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31. 发明授权

US07074610B2 System and method of microdispensing and arrays of biolayers provided by same 失效
标题翻译：微分配系统和方法以及由其提供的生物层阵列
公开(公告)号：US07074610B2
公开(公告)日：2006-07-11
申请号：US09941661
申请日：2001-08-30
申请人： Stephen N. Cozzette , Graham Davis , Jeanne A. Itak , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Susan J. Steiner , Paul Van Der Werf , Henry J. Wieck
发明人： Stephen N. Cozzette , Graham Davis , Jeanne A. Itak , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Susan J. Steiner , Paul Van Der Werf , Henry J. Wieck
IPC分类号： C12M3/00
CPC分类号： B01L3/5027 , B01L3/0268 , B01L3/502707 , B01L3/5088 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/089 , C12Q1/001 , G01N33/5438 , G01N35/0099 , G01N35/109 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , Y10S435/81 , Y10S436/809
摘要： An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using a substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.
摘要翻译：描述了适用于分析生物学重要的分析物种的电子装置的微细加工的有效方法。本发明的技术允许对在合适的衬底上建立的各种组件和层的尺寸特征进行密切的控制。这种控制延伸到结合生物组分的装置的那些部分，使得这些装置能够用作生物传感器。因此，本文公开的材料和方法提供了用于批量生产均匀的全微生物传感器的有效手段。本文描述了装置本身的各种实施例，其特别适用于临床环境中的生物样品的实时分析。特别地，本发明描述了可以使用某些基于配体/配体受体的生物传感器实施方案进行的测定。本发明还公开了一种利用基板/标记信号产生对电化学检测特定分析物种的生物学和生理学意义的新方法，其产生选自二氧和过氧化氢的电活性物质的浓度变化。

32. 发明授权

US06379883B2 Microfabricated aperture-based sensor 有权
标题翻译：微型孔径传感器
公开(公告)号：US06379883B2
公开(公告)日：2002-04-30
申请号：US09741347
申请日：2000-12-21
申请人： Graham Davis , Chao Lin , Imants R. Lauks , Raymond J. Pierce
发明人： Graham Davis , Chao Lin , Imants R. Lauks , Raymond J. Pierce
IPC分类号： C12Q100
CPC分类号： C12Q1/004 , C12Q1/002 , Y10S435/817
摘要： A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.
摘要翻译：化学传感器包括位于扩散层上的酶层，扩散层和分析物阻挡层。通过在分析物阻挡层中的微细加工形成孔径，以允许控制的分析物通量到扩散层。

33. 发明授权

US5466575A Process for the manufacture of wholly microfabricated biosensors 失效
标题翻译：制造完全微生物传感器的方法
公开(公告)号：US5466575A
公开(公告)日：1995-11-14
申请号：US943345
申请日：1992-09-10
申请人： Stephen N. Cozzette , Graham Davis , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Paul Van Der Werf , Henry J. Wieck
发明人： Stephen N. Cozzette , Graham Davis , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Paul Van Der Werf , Henry J. Wieck
IPC分类号： H04R1/44 , B01L3/00 , B01L3/02 , C12Q1/00 , G01N1/28 , G01N27/07 , G01N27/327 , G01N27/333 , G01N27/414 , G01N27/416 , G01N33/543 , G01N35/00 , G01N35/10 , G01V9/00 , G10K11/00 , H04R20060101 , H04R1/02 , H04R15/00
CPC分类号： B01L3/0268 , B01L3/5027 , C12Q1/001 , G01N33/5438 , G01N35/0099 , G01V9/00 , G10K11/006 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L3/5088 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , G01N35/109 , Y10S435/817 , Y10S436/806
摘要： An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.
摘要翻译：描述了适用于分析生物学重要的分析物种的电子装置的微细加工的有效方法。本发明的技术允许对在合适的衬底上建立的各种组件和层的尺寸特征进行密切的控制。这种控制延伸到结合生物组分的装置的那些部分，使得这些装置能够用作生物传感器。因此，本文公开的材料和方法提供了用于批量生产均匀的全微生物传感器的有效手段。本文描述了装置本身的各种实施例，其特别适用于临床环境中的生物样品的实时分析。特别地，本发明描述了可以使用某些基于配体/配体受体的生物传感器实施方案进行的测定。本发明还公开了一种利用基板/标记信号产生对电化学检测特定分析物种的生物学和生理意义的新方法，其产生选自二氧和过氧化氢的电活性物质浓度的变化。

34. 发明授权

US09050595B2 Assay devices with integrated sample dilution and dilution verification and methods of using same 有权
标题翻译：具有集成样品稀释和稀释验证的测定装置及其使用方法
公开(公告)号：US09050595B2
公开(公告)日：2015-06-09
申请号：US13308968
申请日：2011-12-01
申请人： Cary James Miller , Graham Davis , Michael Zelin
发明人： Cary James Miller , Graham Davis , Michael Zelin
IPC分类号： B01L3/00 , G01N33/543 , B01F11/00
CPC分类号： G01N33/54373 , B01F11/0071 , B01L3/502 , B01L3/5027 , B01L3/50273 , B01L2200/10 , B01L2200/16 , B01L2300/045 , B01L2300/0645 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/126 , B01L2400/0481 , B01L2400/0672 , G01N21/25 , G01N21/78 , G01N27/02 , G01N27/26 , G01N27/3272 , G01N27/3274 , G01N27/413 , G01N27/49 , G01N33/54366 , G01N33/76
摘要： The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.
摘要翻译：本发明是用于通过各种测定法快速测定液体样品中分析物的装置和方法，其包括结合用于形成用于分析的稀释样品的样品稀释特征的免疫测定。该装置和方法还包括用于验证稀释样品的稀释程度的稀释验证特征。优选地，这些装置能够用于提供的护理点诊断领域。

35. 发明授权

US08679827B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US08679827B2
公开(公告)日：2014-03-25
申请号：US13495224
申请日：2012-06-13
申请人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及用于在包括传感器的导管中使用电化学测定来测量分析物的量的方法，其中所述传感器包括具有结合所述分析物的固定化抗体表面层的电极，以及设置在说导管。包含用于所述酶的底物和至少一个空气区段的溶液与传感器接触以从传感器的区域去除未结合的分析物和标记的抗体。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

36. 发明授权

US08308020B2 Shipping device and related methods 有权
标题翻译：运输装置及相关方法
公开(公告)号：US08308020B2
公开(公告)日：2012-11-13
申请号：US12701742
申请日：2010-02-08
申请人： Graham Davis , Frederick A. Moyer , Thomas A. Petrilli , Steven A. Wilson , Thomas O'Malley
发明人： Graham Davis , Frederick A. Moyer , Thomas A. Petrilli , Steven A. Wilson , Thomas O'Malley
IPC分类号： B65D25/04 , B65D90/00
CPC分类号： G09F3/02 , B65D25/10 , B65D85/68 , B65D2585/6875 , G09F23/00 , Y10T29/49817 , Y10T29/49826
摘要： A containment assembly may be used with a shipping container and may include: a cargo net having a pair of sleeves; and, a pair of tethering members that are received within the sleeves and that have ends that extends out from the sleeves. The ends of the tethering members may be attachable to multiple attachment surfaces on the shipping container to change the orientation of the cargo net with respect to the shipping container.
摘要翻译：容纳组件可以与运输容器一起使用，并且可以包括：具有一对套筒的货物网; 以及一对束缚构件，其接收在所述套筒内并且具有从所述套筒延伸出的端部。系链构件的端部可以附接到运输容器上的多个附接表面以改变货物网相对于运输容器的取向。

37. 发明授权

US08222024B2 Apparatus and methods for analyte measurement and immunoassay 有权
标题翻译：用于分析物测量和免疫测定的装置和方法
公开(公告)号：US08222024B2
公开(公告)日：2012-07-17
申请号：US13198253
申请日：2011-08-04
申请人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
发明人： Graham Davis , Imants Lauks , Chao Lin , Cary James Miller
IPC分类号： C12M3/00
CPC分类号： G01N33/543 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/087 , B01L2400/0421 , B01L2400/046 , B01L2400/0481 , B01L2400/0683 , G01N33/54366 , G01N35/08 , G01N2035/0436
摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.
摘要翻译：本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器能够适应不同的分析物测量。所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

38. 发明申请

US20110256573A1 METHOD AND APPARATUS FOR DETERMINING AT LEAST ONE HEMOGLOBIN RELATED PARAMETER OF A WHOLE BLOOD SAMPLE 有权
标题翻译：用于确定至少一种HEMOGLOBIN相关参数的全血样品的方法和装置
公开(公告)号：US20110256573A1
公开(公告)日：2011-10-20
申请号：US13051705
申请日：2011-03-18
申请人： Graham Davis , Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten Lalpuria , Paul G. Mitsis
发明人： Graham Davis , Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten Lalpuria , Paul G. Mitsis
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： G01N33/726 , G01N15/1475 , G01N2015/0073
摘要： A method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by an interior surface of a first panel, and an interior surface of a second panel, and the chamber has a height extending between the interior surfaces of the panels, wherein the chamber is configured to increase the oxygenation state of the sample to a substantially oxygenated state within a predetermined amount of time after entry into the chamber; b) imaging the at least one red blood cell contacting the interior surfaces, and producing image signals; c) determining an optical density of at least a portion of the imaged red blood cell contacting both interior surfaces; and d) determining the at least one hemoglobin related parameter of the red blood cell contacting the interior surfaces, using the determined optical density and a molar extinction coefficient for oxygenated hemoglobin.
摘要翻译：提供了一种用于确定全血样品的至少一种血红蛋白相关参数的方法和装置。该方法包括以下步骤：a）将样品沉积到适于静态保持样品进行分析的分析室中，所述室由第一面板的内表面和第二面板的内表面限定，并且所述室具有在所述面板的内表面之间延伸的高度，其中所述腔被配置为在进入所述腔室之后的预定量的时间内将所述样品的氧合状态增加到基本上氧合状态; b）对与内表面接触的至少一个红细胞进行成像，并产生图像信号; c）确定接触两个内表面的成像红细胞的至少一部分的光密度; 以及d）使用确定的光密度和氧合血红蛋白的摩尔消光系数来确定与内表面接触的红细胞的至少一种血红蛋白相关参数。

39. 发明申请

US20100206894A1 SHIPPING DEVICE AND RELATED METHODS 有权
标题翻译：运输装置及相关方法
公开(公告)号：US20100206894A1
公开(公告)日：2010-08-19
申请号：US12701742
申请日：2010-02-08
申请人： Graham Davis , Frederick A. Moyer , Thomas A. Petrilli , Steven A. Wilson , Thomas O'Malley
发明人： Graham Davis , Frederick A. Moyer , Thomas A. Petrilli , Steven A. Wilson , Thomas O'Malley
IPC分类号： B65D90/00 , B61D45/00 , G09F3/00 , B23P11/00 , B23P19/00
CPC分类号： G09F3/02 , B65D25/10 , B65D85/68 , B65D2585/6875 , G09F23/00 , Y10T29/49817 , Y10T29/49826
摘要： A containment assembly may be used with a shipping container and may include: a cargo net having a pair of sleeves; and, a pair of tethering members that are received within the sleeves and that have ends that extends out from the sleeves. The ends of the tethering members may be attachable to multiple attachment surfaces on the shipping container to change the orientation of the cargo net with respect to the shipping container.
摘要翻译：容纳组件可以与运输容器一起使用，并且可以包括：具有一对套筒的货物网; 以及一对束缚构件，其接收在所述套筒内并且具有从所述套筒延伸出的端部。系链构件的端部可以附接到运输容器上的多个附接表面以改变货物网相对于运输容器的取向。

40. 发明申请

US20070233583A1 POINT-OF-CARE INVENTORY MANAGEMENT SYSTEM AND METHOD 有权
标题翻译：点保存管理系统和方法
公开(公告)号：US20070233583A1
公开(公告)日：2007-10-04
申请号：US11761142
申请日：2007-06-11
申请人： Jody TIRINATO , Michael Zelin , Paul Gibson , Lyudmila Zaltsman , Graham Davis
发明人： Jody TIRINATO , Michael Zelin , Paul Gibson , Lyudmila Zaltsman , Graham Davis
IPC分类号： G06Q10/00
CPC分类号： G01K13/00 , G01K1/02 , G01K3/04 , G06Q10/087 , G06Q20/203 , G06Q30/0223 , G06Q30/0639 , Y10S707/99931
摘要： A system and method are disclosed for controlling an inventory of point-of-care diagnostic devices. The inventory includes a main inventory and at least one subinventory. Each device has an ambient temperature shelf life. Data associated with the devices is entered, including: the current quantity and predetermined minimum quantity of devices in the main inventory; and the current quantity and predetermined minimum quantity of devices in the subinventory. A first timestamp is associated with each device when the device is transferred from the main inventory to the ambient temperature subinventory. The first timestamp is compared to a second timestamp prior to use of the device to determine whether the device's ambient temperature shelf life is exceeded. The current quantity of devices in the subinventory is updated in response to an event that causes a change in the current quantity of devices in the subinventory.
摘要翻译：公开了一种用于控制点护理诊断装置的库存的系统和方法。库存包括主要库存和至少一个子库存。每个设备具有环境温度保质期。输入与设备相关的数据，包括：主库存中的当前数量和预定最小数量的设备; 以及子库存中的当前数量和预定的最小数量的设备。当设备从主库存转移到环境温度子库时，第一个时间戳与每个设备相关联。在使用设备之前，将第一个时间戳与第二个时间戳进行比较，以确定设备的环境温度保质期是否超过。响应于导致子库中当前设备数量发生变化的事件，子库中当前的设备数量被更新。

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