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    • 39. 发明申请
    • System and method for forming bioengineered tubular graft prostheses
    • 用于形成生物工程管状移植假体的系统和方法
    • US20070003633A1
    • 2007-01-04
    • US11105963
    • 2005-04-14
    • Ginger AbrahamMaury CosmanKristen BilliarRyan MercerBruce Miller
    • Ginger AbrahamMaury CosmanKristen BilliarRyan MercerBruce Miller
    • A61K35/38A61K35/37
    • A61F2/062B29C53/562
    • An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning and engaging the mandrel on the opposing mounts; and a means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod has a lumen running its length and has pores that communicate between the lumen of the porous rod through to the surface of the rod for water to uniformly pass through. The spring-loaded roller runs along the length of the porous rod creating a line of contact between the roller and the mandrel. The mandrel is contacted with a planar sheet of matrix and is rotated such that successive portions of the matrix contact the porous rod and become lightly moistened by the water passing through the pores of the porous rod and become wrapped around the mandrel to form a tube construct.
    • 用于从平面片状基体形成管构造的装置包括支撑两个相对的安装件并跨过相对的安装件的支架是平行布置地保持的心轴,多孔杆和弹簧加载的辊; 用于在相对的安装件上对准和接合心轴的引导件; 以及用于在平面片基体上施加切向力以防止起皱的装置。 多孔棒具有延伸其长度的内腔,并且具有在多孔棒的内腔之间连通到杆的表面以使水均匀通过的孔。 弹簧加载的滚筒沿着多孔棒的长度延伸,在滚筒和心轴之间形成一条接触线。 心轴与平面的基质片材接触并且旋转,使得基质的连续部分接触多孔棒并被穿过多孔棒的孔的水轻轻地润湿,并且缠绕在心轴上以形成管构造 。