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31. 发明授权

US06469043B1 Sulfonamide-containing indole compounds 有权
标题翻译：含磺酰胺的吲哚化合物
公开(公告)号：US06469043B1
公开(公告)日：2002-10-22
申请号：US09647215
申请日：2000-09-28
申请人： Toru Haneda , Akihiko Tsuruoka , Junichi Kamata , Tadashi Okabe , Keiko Takahashi , Kazumasa Nara , Shinichi Hamaoka , Norihiro Ueda , Takashi Owa , Toshiaki Wakabayashi , Yasuhiro Funahashi , Taro Semba , Naoko Hata , Yuji Yamamoto , Yoichi Ozawa , Noako Tsukahara
发明人： Toru Haneda , Akihiko Tsuruoka , Junichi Kamata , Tadashi Okabe , Keiko Takahashi , Kazumasa Nara , Shinichi Hamaoka , Norihiro Ueda , Takashi Owa , Toshiaki Wakabayashi , Yasuhiro Funahashi , Taro Semba , Naoko Hata , Yuji Yamamoto , Yoichi Ozawa , Noako Tsukahara
IPC分类号： A61K31404
CPC分类号： C07D401/12 , C07D209/04 , C07D209/30 , C07D209/42 , C07D403/12 , C07D409/12
摘要： The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof. In the formula, R1 represents hydrogen atom, a halogen atom or cyano group; R2 and R3 are the same as or different from and each represents hydrogen atom, a C1˜C4 lower alkyl group or a halogen atom; R4 represents hydrogen atom or a C1˜C4 lower alkyl group; and the ring A represents cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, a halopyridyl group or cyanothiophenyl group, provided that the case where all of R1, R2 and R3 are hydrogen atoms, where both R2 and R3 are hydrogen atoms or where the ring A is aminosulfonyl group and both R1 and R2 are halogen atoms is excluded. Further, when the ring A is cyanophenyl group, 2-amino-5-pyridyl group or a 2-halo-5-pyridyl group and R1 is cyano group or a halogen atom, at least one of R2 and R3 should not be a hydrogen atom.
摘要翻译：本发明创造出一种新型抗血管生成剂，并提供与常规抗肿瘤剂相比显示出高安全性的抗肿瘤剂，具有确定的作用并且能够长时间施用。也就是说，其提供由下式（I）表示的吲哚化合物，其药理学上可接受的盐或其水合物。在该式中，R1表示氢原子，卤素原子或氰基; R2和R3相同或不同，各自表示氢原子，C1〜C4低级烷基或卤原子; R4表示氢原子或C1〜C4低级烷基; 并且环A表示氰基苯基，氨基磺酰基苯基，氨基吡啶基，氨基嘧啶基，卤代吡啶基或氰基噻吩基，条件是所有的R 1，R 2和R 3均为氢原子，其中R 2和R 3均为氢原子或环A为氨基磺酰基，R1和R2均为卤素原子。此外，当环A为氰基苯基，2-氨基-5-吡啶基或2-卤代-5-吡啶基并且R 1为氰基或卤素原子时，R 2和R 3中的至少一个不应为氢原子。

32. 发明授权

US5700874A Alkoxysilane-modified polymer and adhesive composition using said polymer 失效
标题翻译：使用所述聚合物的烷氧基硅烷改性聚合物和粘合剂组合物
公开(公告)号：US5700874A
公开(公告)日：1997-12-23
申请号：US518324
申请日：1995-08-23
申请人： Hideo Takeichi , Yoichi Ozawa , Sei Aoki , Takashi Shimizu
发明人： Hideo Takeichi , Yoichi Ozawa , Sei Aoki , Takashi Shimizu
IPC分类号： C08C19/44 , C08F8/42 , C08F275/00
CPC分类号： C08F8/42 , C08C19/44
摘要： A polymer modified with an alkoxysilane is prepared by a reaction forming a bond between an alkoxysilane compound represented by General Formula (I) and at least one of end parts of a conjugated diene/vinylaromatic hydrocarbon copolymer obtained by copolymerization of a conjugated diene and a vinylaromatic hydrocarbon using a lithium compound as an initiator. An adhesive composition contains 3% by weight or more of the polymer modified with an alkoxysilane. The polymer is used for an adhesive composition, can be prepared by a simple process, has excellent adhesive property and durability so that an additive such as a tackifier is not always required, and has essentially enhanced adhesive property to inorganic materials, in particular. The adhesive composition in which the polymer is used has excellent adhesive property and durability. ##STR1##
摘要翻译：用烷氧基硅烷改性的聚合物通过在通式（I）表示的烷氧基硅烷化合物与通过共轭二烯和乙烯基芳族化合物的共聚获得的共轭二烯/乙烯基芳族烃共聚物的至少一个端部之间形成键的反应来制备使用锂化合物作为引发剂的烃。粘合剂组合物含有3重量％以上的用烷氧基硅烷改性的聚合物。聚合物用于粘合剂组合物，可以通过简单的方法制备，具有优异的粘合性和耐久性，使得不一定需要诸如增粘剂的添加剂，并且具有基本上增强的对无机材料的粘合性能。使用聚合物的粘合剂组合物具有优异的粘合性和耐久性。通用（I）

33. 发明申请

US20120309906A1 POLYMERS FUNCTIONALIZED WITH HALOSILANES CONTAINING AN AMINO GROUP 有权
标题翻译：聚合物与含有氨基酸的半胱氨酸官能化
公开(公告)号：US20120309906A1
公开(公告)日：2012-12-06
申请号：US13588033
申请日：2012-08-17
申请人： Terrence E. Hogan , Steven Luo , Yoichi Ozawa , Matsushita Junko , Nakagawa Ryuji , Suzuki Eiju , Ken Tanaka
发明人： Terrence E. Hogan , Steven Luo , Yoichi Ozawa , Matsushita Junko , Nakagawa Ryuji , Suzuki Eiju , Ken Tanaka
IPC分类号： C08F236/06 , C08F8/32
CPC分类号： C08C19/44 , C08F8/42 , C08L15/00 , C08L19/006 , C08F297/04
摘要： A method for preparing a functionalized polymer, the method comprising the steps of preparing a reactive polymer, and reacting the reactive polymer with a halosilane compound containing an amino group.
摘要翻译：一种制备官能化聚合物的方法，该方法包括如下步骤：制备反应性聚合物，并使反应性聚合物与含有氨基的卤代硅烷化合物反应。

34. 发明授权

US08236892B2 Functionalized polymer and methods for making and using 有权
标题翻译：官能化聚合物和制造和使用方法
公开(公告)号：US08236892B2
公开(公告)日：2012-08-07
申请号：US12810845
申请日：2008-12-26
申请人： Steven Luo , Yoichi Ozawa , Jason Poulton , Dennis R Brumbaugh , Michael W. Hayes
发明人： Steven Luo , Yoichi Ozawa , Jason Poulton , Dennis R Brumbaugh , Michael W. Hayes
IPC分类号： C08F8/28
CPC分类号： C08F8/42 , C08C19/44 , C08F8/30 , C08K3/04 , C08L9/00 , C08L15/00 , C08L2666/08
摘要： A functionalized polymer includes a polymer chain and a terminal functionality that includes at least one disilylamino group. The polymer can be the reaction product of a terminally active polymer chain and a compound that includes at least one disilylamino group and a group capable of reacting with terminally active polymers. Methods for making and using such polymers also are provided, as are compositions containing the polymer and one or more types of filler particles as well as vulcanizates provided from such compositions.
摘要翻译：官能化聚合物包括聚合物链和包括至少一个二甲硅烷基氨基的末端官能团。聚合物可以是末端活性聚合物链和包含至少一个二甲硅烷基氨基和能够与末端活性聚合物反应的基团的化合物的反应产物。还提供了制备和使用这些聚合物的方法，以及含有聚合物和一种或多种类型的填料颗粒的组合物以及由这种组合物提供的硫化橡胶。

35. 发明授权

US08153723B2 Process for producing conjugated diene polymer, conjugated diene polymer, and rubber composition 有权
标题翻译：用于制备共轭二烯聚合物，共轭二烯聚合物和橡胶组合物的方法
公开(公告)号：US08153723B2
公开(公告)日：2012-04-10
申请号：US12096263
申请日：2006-12-05
申请人： Takahiro Nakamura , Kouichirou Tani , Ryouji Tanaka , Takuo Sone , Toshihiro Tadaki , Junko Kurazumi , Koji Masaki , Yoichi Ozawa
发明人： Takahiro Nakamura , Kouichirou Tani , Ryouji Tanaka , Takuo Sone , Toshihiro Tadaki , Junko Kurazumi , Koji Masaki , Yoichi Ozawa
IPC分类号： C08L9/00 , C08F4/44
CPC分类号： C08L9/00 , C08F36/04 , C08K3/013 , C08F4/545
摘要： A process for simply and inexpensively producing a conjugated diene polymer with a narrow molecular weight distribution and a high cis-bond content at a low cost is provided. The process comprises a polymerization step, wherein a conjugated diene polymer having a cis-1,4-bond content of 98.5 mass % or more and a ratio (Mw/Mn) of the weight average molecular weight (Mw) to the number average molecular weight (Mn) measured by gel permeation chromatography of 2.5 or less is obtained by carrying out a polymerization reaction in conjugated diene compounds using a catalyst composition containing a rare earth element-containing compound or a reaction product of the rare earth element-containing compound with a Lewis base, an aluminoxane and/or organoaluminum compound, and an iodine-containing compound.
摘要翻译：提供了一种以低成本简单且廉价地制备具有窄分子量分布和高顺式键含量的共轭二烯聚合物的方法。该方法包括聚合步骤，其中顺式-1,4-键含量为98.5质量％以上的共轭二烯聚合物和重均分子量（Mw）与数均分子量（Mw）的比（Mw / Mn）通过凝胶渗透色谱法测定的重量（Mn）为2.5以下，通过使用含有含稀土元素化合物的催化剂组合物或含稀土元素化合物的反应产物与共轭二烯化合物的反应，路易斯碱，铝氧烷和/或有机铝化合物，以及含碘化合物。

36. 发明授权

US08017695B2 Method for producing functionalized cis-1,4-polydienes having high cis-1,4-linkage content and high functionality 有权
标题翻译：具有高顺式-1,4-键含量和高官能度的官能化顺式-1,4-聚二烯的方法
公开(公告)号：US08017695B2
公开(公告)日：2011-09-13
申请号：US11964848
申请日：2007-12-27
申请人： Steven Luo , Junko Kurazumi , Yoichi Ozawa , Timothy L. Tartamella , Mark Smale , Kevin McCauley
发明人： Steven Luo , Junko Kurazumi , Yoichi Ozawa , Timothy L. Tartamella , Mark Smale , Kevin McCauley
IPC分类号： C08F8/00 , C08F4/52 , B60C5/00
CPC分类号： C08C19/44 , B60C1/00 , B60C1/0016 , B60C1/0025 , C08L15/00 , Y10S525/902 , Y10T152/10495
摘要： This invention relates to a method for producing functionalized cis-1,4-polydienes having a combination of a high cis-1,4-linkage content and a high functionality, the resulting polymers and the vulcanized products containing the polymers. The functionalized cis-1,4-polydienes of the present invention are produced by a method comprising the steps of: (1) preparing a reactive polymer by polymerizing conjugated diene monomer with a lanthanide-based catalyst in the presence of less than 20% by weight of organic solvent based on the total weight of monomer, organic solvent, and resulting polymer, where the lanthanide-based catalyst is the combination of or reaction product of (a) a lanthanide compound, (b) an aluminoxane, (c) an organoaluminum compound other than an aluminoxane, and (d) a halogen-containing compound; and (2) contacting the reactive polymer with a functionalizing agent.
摘要翻译：本发明涉及具有高顺式-1,4-键含量和高官能度组合的官能化顺式-1,4-聚二烯的方法，所得聚合物和含有聚合物的硫化产物。本发明的官能化顺式-1,4-聚二烯通过包括以下步骤的方法制备：（1）通过将共轭二烯单体与镧系元素基催化剂在少于20％基于单体，有机溶剂和所得聚合物的总重量的有机溶剂的重量，其中镧系元素基催化剂是（a）镧系元素化合物，（b）铝氧烷，（c）除铝氧烷以外的有机铝化合物，和（d）含卤素化合物; 和（2）使反应性聚合物与官能化剂接触。

37. 发明授权

US07919571B2 Polybutadiene as well as rubber composition using the same and tire 有权
标题翻译：聚丁二烯以及使用相同和轮胎的橡胶组合物
公开(公告)号：US07919571B2
公开(公告)日：2011-04-05
申请号：US12601364
申请日：2008-05-19
申请人： Ryuji Nakagawa , Junko Matsushita , Yoichi Ozawa , Shojiro Kaita , Olivier Tardif
发明人： Ryuji Nakagawa , Junko Matsushita , Yoichi Ozawa , Shojiro Kaita , Olivier Tardif
IPC分类号： C08F136/06 , C08F4/52 , C08L9/00
CPC分类号： C08L9/00 , B60C1/0016 , C08F36/04 , Y10S152/905 , Y10T152/10495 , C08F4/54
摘要： This invention provides a polybutadiene capable of improving wear resistance and resistance to crack growth in a rubber composition and a tire, wherein values of e, f and g derived from the following determinant (I): ( 1.7455 0 - 0.0151 - 0.0454 0.4292 - 0.0129 - 0.007 0 0.3746 ) ⁢ ( log 10 ⁡ ( a / d ) log 10 ⁡ ( a / b ) log 10 ⁡ ( a / c ) ) = ( e f g ) ( I ) (wherein a is a mountain peak value around 1130 cm−1 in a transmittance spectrum through Fourier transform infrared spectroscopy (FT-IR), and b is a valley peak value around 967 cm−1, and c is a valley peak value around 911 cm−1, and d is a valley peak value around 736 cm−1) satisfy relationships of equation (II): (Calculated value of cis-1,4 bond)=e/(e+f+g)×100≧99 and equation (III): (Calculated value of vinyl bond)=g/(e+f+g)×100≦0.
摘要翻译：本发明提供一种能够改善橡胶组合物和轮胎中的耐磨性和抗裂纹生长性的聚丁二烯，其中衍生自以下决定基（I）的e，f和g的值：（1.7455-0.0151-0.0454±0.4292-0.0129 - 0.007 0 0.3746）（log 10⁡（a / d）log 10⁡（a / b）log 10⁡（a / c））=（efg）（I）（其中a为1130cm左右的山峰值 -1，傅立叶变换红外光谱（FT-IR）为透射光谱，b为967cm -1左右的谷峰值，c为911cm -1附近的谷峰值，d为谷峰值约736厘米-1）满足式（II）的关系：（顺式-1,4-键的计算值）= e /（e + f + g）×100≧99和式（III）:(乙烯基的计算值键）= g /（e + f + g）×100＆nlE; 0。

38. 发明授权

US07786236B2 Polymeric nano-particles of flower-like structure and applications 有权
标题翻译：花状结构和应用的聚合纳米颗粒
公开(公告)号：US07786236B2
公开(公告)日：2010-08-31
申请号：US11697801
申请日：2007-04-09
申请人： Xiaorong Wang , Yoichi Ozawa , James E. Hall
发明人： Xiaorong Wang , Yoichi Ozawa , James E. Hall
IPC分类号： C08F36/00 , C08F12/34 , C08F12/02 , C08F112/06 , C08F279/00 , C08F293/00 , C08F112/36 , C08K5/11 , C08K5/10 , C08K5/36
CPC分类号： C08F297/02 , C08L21/00 , C08L53/02 , C08L2666/24
摘要： A flower-like nano-particle composition including a poly(alkenylbenzene) core and a poly(conjugated diene) or a poly(alkylene) surface layer is provided. The nano-particles have a mean average diameter less than about 100 nm and are substantially free of chain ends. The nano-particles can be modified via, for example, hydrogenation. The nano-particles can advantageously be incorporated into rubbers, elastomers, and thermoplastics.
摘要翻译：提供了包含聚（烯基苯）芯和聚（共轭二烯）或聚（亚烷基）表面层的花状纳米颗粒组合物。纳米颗粒的平均直径小于约100nm，基本上不含链末端。可以通过例如氢化来改变纳米颗粒。纳米颗粒可以有利地结合到橡胶，弹性体和热塑性塑料中。

39. 发明申请

US20090047365A1 Novel Concomitant Use of Sulfonamide Compound with Anti-Cancer Agent 审中-公开
标题翻译：磺酰胺化合物与抗癌剂的新型伴随使用
公开(公告)号：US20090047365A1
公开(公告)日：2009-02-19
申请号：US11885129
申请日：2006-02-28
申请人： Takashi Owa , Yoichi Ozawa , Taro Semba , Naoko Hata
发明人： Takashi Owa , Yoichi Ozawa , Taro Semba , Naoko Hata
IPC分类号： A61K33/24 , A61K31/404 , A61K31/4375 , A61K31/513 , A61K31/517 , A61K31/704 , A61K31/18 , A61K31/381 , A61K31/498
CPC分类号： A61K31/498 , A61K31/18 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/4741 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition, a kit, a method of treating cancer and/or a method of inhibiting angiogenesis comprising a sulfonamide compound in combination with a platinum complex, a DNA-topoisomerase I inhibitor, an antimetabolite, a microtubule inhibitor or an antibiotic.
摘要翻译：本发明涉及药物组合物，试剂盒，治疗癌症的方法和/或抑制血管发生的方法，其包括与铂络合物，DNA拓扑异构酶I抑制剂，抗代谢物，微管抑制剂一种抗生素。

40. 发明申请

US20080190532A1 Rubber Composition and Tire Using the Same 有权
标题翻译：橡胶成分和轮胎使用它
公开(公告)号：US20080190532A1
公开(公告)日：2008-08-14
申请号：US10562947
申请日：2004-06-25
申请人： Eiju Suzuki , Yoichi Ozawa
发明人： Eiju Suzuki , Yoichi Ozawa
IPC分类号： B60C11/00 , C08L15/00 , C08L47/00
CPC分类号： C08L7/00 , B60C1/00 , B60C9/02 , B60C9/18 , B60C11/0008 , C08L9/00 , Y10T152/10495 , C08L2666/08 , C08F36/04 , C08F4/545
摘要： This invention relates to a rubber composition including a polyisoprene rubber having a very high cis-1,4-bond content and having an excellent balance between dynamic properties and processability, and more particularly to a rubber composition comprising as a rubber component (A) a synthetic polyisoprene rubber having a cis-1,4-bond content of not less than 99.0%, a 3,4-bond content of not more than 0.5% and a Mooney viscosity ML1+4 (100° C.) of 20-110 and (B) a natural rubber.
摘要翻译：本发明涉及一种橡胶组合物，其包含具有非常高的顺式-1,4-键含量并且在动态性能和加工性之间具有优异平衡性的聚异戊二烯橡胶，更具体地说，涉及一种橡胶组合物，其包含橡胶组分（A）a 顺式-1,4-键含量不小于99.0％，3,4-键含量不大于0.5％，门尼粘度ML 1 + 4（100）的合成聚异戊二烯橡胶 ℃）和（B）天然橡胶。

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