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31. 发明授权

US09364568B2 Methods to diagnose degenerative disc disease 有权
标题翻译：诊断退行性椎间盘疾病的方法
公开(公告)号：US09364568B2
公开(公告)日：2016-06-14
申请号：US12836609
申请日：2010-07-15
申请人： Josee Roy
发明人： Josee Roy
IPC分类号： A61K49/00 , A61B6/00
CPC分类号： A61K51/08 , A61B5/4824 , A61B6/481 , A61B6/506 , A61K49/0054 , A61K51/0455 , A61K51/0491 , A61M5/007
摘要： Methods are provided that better describe, and localize the pain generator or suspected pain generator in and around spinal discs in relation to neck or back pain so as to improve the diagnosis of degenerative disc disease. In some embodiments, there are methods for diagnosing a pain generator or a suspected pain generator in a patient suffering from back pain, the methods comprise labeling an inflammatory, vascular, neuronal, and/or metabolic pain marker at a location inside of or adjacent to an intervertebral disc in the patient suffering from back pain to increase an image of the pain marker with an imaging procedure; and imaging the labeled inflammatory, vascular, neuronal, and/or metabolic pain marker in a manner sufficient to diagnose the pain generator or suspected pain generator.
摘要翻译：提供了更好地描述和定位相对于颈部或背部疼痛的脊椎盘内和周围的疼痛发生器或疑似疼痛发生器，以改善退行性椎间盘疾病的诊断。在一些实施方案中，存在用于诊断患有背痛的患者中的疼痛发生器或疑似疼痛发生器的方法，所述方法包括在内侧或与其邻近的位置标记炎性，血管，神经元和/或代谢性疼痛标记物患有背部疼痛的患者中的椎间盘以成像程序增加疼痛标记物的图像; 并以足以诊断疼痛发生器或疑似疼痛发生器的方式对标记的炎症，血管，神经元和/或代谢性疼痛标记进行成像。

32. 发明授权

US09301946B2 Clonidine and GABA compounds in a biodegradable polymer carrier 有权
标题翻译：可乐定和GABA化合物在可生物降解的聚合物载体中
公开(公告)号：US09301946B2
公开(公告)日：2016-04-05
申请号：US13309766
申请日：2011-12-02
申请人： Jared T. Wilsey , Danielle L. Biggs , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
发明人： Jared T. Wilsey , Danielle L. Biggs , Jeffrey C. Marx , William F. McKay , Josee Roy , John Myers Zanella
IPC分类号： A61K31/66 , A61K31/415 , A61K31/4168 , A61K9/00 , A61K45/06 , A61K31/662 , A61K47/34
CPC分类号： A61K31/195 , A61K9/0024 , A61K31/4168 , A61K31/662 , A61K45/06 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译：提供长时间有效的疼痛治疗。通过在目标部位或其附近施用有效量的可乐定和γ-氨基丁酸化合物，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘突出背痛和关节疼痛，以及手术附带的疼痛。当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

33. 发明授权

US08840933B2 Method of treating neuronal injury by administering magnesium chloride and PEG 有权
标题翻译：通过施用氯化镁和PEG治疗神经元损伤的方法
公开(公告)号：US08840933B2
公开(公告)日：2014-09-23
申请号：US11418153
申请日：2006-05-03
申请人： Josee Roy , William F. McKay , Jeffrey C Marx
发明人： Josee Roy , William F. McKay , Jeffrey C Marx
IPC分类号： A61K33/14 , A61K31/765 , A61K9/08 , A61K9/00 , A61K31/717 , A61K31/787 , A61K33/06
CPC分类号： A61K33/14 , A61K9/0019 , A61K9/0085 , A61K31/717 , A61K31/765 , A61K31/787 , A61K33/06 , A61K2300/00
摘要： The invention provides methods and kits for treatment of pain or inflammation. In one embodiment, the kit comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, an intra-articular administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.
摘要翻译：本发明提供了治疗疼痛或炎症的方法和试剂盒。在一个实施方案中，试剂盒包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。生物膜密封剂和/或生物活性剂，静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，关节内给药，直接施用于或邻近病理状况及其任何组合。或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

34. 发明申请

US20120142648A1 METHODS FOR DELIVERING CLONIDINE COMPOSITIONS IN BIODEGRADABLE POLYMER CARRIER AND LOCAL STERIODS TO A TARGET TISSUE SITE 审中-公开
标题翻译：将生物可降解聚合物载体和局部体内的螯合物组合物递送到目标组织位点的方法
公开(公告)号：US20120142648A1
公开(公告)日：2012-06-07
申请号：US13309725
申请日：2011-12-02
申请人： Danielle L. Biggs , Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Jared T. Wilsey , John Myers Zanella
发明人： Danielle L. Biggs , Jonathan K. Gray , Jeffrey C. Marx , William F. McKay , Josee Roy , Jared T. Wilsey , John Myers Zanella
IPC分类号： A61K31/56 , A61P29/00
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/0024 , A61K31/4168 , A61K31/573 , A61K47/34 , A61K2300/00
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a steroid at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译：提供长时间有效的疼痛治疗。通过在目标部位或附近施用有效量的可乐定和类固醇，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛。当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

35. 发明申请

US20070258938A1 Compositions comprising biomembrane sealing agent for treatment of pain or inflammation, and methods of use 有权
标题翻译：包含用于治疗疼痛或炎症的生物膜密封剂的组合物和使用方法
公开(公告)号：US20070258938A1
公开(公告)日：2007-11-08
申请号：US11418153
申请日：2006-05-03
申请人： Josee Roy , William McKay , Jeffrey Marx
发明人： Josee Roy , William McKay , Jeffrey Marx
IPC分类号： A61K31/787 , A61K31/717 , A61K31/765
CPC分类号： A61K33/14 , A61K9/0019 , A61K9/0085 , A61K31/717 , A61K31/765 , A61K31/787 , A61K33/06 , A61K2300/00
摘要： The invention provides methods and kits for treatment of pain or inflammation. In one embodiment, the kit comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, an intra-articular administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.
摘要翻译：本发明提供了治疗疼痛或炎症的方法和试剂盒。在一个实施方案中，试剂盒包括生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。生物膜密封剂和/或生物活性剂，静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，关节内给药，直接施用于或邻近病理状况及其任何组合。或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

36. 发明授权

US09244060B2 Site localization and methods for monitoring treatment of disturbed blood vessels 有权
标题翻译：现场定位和监测受干扰血管治疗的方法
公开(公告)号：US09244060B2
公开(公告)日：2016-01-26
申请号：US12411666
申请日：2009-03-26
申请人： Josee Roy , Roger Harrington
发明人： Josee Roy , Roger Harrington
IPC分类号： A61K49/00 , G01N33/50 , G01N33/58
CPC分类号： G01N33/5091 , A61K49/006 , G01N33/58 , G01N2800/32
摘要： Methods for identifying defects in blood vessels and treating such defects are provided. The methods comprise administering to a patient a composition comprising a labeled delivery ligand capable of preferentially accumulating at or near blood vessels defects. In some embodiments, the delivery ligand may carry one or more active agents to the defect.
摘要翻译：提供了鉴别血管缺陷和治疗这些缺陷的方法。所述方法包括向患者施用包含能够在血管或血管附近存在缺陷的标记的递送配体的组合物。在一些实施方案中，递送配体可携带一种或多种活性剂至缺陷。

37. 发明授权

US08956667B2 Methods of identifying potential components for targeted drug delivery compositions 有权
标题翻译：鉴定靶向药物递送组合物的潜在成分的方法
公开(公告)号：US08956667B2
公开(公告)日：2015-02-17
申请号：US12731822
申请日：2010-03-25
申请人： Josee Roy , Victor Kelley , Roger E. Harrington
发明人： Josee Roy , Victor Kelley , Roger E. Harrington
IPC分类号： A61K33/06 , A61K33/14 , A61K47/48
CPC分类号： G01N33/15 , A61K33/06 , A61K47/60
摘要： Methods of preparing compositions for preferential distribution of active agents to injury sites are provided. The compositions may comprise a polymer with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature. Methods of identifying suitable components for such compositions are also disclosed.
摘要翻译：提供了将活性剂优先分配给损伤部位的组合物的制备方法。组合物可以包含具有亲水性质的聚合物和一种或多种活性剂，例如包含亲水金属离子的化合物。因为递送配体和活性剂被特异选择，所以它们之间的相互作用主要是离子性质的。还公开了用于鉴定这些组合物的合适组分的方法。

38. 发明授权

US08945623B2 Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use 有权
标题翻译：包含用于治疗神经元损伤的生物膜密封剂的组合物和使用方法
公开(公告)号：US08945623B2
公开(公告)日：2015-02-03
申请号：US11418152
申请日：2006-05-03
申请人： Josee Roy , William F. McKay , Jeffrey C. Marx
发明人： Josee Roy , William F. McKay , Jeffrey C. Marx
IPC分类号： A61K38/20 , A61K38/18 , A61K38/11 , A61K38/05 , A61K31/65 , A61K31/56 , A61K9/14 , A61K9/00 , A61K33/06 , A61K47/10
CPC分类号： A61K33/06 , A61K9/0019 , A61K31/56 , A61K31/65 , A61K31/765 , A61K47/10
摘要： The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.
摘要翻译：本发明提供用于治疗神经元损伤的组合物，试剂盒和方法。在一个实施方案中，组合物包含生物膜密封剂，例如PEG，以及生物活性剂，例如镁化合物。静脉内给药，肌内给药，鞘内给药，皮下给药，硬膜外给药，胃肠外给药，直接施用于病理状况的部位或其附近的生物膜密封剂和/或生物活性剂，以及任何其组合。或者，生物膜密封剂和/或生物活性剂可以从泵或植入物递送。

39. 发明授权

US08858924B2 Compositions and methods for treatment of hemorrhage 有权
标题翻译：用于治疗出血的组合物和方法
公开(公告)号：US08858924B2
公开(公告)日：2014-10-14
申请号：US12411548
申请日：2009-03-26
申请人： Josee Roy
发明人： Josee Roy
IPC分类号： A61K31/765 , A61K45/06 , A61K31/77 , A61K31/74 , A61K9/00 , A61K47/10 , A61K33/06 , C07C31/20 , C07F3/02
CPC分类号： A61K33/06 , A61K9/0019 , A61K31/08 , A61K31/74 , A61K31/77 , A61K45/06 , A61K47/10 , A61K2300/00
摘要： Methods of treating hemorrhage are provided, comprising diagnosing one or more hemorrhaging or potentially hemorrhaging vessels in a patient and administering to the patient a therapeutically effective amount of a composition comprising a vessel closing compound at a concentration between about 0.1% and about 45%. The vessel closing compound may comprise a polymer with hydrophilic properties, such as polyethylene glycol (PEG). The composition may also comprise one or more active agent such as a blood flow modifier with a potential to form ionic bonds with the vessel closing agent.
摘要翻译：提供治疗出血的方法，包括诊断患者中的一种或多种出血或潜在的出血血管，并向患者施用治疗有效量的组合物，其包含浓度在约0.1％至约45％之间的血管封闭化合物。容器封闭化合物可以包含具有亲水性质的聚合物，例如聚乙二醇（PEG）。组合物还可以包含一种或多种活性剂，例如具有与容器封闭剂形成离子键的潜力的血液流动改性剂。

40. 发明授权

US08852566B2 Compositions and methods for preferential distribution of active agents to injury sites 有权
标题翻译：将活性剂优先分配到损伤部位的组合物和方法
公开(公告)号：US08852566B2
公开(公告)日：2014-10-07
申请号：US12411572
申请日：2009-03-26
申请人： Josee Roy , Toya Kimble
发明人： Josee Roy , Toya Kimble
IPC分类号： A61K31/765 , A61K45/06 , A61K47/10 , A61K33/06 , A61K9/00 , A61K33/14 , C07C31/20 , C07F3/02
CPC分类号： A61K33/06 , A61K9/0019 , A61K45/06 , A61K47/10
摘要： Compositions are provided for preferential distribution of active agents to injury sites. Such compositions may comprise a ligand with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature so that binding of the active agent to the delivery ligand and release of the active agent into the target site are not dependent on enzymatic activity. Methods of using such compositions are also disclosed.
摘要翻译：提供组合物用于将活性剂优先分配到损伤部位。这样的组合物可以包含具有亲水性质的配体和一种或多种活性剂，例如包含亲水金属离子的化合物。因为递送配体和活性剂被特异选择，所以它们之间的相互作用主要是离子性质的，使得活性剂与递送配体的结合和活性剂向靶位点的释放不依赖于酶活性。还公开了使用这些组合物的方法。

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