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31. 发明申请

US20110052623A1 DRIED MICROBIAL CELLS OR MICROORGANISM EXTRACT CONTAINING STABILIZED (SS)-S-ADENOSYL-L-METHIONINE AND METHOD FOR PRODUCTION OF THE DRIED MICROORGANISM CELL OR MICROORGANISM EXTRACT 审中-公开
标题翻译：干燥的微生物细胞或含有稳定的（SS）-S-腺苷-L-甲硫氨酸的微生物提取物及其生产干细胞微生物细胞或微生物提取物的方法
公开(公告)号：US20110052623A1
公开(公告)日：2011-03-03
申请号：US12809474
申请日：2008-12-18
申请人： Makoto Ueda , Yui Kawashima , Ryuuji Miki , Takahiro Ueda , Shiro Kitamura , Hiroshi Kubo
发明人： Makoto Ueda , Yui Kawashima , Ryuuji Miki , Takahiro Ueda , Shiro Kitamura , Hiroshi Kubo
IPC分类号： A61K36/06 , A61P25/28 , A61P25/24 , A61P1/16
CPC分类号： C12N1/16 , A23K20/142 , A23L33/13 , A23L33/135 , A61K31/7076
摘要： Dried microbial cells or microbial extract containing (SS)-SAM in which the progress in SAM chemical degradation or (SS)-SAM epimerization is significantly delayed can be obtained by drying microbial cells or microbial extract containing S-adenosyl-L-methionine (SAM), followed by maturing treatment. It is possible to stabilize SAM in a composition comprising dried microbial cells or microbial extract containing SAM (1% by weight or more) without the need of strict environment control.
摘要翻译：通过干燥含有S-腺苷-L-甲硫氨酸（SAM）的微生物细胞或微生物提取物，可以获得含有（SS）-SAM的干燥的微生物细胞或微生物提取物，其中SAM化学降解或（SS）-SAM差向异构体的进展显着延迟），然后成熟处理。可以将SAM稳定在包含干燥的微生物细胞或含有SAM（1重量％以上）的微生物提取物的组合物中，而不需要严格的环境控制。

32. 发明授权

US07524993B2 Method of producing reduced coenzyme Q10 as oily product 有权
标题翻译：还原型辅酶Q10作为油性产品的生产方法
公开(公告)号：US07524993B2
公开(公告)日：2009-04-28
申请号：US11716828
申请日：2007-03-12
申请人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C07C41/18
CPC分类号： C07C41/26 , C07C41/34 , C07C43/23
摘要： The present invention provides a method for obtaining reduced coenzyme Q10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. suited for a commercial scale production in high quality and efficiently. The high-quality oily reduced coenzyme Q10 which has low viscosity and thereby easily handled may be produced by separating an aqueous phase from the reaction mixture obtainable by oily reacting oxidized coenzyme Q10 with a reducing agent in water, or by distilling off an coexisting organic solvent at or above the melting temperature of reduced coenzyme Q10 in concentrating the organic phase containing reduced coenzyme Q10. Moreover, a solution or slurry of reduced coenzyme Q10 may be obtained by adding a desired solvent to the obtained oily product, or a solid of reduced coenzyme Q10 may be produced by contacting the oily product with a seed crystal.
摘要翻译：本发明提供一种用于获得还原型辅酶Q10的方法，其可用作食品中的成分，功能性营养食品，特定保健食品，营养补充剂，营养物质，饮料，饲料，化妆品，药物，补救剂，预防药物等。商业规模生产高品质高效。低粘度且易于处理的优质油性还原型辅酶Q10可以通过将氧化型辅酶Q10与还原剂在水中油性反应得到的反应混合物中分离出水相，或者蒸馏出共存的有机溶剂在浓缩还原型辅酶Q10的有机相时，还原型辅酶Q10的熔点以上。此外，可以通过向获得的油性产品中加入所需的溶剂来获得还原型辅酶Q10的溶液或浆液，或者可以通过使油状产物与晶种接触来制备还原型辅酶Q10的固体。

33. 发明申请

US20080026063A1 Composition containing reduced coenzyme Q10 and production method thereof 有权
标题翻译：含有还原型辅酶Q10的组合物及其制备方法
公开(公告)号：US20080026063A1
公开(公告)日：2008-01-31
申请号：US11812887
申请日：2007-06-22
申请人： Takashi Ueda , Shinsuke Akao , Shiro Kitamura , Hideyuki Kishida , Takahiro Ueda
发明人： Takashi Ueda , Shinsuke Akao , Shiro Kitamura , Hideyuki Kishida , Takahiro Ueda
IPC分类号： A61K31/122 , A61K9/00 , C07C49/76
CPC分类号： C07C50/28 , A61K9/0056 , A61K9/107 , A61K9/1652 , A61K9/1664 , A61K9/2018 , A61K9/4858 , A61K9/4875 , A61K31/122
摘要： The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q10 is polydispersed forming a domain in a matrix containing a water-soluble excipient, which simultaneously shows high oxidative stability and high oral absorbability, a production method thereof, and a stabilizing method thereof. It also provides a food, food with nutrient function claims, food for specified health uses, dietary supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the composition.
摘要翻译：本发明提供一种颗粒组合物，其中含有还原型辅酶Q 10的油组分是多分散的，在含有水溶性赋形剂的基质中形成一个结构域，其同时表现出高氧化稳定性和高口服吸收性，其制造方法及其稳定化方法。它还提供食物，具有营养功能的食物，特定健康用途的食物，膳食补充剂，营养产品，动物药物，饮料，饲料，宠物食品，化妆品，药物，治疗药物，预防药物等，其含有组成。

34. 发明申请

US20070196349A1 Whitening composition containing reduced coenzyme Q 审中-公开
标题翻译：含有还原型辅酶Q的美白组合物
公开(公告)号：US20070196349A1
公开(公告)日：2007-08-23
申请号：US11653974
申请日：2007-01-17
申请人： Shiro Kitamura , Takahiro Ueda , Yasuyoshi Ueda , Hideyuki Kishida , Kenji Fujii , Kazunori Hosoe
发明人： Shiro Kitamura , Takahiro Ueda , Yasuyoshi Ueda , Hideyuki Kishida , Kenji Fujii , Kazunori Hosoe
IPC分类号： A61K8/18
CPC分类号： A61Q19/02 , A23L33/10 , A23V2002/00 , A61K8/355 , A23V2200/318 , A23V2250/314
摘要： The present invention provides a cosmetic or food composition which is excellent in a skincare effect, particularly an effect of whitening the skin browned due to ultraviolet radiation or aging, and which can be safely used for many mammals. The present invention provides a whitening composition comprising reduced coenzyme Q represented by formula (1) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a whitening composition further comprising oxidized coenzyme Q represented by formula (2) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a method for whitening the skin of a mammal, the method comprising administering the mammal with the composition.
摘要翻译：本发明提供一种护肤效果优异的化妆品或食品组合物，特别是由于紫外线照射或老化而使皮肤变白而变白的效果，可以安全地用于许多哺乳动物。本发明提供一种美白组合物，其包含由式（1）表示的还原型辅酶Q作为有效成分：其中n表示1〜12的整数。本发明还提供了还含有由式（2）表示的氧化型辅酶Q ）作为有效成分：其中n表示1至12的整数。本发明还提供了一种使哺乳动物的皮肤变白的方法，所述方法包括给哺乳动物施用该组合物。

35. 发明申请

US20070104701A1 Method for stabilizing reduced coenzyme Q10 有权
标题翻译：稳定还原型辅酶Q10的方法
公开(公告)号：US20070104701A1
公开(公告)日：2007-05-10
申请号：US11586511
申请日：2006-10-26
申请人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K38/43 , A61K9/48
CPC分类号： A61K9/4866 , A61K47/14 , A61K47/24 , A61K47/44
摘要： The present invention has its object to provide a method for stabilizing reduced coenzyme Q10, which is usable as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs and the like. Reduced coenzyme Q10, which is readily oxidized in the air, is stabilized by causing ascorbic acid or a related compound thereof to coexist with a polyglycerol fatty acid ester with a polymerization degree of glycerol being not lower than 3 and/or a condensed ricinoleic acid polyglyceride in a mixture of the reduced coenzyme Q10 and an oil and fat.
摘要翻译：本发明的目的是提供一种用于稳定还原型辅酶Q 10的方法，其可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药品，补救措施，预防药物等。通过使抗坏血酸或其相关化合物与甘油的聚合度不低于3的聚甘油脂肪酸酯共存而使在空气中容易氧化的还原型辅酶Q 10被稳定化和/或缩合蓖麻油酸聚甘油酯在还原型辅酶Q 10与油脂之间的混合物中。

36. 发明申请

US20070053985A1 Coenzyme Q10-containing fine particle with excellent dispersibility 审中-公开
标题翻译：含辅酶Q10的微粒具有优异的分散性
公开(公告)号：US20070053985A1
公开(公告)日：2007-03-08
申请号：US11509100
申请日：2006-08-23
申请人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K38/43 , A61K9/14 , A61K31/12
CPC分类号： A61K9/146 , A61K9/1647 , A61K31/12
摘要： The present invention has an object to provide coenzyme Q10-containing particles, which can be easily and simply dispersed into water without any surfactants or other additives, and their production method. The present invention makes it easier to prepare an aqueous dispersion containing coenzyme Q10, which is hard to disperse in water, as fine particles by modifying coenzyme Q10 into a coenzyme Q10-containing fine particle comprising coenzyme Q10 covered with a biocompatible polymer. Therefore, compositions containing dispersed coenzyme Q10 in water, such as drinkable preparations, lotions, etc., can be produced in easy and simple manners.
摘要翻译：本发明的目的是提供含有辅酶Q 10的含有颗粒，其可以容易且简单地分散在水中而没有任何表面活性剂或其它添加剂及其制备方法。本发明通过将辅酶Q 10修饰成辅酶Q容易地制备含有辅酶Q 10的水分散体，其难以分散在水中作为细颗粒包含含有生物相容性聚合物的辅酶Q 10 N的细小颗粒。因此，含有分散的辅酶Q 10在水中的组合物，例如可饮用的制剂，洗剂等，可以以简单和简单的方式制备。

37. 发明申请

US20050092969A1 Method of stabilizing compound having quinone skeleton and stabilized composition 审中-公开
标题翻译：稳定具有醌骨架化合物和稳定组合物的方法
公开(公告)号：US20050092969A1
公开(公告)日：2005-05-05
申请号：US10959052
申请日：2004-10-07
申请人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K9/50 , A61K31/122 , A61K45/06 , C09K15/04
CPC分类号： A61K45/06 , A61K9/5015 , A61K9/5036 , A61K9/5052 , A61K31/122 , A61K2300/00
摘要： The present invention has for its object to provide a method of stabilizing a compound having a quinone skeleton in the state that the compound having a quinone skeleton and an antioxidant being coexisted, and a composition containing a stabilized compound having a quinone skeleton. The present invention relates to a method of stabilizing a compound having a quinone skeleton in a composition comprising a compound having a quinone skeleton and an antioxidant which comprises coating at least one of said compound having a quinone skeleton and an antioxidant with an oil-insoluble coating medium to make both constituents coexist in an oily substance, or coating at least one of said compound having a quinone skeleton and an antioxidant with a water-insoluble coating medium to make both constituents coexist in an aqueous substance, and a composition containing a compound comprising a quinone skeleton. According to the present invention, the compound having a quinone skeleton can be stably retained even the compound having a quinone skeleton and an antioxidant being coexisted.
摘要翻译：本发明的目的是提供一种在具有醌骨架和抗氧化剂的化合物共存的状态下稳定具有醌骨架的化合物的方法，以及含有具有醌骨架的稳定化合物的组合物。本发明涉及在包含具有醌骨架和抗氧化剂的化合物的组合物中稳定具有醌骨架的化合物的方法，该方法包括用至少一种具有醌骨架和抗氧化剂的化合物与油不溶性涂层培养基以使两种成分共存于油性物质中，或者使用具有醌骨架的化合物和抗氧化剂中的至少一种与水不溶性涂布介质一起使用，以使两种成分在水性物质中共存;以及组合物，其含有醌骨架。根据本发明，即使具有醌骨架和抗氧化剂的化合物共存，也可以稳定地保持具有醌骨架的化合物。

38. 发明申请

US20050008630A1 Method of stabilizing reduced coenzyme q10 有权
标题翻译：稳定还原型辅酶Q10的方法
公开(公告)号：US20050008630A1
公开(公告)日：2005-01-13
申请号：US10492122
申请日：2002-10-10
申请人： Takahiro Ueda , Tadao Ono , Mitsutoshi Moro , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Tadao Ono , Mitsutoshi Moro , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K31/122 , A61K47/12 , A61K47/22 , A61K47/34 , A61P3/02 , A61K38/43 , C07C43/20
CPC分类号： A61K31/122 , A61K9/4866 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , B01D9/00 , C07C41/26 , C07C41/40 , C07C41/46 , C07C43/23
摘要： The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q10, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q10 with an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q10 as a byproduct is minimized by crystallizing reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof, etc., and thus a reduced coenzyme Q10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof after reducing oxidized coenzyme Q10 to reduced coenzyme Q10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q10 of high quality is produced.
摘要翻译：本发明提供还原型辅酶Q10的稳定化方法，保存方法等，其作为功能性营养食品，特定健康食品等有用。此外，本发明提供了一种有效地获得高质量的还原型辅酶Q10的方法，以及适用于商业生产的方法。在减少的辅酶Q10与抗坏血酸和柠檬酸或其相关化合物接触的条件下，通过分子氧的氧化被抑制的条件下，可以处理和稳定地保持还原型辅酶Q10，从而得到稳定的组合物。此外，将还原型辅酶Q10转化为结晶状态，使得在抗坏血酸或其相关化合物等的存在下使还原型辅酶Q10结晶化，使作为副产物的氧化型辅酶Q10的形成最小化，生产高品质的还原型辅酶Q10晶体。此外，通过使用抗坏血酸或其相关化合物将氧化型辅酶Q 10还原为还原型辅酶Q10后，在抗坏血酸或其相关化合物的存在下，依次结晶生成的还原型辅酶Q10，操作简化，最小化，从而减少了辅酶Q10 生产高品质。

39. 发明授权

US08972094B2 Mining machine movement management system 有权
标题翻译：矿机运动管理系统
公开(公告)号：US08972094B2
公开(公告)日：2015-03-03
申请号：US13825207
申请日：2012-09-13
申请人： Takashi Itoi , Tadashi Taninaga , Hisataka Fukasu , Takahiro Ueda
发明人： Takashi Itoi , Tadashi Taninaga , Hisataka Fukasu , Takahiro Ueda
IPC分类号： G01C22/00 , G05D1/02 , G06Q50/02 , G07C5/00
CPC分类号： G05D1/0276 , E02F9/2054 , E02F9/267 , G06Q50/02 , G07C5/008 , H04Q9/00 , H04Q2209/40 , H04Q2209/50
摘要： An information collection device transmits a position information request command for requesting transmission of position information of a dump truck at a predetermined point in time via a second wireless communication device and determines a state of at least one of the dump truck, a relay that relays communication from a first wireless communication device included in the dump truck to the second wireless communication device, and a travel route of the dump truck based on a response to the position information request command.
摘要翻译：信息收集装置经由第二无线通信装置发送用于请求在预定时间点发送自卸车的位置信息的位置信息请求命令，并且确定自卸车，继电器中的至少一个的状态从包括在自卸车中的第一无线通信设备到第二无线通信设备，以及基于对位置信息请求命令的响应的自卸车的行驶路线。

40. 发明申请

US20110309098A1 OPENABLE AND CLOSABLE CONTAINER 审中-公开
标题翻译：可开启和关闭的集装箱
公开(公告)号：US20110309098A1
公开(公告)日：2011-12-22
申请号：US13129444
申请日：2009-10-29
申请人： Hiroo Hayashi , Takeshi Bandoh , Takahiro Ueda , Masaho Hayashi , Hiroshi Uematsu , Toshihiko Uenishi , Norio Ochi
发明人： Hiroo Hayashi , Takeshi Bandoh , Takahiro Ueda , Masaho Hayashi , Hiroshi Uematsu , Toshihiko Uenishi , Norio Ochi
IPC分类号： B65D43/24 , B65D43/16
CPC分类号： B65D83/0805 , B65D43/164 , B65D43/22 , B65D43/24 , E05D11/06 , E05D11/10 , E05D11/105 , E05F1/1083 , E05Y2900/602
摘要： An openable and closeable container that includes a container body having a take-out opening; an opening-closing lid provided on the container body swingably about a swing axis X-X on a base end side, the opening-closing lid opening/closing the take-out opening; and plate rubber (an elastic member) provided between the container body and the opening-closing lid. A spring body is provided on the base end side of the opening-closing lid and a sloping portion (a braking portion) with which the spring body comes into contact is provided on the container body side. The spring body is gradually compressed from the state where the opening-closing lid is closed toward the state where the opening-closing lid is opened.
摘要翻译：一种可开闭的容器，其包括具有取出开口的容器体; 开闭盖，其在基端侧围绕摆动轴线X-X摆动地设置在所述容器主体上，所述开闭盖打开/关闭所述取出开口; 以及设置在容器主体和开闭盖之间的板状橡胶（弹性部件）。在开闭盖的基端侧设置有弹簧体，在容器主体侧设置有与弹簧体接触的倾斜部（制动部）。从开闭盖关闭的状态朝开闭盖打开的状态逐渐压缩弹簧体。

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