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31. 发明授权

US06391538B1 Stabilization of implantable bioprosthetic tissue 失效
公开(公告)号：US06391538B1
公开(公告)日：2002-05-21
申请号：US09501331
申请日：2000-02-09
申请人： Narendra Vyavahare , Ivan Alferiev , Robert J. Levy
发明人： Narendra Vyavahare , Ivan Alferiev , Robert J. Levy
IPC分类号： A01N100
CPC分类号： A61L27/3687 , A61L27/3641 , A61L27/50 , A61L27/507
摘要： The invention relates to implantable bioprostheses (e.g. implantable biological tissues) and to compositions and methods for stabilizing them. Implantable bioprostheses stabilized as described herein exhibit improved mechanical properties and reduced post-implantation calcification. The implantable bioprosthesis is made by contacting a bioprosthesis (e.g. a tissue obtained from an animal or an article comprising a tissue and a synthetic material) with a polyepoxy amine compound.

32. 发明授权

US10058419B2 Oxidation resistant bioprosthetic tissues and preparation thereof 有权
公开(公告)号：US10058419B2
公开(公告)日：2018-08-28
申请号：US14232005
申请日：2012-07-11
申请人： Robert J. Levy , Ivan Alferiev , Stanley Stachelek , Jeanne M. Connolly , Abigail Christian
发明人： Robert J. Levy , Ivan Alferiev , Stanley Stachelek , Jeanne M. Connolly , Abigail Christian
IPC分类号： A61L27/36 , A61F2/24 , A61L27/50 , A61K35/12
CPC分类号： A61F2/2412 , A61K35/12 , A61L27/3604 , A61L27/3687 , A61L27/505 , F04C2270/041
摘要： Oxidation resistant bioprosthetic tissues and oxidation resistant bioprosthetic heart valve leaflets are described. Also provided are methods for preparing the oxidation resistant bioprosthetic tissues and bioprosthetic heart valve leaflets, and methods for preventing oxidative degeneration in bioprosthetic tissues, including immobilizing covalently an effective amount of an antioxidant to the bioprosthetic tissue.

33. 发明授权

US09233163B2 Hydrolytically releasable prodrugs for sustained release nanoparticle formulations 有权
标题翻译：用于缓释纳米颗粒制剂的水解可释放的前药
公开(公告)号：US09233163B2
公开(公告)日：2016-01-12
申请号：US13976776
申请日：2011-12-28
申请人： Ivan Alferiev , Michael Chorny , Robert J. Levy
发明人： Ivan Alferiev , Michael Chorny , Robert J. Levy
IPC分类号： A61K47/48 , C08B37/02
CPC分类号： A61K47/48123 , A61K47/551 , A61K47/554 , A61K47/645 , C08B37/0021
摘要： A prodrug according to formula (I) wherein R2 is a residue of a drug, said drug having a hydroxyl group by which the COOR2 group is formed; Z is O or NH; m is 0 or 1; and R3 is an organic moiety comprising a lipophilic group or a residue of a polymer, provided that Z is 0 if the polymer is carboxymethyl dextran. A system includes a plurality of magnetic nanoparticles including a prodrug as described above, a stent and a source of uniform magnetic field capable of producing temporary magnetization of the stent and/or the magnetic nanoparticles. A method of treating a medical condition with a drug includes administering to a patient in need of the drug a prodrug as described above, the prodrug being capable of releasing the drug in the patient after the administration step.
摘要翻译：根据式（I）的前药，其中R2是药物的残基，所述药物具有形成COOR 2基团的羟基; Z是O或NH; m为0或1; 并且R3是包含亲油基团或聚合物残基的有机部分，条件是如果聚合物是羧甲基葡聚糖，则Z为0。一种系统包括多个磁性纳米颗粒，包括如上所述的前体药物，能够产生支架和/或磁性纳米颗粒的暂时磁化的支架和均匀磁场源。用药物治疗医学病症的方法包括向需要该药物的患者施用如上所述的前药，该前药能够在施用步骤后释放患者的药物。

34. 发明授权

US08465542B2 Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof 有权
标题翻译：类固醇脂质改性聚氨酯作为可植入生物材料，其制备和用途
公开(公告)号：US08465542B2
公开(公告)日：2013-06-18
申请号：US13487984
申请日：2012-06-04
申请人： Robert J. Levy , Ivan Alferiev , Stanley J. Stachelek
发明人： Robert J. Levy , Ivan Alferiev , Stanley J. Stachelek
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： C08G18/3876 , A61F2/06 , A61F2/08 , A61F2/24 , A61F2/82 , A61L27/18 , C08F283/006 , C08F283/04 , C08G18/83 , C08L101/02 , C08L75/04
摘要： A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.
摘要翻译：包含来自改性聚氨酯的至少一种尿烷氮和/或至少一个碳原子的脂质取代基侧链的改性聚氨酯，其制备改性聚氨酯的方法及其作为可植入生物材料的用途。

35. 发明授权

US08193290B2 Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof 有权
标题翻译：类固醇脂质改性聚氨酯作为可植入生物材料，其制备和用途
公开(公告)号：US08193290B2
公开(公告)日：2012-06-05
申请号：US12143275
申请日：2008-06-20
申请人： Robert J. Levy , Ivan Alferiev , Stanley J. Stachelek
发明人： Robert J. Levy , Ivan Alferiev , Stanley J. Stachelek
IPC分类号： C08L89/00
CPC分类号： C08G18/3876 , A61F2/06 , A61F2/08 , A61F2/24 , A61F2/82 , A61L27/18 , C08F283/006 , C08F283/04 , C08G18/83 , C08L101/02 , C08L75/04
摘要： A modified polyurethane including a lipid substituent from at least one urethane nitrogen and/or at least carbon atom of the modified polyurethane.
摘要翻译：一种改性聚氨酯，其包含来自改性聚氨酯的至少一个氨基甲酸酯氮和/或至少碳原子的脂质取代基。

36. 发明授权

US08618242B2 Photo-activated attachment of cholesterol to polyurethane surfaces for adhesion of endothelial cells 失效
标题翻译：胆固醇与聚氨酯表面的光激活附着，用于粘附内皮细胞
公开(公告)号：US08618242B2
公开(公告)日：2013-12-31
申请号：US13263244
申请日：2010-04-09
申请人： Robert J. Levy , Ivan Alferiev , Stanley J. Stachelek
发明人： Robert J. Levy , Ivan Alferiev , Stanley J. Stachelek
IPC分类号： C08G64/00 , C08G63/02
CPC分类号： A61L27/34 , A61L27/18 , A61L27/50 , A61L2400/18 , A61L2430/20 , C08F226/02 , C08J7/047 , C08J7/18 , C08J2375/04 , Y10T428/31551 , C08L75/04
摘要： A polymer is provided according to structure I wherein Y is a thiol-reactive group and Z is an ionogenic group. The surface of a polymeric substrate is modified by contacting the surface with a polymer according to structure II or structure III and exposing the surface to ultraviolet light, optionally followed by contacting the modified surface with the polymer according to structure I.
摘要翻译：根据结构I提供聚合物，其中Y是硫醇反应性基团，Z是离子型基团。通过使表面与根据结构II或结构III的聚合物接触并将表面暴露于紫外线，任选然后使改性表面与根据结构I的聚合物接触来改性聚合物基材的表面。

37. 发明申请

US20120316295A1 STEROID LIPID-MODIFIED POLYURETHANE AS AN IMPLANTABLE BIOMATERIAL, THE PREPARATION AND USES THEREOF 有权
标题翻译：甾体脂质改性聚氨酯作为可植入的生物材料，其制备及其用途
公开(公告)号：US20120316295A1
公开(公告)日：2012-12-13
申请号：US13487984
申请日：2012-06-04
申请人： Robert J. Levy , Ivan Alferiev , Stanley J. Stachelek
发明人： Robert J. Levy , Ivan Alferiev , Stanley J. Stachelek
IPC分类号： C08G18/83
CPC分类号： C08G18/3876 , A61F2/06 , A61F2/08 , A61F2/24 , A61F2/82 , A61L27/18 , C08F283/006 , C08F283/04 , C08G18/83 , C08L101/02 , C08L75/04
摘要： A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.
摘要翻译：改性聚氨酯，其包含来自改性聚氨酯的至少一个氨基甲酸酯氮和/或至少一个碳原子的脂质取代基侧链，制备改性聚氨酯的方法及其作为可植入生物材料的用途。

38. 发明授权

US07156881B2 Counteracting bioprosthetic calcification 失效
标题翻译：抵制生物假体钙化
公开(公告)号：US07156881B2
公开(公告)日：2007-01-02
申请号：US10336857
申请日：2003-01-06
申请人： Robert J. Levy , Ivan Alferiev
发明人： Robert J. Levy , Ivan Alferiev
IPC分类号： A61F2/02
CPC分类号： A61K31/663 , A61L27/3687 , A61L27/54 , A61L31/16 , A61L2400/02
摘要： Adapting crosslinking with triglycidyl amine (TGA) to incorporate the use of a particular type of anti-calcification agent provides a broad-reaching solution to the problem in vivo bioprosthesis calcification. The anti-calcification agent in question includes a polyphosphonate compound that contains a functional group, which serves as a reaction site between the polyphosphonate and a polyepoxide. The functional group is reactive enough to dominate the reaction between the polyphosphonate and the polyepoxide, thereby excluding the chelating oxygen atoms of polyphosphonate from the reaction, protecting their anti-calcification ability. Furthermore, the high reactivity of the functional group allows the polyphosphonate to attach to the polyepoxide more completely, which improves the calcification resistance of bioprosthetic material with which the polyepoxide is crosslinked.
摘要翻译：使用三缩水甘油胺（TGA）进行交联以引入特定类型的抗钙化剂的使用为体内生物假体钙化提供了广泛的解决方案。所讨论的抗钙化剂包括含有官能团的聚膦酸酯化合物，其用作聚膦酸盐和聚环氧化物之间的反应位点。官能团反应性足以支配聚膦酸酯与聚环氧化物之间的反应，从反应中排除多膦酸的螯合氧原子，保护其抗钙化能力。此外，官能团的高反应性允许聚膦酸盐更加完全地附着到聚环氧化物上，这提高了聚环氧化物交联的生物纤维材料的耐钙性。

39. 发明授权

US06689861B2 Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same 失效
标题翻译：在生物系统中表现出增强的稳定性的衍生的聚氨酯组合物及其制备方法
公开(公告)号：US06689861B2
公开(公告)日：2004-02-10
申请号：US09985316
申请日：2001-11-02
申请人： Robert J. Levy , Ivan Alferiev
发明人： Robert J. Levy , Ivan Alferiev
IPC分类号： C08G1883
CPC分类号： C08G18/4854 , C08G18/6674 , C08G18/836
摘要： The invention relates to methods of making polyurethane derivatives which can be readily further derivatized using stabilizing agents such as anti-calcification agents, anti-thrombogenesis agents, and chemical and mechanical degradation-inhibiting agents. The invention also includes methods of making polyurethane derivatives so further derivatized and to polyurethanes derivatives made using such methods.
摘要翻译：本发明涉及制备聚氨酯衍生物的方法，其可以使用稳定剂如抗钙化剂，抗血栓形成剂和化学和机械降解抑制剂容易地进一步衍生化。本发明还包括制备如此进一步衍生的聚氨酯衍生物和使用这些方法制备的聚氨酯衍生物的方法。

40. 发明授权

US06320011B1 Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same 有权
标题翻译：在生物系统中表现出增强的稳定性的衍生的聚氨酯组合物及其制备方法
公开(公告)号：US06320011B1
公开(公告)日：2001-11-20
申请号：US09620857
申请日：2000-07-21
申请人： Robert J. Levy , Ivan Alferiev
发明人： Robert J. Levy , Ivan Alferiev
IPC分类号： C08G1883
CPC分类号： C08G18/4854 , C08G18/6674 , C08G18/836
摘要： The invention relates to methods of making polyurethane derivatives which can be readily further derivatized using stabilizing agents such as anti-calcification agents, anti-thrombogenesis agents, and chemical and mechanical degradation-inhibiting agents. The invention also includes methods of making polyurethane derivatives so further derivatized and to polyurethanes derivatives made using such methods.
摘要翻译：本发明涉及制备聚氨酯衍生物的方法，其可以使用稳定剂如抗钙化剂，抗血栓形成剂和化学和机械降解抑制剂容易地进一步衍生化。本发明还包括制备如此进一步衍生的聚氨酯衍生物和使用这些方法制备的聚氨酯衍生物的方法。

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