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    • 33. 发明授权
    • Substrate polyeptides for von Willebrand factor cleaving protease ADAMTS-13
    • von Willebrand因子切割蛋白酶ADAMTS-13的底物多肽
    • US07718763B2
    • 2010-05-18
    • US10531427
    • 2002-10-18
    • Toshiyuki MiyataKoichi Kokame
    • Toshiyuki MiyataKoichi Kokame
    • A61K38/00A01N37/18C08H1/00C12P21/04
    • C12N9/6489C07K14/755C12Q1/37
    • The present invention relates to specific substrates for a von Willebrand factor cleaving enzyme, ADAMTS-13, as well as to diagnosis of ADAMTS-13 deficient patients, diagnostic compositions, and kits employing the substrates. Particularly preferable substrate polypeptides for ADAMTS-13 are the polypeptide which begins at amino acid 1587 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing, and the polypeptide which begins at amino acid 1596 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing. These substrate polypeptides for ADAMTS-13 have high substrate specificity and also superior quantitativeness, and a suitable size for production by recombinant methods.
    • 本发明涉及von Willebrand因子切割酶,ADAMTS-13的特异性底物,以及ADAMTS-13缺陷患者的诊断,诊断组合物和使用该底物的试剂盒。 用于ADAMTS-13的特别优选的底物多肽是从序列表中SEQ ID NO:1的氨基酸1587开始并结束于SEQ ID NO:1的氨基酸1668的多肽,以及在氨基酸1596开始并以氨基酸1668结束的多肽 序列表中的SEQ ID NO:1。 用于ADAMTS-13的这些底物多肽具有高底物特异性,并且还具有优异的定量性,以及通过重组方法生产的合适尺寸。
    • 38. 发明申请
    • SLIDING MEMBER AND FIXING DEVICE, AND IMAGE FORMING APPARATUS USING THE SAME
    • 滑动构件和固定装置,以及使用其的图像形成装置
    • US20090080954A1
    • 2009-03-26
    • US12050689
    • 2008-03-18
    • Toshiyuki MiyataMotofumi Baba
    • Toshiyuki MiyataMotofumi Baba
    • G03G15/20
    • G03G15/2064G03G2215/2035
    • Provided is a sliding member, including: a substrate; and a non-continuous diamond-like carbon layer provided on a surface of the substrate, the non-continuous diamond-like carbon layer being formed from a plurality of diamond-like carbon layer portions that are separated from one another by grooves. Also provided is a fixing device including: a fixing belt; a pressure member that contacts the outer peripheral surface of the fixing belt; and at least one fixed sliding member on which the fixing belt slides, the fixed sliding member contacting the inner peripheral surface of the fixing belt, at least one of the fixing belt and the fixed sliding member comprising a non-continuous diamond-like carbon layer on a sliding surface between the fixing belt and the fixed sliding member, the non-continuous diamond-like carbon layer being formed from a plurality of diamond-like carbon layer portions that are separated from one another by grooves. Furthermore, provided is an image forming apparatus using the sliding member or the fixing device.
    • 提供一种滑动构件,包括:基板; 以及设置在基板的表面上的不连续的类金刚石碳层,非连续的类金刚石碳层由多个通过凹槽彼此分离的类金刚石碳层部分形成。 还提供了一种定影装置,包括:定影带; 与所述定影带的外周面接触的压力部件; 以及至少一个固定滑动构件,所述定影带在所述固定滑动构件上滑动,所述固定滑动构件与所述定影带的内周面接触,所述定影带和所述固定滑动构件中的至少一个包括非连续的类金刚石碳层 在定影带和固定滑动构件之间的滑动表面上,非连续的类金刚石碳层由通过凹槽彼此分离的多个类金刚石碳层部分形成。 此外,提供了使用滑动构件或定影装置的图像形成装置。