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31. 发明授权

US09097672B2 Method and system for detecting biological molecules in samples 有权
标题翻译：检测样品中生物分子的方法和系统
公开(公告)号：US09097672B2
公开(公告)日：2015-08-04
申请号：US13704719
申请日：2011-06-17
申请人： R. Stephen Brown , Eric Marcotte , Doug Wilton , Peter Gallant , David Dolphin , Lee Underwood
发明人： R. Stephen Brown , Eric Marcotte , Doug Wilton , Peter Gallant , David Dolphin , Lee Underwood
IPC分类号： G01N21/64 , G01N33/12 , G01N33/18 , B01L3/00
CPC分类号： G01N21/6486 , B01L3/50825 , G01N21/6428 , G01N21/6452 , G01N33/12 , G01N33/1826 , G01N2021/6417 , G01N2021/6482 , G01N2021/6484 , G01N2201/062
摘要： A system for detecting presence of an organism having an enzyme in a sample, comprising: a cartridge for containing the sample and a substrate such that the enzyme can react with the substrate to produce a biological molecule; a partitioning element mounted in a recess in a base of the cartridge, the partitioning element allowing partitioning of the biological molecule thereinto; a light source for irradiating the biological molecule partitioned into the partitioning element; and, a detector for detecting fluorescence of the biological molecule partitioned into the partitioning element, the detected fluorescence being indicative of presence of the organism in the sample; wherein the light source is in a raised cartridge mount of the system that mates with the recess in the base of the cartridge.
摘要翻译：一种用于检测样品中具有酶的生物体的存在的系统，包括：用于容纳样品和底物的筒，使得酶可以与底物反应以产生生物分子; 安装在所述盒的基部中的凹部中的分隔元件，所述分隔元件允许生物分子在其中分配; 用于照射被划分成分隔元件的生物分子的光源; 以及检测器，用于检测划分成分隔元件的生物分子的荧光，检测到的荧光指示样品中生物体的存在; 其中所述光源位于所述系统的凸起的盒安装件中，以与所述盒的所述底座中的凹部配合。

33. 发明授权

US07282215B2 Supports for photosensitizer formulations 有权
标题翻译：支持光敏剂配方
公开(公告)号：US07282215B2
公开(公告)日：2007-10-16
申请号：US09851606
申请日：2001-05-08
申请人： Rubinah K. Chowdhary , David Dolphin
发明人： Rubinah K. Chowdhary , David Dolphin
IPC分类号： A61K9/127 , A61K9/14
CPC分类号： A61K41/0057 , A61K41/0071
摘要： The invention is generally related to the field of formulating medicaments in association with a solid support. Such formulations comprising photosensitizers, and their use in photodynamic therapy, are also provided. Methods for the production of the medicament formulations are also disclosed.
摘要翻译：本发明通常涉及与固体支持物相关联的配制药物领域。还提供了包含光敏剂的这种制剂及其在光动力疗法中的用途。还公开了用于制备药物制剂的方法。

34. 发明授权

US07022843B1 β,β′-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins 失效
标题翻译： β，β'-二羟基内消旋二卟啉，异菌二氢卟酚和细菌二氢卟酚
公开(公告)号：US07022843B1
公开(公告)日：2006-04-04
申请号：US09551159
申请日：2000-04-14
申请人： Jill Kirsten MacAlpine , Christian Brückner , David Dolphin
发明人： Jill Kirsten MacAlpine , Christian Brückner , David Dolphin
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： Improved β,β′-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compounds are provided as photosensitizers. Pharmaceutical compositions and photodynamic therapy comprising them are also disclosed.
摘要翻译：提供了改进的β，β'-二羟基内消旋二ine素，细菌二氢卟酚或异菌二氢卟酚化合物作为光敏剂。还公开了包含它们的药物组合物和光动力疗法。

35. 发明授权

US6093739A Synthesis of long wavelength absorbing photosensitizers 失效
标题翻译：合成长波吸收光敏剂
公开(公告)号：US6093739A
公开(公告)日：2000-07-25
申请号：US196761
申请日：1998-11-20
申请人： Claire K. Johnson , David Dolphin
发明人： Claire K. Johnson , David Dolphin
IPC分类号： C07D471/22 , A61K31/40
CPC分类号： C07D471/22
摘要： The present invention provides for novel therapeutic macrocycle compounds useful in photodynamic therapy that are based on the chlorin ring system. The macrocycle compounds have, in many cases, wavelengths of activation at about 670 nm, characteristics of chlorins, and are stabilized against oxidation by the attachment to the chlorin ring of a structure that comprises one or more exocyclic rings that contribute at least one nitrogen atom. Protonation or covalent modification of this nitrogen atom, or other covalent modification of the one or more exocyclic rings permits optimization of pharmacalogically relevant properties including, for example, solubility. Representative chlorins include the pyridochlorins depicted as follows ##STR1##
摘要翻译：本发明提供了用于基于二氢卟酚环系统的光动力疗法中的新型治疗性大环化合物。在大多数情况下，大环化合物在大约670nm具有激活波长，二氢卟酚的特征，并且通过连接到含有一个或多个有助于至少一个氮原子的环外环的结构的二氢卟酚环而稳定化。该氮原子的质子化或共价修饰或一个或多个环外环的其它共价修饰允许优化药理学相关性质，包括例如溶解度。代表性的二氢卟酚包括如下所示的吡啶二氢卟酚

36. 发明授权

US5656756A 5,15-diarylbenzochlorin-7-one compounds 失效
标题翻译： 5,15-二芳基苯并三氮杂-7-酮化合物
公开(公告)号：US5656756A
公开(公告)日：1997-08-12
申请号：US235174
申请日：1994-04-29
申请人： David Dolphin , Ross Boyle
发明人： David Dolphin , Ross Boyle
IPC分类号： C07D487/22 , A61K31/40
CPC分类号： C07D487/22
摘要： A novel 5,15-diarylbenzochlorin-7-one compound having the formula (I) or (II): ##STR1## wherein M is a metal. A novel method for synthesizing the compound of formula (I) comprises the steps of:a. cyclizing a meso-(formylvinyl) 5,15-diarylporphyrin to form a cyclization reaction mixture, andb. oxidizing said reaction mixture to form the 5,15-diarylbenzochlorin-7-one of formula (I).A novel method for synthesizing the compound of formula (II) comprises the cyclizing and oxidizing steps listed above and, either prior to or after the oxidizing step, adding the step of demetallating the compound.
摘要翻译：具有式（I）或（II）的新的5,15-二芳基苯并二氢卟酚-7-酮化合物：其中M是金属。合成式（I）化合物的新方法包括以下步骤：a。环化内消旋（甲酰基乙烯基）5,15-二芳基卟啉以形成环化反应混合物，和b。氧化所述反应混合物以形成式（I）的5,15-二芳基苯并二氢吡喃-7-酮。用于合成式（II）化合物的新方法包括上述环化和氧化步骤，并且在氧化步骤之前或之后，加入脱金属化合物的步骤。

37. 发明授权

US5648485A .beta., .beta.-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins 失效
标题翻译： β，β-二羟基内消旋二卟啉，异二氢叶酸和细菌二氢卟酚
公开(公告)号：US5648485A
公开(公告)日：1997-07-15
申请号：US329577
申请日：1994-10-26
申请人： David Dolphin , Christian Bruckner
发明人： David Dolphin , Christian Bruckner
IPC分类号： A61K31/40 , A61K31/409 , A61K49/06 , A61K51/04 , A61P35/00 , C07D487/22 , C07F1/08 , C07F3/06 , C07F5/00 , C07F5/06 , C07F7/10 , C07F7/22 , C07F7/30 , C07F13/00 , C07F15/04
CPC分类号： A61K51/0485 , A61K49/06 , C07D487/22
摘要： A .beta.,.beta.'-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compound having the formula (I) or (II): ##STR1## wherein M is a metal. A novel method for synthesizing the compound of formula (I) or (II) comprises the steps of:a. osmylating a .beta...beta.'-unsubstituted, meso-substituted porphyrin to form an osmate ester at the .beta.,.beta.'-position, andb. reducing the osmate ester to form the corresponding .beta.,.beta.'-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin of formula (I) or (II).
摘要翻译：具有式（I）或（II）的β，β'-二羟基内消旋二氯卟酚，细菌二氢卟酚或异细菌二氢卟酚化合物：其中M是金属。合成式（I）或（II）化合物的新方法包括以下步骤：a。渗透一个beta。 β'取代的内消旋卟啉在β，β'位上形成锇酸酯，b。减少锇酸酯以形成式（I）或（II）的相应的β，β'-二羟基内消旋二取代的二氢卟酚，细菌二氢卟酚或异细菌素。

38. 发明申请

US20130217040A1 METHOD AND SYSTEM FOR DETECTING BIOLOGICAL MOLECULES IN SAMPLES 有权
标题翻译：用于检测样品中生物分子的方法和系统
公开(公告)号：US20130217040A1
公开(公告)日：2013-08-22
申请号：US13704719
申请日：2011-06-17
申请人： R. Stephen Brown , Eric Marcotte , Doug Wilton , Peter Gallant , David Dolphin , Lee Underwood
发明人： R. Stephen Brown , Eric Marcotte , Doug Wilton , Peter Gallant , David Dolphin , Lee Underwood
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , B01L3/50825 , G01N21/6428 , G01N21/6452 , G01N33/12 , G01N33/1826 , G01N2021/6417 , G01N2021/6482 , G01N2021/6484 , G01N2201/062
摘要： A system for detecting presence of an organism having an enzyme in a sample, comprising: a cartridge for containing the sample and a substrate such that the enzyme can react with the substrate to produce a biological molecule; a partitioning element mounted in a recess in a base of the cartridge, the partitioning element allowing partitioning of the biological molecule thereinto; a light source for irradiating the biological molecule partitioned into the partitioning element; and, a detector for detecting fluorescence of the biological molecule partitioned into the partitioning element, the detected fluorescence being indicative of presence of the organism in the sample; wherein the light source is in a raised cartridge mount of the system that mates with the recess in the base of the cartridge.
摘要翻译：一种用于检测样品中具有酶的生物体的存在的系统，包括：用于容纳样品和底物的筒，使得酶可以与底物反应以产生生物分子; 安装在所述盒的基部中的凹部中的分隔元件，所述分隔元件允许生物分子在其中分配; 用于照射被划分成分隔元件的生物分子的光源; 以及检测器，用于检测划分成分隔元件的生物分子的荧光，检测到的荧光指示样品中生物体的存在; 其中所述光源位于所述系统的凸起的盒安装件中，以与所述盒的所述底座中的凹部配合。

39. 发明授权

US06331235B1 Chiral separation of benzoporphyrin derivative mono-and di-acids by laser-induced fluorescence capillary electrophoresis 有权
标题翻译：通过激光诱导荧光毛细管电泳手性分离苯并卟啉衍生物单酸和二酸
公开(公告)号：US06331235B1
公开(公告)日：2001-12-18
申请号：US09321893
申请日：1999-05-28
申请人： David Dolphin , Xuejun Peng , Ethan D. Sternberg
发明人： David Dolphin , Xuejun Peng , Ethan D. Sternberg
IPC分类号： G02N2726
CPC分类号： G01N27/44747
摘要： A method for the separation of benzoporphyrin derivative mono and diacid (BPD-MA, BPD-DA) enantiomers by Laser-Induced Fluorescence Capillary Electrophoresis has been developed. The limits of detection are 2.06×10−6 M, and the relative standard deviation for the separation was 2.90% to 4.64%. The BPD enantiomers can be quantitatively determined in the range of 10−2 to 10−5 mg mL−1. In comparison with HPLC, CE has better resolution and efficiency. This separation method was successfully applied to the BPD enantiomers obtained from a matrix of bovine serum and from liposomally formulated material as well as from studies with rat, dog and human microsomes.
摘要翻译：已经开发了通过激光诱导荧光毛细管电泳分离苯并卟啉衍生物单和二酸（BPD-MA，BPD-DA）对映异构体的方法。检测限为2.06×10-6 M，分离相对标准偏差为2.90％〜4.64％。 BPD对映异构体可以在10-2至10-5mg mL-1的范围内定量测定。与HPLC相比，CE具有更好的分辨率和效率。该分离方法成功应用于从牛血清基质和脂质体配制物质以及从大鼠，狗和人微粒体研究中获得的BPD对映异构体。

40. 发明授权

US6022981A Meso-substituted tripyrrane compounds, compositions, and methods for making and using the same 失效
标题翻译：中间取代的三卤化合物，组合物及其制备和使用方法
公开(公告)号：US6022981A
公开(公告)日：2000-02-08
申请号：US313030
申请日：1999-05-17
申请人： Christian Bruckner , Ross W. Boyle , David Dolphin
发明人： Christian Bruckner , Ross W. Boyle , David Dolphin
IPC分类号： A61K31/409 , A61K41/00 , A61K49/00 , A61P43/00 , C07D207/32 , C07D207/323 , C07D487/22 , C09B57/00 , C07D403/06
CPC分类号： C07D207/323
摘要： The invention provides for tripyrrane compounds of the formula ##STR1## wherein: each Q represents, typically, an alkyl group, cycloalkyl group, aryl group, or a heteroaryl group; and each R represents hydrogen, an alkyl group, alcohol group, or a carbonyl-containing group.Additionally, there are described methods to prepare such compounds, for example, comprising the steps of:(a) reacting a compound of the formula:Q--CHO or Q--CH(OS)(OS')wherein S and S' are independently lower alkyl, an aryl group containing from 5 to 14 ring atoms, and --(CH.sub.2).sub.n -- where n =2-4;with a stoichiometric excess of a pyrrole having the formula: ##STR2## in the presence of a catalytic amount of an acid; (b) removing the unreacted pyrrole or any other solvents used in (a) by evaporation to form a residue; and(c) treating the residue to remove high molecular weight polymeric materials and the corresponding dipyrromethane by-product, leaving the desired compound.
摘要翻译：本发明提供下式的三吡咯化合物，其中：每个Q通常为烷基，环烷基，芳基或杂芳基; 并且每个R表示氢，烷基，醇基或含羰基。此外，描述了制备这种化合物的方法，例如包括以下步骤：（a）使下式化合物：Q-CHO或Q-CH（OS）（OS'）其中S和S'独立地低级烷基，含有5至14个环原子的芳基和 - （CH 2）n - ，其中n = 2-4; 化学计量过量的具有下式的吡咯：在催化量的酸存在下; （b）通过蒸发除去（a）中使用的未反应的吡咯或任何其它溶剂以形成残余物; 和（c）处理残留物以除去高分子量聚合物材料和相应的二吡咯甲烷副产物，留下所需化合物。

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