 2）m CH = CH 2，其中m是0-2; 或（c） - （CH 2）n -O-G，其中G是单糖或寡糖; （d） - （CH2）2n-X，其中X是氨基酸，通过醚 - ，酯 - 或胺键共价结合的寡肽或-Y-（CH 2）n - 卟吩二（卟吩2是相同的化合物）结构，Y是直接键; -O-;或-CH = CH 2）; 或（e）其中一个，两个或三个取代基R 1为C 1-6烷基或芳基，其余取代基如上述（a） - （d）所述，及其盐和金属络合物。含有这些化合物的卟吩化合物和药物组合物可用于肿瘤和牛皮癣的光动力疗法治疗。

34. 发明授权

US5248755A Process for the preparation of asymmetrically substituted ureas, carbamates or thiocarbamates 失效
标题翻译：制备不对称取代的脲，氨基甲酸酯或硫代氨基甲酸酯的方法
公开(公告)号：US5248755A
公开(公告)日：1993-09-28
申请号：US958155
申请日：1992-10-09
申请人： Martin Muller , Gerhard Stern , Erich Schulz , Markus Rossler
发明人： Martin Muller , Gerhard Stern , Erich Schulz , Markus Rossler
IPC分类号： C07C273/18 , C07C333/04
CPC分类号： C07C273/1818 , C07C273/1827 , C07C333/04
摘要： Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates or substituted isocyanates by reaction of an adduct of isocyanic acid and a tertiary amine with a primary and secondary amine, an alcohol, a thiol or a compound having one or two non-cumulated olefinic double bonds, and a process for the preparation of N-mono- or N,N-disubstituted ureas by reaction of ammonium isocyanate with a primary or secondary amine in a diluent.
摘要翻译：通过异氰酸和叔胺的加合物与伯胺和仲胺，醇，硫醇或具有一个或两个非累积烯烃的化合物的反应制备不对称取代的脲，氨基甲酸酯，硫代氨基甲酸酯或取代的异氰酸酯的方法双键，以及通过异氰酸铵与稀释剂中的伯胺或仲胺反应制备N-单或N，N-二取代脲的方法。

35. 发明授权

US5123626A Electromagnetic on-off valve 失效
标题翻译：电磁开关阀
公开(公告)号：US5123626A
公开(公告)日：1992-06-23
申请号：US663925
申请日：1991-03-25
申请人： Walter Schlagmuller , Helmut Rembold , Martin Muller , Ehrtfried Baumel
发明人： Walter Schlagmuller , Helmut Rembold , Martin Muller , Ehrtfried Baumel
IPC分类号： F02M51/00 , F02M59/46 , F02M63/00 , F16K31/06
CPC分类号： F02M51/00 , F02M59/466 , F02M2200/30
摘要： An electro-magnetic on-off valve for controlling the opening area of a fluid line, in particular for fuel injection pumps, having a valve element constructed on a valve needle, said valve element cooperating with a valve seat. The valve needle is connected to a magnetic armature of an electromagnet, the magnetic armature moving in a fluid for the purpose of achieving high switching speeds, and being sealed with respect to the liquid-conducting region of the valve. For any purpose of extensive damping of the rebound oscillations which occur when the valve closes and lead to the re-opening of the valve, the connection between the magnetic armature and valve needle is produced by a coupling and which is designed in such a way that after the rebound of the valve element against the valve seat occurring when the valve closes, the magnetic armature and the valve needle oscillate in phase opposition with respect to one another.
摘要翻译： PCT No.PCT / DE90 / 00574 Sec。 371日期1991年3月25日 102（e）1991年3月25日PCT提交1990年7月26日PCT公布。公开号WO91 / 03641 日期1991年3月21日。一种用于控制流体管线的开口面积的电磁开关阀，特别是用于燃料喷射泵的开口面积，其具有构造在阀针上的阀元件，所述阀元件与阀座。阀针连接到电磁体的磁性衔铁，磁性衔铁以流体的形式移动，以实现高开关速度，并且相对于阀的导液区域被密封。对于当阀关闭并导致阀重新开启时发生的回弹振荡的广泛阻尼的任何目的，磁性衔铁和阀针之间的连接是通过联接产生的，并且其设计使得在阀关闭时阀元件抵靠阀座的反弹之后，磁性衔铁和阀针相对于彼此相反地摆动。

36. 发明授权

US4214689A Automatic counteracting of transverse shift of a longitudinally transported strip 失效
标题翻译：自动抵消纵向运输的钢带的横向位移
公开(公告)号：US4214689A
公开(公告)日：1980-07-29
申请号：US927521
申请日：1978-07-24
申请人： Siegfried Bartel , Ernst Biedermann , Heinz Rapp , Martin Muller
发明人： Siegfried Bartel , Ernst Biedermann , Heinz Rapp , Martin Muller
IPC分类号： B65H23/038 , G03B27/58 , B65H25/26
CPC分类号： G03B27/587 , B65H23/038
摘要： The longitudinally transported strip passes and is pressed between two cooperating transport rollers. The rotation axes of the two rollers are normally parallel to each other. One roller is swingably mounted about a swing axis which intersects and is perpendicular to the rotation axis of the other, non-swingable roller. Edge sensors are displaced by the lateral edges of the transported strip, when the strip improperly shifts transversely. The force thusly exerted upon an edge sensor is transmitted, via a force-multiplying lever system, to the swingable transport roller, swinging the latter to a position such that the swung transport roller exerts upon a major surface of the transported strip a force whose transverse component is directed opposite to the direction of the improper transverse shift, resulting in automatic recentering.
摘要翻译：纵向输送的条带通过并在两个协作的输送辊之间被按压。两个辊的旋转轴线通常彼此平行。一个滚筒围绕摆动轴可摆动地安装，该摆动轴线与另一个不可摆动的滚子的旋转轴线相交并垂直。当传送带横向移动时，边缘传感器被横向移动。由此施加在边缘传感器上的力通过加力杆系统传递到摆动传送辊，将其摆动到一个位置，使得摆动的输送辊在被输送带的主表面上施加力，其横向部件与不正确的横向移动方向相反，导致自动重新起动。

37. 发明授权

US4040850A Production of porous gypsum moldings 失效
标题翻译：生产多孔石膏模制品
公开(公告)号：US4040850A
公开(公告)日：1977-08-09
申请号：US604856
申请日：1975-08-14
申请人： Hans Kyri , Karl Brandle , Martin Muller , Heinrich Heine
发明人： Hans Kyri , Karl Brandle , Martin Muller , Heinrich Heine
IPC分类号： C04B38/02 , C04B28/14 , C04B11/00
CPC分类号： C04B28/14
摘要： In the production of a gypsum-based porous body of high strength by foaming a gypsum-water mixture, the improvement which comprises including in said mixture about 0.1 to 1 part of a water-soluble aluminum compound per 100 parts by weight of gypsum, calcium oxide or calcium hydroxide in such a quantity that the final mixture has a pH-value in the range of about 10 to 13, a decomposition catalyst, and about 0.5 to 5 parts of hydrogen peroxide, expressed as a 35% solution, per 100 parts by weight of mixture, the ratio of solids to liquid being about 1 : 0.4 - 1.The preferred aluminum compound is aluminum nitrate. The preferred decomposition catalysts are manganese compounds such as manganates or permanganates, e.g. potassium permanganate.
摘要翻译：在通过发泡石膏 - 水混合物生产高强度的石膏基多孔体时，其改进包括在每100重量份的石膏中加入约0.1至1份的水溶性铝化合物，石膏，钙氧化物或氢氧化钙，其量为最终混合物的pH值为约10至13，分解催化剂和约0.5至5份以35％溶液表示的过氧化氢，每100份的混合物，固体与液体的比例为约1:0.4-1。

38. 发明申请

US20110015376A1 Papilloma Virus-Like Particles, Fusion Proteins as Well as Processes for Their Production 审中-公开
标题翻译：乳头状病毒样颗粒，融合蛋白以及其生产过程
公开(公告)号：US20110015376A1
公开(公告)日：2011-01-20
申请号：US12197591
申请日：2008-08-25
申请人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
发明人： Lutz Gissmann , Jian Zhou , Martin Muller , Jeanette Painstil
IPC分类号： C07K14/025
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
摘要翻译：本发明涉及适合作为治疗和预防性接种疫苗的蛋白质以及VLP的重组生产。本发明还涉及生产和纯化重组乳头状瘤病毒蛋白和融合蛋白的方法。

39. 发明申请

US20090076198A1 Functionalized nanoparticles 审中-公开
标题翻译：官能化纳米粒子
公开(公告)号：US20090076198A1
公开(公告)日：2009-03-19
申请号：US11665627
申请日：2005-10-17
申请人： Thomas Giesenberg , Andreas Muhlebach , Tunja Jung , Francois Rime , Laurent Michau , Martin Muller , Didier Bauer
发明人： Thomas Giesenberg , Andreas Muhlebach , Tunja Jung , Francois Rime , Laurent Michau , Martin Muller , Didier Bauer
IPC分类号： B32B5/16 , C08K5/00 , C08K5/34 , C08K5/45 , C08K5/15 , C08K5/51 , C08K5/53 , B05D3/02
CPC分类号： C09D7/63 , C01P2002/84 , C01P2002/88 , C01P2004/64 , C08K9/06 , C09C1/3081 , C09C1/40 , C09C1/407 , C09D7/48 , Y10T428/2982
摘要： The present invention discloses functionalized nanoparticles comprising on the surface a covalently bound radical of the formula (I) wherein the nanoparticles are SiO2, Al2O3 or mixed SiO2 and Al2O3 nanoparticles, and wherein the general symbols are as defined in claim 1. These functionalized nanoparticles are for example useful as stabilizers and/or compatibilizers in organic materials, or as photoinitiators in pre-polymeric or pre-crosslinking formulations, or as reinforcer of coatings and improver of scratch resistance in coating compositions for surfaces.
摘要翻译：本发明公开了在表面上包含共价结合的式（I）基团的官能化纳米颗粒，其中纳米颗粒是SiO 2，Al 2 O 3或混合SiO 2和Al 2 O 3纳米颗粒，其中通式符号如权利要求1中所定义。这些官能化纳米颗粒是例如在有机材料中用作稳定剂和/或增容剂，或作为预聚物或预交联制剂中的光引发剂，或用作表面涂料组合物中涂料的增强剂和耐划伤性改进剂。

40. 发明申请

US20090028894A1 Papilloma Virus Capsomere Vaccine Formulations and Methods of Use 失效
标题翻译：乳头状瘤病毒Capsomere疫苗配方及使用方法
公开(公告)号：US20090028894A1
公开(公告)日：2009-01-29
申请号：US12105013
申请日：2008-04-17
申请人： Lutz Gissmann , Martin Muller
发明人： Lutz Gissmann , Martin Muller
IPC分类号： A61K39/12 , A61P31/12
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5258 , C07K14/005 , C07K2319/00 , C12N2710/20022 , C12N2710/20023 , Y10S977/802 , Y10S977/917
摘要： Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.
摘要翻译：公开了包含病毒壳聚糖的疫苗制剂及其制备方法。还公开了用于疫苗制剂的治疗和预防方法。

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