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31. 发明授权

US08321022B2 Adaptive therapy for disordered breathing 有权
标题翻译：呼吸紊乱的自适应治疗
公开(公告)号：US08321022B2
公开(公告)日：2012-11-27
申请号：US12731103
申请日：2010-03-24
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
IPC分类号： A61N1/36
CPC分类号： A61N1/362 , A61N1/3601
摘要： An approach to providing disordered breathing therapy includes detecting disordered breathing and adapting a therapy to mitigate the disordered breathing. The therapy may be adapted to enhance therapy effectiveness, to provide therapy that reduces an impact of the therapy on the patient, or to achieve other therapeutic goals. Cardiac electrical therapy to mitigate the disordered breathing may include various cardiac pacing regimens and/or delivery of non-excitatory electrical stimulation to the heart.
摘要翻译：提供无序呼吸治疗的方法包括检测无序呼吸并适应治疗以减轻无序呼吸。治疗可以适应于增强治疗有效性，提供减少治疗对患者的影响或实现其它治疗目标的治疗。减轻无序呼吸的心脏电疗可能包括各种心脏起搏方案和/或向心脏递送非兴奋性电刺激。

32. 发明申请

US20110306850A1 Sleep quality data collection and evaluation 有权
标题翻译：睡眠质量数据收集和评估
公开(公告)号：US20110306850A1
公开(公告)日：2011-12-15
申请号：US13215592
申请日：2011-08-23
申请人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
发明人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
IPC分类号： A61B5/00
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0809 , A61B5/11 , A61B5/4528 , A61B5/4818 , A61N1/3621 , G06F19/00
摘要： A sleep quality assessment approach involves collecting data based on detected physiological or non-physiological patient conditions. At least one of detecting patient conditions and collecting data is performed using an implantable device. Sleep quality may be evaluated using the collected data by an implantable or patient-external sleep quality processor. One approach to sleep quality evaluation involves computing one or more summary metrics based on occurrences of movement disorders or breathing disorders during sleep.
摘要翻译：睡眠质量评估方法包括基于检测到的生理或非生理性患者状况收集数据。使用可植入装置执行检测患者状况和收集数据中的至少一个。可以使用可植入或患者外部的睡眠质量处理器收集的数据来评估睡眠质量。睡眠质量评估的一种方法包括基于睡眠期间的运动障碍或呼吸障碍的发生来计算一个或多个总结度量。

33. 发明申请

US20100094102A1 MULTI-SENSOR STRATEGY FOR HEART FAILURE PATIENT MANAGEMENT 有权
标题翻译：心脏失败患者管理的多传感器策略
公开(公告)号：US20100094102A1
公开(公告)日：2010-04-15
申请号：US12576453
申请日：2009-10-09
申请人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
发明人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
IPC分类号： A61B5/02
CPC分类号： A61B5/02055 , A61B5/0008 , A61B5/0031 , A61B5/01 , A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/0531 , A61B5/0538 , A61B5/0816 , A61B5/085 , A61B5/1118 , A61B5/121 , A61B5/14542 , A61B5/686 , A61B5/6869 , A61B5/7275 , A61B7/04 , A61N1/36585 , G06F19/00
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.
摘要翻译：一种装置包括多个传感器和一个处理器。每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化状态根据第一和第二规则发生。

34. 发明申请

US20080262360A1 USING RESPIRATION DISTRESS MANIFESTATIONS FOR HEART FAILURE DETECTION 有权
标题翻译：使用呼吸部分心理失调检测
公开(公告)号：US20080262360A1
公开(公告)日：2008-10-23
申请号：US11736058
申请日：2007-04-17
申请人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
发明人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.
摘要翻译：讨论了通过可植入地识别其发生并评估关于其的信息来诊断一种或多种呼吸困扰表现的系统和方法，以提供现在或即将恶化的心力衰竭的指征。使用由可植入呼吸传感器电路和植入式生理传感器电路产生的信息，例如物理活动传感器电路或姿势传感器电路中的至少一个，可植入或外部处理器电路可以检测呼吸障碍和相关联的随后的唤醒稳定状态发生，然后评估来自稳定状态发生的随着时间的兴奋，以提供目前或即将恶化的心力衰竭的指征。在一个示例中，关于受试者内的液位水平的信息用于确定恶化的心力衰竭的指示。在各种实例中，响应于目前或即将恶化的心力衰竭的指征开始或调整方案。

35. 发明授权

US09943234B2 Using respiration distress manifestations for heart failure detection 有权
公开(公告)号：US09943234B2
公开(公告)日：2018-04-17
申请号：US11736058
申请日：2007-04-17
申请人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
发明人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
IPC分类号： A61B5/08 , A61B5/0205 , A61B5/11 , A61B5/00 , A61N1/362
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.

36. 发明授权

US08738119B2 Multi-sensor strategy for heart failure patient management 有权
标题翻译：心脏病患者管理的多传感器策略
公开(公告)号：US08738119B2
公开(公告)日：2014-05-27
申请号：US12576453
申请日：2009-10-09
申请人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
发明人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
IPC分类号： A61B5/02
CPC分类号： A61B5/02055 , A61B5/0008 , A61B5/0031 , A61B5/01 , A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/0531 , A61B5/0538 , A61B5/0816 , A61B5/085 , A61B5/1118 , A61B5/121 , A61B5/14542 , A61B5/686 , A61B5/6869 , A61B5/7275 , A61B7/04 , A61N1/36585 , G06F19/00
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.
摘要翻译：一种装置包括多个传感器和一个处理器。每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化状态根据第一和第二规则发生。

37. 发明授权

US07744542B2 Implanted air passage sensors 有权
标题翻译：植入式通风传感器
公开(公告)号：US07744542B2
公开(公告)日：2010-06-29
申请号：US11379396
申请日：2006-04-20
申请人： Thomas Piaget , Paul Huelskamp , Jeffrey E. Stahmann , John D. Hatlestad
发明人： Thomas Piaget , Paul Huelskamp , Jeffrey E. Stahmann , John D. Hatlestad
IPC分类号： A61B5/0205
CPC分类号： A61B5/0031 , A61B5/036 , A61B5/08 , A61B5/0833 , A61B5/0836 , A61B5/1459 , A61B5/4818 , A61B5/68 , A61B7/003 , A61B2560/0242
摘要： A physiological sensor is located within the airway of the subject's body, such as for measuring barometric pressure and communicating this value to a blood pressure or other monitoring device, which can derive gauge pressure using the barometric pressure and a measured absolute pressure within the body. The physiological sensor may also detect one or more other physiological parameters such as air flow, sound, or a chemical property. It may be anchored within the airway with the ability to communicate wirelessly to one or more other medical devices, such as an implanted cardiac function management device. Methods of use are also described.
摘要翻译：生理传感器位于受试者身体的气道内，例如用于测量大气压力并将该值传递到血压或其他监测装置，其可以使用大气压力和体内测量的绝对压力来导出表压。生理传感器还可以检测一个或多个其它生理参数，例如气流，声音或化学性质。它可以锚定在气道内，具有与一个或多个其它医疗装置（例如植入式心脏功能管理装置）无线通信的能力。还描述了使用方法。

38. 发明授权

US07720541B2 Adaptive therapy for disordered breathing 有权
标题翻译：呼吸紊乱的自适应治疗
公开(公告)号：US07720541B2
公开(公告)日：2010-05-18
申请号：US10643203
申请日：2003-08-18
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
IPC分类号： A61N1/00
CPC分类号： A61N1/362 , A61N1/3601
摘要： An approach to providing disordered breathing therapy includes detecting disordered breathing and adapting a therapy to mitigate the disordered breathing. The therapy may be adapted to enhance therapy effectiveness, to provide therapy that reduces an impact of the therapy on the patient, or to achieve other therapeutic goals. Cardiac electrical therapy to mitigate the disordered breathing may include various cardiac pacing regimens and/or delivery of non-excitatory electrical stimulation to the heart.
摘要翻译：提供无序呼吸治疗的方法包括检测无序呼吸并适应治疗以减轻无序呼吸。治疗可以适应于增强治疗有效性，提供减少治疗对患者的影响或实现其它治疗目标的治疗。减轻无序呼吸的心脏电疗可能包括各种心脏起搏方案和/或向心脏递送非兴奋性电刺激。

39. 发明申请

US20100010378A1 Apparatus and Method for Detecting Lung Sounds Using an Implanted Device 有权
标题翻译：使用植入装置检测肺声的装置和方法
公开(公告)号：US20100010378A1
公开(公告)日：2010-01-14
申请号：US12545652
申请日：2009-08-21
申请人： John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann
发明人： John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann
IPC分类号： A61B7/00
CPC分类号： A61B7/003 , A61N1/36514 , A61N1/36535
摘要： Adventitious lung sounds indicative of lung congestion are detected using an implantable sensor. The sensor is adapted to be positioned adjacent to a pulmonary system and to output signals indicative of lung sounds in response to pulmonary system activity. A controller receives the signals and processes the signals to detect the presence of adventitious lung sounds. A respiratory cycle sensor operating in conjunction with the lung-sound sensor enables classification of an adventitious lung sound according to its time occurrence within the respiratory cycle. Posture sensing in conjunction with lung-sound sensing provides valuable additional information as to the severity of the lung congestion.
摘要翻译：使用植入式传感器检测到指示肺充血的不定肺声。传感器适于邻近肺部系统定位，并响应于肺部系统活动而输出指示肺部声音的信号。控制器接收信号并处理信号以检测不定肺声的存在。与肺声传感器一起操作的呼吸循环传感器可以根据呼吸周期内的时间发生分类不定肺声。结合肺部感觉的姿势感知提供了关于肺充血严重程度的有价值的附加信息。

40. 发明申请

US20080221468A1 Prediction of disordered breathing 有权
公开(公告)号：US20080221468A1
公开(公告)日：2008-09-11
申请号：US12152029
申请日：2008-05-12
申请人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
发明人： Jeffrey E. Stahmann , John D. Hatlestad , Quan Ni , Jesse Hartley , Douglas R. Daum , Kent Lee
IPC分类号： A61B5/08 , A61B5/053
CPC分类号： A61B5/02405 , A61B5/0031 , A61B5/08 , A61B5/0816 , A61B5/1116 , A61B5/1118 , A61B5/4812 , A61B5/4815 , A61B5/4818 , A61B2560/0242 , A61B2562/0219 , A61N1/362 , A61N1/36514
摘要： An approach for predicting disordered breathing involves detecting one or more conditions associated with disordered breathing. The detected conditions are compared to disordered breathing prediction criteria. A prediction of disordered breathing is performed based on the comparison of the detected conditions to the prediction criteria. At least one of comparing the detected conditions to the prediction criteria and predicting disordered breathing is performed at least in part implantably.

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