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31. 发明授权

US5617335A System for and method of recognizating and tracking target mark 失效
标题翻译：识别和跟踪目标标记的系统和方法
公开(公告)号：US5617335A
公开(公告)日：1997-04-01
申请号：US588320
申请日：1996-01-18
申请人： Masayoshi Hashima , Fumi Hasegawa , Keiju Okabayashi , Ichiro Watanabe , Shinji Kanda , Naoyuki Sawasaki , Yuichi Murase
发明人： Masayoshi Hashima , Fumi Hasegawa , Keiju Okabayashi , Ichiro Watanabe , Shinji Kanda , Naoyuki Sawasaki , Yuichi Murase
IPC分类号： B25J9/16 , G01S3/786 , G01S5/16 , G05D1/02 , G06K9/46 , G06T7/20 , G01S5/00
CPC分类号： G06K9/4647 , B25J9/1697 , B64G1/646 , G01S3/7864 , G01S5/163 , G06K9/3216 , G06T7/2033 , G05B2219/39387 , G05B2219/39397 , G05B2219/40613 , G06K2009/3225
摘要： A system for and a method of recognizing and tracking a target mark with a video camera is disclosed. The system includes a target mark (10) disposed on an object (1) and composed of a black circle and a white triangle mounted centrally on the black circle and three-dimensionally shifted from the black circle, a video camera (20) for imaging the target mark (10), a robot (30) supporting the video camera (20) and movable in directions with six degrees of freedom, an image processor (40) for processing image data of the target mark which is produced by the video camera (20), a shift calculating unit (50) for detecting a shift of the target mark (10) from projected histogram information of the target mark (10) which is produced by the image processor (40), and a robot controller (60) for controlling movement of the robot depending on the shift to enable the video camera (20) to track the target mark (10). The system is capable of tracking the target mark (20) attached to the object (1) on a real-time basis. Mark recognizing apparatus capable of accurately recognizing target marks of other shapes is also disclosed.
摘要翻译：公开了一种使用摄像机识别和跟踪目标标记的系统和方法。该系统包括设置在物体（1）上并由黑色圆圈和白色三角形组成的目标标记（10），其安装在黑色圆圈的中心并从黑色圆圈三维位移，用于成像的摄像机（20）所述目标标记（10），支持所述摄像机（20）并且能够以六自由度的方向移动的机器人（30），用于处理由所述摄像机产生的所述目标标记的图像数据的图像处理器（20），用于根据由图像处理器（40）产生的目标标记（10）的投影直方图信息和机器人控制器（60）检测目标标记（10）的偏移的移位计算单元（50）），用于根据移动来控制机器人的运动，以使得摄像机（20）能够跟踪目标标记（10）。该系统能够实时跟踪附接到对象（1）的目标标记（20）。还公开了能够准确地识别其他形状的目标标记的标记识别装置。

32. 发明授权

US4943528A Process for the production of optically active (R)-(-)-3-halo-1,2-propanediol 失效
标题翻译：用于制备光学活性（R） - （ - ） - 3-卤代-1,2-丙二醇的方法
公开(公告)号：US4943528A
公开(公告)日：1990-07-24
申请号：US438124
申请日：1989-11-20
申请人： Tetsuji Nakamura , Ichiro Watanabe
发明人： Tetsuji Nakamura , Ichiro Watanabe
IPC分类号： C12P7/18 , C12P41/00
CPC分类号： C12P41/00 , C12P7/18
摘要： A process for the production of an optically active (R)-(-)-3-halo-1,2-propanediol which comprises contacting a 1,3-dihalo-2-propanol with a dehalogenase originating from a microorganism belonging to the genus Corynebacterium or Microbacterium. This process makes it possible to produce the (R)-(-)-3-halo-1,2-propanediol, which is highly useful as a starting material in the synthesis of various drugs and physiologically active substances, theoretically at a yield of 100%.
摘要翻译：一种制备光学活性（R） - （ - ） - 3-卤代-1,2-丙二醇的方法，该方法包括使1,3-二卤-2-丙醇与源自属于该属的微生物的脱卤素酶接触棒状杆菌或微杆菌。该方法使得可以生产在各种药物和生理活性物质的合成中作为原料高度有用的（R） - （ - ） - 3-卤代-1,2-丙二醇，理论上以产率 100％。

33. 发明授权

US4421855A Production of acrylamide using immobilized cells 失效
标题翻译：使用固定化细胞生产丙烯酰胺
公开(公告)号：US4421855A
公开(公告)日：1983-12-20
申请号：US292848
申请日：1981-08-14
申请人： Ichiro Watanabe , Keiichi Sakashita , Yasuo Ogawa
发明人： Ichiro Watanabe , Keiichi Sakashita , Yasuo Ogawa
IPC分类号： C12N11/04 , C12N11/08 , C12P13/02 , C12R1/15 , C12R1/365
CPC分类号： C12N11/04 , C12P13/02
摘要： A process is described for producing acrylamide from acrylonitrile using an immobilized microorganism containing gel, which comprises immobilizing a microorganism having nitrilasic activity with a cationic acrylamide-based polymer gel and bringing acrylonitrile into contact with the immobilized microorganism gel in an aqueous medium containing substantially no salt.
摘要翻译：描述了一种用于使用固定化的含有微生物的凝胶从丙烯腈制备丙烯酰胺的方法，该方法包括用阳离子丙烯酰胺类聚合物凝胶固定具有亚硝酸活性的微生物，并使丙烯腈与基本上不含盐的水性介质中的固定化微生物凝胶接触。

34. 发明授权

US4414331A Process for producing a highly concentrated aqueous acrylamide solution by means of microorganisms 失效
标题翻译：通过微生物生产高浓度丙烯酰胺水溶液的方法
公开(公告)号：US4414331A
公开(公告)日：1983-11-08
申请号：US160792
申请日：1980-06-19
申请人： Ichiro Watanabe , Yoshiaki Satoh , Yasumasa Yamaguchi
发明人： Ichiro Watanabe , Yoshiaki Satoh , Yasumasa Yamaguchi
IPC分类号： C07C233/09 , C12P13/02 , C12N11/04 , C12R1/00 , C12R1/07 , C12R1/13 , C12R1/15 , C12R1/265 , C12R1/365
CPC分类号： C12P13/02 , Y10S435/813 , Y10S435/819 , Y10S435/822 , Y10S435/832 , Y10S435/84 , Y10S435/843 , Y10S435/859 , Y10S435/872
摘要： A process for producing acrylamide from acrylonitrile by utilizing a microorganism or enzyme capable of hydrating acrylonitrile into acrylamide in the form of a highly concentrated aqueous solution of acrylamide which comprises bringing acrylonitrile in contact with the microorganism or enzyme in an aqueous medium at a pH of from 6 to 10, at a temperature of from the freezing point to 50.degree. C., and under such conditions that the concentration of acrylamide in the reaction solution after the completion of the reaction is from 5% by weight to less than 20% by weight, and concentrating the resulting reaction solution; this invention further includes an embodiment wherein the reaction solution is concentrated by cooling the reaction solution after the reaction to from -4.degree. C. to -9.degree. C. to crystallize ice, separating the ice, and using the ice so separated for cooling during the hydration reaction. In addition, this invention includes an embodiment wherein the concentrated solution obtained by the above embodiment is further concentrated by evaporating the water contained in the concentrated solution.
摘要翻译：通过使用能够将丙烯腈水合至丙烯酰胺的微生物或酶以丙烯酰胺的高度浓缩水溶液的形式从丙烯腈制备丙烯酰胺的方法，其包括使丙烯腈与微生物或酶接触的水性介质中，pH为在冰点至50℃的温度下，在反应溶液中丙烯酰胺浓度为5重量％至小于20重量％的条件下，并浓缩得到的反应溶液; 本发明还包括一个实施方案，其中通过将反应溶液冷却至-4℃至-9℃来浓缩反应溶液，使冰结晶，分离冰，并使用冰分离以冷却水化反应。此外，本发明包括其中通过蒸发浓缩溶液中包含的水进一步浓缩由上述实施方案获得的浓缩溶液的实施方案。

35. 发明授权

US09114131B2 Antibody targeting osteoclast-related protein Siglec-15 有权
标题翻译：抗体靶向破骨细胞相关蛋白Siglec-15
公开(公告)号：US09114131B2
公开(公告)日：2015-08-25
申请号：US13877779
申请日：2011-10-04
申请人： Ichiro Watanabe , Yoshiharu Hiruma , Eisuke Tsuda , Tatsuji Matsuoka , Toshiaki Ohtsuka , Tohru Takahashi , Toshinori Agatsuma , Sandra Miller , Robert Mühlbacher , Kathrin-Ladetzki Baehs , Steffen Runz , Ulrike Schubert , Ingrid Schuster , Dirk Ponsel
发明人： Ichiro Watanabe , Yoshiharu Hiruma , Eisuke Tsuda , Tatsuji Matsuoka , Toshiaki Ohtsuka , Tohru Takahashi , Toshinori Agatsuma , Sandra Miller , Robert Mühlbacher , Kathrin-Ladetzki Baehs , Steffen Runz , Ulrike Schubert , Ingrid Schuster , Dirk Ponsel
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/22 , C12N5/10 , C12N15/11 , C12N15/63 , C07K16/28 , A61K45/06
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2803 , C07K2317/21 , C07K2317/55 , C07K2317/92
摘要： An isolated antibody capable of binding Siglec-15 which inhibits osteoclast formation and/or osteoclastic bone resorption, or a functional fragment thereof. The heavy chain of the antibody comprises a CDRH1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 106, a CDRH2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 107, and a CDRH3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 35, 45, 55, 65 or 80. The light chain of the antibody comprises a CDRL1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 73 or 83, a CDRL2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 108, and a CDRL3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 40, 50, 60, 70, 90, 100 or 109.
摘要翻译：能够结合抑制破骨细胞形成和/或破骨细胞骨吸收的Siglec-15的分离抗体或其功能片段。抗体的重链包含CDRH1，其包含与SEQ ID NO：106具有至少80％序列同一性的序列，CDRH2包含与SEQ ID NO：107具有至少80％序列同一性的序列，以及CDRH3，其包含具有与SEQ ID NO：35,45,55,65或80之一具有至少80％序列同一性的序列。抗体的轻链包含CDRL1，其包含与SEQ ID NO：73具有至少80％序列同一性的序列或83，CDRL2，其包含与SEQ ID NO：108具有至少80％序列同一性的序列，和CDRL3，其包含与SEQ ID NO：40,50,60,70， 90，100或109。

36. 发明申请

US20130280276A1 ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN SIGLEC-15 有权
标题翻译：抗体靶向与OSTEOCLAST相关的蛋白质信号15
公开(公告)号：US20130280276A1
公开(公告)日：2013-10-24
申请号：US13877779
申请日：2011-10-04
申请人： Ichiro Watanabe , Yoshiharu Hiruma , Eisuke Tsuda , Tatsuji Matsuoka , Toshiaki Ohtsuka , Tohru Takahashi , Toshinori Agatsuma , Sandra Miller , Robert Mühlbacher , Kathrin-Ladetzki Baehs , Steffen Runz , Ulrike Schubert , Ingrid Schuster , Dirk Ponsel
发明人： Ichiro Watanabe , Yoshiharu Hiruma , Eisuke Tsuda , Tatsuji Matsuoka , Toshiaki Ohtsuka , Tohru Takahashi , Toshinori Agatsuma , Sandra Miller , Robert Mühlbacher , Kathrin-Ladetzki Baehs , Steffen Runz , Ulrike Schubert , Ingrid Schuster , Dirk Ponsel
IPC分类号： A61K39/395 , A61K45/06
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2803 , C07K2317/21 , C07K2317/55 , C07K2317/92
摘要： An isolated antibody capable of binding Siglec-15 which inhibits osteoclast formation and/or osteoclastic bone resorption, or a functional fragment thereof. The heavy chain of the antibody comprises a CDRH1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 106, a CDRH2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 107, and a CDRH3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 35, 45, 55, 65 or 80. The light chain of the antibody comprises a CDRL1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 73 or 83, a CDRL2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 108, and a CDRL3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 40, 50, 60, 70, 90, 100 or 109.
摘要翻译：能够结合抑制破骨细胞形成和/或破骨细胞骨吸收的Siglec-15的分离抗体或其功能片段。抗体的重链包含CDRH1，其包含与SEQ ID NO：106具有至少80％序列同一性的序列，CDRH2包含与SEQ ID NO：107具有至少80％序列同一性的序列，以及CDRH3，其包含具有与SEQ ID NO：35,45,55,65或80之一具有至少80％序列同一性的序列。抗体的轻链包含CDRL1，其包含与SEQ ID NO：73具有至少80％序列同一性的序列或83，CDRL2，其包含与SEQ ID NO：108具有至少80％序列同一性的序列，和CDRL3，其包含与SEQ ID NO：40,50,60,70， 90，100或109。

37. 发明申请

US20070224527A1 Apparatus for and method of recording image 有权
标题翻译：记录图像的装置和方法
公开(公告)号：US20070224527A1
公开(公告)日：2007-09-27
申请号：US11723578
申请日：2007-03-21
申请人： Hideaki Ogawa , Hiroshi Okamoto , Keisuke Hirayama , Yuji Kurokawa , Hiroyuki Fujisawa , Ichiro Watanabe
发明人： Hideaki Ogawa , Hiroshi Okamoto , Keisuke Hirayama , Yuji Kurokawa , Hiroyuki Fujisawa , Ichiro Watanabe
IPC分类号： G03C5/00
CPC分类号： B41J2/45
摘要： An image recording apparatus (1) causes a recording head (20) to move through a distance corresponding to one half of the recording width of the recording head (20) in a sub-scanning direction each time a recording drum (10) makes one rotation. This, light emitting devices (23, 24) record two line data in advance, and thereafter following light emitting devices (21, 22) record the same line data repeatedly at the same position. This increases the energy of laser light beams given to a recording position on a printing plate (P) to accomplish the recording of an image with reliability. The recording speed is not extremely decreased because not all light emitting devices (21 to 24) are used to make the repeated recordings at the same position on the printing plate (P). Further, the construction of optical systems and driving systems in the image recording apparatus is not complicated.
摘要翻译：图像记录装置（1）使得记录头（20）在每次记录鼓（10）形成一个时，在副扫描方向上使记录头（20）相对于记录头（20）的记录宽度的一半的距离移动回转。这样，发光装置（23,24）预先记录两行数据，之后，发光装置（21,22）在同一位置重复记录同一行数据。这增加了赋予印版（P）上的记录位置的激光束的能量，从而可靠地完成图像的记录。由于不是所有的发光装置（21〜24）用于在印版（P）上的同一位置进行重复记录，因此记录速度不会极度降低。此外，图像记录装置中的光学系统和驱动系统的构造并不复杂。

38. 发明授权

US06721247B2 Disk apparatus and track following control method 失效
标题翻译：磁盘设备跟踪跟踪控制方法
公开(公告)号：US06721247B2
公开(公告)日：2004-04-13
申请号：US09899434
申请日：2001-07-05
申请人： Ichiro Watanabe
发明人： Ichiro Watanabe
IPC分类号： G11B700
CPC分类号： G11B5/59627 , G11B7/0945 , G11B7/0953 , G11B11/10576
摘要： A disk apparatus has a head, a positional signal detection section that detects a track of a medium, a feedback control section which computes a control signal for moving the head from the location of a positional signal generated by a position signal detector, and a learning control section which generates and stores an unknown function for one disk rotation, which includes a periodic disturbance, in a memory which is comprised of N number of memory cells by a learning algorithm as an approximate function which is approximated by the height of each of several blocks in the medium. The learning control section reads the learning result of the two memory cells at locations which are moved forward for a predetermined amount of time, and interpolates the results so as to generate a periodic disturbance compensation signal.
摘要翻译：磁盘装置具有头部，位置信号检测部分，其检测介质的轨道;反馈控制部分，其从位置信号检测器产生的位置信号的位置计算用于移动头部的控制信号;以及学习控制部分，其通过学习算法生成并存储包括周期性干扰的未知功能，该存储器由N个存储器单元组成，作为近似函数，其近似于几个在媒体中的块。学习控制部分在向前移动预定时间量的位置处读取两个存储单元的学习结果，并且内插该结果以产生周期性的干扰补偿信号。

39. 发明授权

US06628579B2 Storage apparatus 失效
标题翻译：储存装置
公开(公告)号：US06628579B2
公开(公告)日：2003-09-30
申请号：US09454627
申请日：1999-12-06
申请人： Ichiro Watanabe , Takayuki Kawabe
发明人： Ichiro Watanabe , Takayuki Kawabe
IPC分类号： G11B700
CPC分类号： G11B7/095 , G11B5/59627 , G11B21/106
摘要： A learning control unit is provided between a feedback calculating unit and a driving unit. When a period for one medium rotation period is assumed to be TL, an unknown drive current function Irepeat(t) which repeats for a period of time from a start time t=0 for one medium rotation period to an end time t=TL is obtained by a learning algorithm as an approximated function I{circumflex over ( )}repeat(t) that is approximately presumed by a set of the heights Ci of N rectangular functions having interval numbers i=0˜ (N−1) whose time widths are obtained by dividing the period for one medium rotation period into N intervals. After the learning, a learning control signal I{circumflex over ( )}repeat is outputted synchronously with the medium rotation and a feed-forward control is performed. The learning control unit can be provided between a position signal detecting unit and a feedback calculating unit and can learn a position function TESrepeat(t) as an approximated function TES{circumflex over ( )}repeat(t) in a similar manner.
摘要翻译：学习控制单元设置在反馈计算单元和驱动单元之间。当一个中等旋转周期的周期被假设为TL时，从一个中间旋转周期到结束时间t = TL的开始时间t = 0重复一段时间的未知驱动电流函数Irepeat（t）是通过学习算法获得的近似函数I repeat（t），其近似假设为具有间隔数为i = 0〜（N-1）的N个矩形函数的高度Ci的集合，其中时间宽度是通过将周期对于一个中等旋转周期到N个间隔。在学习之后，与介质旋转同步地输出学习控制信号I repeat，并且执行前馈控制。学习控制单元可以设置在位置信号检测单元和反馈计算单元之间，并且可以以类似的方式学习位置函数TESrepeat（t）作为近似函数TES repeat（t）。

40. 发明授权

US5830695A Actinomycete promoter 失效
标题翻译：放线菌启动子
公开(公告)号：US5830695A
公开(公告)日：1998-11-03
申请号：US756592
申请日：1996-11-27
申请人： Nobufusa Serizawa , Ichiro Watanabe
发明人： Nobufusa Serizawa , Ichiro Watanabe
IPC分类号： C12N15/11 , C12N1/15 , C12N1/21 , C12N9/02 , C12N15/53 , C12N15/76 , C12P1/06 , C12P7/62 , C12R1/04 , C12R1/465 , C12P21/02 , C07H21/04 , C12N15/67
CPC分类号： C12N9/0077 , C12N15/76 , C12P7/62
摘要： A 1 kbp length of the 5'-noncoding region of the gene encoding cytochrome P-450.sub.sca-2 in the actinomycete Streptomyces carbophilus has transcription promoter activity which is substrate inducible. When the 1 kbp region is shortened, transcription activity becomes constitutive and the shortened promoters can be used advantageously in expression systems, especially those expressing P-450.sub.sca-2 in the presence of ML-236B to produce pravastatin sodium.
摘要翻译：在放线菌Streptomyces carbophilus中编码细胞色素P-450sca-2的基因的5'-非编码区的1kbp长度具有可诱导底物的转录启动子活性。当1kbp区域缩短时，转录活性变为组成型的，并且缩短的启动子可以有利地用于表达系统，特别是在ML-236B存在下表达P-450sca-2的那些，以产生普伐他汀钠。

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