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31. 发明授权

US6132760A Transdermal device for the delivery of testosterone 失效
标题翻译：用于输送睾酮的透皮装置
公开(公告)号：US6132760A
公开(公告)日：2000-10-17
申请号：US31619
申请日：1998-02-27
申请人： John C. Hedenstrom , Michael L. Husberg , Shari L. Wilking , Matthew T. Scholz
发明人： John C. Hedenstrom , Michael L. Husberg , Shari L. Wilking , Matthew T. Scholz
IPC分类号： A61K9/70 , A61K31/568 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32 , A61P5/26 , A61F13/02 , A61F13/00
CPC分类号： A61K31/568 , A61K47/10 , A61K9/7053 , A61K9/7061
摘要： A transdermal delivery device including an adhesive layer that contains a therapeutically effective amount of testosterone and a delivery enhancing adjuvant comprising a terpene.
摘要翻译：一种透皮递送装置，其包括含有治疗有效量的睾酮和包含萜烯的递送增强佐剂的粘合剂层。

32. 发明授权

US6074354A Orthopedic casting article comprising an apertured, extruded sheet 失效
标题翻译：骨科铸造制品包括有孔的挤压片材
公开(公告)号：US6074354A
公开(公告)日：2000-06-13
申请号：US744252
申请日：1996-05-06
申请人： Matthew T. Scholz , Jason L. Edgar , Dennis G. Welygan
发明人： Matthew T. Scholz , Jason L. Edgar , Dennis G. Welygan
IPC分类号： A61F13/04 , A61L15/07 , A61F5/00
CPC分类号： A61L15/07 , A61F13/04 , Y10T428/249921
摘要： The present invention provides an orthopedic casting article comprising an apertured, extruded sheet. The present invention also provides a method of enclosing a body member, comprising the steps of: heating an apertured, extruded sheet comprising a low temperature thermoplastic polymer having a softening or melting temperature less than about 90.degree. C.; wrapping the article about the body member; and molding the wrapped article about the body member such that the article is used as an orthopedic casting material and has a sufficient number of apertures after application to the patient to allow moisture vapors produced by the skin to freely escape through the cast or splint. The present invention also provides a method of enclosing a body member, comprising the steps of: initiating the curing of an apertured, extruded sheet comprising a viscous curable resin having a sufficient yield stress to resist flow at ambient temperature for extended periods of time; wrapping the article about the body member; and molding the wrapped article about the body member such that the article is used as an orthopedic casting material and has a sufficient number of apertures after application to the patient to allow moisture vapors produced by the skin to freely escape through the cast or splint. The apertured, extruded sheet may optionally contain a filler associated with the resin. The incorporation of fillers adds substantially to the strength of the cured casting material as well as to the handling properties of the uncured casting tape or bandage.
摘要翻译：本发明提供一种包括有孔挤压片材的整形外科制品。本发明还提供一种封闭主体部件的方法，包括以下步骤：加热具有软化或熔化温度低于约90℃的低温热塑性聚合物的多孔挤压片材; 包裹身体成员的文章; 并且将包裹的制品模制在身体构件周围，使得该制品用作矫形铸造材料，并且在施用到患者之后具有足够数量的孔，以允许由皮肤产生的水分蒸汽通过铸件或夹板自由逸出。本发明还提供一种封闭主体部件的方法，包括以下步骤：启动具有足够屈服应力的粘性可固化树脂的有孔挤出片材的固化，以抵抗在环境温度下长时间流动; 包裹身体成员的文章; 并且将包裹的制品模制在身体构件周围，使得该制品用作矫形铸造材料，并且在施用到患者之后具有足够数量的孔，以允许由皮肤产生的水分蒸汽通过铸件或夹板自由逸出。有孔的挤出片材可以任选地含有与树脂相关的填料。填充剂的添加基本上增加了固化的浇铸材料的强度以及未固化的浇铸胶带或绷带的操作性能。

33. 发明授权

US6027465A Method of immobilizing a body member using a composite article 失效
标题翻译：使用复合制品固定身体构件的方法
公开(公告)号：US6027465A
公开(公告)日：2000-02-22
申请号：US463990
申请日：1995-06-05
申请人： Matthew T. Scholz , Jason L. Edgar , Andrew J. Callinan , Dean A. Ersfeld , Worku A. Mindaye , Andrew J. Mahler, Jr.
发明人： Matthew T. Scholz , Jason L. Edgar , Andrew J. Callinan , Dean A. Ersfeld , Worku A. Mindaye , Andrew J. Mahler, Jr.
IPC分类号： A61F13/04 , A61L15/12 , A61F5/00
CPC分类号： A61L15/12 , A61F13/04 , A61L15/125 , Y10T428/249978
摘要： The present invention provides an article comprising a curable resin and a filler associated with the resin. The incorporation of fillers into the casting materials of the present invention adds substantially to the strength of the cured casting material as well as to the handling properties of the uncured casting tape or bandage. The incorporation of fillers into the casting materials of the present invention also imparts air and vapor porosity to the cured casting materials. If desired articles of the present invention may also incorporate fibers (either individually, bundled, or in the form of a light-weight scrim) to provide increased cohesiveness to the uncured article. Extremely moldable casting tapes are also provided which comprise a highly-filled composite material coated on a light-weight scrim. The casting tapes of this embodiment handle like traditional plaster of Paris casts yet cure to a weight-bearing cast in less than one hour.
摘要翻译：本发明提供一种包含可固化树脂和与树脂相关的填料的制品。本发明的浇铸材料中填充剂的添加基本上增加了固化的浇铸材料的强度以及未固化的浇铸胶带或绷带的操作性能。将填料掺入本发明的铸造材料中也赋予固化的浇铸材料空气和蒸汽孔隙率。如果需要，本发明的制品还可以加入纤维（单独地，捆扎的或以轻质稀松布的形式），以提供对未固化制品的增加的粘合性。还提供了非常可成型的铸造带，其包括涂覆在轻质稀松布上的高填充复合材料。本实施例的铸造胶带处理像传统的巴黎铸造石膏，但在不到一小时的时间内固化成承重铸件。

34. 发明授权

US6019997A Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents 失效
标题翻译：用于药剂透皮渗透的水醇组合物
公开(公告)号：US6019997A
公开(公告)日：2000-02-01
申请号：US781097
申请日：1997-01-09
申请人： Matthew T. Scholz , Robert A. Asmus , John C. Hedenstrom
发明人： Matthew T. Scholz , Robert A. Asmus , John C. Hedenstrom
IPC分类号： A61K9/00 , A61K47/10 , A61K47/14 , A61K47/26 , A61F13/00
CPC分类号： A61K47/10 , A61K47/14 , A61K47/26 , A61K9/0014 , Y10S514/937 , Y10S514/946 , Y10S514/947
摘要： Hydroalcoholic compositions useful for the enhancement of the transdermal delivery of a pharmaceutical agent, methods of preparation, transdermal delivery systems, and methods of delivering the pharmaceutical agent are provided. The composition includes a lower alcohol and water in a weight ratio of at least about 20:80, a pharmaceutical agent, and an emulsifier system.
摘要翻译：提供了可用于增强药剂的透皮递送的水醇组合物，制备方法，透皮递送系统和递送药剂的方法。组合物包含重量比为至少约20:80的低级醇和水，药剂和乳化剂体系。

35. 发明授权

US5951993A Stable hydroalcoholic compositions 失效
公开(公告)号：US5951993A
公开(公告)日：1999-09-14
申请号：US781090
申请日：1997-01-09
申请人： Matthew T. Scholz , Robert A. Asmus , Jill R. Charpentier
发明人： Matthew T. Scholz , Robert A. Asmus , Jill R. Charpentier
IPC分类号： A61K9/08 , A01N25/00 , A01N25/30 , A01N31/02 , A01N31/08 , A01N37/52 , A01N59/12 , A61K8/00 , A61K8/06 , A61K8/20 , A61K8/34 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/46 , A61K8/60 , A61K8/86 , A61K8/92 , A61K31/045 , A61K31/70 , A61Q17/00 , A61Q19/00 , A61Q19/10 , C11D13/00
CPC分类号： A61K8/34 , A61K8/342 , A61K8/37 , A61K8/39 , A61K8/416 , A61K8/604 , A61K8/86 , A61Q17/005 , A61Q19/00 , Y10S514/846 , Y10S514/873 , Y10S514/944 , Y10S514/945 , Y10S514/946 , Y10S514/975
摘要： Disclosed is a composition including a lower alcohol and water in a weight ratio of about 35:65 to 100:0, between at least 0.5% and 8.0% by weight thickener system comprised of at least two emulsifiers, each emulsifier present in at least 0.05% by weight wherein the composition free of auxiliary thickeners has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein each emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The composition is useful as a presurgical scrub replacement, a lotion or other hand preparation.

36. 发明授权

US5873931A Coating composition having anti-reflective and anti-fogging properties 失效
公开(公告)号：US5873931A
公开(公告)日：1999-02-23
申请号：US741334
申请日：1996-10-29
申请人： Matthew T. Scholz , William L. Kausch , David R. Boston , Joseph M. Zoborowski
发明人： Matthew T. Scholz , William L. Kausch , David R. Boston , Joseph M. Zoborowski
IPC分类号： A41D13/11 , A61F9/02 , C09D1/00 , C09D5/00 , B32B27/36
CPC分类号： A61F9/022 , A41D13/11 , C09D1/00 , C09D5/00 , Y10S516/907 , Y10S516/909 , Y10S516/91 , Y10S516/911 , Y10S516/912 , Y10S516/913 , Y10S516/914 , Y10S516/922 , Y10T428/31507 , Y10T428/31612 , Y10T428/31663 , Y10T428/31667
摘要： A coating composition which imparts anti-reflective and anti-fog properties to substrates coated therewith. The coating composition utilizes an inorganic metal oxide in combination with particular anionic surfactants. The coating compositions are particularly useful in the manufacture of disposable surgical masks and face shields.

37. 发明授权

US5750134A Bioadhesive composition and patch 失效
公开(公告)号：US5750134A
公开(公告)日：1998-05-12
申请号：US510046
申请日：1995-05-31
申请人： Matthew T. Scholz , Robert A. Scherrer , Nelda M. Marecki , Yen-Lane Chen , Joan K. Barkhaus
发明人： Matthew T. Scholz , Robert A. Scherrer , Nelda M. Marecki , Yen-Lane Chen , Joan K. Barkhaus
IPC分类号： A61K9/00 , A61K9/70 , A61L15/58 , A61K47/32
CPC分类号： A61K9/7053 , A61K9/006 , A61L15/585
摘要： A bioadhesive composition that adheres suitably to a mucosal surface and is capable of delivering drugs in sustained fashion, and a patch comprising the bioadhesive composition. Methods of using and processes for preparing the bioadhesive composition are also described.

38. 发明授权

US5658650A Compacted fabrics for orthopedic casting tapes 失效
标题翻译：矫形胶带压实织物
公开(公告)号：US5658650A
公开(公告)日：1997-08-19
申请号：US454652
申请日：1995-05-31
申请人： Scott A. Neamy , James C. Novack , Matthew T. Scholz
发明人： Scott A. Neamy , James C. Novack , Matthew T. Scholz
IPC分类号： A61F13/04 , A61L15/12 , D03D3/00 , B32B7/00
CPC分类号： A61L15/12 , A61F13/04 , Y10T442/2861 , Y10T442/2893 , Y10T442/291 , Y10T442/2992
摘要： The present invention provides an article, comprising: a fabric sheet which has been compacted using a heat shrink yarn; and a curable or hardenable resin coated onto the fabric sheet. The present invention involves compacting a fabric sheet to impart stretchability and conformability to the fabric while minimizing undesirable recovery forces. Suitable fabrics for compacting are fabrics which comprise fiberglass fibers which are capable of first being compacted and then being heat set or annealed in the compacted state. The article may be in the form of an orthopedic bandage and may optionally contain a micro fiber filler associated with the resin.
摘要翻译：本发明提供一种制品，其特征在于，包括：使用热收缩丝压实的织物片; 以及涂覆在织物片上的可固化或可硬化的树脂。本发明包括压实织物片材以赋予织物拉伸性和适形性，同时最小化不希望的恢复力。用于压实的合适的织物是包括玻璃纤维的织物，其能够首先被压实，然后在压实状态下进行热定型或退火。制品可以是矫形绷带的形式，并且可以任选地包含与树脂相关联的微纤维填料。

39. 发明授权

US5584800A Method of enclosing a body member using an apertured, extruded sheet 失效
标题翻译：使用有孔挤出片材封闭主体部件的方法
公开(公告)号：US5584800A
公开(公告)日：1996-12-17
申请号：US391111
申请日：1995-02-21
申请人： Matthew T. Scholz , Jason L. Edgar , Dennis G. Welygan
发明人： Matthew T. Scholz , Jason L. Edgar , Dennis G. Welygan
IPC分类号： A61F13/04 , A61L15/07 , A61F5/00
CPC分类号： A61L15/07 , A61F13/04 , Y10T428/249921
摘要： The present invention provides a method of enclosing a body member, comprising the steps of: heating an apertured, extruded sheet comprising a low temperature thermoplastic polymer having a softening or melting temperature less than about 90.degree. C.; wrapping the article about the body member; and molding the wrapped article about the body member such that the article is used as an orthopedic casting material and has a sufficient number of apertures after application to the patient to allow moisture vapors produced by the skin to freely escape through the cast or splint. The present invention also provides a method of enclosing a body member, comprising the steps of: initiating the curing of an apertured, extruded sheet comprising a viscous curable resin having a sufficient yield stress to resist flow at ambient temperature for extended periods of time; wrapping the article about the body member; and molding the wrapped article about the body member such that the article is used as an orthopedic casting material and has a sufficient number of apertures after application to the patient to allow moisture vapors produced by the skin to freely escape through the cast or splint. The apertured, extruded sheet may optionally contain a filler associated with the resin. The incorporation of fillers adds substantially to the strength of the cured casting material as well as to the handling properties of the uncured casting tape or bandage.
摘要翻译：本发明提供了一种封闭主体部件的方法，包括以下步骤：加热具有软化或熔化温度低于约90℃的低温热塑性聚合物的多孔挤压片材; 包裹身体成员的文章; 并且将包裹的制品模制在身体构件周围，使得该制品用作矫形铸造材料，并且在施用到患者之后具有足够数量的孔，以允许由皮肤产生的水分蒸汽通过铸件或夹板自由逸出。本发明还提供一种封闭主体部件的方法，包括以下步骤：启动具有足够屈服应力的粘性可固化树脂的有孔挤出片材的固化，以抵抗在环境温度下长时间流动; 包裹身体成员的文章; 并且将包裹的制品模制在身体构件周围，使得该制品用作矫形铸造材料，并且在施用到患者之后具有足够数量的孔，以允许由皮肤产生的水分蒸汽通过铸件或夹板自由逸出。有孔的挤出片材可以任选地含有与树脂相关的填料。填充剂的添加基本上增加了固化的浇铸材料的强度以及未固化的浇铸胶带或绷带的操作性能。

40. 发明授权

US5540982A Fabric backing for orthopedic support materials 失效
标题翻译：用于矫形支撑材料的织物背衬
公开(公告)号：US5540982A
公开(公告)日：1996-07-30
申请号：US183610
申请日：1994-01-19
申请人： Matthew T. Scholz , Miroslav Tochacek , Jason L. Edgar
发明人： Matthew T. Scholz , Miroslav Tochacek , Jason L. Edgar
IPC分类号： A61F13/04 , A61L15/07 , D04B21/00 , D06M15/19 , D06M101/00 , D06M101/16 , D06M101/30 , D06M101/32 , D06M101/34 , D04B1/16 , D04B1/18
CPC分类号： D04B21/12 , D10B2403/0311 , D10B2509/024 , Y10S428/903 , Y10S428/913 , Y10T442/20 , Y10T442/413 , Y10T442/456
摘要： The present invention provides a unique knit construction having a nonfiberglass stiffness-controlling yarn in the fabric of the backing. Preferably, the nonfiberglass stiffness-controlling yarn is used in combination with a heat shrinkable yarn or a stretch yarn, and alternatively a nonfiberglass microdenier yarn. More preferably, the nonfiberglass stiffness-controlling yarn is in combination with a stretch yarn and a nonfiberglass microdenier yarn. Most preferably, the nonfiberglass stiffness-controlling yarn is in combination with a heat shrinkable, elastically extensible yarn, and a nonfiberglass microdenier yarn.
摘要翻译：本发明提供了在背衬织物中具有非纤维刚度控制纱线的独特的针织结构。优选地，非纤维刚度控制纱线与热收缩纱线或拉伸纱线组合使用，或者与非纤维纤维微合纱线组合使用。更优选地，非纤维刚度控制纱线与弹力纱线和非纤维纤维纱线组合。最优选地，非纤维刚度控制纱线与可热收缩的弹性可伸长的纱线和非纤维纤维纱线组合。

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