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    • 35. 发明授权
    • Screening and therapeutic methods for promoting wakefulness and sleep
    • 用于促进觉醒和睡眠的筛查和治疗方法
    • US06884596B2
    • 2005-04-26
    • US09932161
    • 2001-08-17
    • Olivier CivelliSteven Lin
    • Olivier CivelliSteven Lin
    • A61K31/00A61P5/02A61P5/04A61P25/08G01N33/74G01N33/53A61K38/00G01N33/566G01N33/567
    • G01N33/74A61K31/00
    • The invention provides methods of screening for a compound for promoting wakefulness in a mammal. The method is practiced by providing a compound that is a PrRP receptor agonist and determining the ability of the compound to promote wakefulness. Also provided by the invention are methods of screening for a compound for promoting sleep in a mammal. The methods are practiced by providing a compound that is a PrRP receptor antagonist and determining the ability of the compound to promote sleep. In addition, the invention provides a method of promoting wakefulness in a mammal. The method is practiced by administering to a mammal an effective amount of a PrRP receptor agonist. The invention further provides a method of promoting sleep in a mammal. The method is practiced by administering to a mammal an effective amount of a PrRP receptor antagonist.
    • 本发明提供筛选用于促进哺乳动物觉醒的化合物的方法。 该方法通过提供作为PrRP受体激动剂的化合物并确定化合物促进觉醒的能力来实施。 本发明还提供筛选用于促进哺乳动物睡眠的化合物的方法。 该方法通过提供作为PrRP受体拮抗剂的化合物并确定化合物促进睡眠的能力来实施。 此外,本发明提供了一种促进哺乳动物的觉醒的方法。 该方法通过向哺乳动物施用有效量的PrRP受体激动剂来实施。 本发明还提供一种促进哺乳动物睡眠的方法。 该方法通过向哺乳动物施用有效量的PrRP受体拮抗剂来实施。
    • 36. 发明授权
    • Content-based filtering of multicast information
    • 基于内容的组播信息过滤
    • US6055364A
    • 2000-04-25
    • US904219
    • 1997-07-31
    • Tony SpeakmanAlex G. TweedlySteven LinDino Farinacci
    • Tony SpeakmanAlex G. TweedlySteven LinDino Farinacci
    • H04L12/18H04L29/06H04L29/08H04L29/12H04L12/00
    • H04L29/12047H04L12/1886H04L29/06H04L29/12009H04L61/15H04L12/185H04L67/2828H04L69/329
    • The invention provides a method and system for content-based filtering of multicast information. A set of sources (S) which desire to distribute potentially large numbers of categories of differing information each associates a content descriptor (CD) with messages including information in those categories, so that a set of recipients (R) can receive information in at least some of those categories. A mapping server (M) associates a multicast address (MA) and a content mask (CM) with each content descriptor, so that network elements (N), such as routers, in the network can distribute only those messages which are of interest to recipients in multicast distribution trees for those multicast addresses. Each source generates content descriptors for each differentiable topic in a tree structured hierarchy, and obtains a multicast address and a content mask for the broadest content descriptor it is capable of distributing. Each recipient obtains the associated source, multicast address, and content mask, for each content descriptor of interest, and uses that information to join the multicast distribution tree for that information. Each network element between the source and the recipient determines what information it must forward for further distribution in response to the content descriptors, content masks, multicast addresses, and multicast distribution trees.
    • 本发明提供了一种用于基于内容的组播信息过滤的方法和系统。 一组希望分发潜在的大量不同信息类别的源(S),每个源将内容描述符(CD)与包括这些类别中的信息的消息相关联,使得一组接收者(R)可以至少接收信息 其中一些类别。 映射服务器(M)将多播地址(MA)和内容掩码(CM)与每个内容描述符相关联,使得网络中的诸如路由器的网络元素(N)可以仅分发那些感兴趣的消息 这些组播地址的组播分发树中的接收者。 每个源在树结构化层次中为每个可区分主题生成内容描述符,并获得能够分发的最广泛内容描述符的多播地址和内容掩码。 每个收件人为每个感兴趣的内容描述符获取相关联的源,多播地址和内容掩码,并使用该信息加入该信息的多播分发树。 源和接收方之间的每个网络元素确定响应于内容描述符,内容掩码,多播地址和多播分发树,它必须转发用于进一步分发的信息。