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31. 发明授权

US06376619B1 High density, miniaturized arrays and methods of manufacturing same 有权
标题翻译：高密度，小型化阵列及其制造方法
公开(公告)号：US06376619B1
公开(公告)日：2002-04-23
申请号：US09287379
申请日：1999-04-07
申请人： Kurt J. Halverson , Sanjay L. Patil , Jerald K. Rasmussen
发明人： Kurt J. Halverson , Sanjay L. Patil , Jerald K. Rasmussen
IPC分类号： C08F830
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , Y10T428/24174 , Y10T428/31667 , Y10T428/31902 , Y10T428/3192 , Y10T428/31938
摘要： High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.
摘要翻译：高密度，小型化阵列，包括高表面积。所描述的阵列包括具有连接剂涂层的底物，以及附着在基材上的反应物的阵列。制造高密度反应物阵列的方法。这些方法包括使用取向的热收缩膜和弹性体材料。使用连接剂官能化底物的方法用于随后的反应物固定也在本文中公开。

32. 发明授权

US09470612B2 Systems and methods for detecting an analyte of interest in a sample using filters and microstructured surfaces 有权
标题翻译：使用过滤器和微结构化表面检测样品中感兴趣的分析物的系统和方法
公开(公告)号：US09470612B2
公开(公告)日：2016-10-18
申请号：US14122373
申请日：2012-06-26
申请人： Raj Rajagopal , Kurt J. Halverson , Ramasubramani Kuduva Raman Thanumoorthy
发明人： Raj Rajagopal , Kurt J. Halverson , Ramasubramani Kuduva Raman Thanumoorthy
IPC分类号： G01N1/40 , B01L3/00 , G01N15/04 , C12Q1/04
CPC分类号： G01N1/4077 , B01L3/5021 , B01L2300/042 , B01L2300/047 , B01L2300/0681 , B01L2300/069 , B01L2400/0409 , C12Q1/04 , G01N15/042 , G01N2001/4083 , G01N2001/4088
摘要： Systems and methods for detecting an analyte of interest in a sample. The system can include a first container comprising a filter portion. The filter portion can include a filter comprising a filtrand of the sample on a first side of the filter. The system can further include a second container comprising the filter portion coupled to a detection portion comprising a microstructured surface. The method can include providing the first container, coupling the filter portion to the detection portion to form the second container where the first side of the filter faces the microstructured surface, and centrifuging the second container toward the microstructured surface. The method can further include inverting the second container after centrifuging to decant the supernatant from the detection portion, such that a concentrate comprising a sediment of the sample is retained in the microstructured surface, which can be interrogated for an analyte of interest.
摘要翻译：用于检测样品中感兴趣的分析物的系统和方法。该系统可以包括包括过滤器部分的第一容器。过滤器部分可以包括在过滤器的第一侧上包括样品的过滤器的过滤器。该系统还可以包括第二容器，其包括耦合到包括微结构化表面的检测部分的过滤器部分。该方法可以包括提供第一容器，将过滤部分连接到检测部分，以形成第二容器，其中过滤器的第一侧面向微结构化表面，并将第二容器离心到微结构化表面。该方法还可包括在离心后将第二容器倒置以从检测部分倾析上清液，使得包含样品沉淀物的浓缩物保留在微结构化表面中，该微结构化表面可被询问用于感兴趣的分析物。

33. 发明授权

US09329311B2 Light control film 有权
标题翻译：光控膜
公开(公告)号：US09329311B2
公开(公告)日：2016-05-03
申请号：US14119725
申请日：2012-05-24
申请人： Kurt J. Halverson , Raymond J. Kenney , Brian W. Lueck , Kenneth A.P. Meyer , Scott M. Tapio , Michael E. Lauters , Olester Benson, Jr. , Gary E. Gaides
发明人： Kurt J. Halverson , Raymond J. Kenney , Brian W. Lueck , Kenneth A.P. Meyer , Scott M. Tapio , Michael E. Lauters , Olester Benson, Jr. , Gary E. Gaides
IPC分类号： G02B5/02 , G02F1/1335
CPC分类号： G02B5/02 , G02B2207/123 , G02F1/133524
摘要： The present disclosure provides a light control film that is capable of transmitting light, or allowing a viewer to observe information, only within a viewing region centered around the normal (perpendicular line) to a surface. The light control film generally blocks information or light outside of this viewing region, and provides security in all directions including right-and-left and up-and-down of the film. The light control film includes a plurality of light-transmissive cavities that are surrounded by a light absorbing material, such that each of the plurality of cavities is optically isolated from adjacent cavities. Each of the light-transmissive cavities effectively block light which enters the cavity outside of a viewing (that is, cutoff) angle.
摘要翻译：本公开提供了一种光控制膜，其能够仅在围绕与表面的法线（垂直线）对齐的观察区域内透光或允许观察者观察信息。光控膜通常阻挡该观看区域外的信息或光，并且在所有方向提供电影的安全性，包括右上和左右。光控制膜包括被光吸收材料包围的多个光透射腔，使得多个空腔中的每一个与相邻空腔光学隔离。每个透光腔有效地阻挡在观察（即截止）角度之外进入空腔的光。

34. 发明授权

US08647574B2 Sample preparation container and method 有权
标题翻译：样品制备容器和方法
公开(公告)号：US08647574B2
公开(公告)日：2014-02-11
申请号：US12743252
申请日：2008-11-19
申请人： Kurt J. Halverson , Stephen C. P. Joseph , Raj Rajagopal , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati , Daniel E. Siltberg , Paul J. Cobian , Theresa J. Gerten
发明人： Kurt J. Halverson , Stephen C. P. Joseph , Raj Rajagopal , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati , Daniel E. Siltberg , Paul J. Cobian , Theresa J. Gerten
IPC分类号： G01N15/06
CPC分类号： G01N1/38 , G01N1/4077 , G01N2001/4088
摘要： A system and method for preparing and collecting samples for analyte testing. The system can include a sample preparation system and a sample collection system coupled to the sample preparation system. The sample preparation system can include at least one of a deformable self-supporting receptacle comprising a reservoir and a freestanding receptacle comprising a reservoir. The reservoir can be adapted to contain a liquid composition. The sample collection system can be positioned in fluid communication with a reservoir of the sample preparation system, and can be adapted to capture an analyte of interest. The method can include providing a fluid path defined at least partially by the sample preparation system and the sample collection system, positioning the liquid composition in a reservoir of the sample preparation system, and moving at least a portion of the liquid composition in the fluid path to the sample collection system.
摘要翻译：用于制备和收集样品用于分析物测试的系统和方法。该系统可以包括与样品制备系统耦合的样品制备系统和样品收集系统。样品制备系统可以包括可变形的自支撑容器中的至少一个，其包括储存器和包括储存器的独立容器。储存器可以适于容纳液体组合物。样品收集系统可以定位成与样品制备系统的储存器流体连通，并且可以适于捕获感兴趣的分析物。该方法可以包括提供至少部分地由样品制备系统和样品收集系统限定的流体路径，将液体组合物定位在样品制备系统的储存器中，并且将至少一部分液体组合物移动到流体路径到采样系统。

35. 发明授权

US08535945B2 System and method for concentrating samples 有权
标题翻译：浓缩样品的系统和方法
公开(公告)号：US08535945B2
公开(公告)日：2013-09-17
申请号：US13131641
申请日：2009-11-30
申请人： Kurt J. Halverson
发明人： Kurt J. Halverson
IPC分类号： G01N35/00 , B04B1/00 , B01L3/14 , G01N1/40 , C12Q1/14 , B01D33/00
CPC分类号： G01N35/00 , B01L3/5021 , B01L3/50825 , B01L2300/042 , B01L2300/043 , B01L2300/047 , G01N1/405 , G01N1/4077 , G01N2001/4088 , Y10T436/111666
摘要： A system and method for concentrating samples. The system can include a first container adapted to contain a sample. The first container can include a first portion and a second portion adapted to be removably coupled to the first portion. The system can further include a second container comprising the second portion and a third portion adapted to be removably coupled to the second portion. The method can include centrifuging the first container in a first orientation toward the second portion of the first container; retaining a concentrate of the sample in the second portion of the first container; and centrifuging the second container in a second orientation toward the third portion of the second container, such that the concentrate retained in the second portion is moved into the third portion of the second container, the second orientation being different from the first orientation.
摘要翻译：用于浓缩样品的系统和方法。该系统可以包括适于容纳样品的第一容器。第一容器可以包括适于可拆卸地联接到第一部分的第一部分和第二部分。该系统可进一步包括包括第二部分的第二容器和适于可拆卸地联接到第二部分的第三部分。该方法可以包括使第一容器以第一取向离开第一容器的第二部分; 将样品的浓缩物保留在第一容器的第二部分中; 并且以第二取向朝第二容器的第三部分离心第二容器，使得保留在第二部分中的浓缩物移动到第二容器的第三部分中，第二取向与第一取向不同。

36. 发明申请

US20130109080A1 INTEGRATED SYSTEMS AND ASSEMBLIES FOR SAMPLE PROCESSING 审中-公开
标题翻译：集成系统和样品加工组件
公开(公告)号：US20130109080A1
公开(公告)日：2013-05-02
申请号：US13699763
申请日：2011-05-23
申请人： Joel R. Dufresne , David J. Franta , Theresa J. Gerten , Christopher R. Kokaisel , Kurt J. Halverson , William Bedingham , James E. Aysta , Barry W. Robole , Kenneth B. Wood
发明人： Joel R. Dufresne , David J. Franta , Theresa J. Gerten , Christopher R. Kokaisel , Kurt J. Halverson , William Bedingham , James E. Aysta , Barry W. Robole , Kenneth B. Wood
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/502707 , B01L3/502738 , B01L3/523 , B01L7/52 , B01L9/527 , B01L2200/0642 , B01L2200/0689 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887
摘要： Methods and devices for the thermal processing of samples are disclosed, including portable, integrated processing assemblies for occluding channels in a fluidic device.
摘要翻译：公开了用于样品热处理的方法和装置，包括用于在流体装置中封闭通道的便携式集成处理组件。

37. 发明授权

US08272255B2 System and method for preparing samples 有权
标题翻译：制备样品的系统和方法
公开(公告)号：US08272255B2
公开(公告)日：2012-09-25
申请号：US12301592
申请日：2007-05-22
申请人： Kurt J. Halverson , Stephen C. P. Joseph , Matthew T. Scholz
发明人： Kurt J. Halverson , Stephen C. P. Joseph , Matthew T. Scholz
IPC分类号： G01N1/38 , G01N1/14 , G01N33/487 , G01N1/18 , G01N33/02
CPC分类号： G01N1/38 , A61B10/0038 , A61B10/0096 , B01F11/0005 , B01F15/00837 , B01L3/502 , B01L2300/046 , B01L2300/0681 , G01N1/18 , G01N33/02 , G01N33/487 , G01N2001/4088 , Y10T436/25375 , Y10T436/25625
摘要： A system and method for preparing samples for analyte testing. The sample preparation system can include a freestanding receptacle. The method can include providing a liquid composition comprising a source and a diluent, and positioning the liquid composition in a reservoir defined by the freestanding receptacle. The method can further include filtering the liquid composition to form a filtrate comprising an analyte of interest, removing at least a portion of the filtrate from the sample preparation system to form a sample, and analyzing the sample for the analyte of interest.
摘要翻译：用于制备分析物测试样品的系统和方法。样品制备系统可以包括独立的容器。该方法可以包括提供包含源和稀释剂的液体组合物，并将液体组合物定位在由独立容器限定的储存器中。该方法还可以包括过滤液体组合物以形成包含感兴趣的分析物的滤液，从样品制备系统中除去至少一部分滤液以形成样品，并分析样品中感兴趣的分析物。

38. 发明申请

US20110318814A1 METHODS, KITS AND SYSTEMS FOR PROCESSING SAMPLES 审中-公开
标题翻译：方法，加工样品的工具和系统
公开(公告)号：US20110318814A1
公开(公告)日：2011-12-29
申请号：US13142292
申请日：2009-12-30
申请人： Manjiri T. Kshirsagar , Kurt J. Halverson , Raj Rajagopal
发明人： Manjiri T. Kshirsagar , Kurt J. Halverson , Raj Rajagopal
IPC分类号： C12N7/02 , C12N1/20 , C12N1/14 , C12N3/00 , C12N1/16 , C12N1/10 , C12N1/12
CPC分类号： G01N1/4077 , C12M47/04 , C12Q1/24 , G01N1/405 , G01N33/1866 , G01N2001/4088
摘要： A method for isolating microorganisms from a sample, the sample including sample matrix and microorganisms, the method including the steps of providing a receptacle, the receptacle configured to allow filtering of the sample and to reversibly contain the sample and a concentration agent; adding the sample to the receptacle, wherein a microorganism-bound composition will be formed in the receptacle, the microorganism-bound composition including concentration agent-bound microorganisms and sample matrix; and filtering the microorganism-bound composition through a filter to collect the concentration agent-bound microorganisms on the filter, wherein the filter has an average pore size that is greater than the average size of the microorganisms. Kits and systems are also disclosed herein.
摘要翻译：一种用于从样品中分离微生物的方法，所述样品包括样品基质和微生物，所述方法包括提供容器的步骤，所述容器被配置为允许样品过滤并且可逆地容纳样品和浓缩剂; 将样品加入到容器中，其中将在容器中形成微生物结合的组合物，微生物结合的组合物包括与浓度剂结合的微生物和样品基质; 并通过过滤器过滤微生物结合的组合物以收集过滤器上与浓度剂结合的微生物，其中过滤器的平均孔径大于微生物的平均尺寸。本文还公开了套件和系统。

39. 发明申请

US20110236924A1 SYSTEM AND METHOD FOR PROCESSING SAMPLES 有权
标题翻译：用于处理样品的系统和方法
公开(公告)号：US20110236924A1
公开(公告)日：2011-09-29
申请号：US13131658
申请日：2009-12-01
申请人： Kurt J. Halverson
发明人： Kurt J. Halverson
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： C12Q1/02 , G01N1/4077 , G01N35/00029 , G01N2001/4088 , G01N2035/00148 , Y10T436/255 , Y10T436/2575
摘要： A system and method for processing samples. The system can include a loading chamber, a detection chamber positioned in fluid communication with the loading chamber, and a fluid path defined at least partially by the loading chamber and the detection chamber. The system can further include a filter positioned such that at least one of its inlet and its outlet is positioned in the fluid path. The method can include positioning a sample in the loading chamber, filtering the sample in the fluid path to form a concentrated sample and a filtrate, removing the filtrate from the fluid path at a location upstream of the detection chamber, moving at least a portion of the concentrated sample in the fluid path to the detection chamber, and analyzing at least a portion of the concentrated sample in the detection chamber for an analyte of interest.
摘要翻译：一种用于处理样品的系统和方法。该系统可以包括装载室，与装载室流体连通的检测室，以及至少部分地由装载室和检测室限定的流体路径。该系统还可以包括过滤器，其被定位成使得其入口和出口中的至少一个定位在流体路径中。该方法可以包括将样品定位在装载室中，在流体路径中过滤样品以形成浓缩的样品和滤液，在检测室上游的位置从流体路径移除滤液，移动至少一部分所述浓缩样品在所述检测室的流体路径中，以及分析所述检测室中所述浓缩样品的至少一部分，用于感兴趣的分析物。

40. 发明申请

US20110182770A1 BIOLOGICAL STERILIZATION INDICATOR, SYSTEM, AND METHODS OF USING SAME 有权
标题翻译：生物灭菌指示剂，系统和使用方法
公开(公告)号：US20110182770A1
公开(公告)日：2011-07-28
申请号：US13063945
申请日：2009-10-12
申请人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
发明人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
IPC分类号： A61L2/18
CPC分类号： A61L2/28 , C12Q1/22
摘要： A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
摘要翻译：一种生物灭菌指标，系统和确定灭菌过程有效性的方法。生物灭菌指示剂可以包括孢子的位点，含有液体的储存器和定位成在气氛和孢子的位置之间提供流体连通的消毒剂通道。储存器可以具有闭合状态，其中储存器不与孢子的轨迹流体连通，并且储存器与孢子的轨迹流体连通的打开状态。生物灭菌指示器系统可以包括生物灭菌指示器和适于联接到生物灭菌指示器的检测装置。在一些实施方案中，该方法可以包括测定孢子以获得特征的可检测变化，并且检测基本上所有可检测的变化。

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