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31. 发明申请

US20100166847A1 Method for coating fine particles with lipid membrane 审中-公开
标题翻译：用脂质膜包覆微粒的方法
公开(公告)号：US20100166847A1
公开(公告)日：2010-07-01
申请号：US12656487
申请日：2010-02-01
申请人： Yasuki Kato , Masahiro Yamauchi , Hiroko Kusano , Takeshi Iwata , Takaaki Uochi , Shiro Akinaga
发明人： Yasuki Kato , Masahiro Yamauchi , Hiroko Kusano , Takeshi Iwata , Takaaki Uochi , Shiro Akinaga
IPC分类号： A61K9/127 , A61K38/02 , A61K31/7088
CPC分类号： A61K9/5123 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/141 , A61K9/146 , A61K9/5015 , A61K9/5192 , A61K31/7088 , A61K47/6911 , B01J13/12
摘要： An object of the present invention is to provide a safe, convenient and efficient method for coating fine particles with lipid membrane.There is provided a method for coating fine particles with lipid membrane, characterized in that, the rate of a polar organic solvent in an aqueous solution containing the polar organic solvent where the fine particles are dispersed and lipid is dissolved, is decreased.
摘要翻译：本发明的目的是提供一种安全，方便和有效的用脂质膜涂覆微粒的方法。提供了一种用脂质膜包覆微粒的方法，其特征在于，含有分散有微粒的极性有机溶剂和溶解脂质的水溶液中的极性有机溶剂的比例降低。

32. 发明授权

US07696359B2 Compound modified with glycerol derivative 失效
标题翻译：用甘油衍生物修饰的化合物
公开(公告)号：US07696359B2
公开(公告)日：2010-04-13
申请号：US10570623
申请日：2004-09-03
申请人： Hisao Nemoto , Masahiro Yamauchi , Hiroko Kusano , Yasuki Kato , Motoo Yamasaki , Toshiyuki Suzawa
发明人： Hisao Nemoto , Masahiro Yamauchi , Hiroko Kusano , Yasuki Kato , Motoo Yamasaki , Toshiyuki Suzawa
IPC分类号： C07D207/46 , C07F9/09
CPC分类号： C07D207/452 , A61K47/00 , A61K47/54 , A61K47/6911 , B82Y5/00 , C07C323/60 , C07F9/10 , C07K5/0202
摘要： Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like. The present invention provides a compound in which a substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, is modified with a glycerol derivative represented by the following formula (1): wherein R represents a residue comprising a reactive group for the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance or for a spacer capable of binding the substance to be modified, which is selected from the group consisting of an amphiphilic substance and a hydrophobic substance, to R-X, or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: directly or via the spacer, or a salt thereof; a fine particle comprising the same; and the like.
摘要翻译：本发明的目的是提供一种可用作生产药物载体等的表面改性剂或其盐的化合物; 包含该颗粒的细颗粒; 等等。本发明提供一种化合物，其中选自由两亲物质和疏水性物质组成的组中的被改性物质用下式（1）表示的甘油衍生物进行改性：其中R表示残基包括选自两亲物质和疏水性物质的待修饰物质的反应性基团或能够与被修饰物质结合的间隔基，其选自两亲物质和疏水性物质，至RX或能够转化为反应性基团的基团; n表示3以上的整数， X表示可以直接或经由间隔基或其盐具有n数的以下结构的残基：包含该颗粒的细颗粒; 等等。

33. 发明授权

US07678415B2 Method of coating fine particles with lipid film 有权
标题翻译：用脂质膜包覆微粒的方法
公开(公告)号：US07678415B2
公开(公告)日：2010-03-16
申请号：US10398222
申请日：2001-10-04
申请人： Yasuki Kato , Masahiro Yamauchi , Hiroko Kusano , Takeshi Iwata , Takaaki Uochi , Shiro Akinaga
发明人： Yasuki Kato , Masahiro Yamauchi , Hiroko Kusano , Takeshi Iwata , Takaaki Uochi , Shiro Akinaga
IPC分类号： B01J13/02 , B05D7/00
CPC分类号： A61K9/5123 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/141 , A61K9/146 , A61K9/5015 , A61K9/5192 , A61K31/7088 , A61K47/6911 , B01J13/12
摘要： An object of the present invention is to provide a safe, convenient and efficient method for coating fine particles with lipid membrane.There is provided a method for coating fine particles with lipid membrane, characterized in that, the rate of a polar organic solvent in an aqueous solution containing the polar organic solvent where the fine particles are dispersed and lipid is dissolved, is decreased.
摘要翻译：本发明的目的是提供一种安全，方便和有效的用脂质膜涂覆微粒的方法。提供了一种用脂质膜包覆微粒的方法，其特征在于，含有分散有微粒的极性有机溶剂和溶解脂质的水溶液中的极性有机溶剂的比例降低。

34. 发明申请

US20090317992A1 OBJECT FITTING/REMOVING DRIVE UNIT, AND CONNECTOR UNIT 有权
标题翻译：对象安装/拆卸驱动单元和连接器单元
公开(公告)号：US20090317992A1
公开(公告)日：2009-12-24
申请号：US12482794
申请日：2009-06-11
申请人： Shigeharu AOKI , Masahiro Yamauchi , Keisuke Nakayama
发明人： Shigeharu AOKI , Masahiro Yamauchi , Keisuke Nakayama
IPC分类号： H01R13/62
CPC分类号： H01R43/26 , H01R13/62922
摘要： An object fitting/removing drive unit capable of fitting objects to each other, even if there is not enough working space in a fitting/removing direction of one object. Operation members holding cable connectors are accommodated in an inner frame in a manner movable in the fitting/removing direction. The inner frame is movably supported by outer frames along a direction orthogonal to the fitting/removing direction between initial and fitting-completed positions. A coupling member engaged with header connectors is movably supported by the outer frames along a direction orthogonal to the fitting/removing direction. When the inner frame is moved from the initial position to the fitting-completed position by being pressed by the coupling member, the outer frames guide the operation members toward the header connectors to fit the cable connectors and the header connectors to each other. A drive force transferring unit transfers driving force in the orthogonal direction.
摘要翻译：即使在一个物体的安装/拆卸方向上没有足够的工作空间，也能够将物体彼此嵌合的物体嵌合/移除驱动单元。保持电缆连接器的操作构件以可装配/拆卸方向移动的方式容纳在内框架中。内框架沿着与初始装配完成位置之间的装配/移除方向正交的方向由外框移动地支撑。与插头连接器接合的联接构件沿着与装配/移除方向正交的方向由外框可移动地支撑。当通过被联接构件按压内框架从初始位置移动到配合完成位置时，外框架将操作构件引向头部连接器，以将电缆连接器和插头连接器彼此配合。驱动力传递单元在正交方向上传递驱动力。

35. 发明申请

US20090011003A1 Composition for Suppressing Expression of Target Gene 审中-公开
标题翻译：抑制靶基因表达的组成
公开(公告)号：US20090011003A1
公开(公告)日：2009-01-08
申请号：US11883168
申请日：2005-10-24
申请人： Masahiro Yamauchi , Tsuneaki Tottori , Atsushi Ishihara , Nobuhiro Yagi , Yasuki Kato
发明人： Masahiro Yamauchi , Tsuneaki Tottori , Atsushi Ishihara , Nobuhiro Yagi , Yasuki Kato
IPC分类号： A61K9/127 , A61K31/7105 , A61K48/00
CPC分类号： C12N15/1135 , A61K9/127 , A61K31/7105 , C12N2310/14
摘要： The present invention has its object to provide a composition for suppressing the expression of a target gene and the like, and provides a composition, comprising an RNA-encapsulated liposome which comprises complex particles comprising as constituent components a lead particle and an RNA comprising a sequence consisting of 15 to 30 contiguous nucleotides of a target gene mRNA and a sequence complementary to the sequence, and a lipid membrane for coating the complex particles, wherein constituent components of the lipid membrane can be solved in a polar organic solvent, and wherein the polar organic solvent can be contained in a liquid at such a concentration that the constituent components of the lipid membrane are dispersible and the complex particles are dispersible, and the like.
摘要翻译：本发明的目的是提供抑制靶基因表达等的组合物，提供包含RNA包封的脂质体的组合物，其包含作为铅粒子的构成成分的复合粒子和包含序列的RNA 由靶基因mRNA的15〜30个连续核苷酸和与该序列互补的序列构成，以及用于涂布复合粒子的脂质膜，其中脂质膜的构成成分可以在极性有机溶剂中溶解，其中极性有机溶剂可以以使得脂质膜的组成成分可分散并且复合颗粒可分散的浓度包含在液体中。

36. 发明授权

US07267573B2 Connector for flat cable 失效
标题翻译：扁平电缆连接器
公开(公告)号：US07267573B2
公开(公告)日：2007-09-11
申请号：US11481434
申请日：2006-07-06
申请人： Kazuomi Sato , Masahiro Yamauchi
发明人： Kazuomi Sato , Masahiro Yamauchi
IPC分类号： H01R12/24
CPC分类号： H01R12/774 , H01R12/592 , H01R12/772 , H01R12/78 , H01R12/85 , H01R13/112 , H01R13/5825
摘要： Having conductive contacts (4), a first insulator (1) retaining the contacts, and a cable-side insulator, attachable/detachable relative to the first insulator, for retaining a flat cable (6). The cable-side insulator includes a second insulator (2) for receiving the flat cable, a third insulator (3) disposed so as to confront the second insulator via the flat cable, and a clamp (7) interposed between the flat cable and the third insulator. When the cable-side insulator is mounted to the first insulator, the second and third insulators are engaged with the first insulator to approach each other so that the flat cable is sandwiched between the clamp and the second insulator. In this state, the flat cable is connected to the contacts.
摘要翻译：具有导电触点（4），保持触点的第一绝缘体（1）和相对于第一绝缘体可附接/拆卸的用于保持扁平电缆（6）的电缆侧绝缘体。电缆侧绝缘体包括用于接收扁平电缆的第二绝缘体（2），经由扁平电缆与第二绝缘体相对设置的第三绝缘体（3），以及夹在平板电缆和第三绝缘子。当电缆侧绝缘体安装到第一绝缘体上时，第二和第三绝缘体与第一绝缘体接合以彼此接近，使得扁平电缆夹在夹具和第二绝缘体之间。在这种状态下，扁平电缆连接到触点。

37. 发明授权

US06626692B2 INSERTION AND WITHDRAWAL CONNECTOR APPARATUS, STRUCTURE OF REMOTE CONTROLLING ENGAGEMENT AND SEPARATION THEREOF, AND CONNECTING FRAME BLOCK STRUCTURE FOR INSERTION AND WITHDRAWAL CONNECTOR APPARATUS OR THE LIKE 失效
标题翻译：插入和拔出连接器装置，远程控制结构及其分离结构，以及连接插入和插拔连接器装置的框架结构
公开(公告)号：US06626692B2
公开(公告)日：2003-09-30
申请号：US10054478
申请日：2002-01-22
申请人： Toshihiko Maeda , Yoshinori Mizusawa , Osamu Hashiguchi , Kazuomi Sato , Hisashi Ishida , Hiroyuki Tsuzuki , Masahiro Yamada , Masahiro Yamauchi
发明人： Toshihiko Maeda , Yoshinori Mizusawa , Osamu Hashiguchi , Kazuomi Sato , Hisashi Ishida , Hiroyuki Tsuzuki , Masahiro Yamada , Masahiro Yamauchi
IPC分类号： H01R13627
CPC分类号： H01R13/518 , B63B22/04 , F16B5/02 , H01R13/6272 , H01R13/62905 , H01R13/64 , H04Q1/023 , H04Q1/14 , Y10S439/953 , Y10S439/954
摘要： There is provided an insertion and withdrawal connector apparatus in which a plurality of connectors can move only in a range of capable of engaging and separating with and from a plurality of mating connectors within a connector receiving body. A connector receiving body (1) has a pair of parallel frames (3), a pair of frame blocks (4) positioned at both end portions, and a plurality of partition members (5). One connector (10) and one mating connector are received in each of a plurality of space portions, that is, receiving chambers partitioned by a pair of frames, a pair of frame blocks, and a plurality of partition members. Each of the partition members has a pair of lances (5f, 5g) having a spring characteristic and each of the connectors has a pair of interlocking groove portions (10g) on both side surfaces. The lance (5f) interlocks with the interlocking groove portion on one of the side surfaces in the connector, and the lance (5g) interlocks with the interlocking groove portion on the other of the side surfaces in the connector. Each of the connectors has a convex portion (10d) at an upper end portion on one of the side surfaces and at a lower end portion on the other of the side surfaces, and each of the convex portions interlocks with each of the partition members.
摘要翻译：提供了插入和取出连接器装置，其中多个连接器只能在能够与连接器接收体内的多个配合连接器接合和分离的范围内移动。连接器接收体（1）具有一对平行框架（3），位于两端部的一对框架块（4）和多个分隔构件（5）。一个连接器（10）和一个配合连接器被接收在多个空间部分中的每一个中，即，由一对框架分隔的接收室，一对框架块和多个分隔构件。每个分隔构件具有一对具有弹簧特性的喷枪（5f，5g），并且每个连接器在两个侧表面上具有一对互锁槽部分（10g）。喷枪（5f）与连接器中的一个侧表面上的互锁槽部互锁，并且喷枪（5g）与连接器中的另一侧面上的互锁槽部互锁。每个连接器在一个侧表面上的上端部和另一个侧表面的下端部处具有凸部（10d），并且每个凸部与每个分隔构件互锁。

38. 发明授权

US06149447A Insertion and withdrawal connector apparatus, structure of remote controlling engagement and separation thereof, and connecting frame block structure for insertion and withdrawal connector apparatus or the like 失效
公开(公告)号：US06149447A
公开(公告)日：2000-11-21
申请号：US145844
申请日：1998-09-02
申请人： Toshihiko Maeda , Yoshinori Mizusawa , Osamu Hashiguchi , Kazuomi Sato , Hisashi Ishida , Hiroyuki Tsuzuki , Masahiro Yamada , Masahiro Yamauchi
发明人： Toshihiko Maeda , Yoshinori Mizusawa , Osamu Hashiguchi , Kazuomi Sato , Hisashi Ishida , Hiroyuki Tsuzuki , Masahiro Yamada , Masahiro Yamauchi
IPC分类号： B63B22/04 , H01R13/518 , H01R13/629 , H04Q1/14 , H01R13/62
CPC分类号： H01R13/518 , B63B22/04 , F16B5/02 , H01R13/62905 , H01R13/64 , H04Q1/023 , H04Q1/14 , H01R13/6272 , Y10S439/953 , Y10S439/954
摘要： There is provided an insertion and withdrawal connector apparatus in which a plurality of connectors can move only in a range of capable of engaging and separating with and from a plurality of mating connectors within a connector receiving body. A connector receiving body (1) has a pair of parallel frames (3), a pair of frame blocks (4) positioned at both end portions, and a plurality of partition members (5). One connector (10) and one mating connector are received in each of a plurality of space portions, that is, receiving chambers partitioned by a pair of frames, a pair of frame blocks, and a plurality of partition members. Each of the partition members has a pair of lances (5f, 5g) having a spring characteristic and each of the connectors has a pair of interlocking groove portions (10g) on both side surfaces. The lance (5f) interlocks with the interlocking groove portion on one of the side surfaces in the connector, and the lance (5g) interlocks with the interlocking groove portion on the other of the side surfaces in the connector. Each of the connectors has a convex portion (10d) at an upper end portion on one of the side surfaces and at a lower end portion on the other of the side surfaces, and each of the convex portions interlocks with each of the partition members.

39. 发明授权

US6127001A Recyclable cold curing aqueous coating composition and method for recycling it 失效
标题翻译：可回收冷固化水性涂料组合物及其回收方法
公开(公告)号：US6127001A
公开(公告)日：2000-10-03
申请号：US71953
申请日：1998-05-05
申请人： Susumu Hibi , Masahiro Yamauchi , Junichi Sueyoshi
发明人： Susumu Hibi , Masahiro Yamauchi , Junichi Sueyoshi
IPC分类号： C08J11/00 , B05D1/02
CPC分类号： C08J11/00
摘要： The present invention provide a recyclable cold curing aqueous coating composition comprising an acrylic group-modified epoxidized ester resin with acid vale of 25 to 60, which is formed from an epoxy resin (a), a fatty acid (b) and an ethylenically unsaturated monomer (c) in a component (a)/component (b)/component (c) weigh % ratio of 20 to 70/20 to 50/3 to 50, the sum of (a), (b) and (c) being 100 weight %, and a method for reusing it. For the method of the present invention, the coating composition has improved recycling properties by optimizing the properties such as acid value of the resin, the pH of a collecting solution for use to collect the coating composition and a content of a hydrophilic solvent in the collecting solution.
摘要翻译：本发明提供一种可回收的冷固化水性涂料组合物，其包含由环氧树脂（a），脂肪酸（b）和烯键式不饱和单体形成的酸值为25至60的丙烯酸改性环氧化酯树脂（c）在组分（a）/组分（b）/组分（c）中，重量比为20至70/20至50/3至50，（a），（b）和（c）之和为 100重量％，以及重复使用的方法。对于本发明的方法，涂料组合物通过优化树脂的酸值，用于收集涂料组合物的收集溶液的pH和收集中的亲水性溶剂的含量等性能而具有改进的再循环性能解。

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