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31. 发明申请

US20080114285A1 Energy-activated targeted cancer therapy 审中-公开
标题翻译：能量激活靶向癌症治疗
公开(公告)号：US20080114285A1
公开(公告)日：2008-05-15
申请号：US11906110
申请日：2007-09-27
申请人： James Chen
发明人： James Chen
IPC分类号： A61M5/00
CPC分类号： A61K41/0057 , A61K41/0061 , A61K41/0071 , A61K47/6817 , A61K47/6835 , A61K47/6849 , A61K47/6867 , A61N5/062
摘要： The present invention is drawn to energy activated targeted delivery systems for administering a therapy to a target tissue or target composition in a mammalian subject, using an energy source that preferably transmits energy to a treatment site transcutaneously. The systems provide for administering to the subject a therapeutically effective amount of a targeted substance, which preferably selectively binds to the target tissue. Energy at a wavelength or waveband corresponding to that which is absorbed by the targeted substance is then administered. The energy intensity is relatively low, but a high total fluence is employed to ensure the activation of the targeted energy-activated agent or targeted prodrug product. The claimed energy-activated targeted therapy is useful in the treatment of specifically selected target tissues, such as vascular endothelial tissue, the abnormal vascular walls of tumors, solid tumors of the head and neck, tumors of the gastrointestinal tract, tumors of the liver, tumors of the breast, tumors of the prostate, tumors of the lung, nonsolid tumors, malignant cells of the hematopoietic and lymphoid tissue and other lesions in the vascular system or bone marrow, and tissue or cells related to autoimmune and inflammatory disease.
摘要翻译：本发明涉及能量激活的靶向递送系统，其用于使用优先将能量经由能量传递到治疗部位的能量源向哺乳动物受试者施用对靶组织或靶组成的治疗。所述系统提供给予受试者治疗有效量的目标物质，其优选选择性地结合靶组织。然后施用对应于被靶物质吸收的波长或波段的能量。能量强度相对较低，但是采用高总能量密度来确保目标能量活化剂或靶向前药产品的活化。所要求的能量激活靶向治疗可用于特异性选择的靶组织如血管内皮组织，肿瘤异常血管壁，头颈部实体瘤，胃肠道肿瘤，肝肿瘤，乳腺肿瘤，前列腺肿瘤，肺肿瘤，非固体肿瘤，造血和淋巴组织的恶性细胞以及血管系统或骨髓中的其他损伤，以及与自身免疫性和炎性疾病相关的组织或细胞。

32. 发明申请

US20070292502A1 Chitosan-Embedded or Encapsulated Capsule 审中-公开
标题翻译：壳聚糖嵌入或封装胶囊
公开(公告)号：US20070292502A1
公开(公告)日：2007-12-20
申请号：US10593670
申请日：2004-03-23
申请人： William Chang , James Chen
发明人： William Chang , James Chen
IPC分类号： A61K9/48 , A61K31/715 , A61P3/00
CPC分类号： A61K9/1652 , A61K9/5036
摘要： The present invention relates to a chitosan-embedded or encapsulated capsule, which comprises a chitosan content which is chitosan, a salt thereof, or a derivative thereof, and an edible gum embedding or encapsulating the content.
摘要翻译：本发明涉及一种壳聚糖包埋或胶囊化胶囊，其包含壳聚糖，壳聚糖，其盐或其衍生物的壳聚糖含量，以及嵌入或包封内容物的食用胶囊。

33. 发明申请

US20070262033A1 Method and apparatus to enhance separation performance of a lean and low mean size dispersed phase from a continuous phase 审中-公开
标题翻译：从连续相中提高贫平均尺寸分散相的分离性能的方法和装置
公开(公告)号：US20070262033A1
公开(公告)日：2007-11-15
申请号：US11434596
申请日：2006-05-15
申请人： Shaya Movafaghian , James Chen
发明人： Shaya Movafaghian , James Chen
IPC分类号： B01D17/038
CPC分类号： B01D17/0217 , B04C5/26
摘要： Two hydrocyclones used in series enhances the removal of a dispersed phase from a continuous phase by cyclonic action. The first hydrocyclone has no overflow outlet and serves to coalesce the droplets or particles of the disperse phase together thereby increasing contaminant size distribution. The second hydrocyclone functions as a separator operating at higher removal efficiency. The method and apparatus are useful to clarify produced water from hydrocarbon recovery operations.
摘要翻译：串联使用的两个水力旋流器通过气旋作用增强了从连续相的分散相的去除。第一个水力旋流器没有溢出口，用于将分散相的液滴或颗粒聚结在一起，从而增加污染物的大小分布。第二个水力旋流器作为分离器起作用，具有更高的去除效率。该方法和装置可用于澄清来自烃回收操作的产生的水。

34. 发明申请

US20070260295A1 Light transmission system for photoreactive therapy 有权
标题翻译：用于光反应治疗的光传输系统
公开(公告)号：US20070260295A1
公开(公告)日：2007-11-08
申请号：US11416783
申请日：2006-05-03
申请人： James Chen , Steven Daly , Zihong Guo , Llew Keltner , Jeffrey Storm
发明人： James Chen , Steven Daly , Zihong Guo , Llew Keltner , Jeffrey Storm
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B50/30 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
摘要翻译：向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。集成光导管和控制模块与光活化药物组合使用。所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

35. 发明申请

US20070232661A1 Hedgehog Pathway Antagonists 有权
标题翻译：刺猬通路拮抗剂
公开(公告)号：US20070232661A1
公开(公告)日：2007-10-04
申请号：US10573945
申请日：2004-09-29
申请人： Philip Beachy , James Chen , Anssi Taipale
发明人： Philip Beachy , James Chen , Anssi Taipale
IPC分类号： C07D211/70
CPC分类号： C07D213/56 , C07D209/40 , C07D233/78 , C07D237/34 , C07D239/74 , C07D239/84 , C07D263/57 , C07D277/42 , C07D311/30 , C07D311/36 , C07D311/80 , C07D311/92 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D407/14 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Aromatic compounds for treating various diseases and pathologies are disclosed. The methods use of such compounds are also provided. Accordingly, the present invention makes available methods and compositions for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function.
摘要翻译：公开了用于治疗各种疾病和病症的芳族化合物。还提供了这些化合物的使用方法。因此，本发明提供了用于抑制由刺猬获得功能，ptc功能丧失或平滑获得功能引起的异常生长状态的可用方法和组合物。

36. 发明申请

US20070219257A1 Wnt Pathway Antagonists 失效
标题翻译： Wnt途径拮抗剂
公开(公告)号：US20070219257A1
公开(公告)日：2007-09-20
申请号：US10574248
申请日：2004-09-29
申请人： Philip Beachy , James Chen , Randall Mann
发明人： Philip Beachy , James Chen , Randall Mann
IPC分类号： A61K31/4192 , C07D211/08 , C07D249/24 , C07D487/04 , C12N5/06 , C12N5/08 , C12Q1/06 , C12Q1/18
CPC分类号： G01N33/74 , C04B35/632 , C07D211/08 , C07D249/18 , C07D249/22 , C07D401/12 , C07D487/04 , G01N33/502
摘要： Aromatic compounds for treating various diseases and pathologies are disclosed. The methods use of such compounds are also provided. Accordingly, the present invention makes available methods and compositions for inhibiting aberrant growth states in cells having Wnt receptors.
摘要翻译：公开了用于治疗各种疾病和病症的芳族化合物。也提供了这些化合物的使用方法。因此，本发明提供用于抑制具有Wnt受体的细胞中异常生长状态的可用方法和组合物。

37. 发明申请

US20060217410A1 Pre-organized tricyclic integrase inhibitor compounds 审中-公开
标题翻译：预先组织的三环整合酶抑制剂化合物
公开(公告)号：US20060217410A1
公开(公告)日：2006-09-28
申请号：US10529269
申请日：2003-10-16
申请人： James Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung Kim , Laura Schacherer
发明人： James Chen , Xiaowu Chen , Maria Fardis , Haolun Jin , Choung Kim , Laura Schacherer
IPC分类号： C07D471/14 , A61K31/4745
CPC分类号： C07D471/04 , C07D471/14
摘要： Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. Formula (I). A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
摘要翻译：公开了根据以下结构的三环化合物，其受保护的中间体和用于抑制HIV整合酶的方法。式（I）。 A 1和A 2是形成五，六或七元环的部分。 L是连接Ar与N的环原子的键或连接体.X是O，S或取代的氮。 Ar是芳基或杂芳基。 Q是N，^{+ NR，或CR 4。芳基碳可以独立地被除氢以外的取代基取代。化合物可以包括共价连接在任何位点的前药部分。}

38. 发明申请

US20060088530A1 Photodynamic therapy treatment for eye disease 失效
标题翻译：光动力治疗眼病
公开(公告)号：US20060088530A1
公开(公告)日：2006-04-27
申请号：US11297880
申请日：2005-12-07
申请人： James Chen
发明人： James Chen
IPC分类号： A61K39/395 , A61K31/555 , A61K31/409 , A61K31/198
CPC分类号： A61K41/0057 , A61K41/0071 , A61K41/0076 , A61K47/62 , A61K47/6843 , A61K47/6847 , Y10S514/912
摘要： This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light of specific wavelength sufficient to photoactivate photosensitizing agent. The photosensitizing agent is bound to a composition that mediates site specific delivery to a neovasculature target tissue of a therapeutically effective amount of a photosensitizing agent that is activated by a relatively low fluence rate of light over a prolonged period of time. Diseases treatable under this invention, include: diabetic retinopathy; macular degeneration; and malignant uveal melanomas.
摘要翻译：本发明公开了通过施用靶向光敏剂并随后暴露于足以光敏化剂的特定波长的光来治疗眼睛新生血管疾病的方法，试剂盒和说明书。光敏剂与一种组合物结合，该组合物介导在新的脉管系统靶组织中治疗有效量的光敏剂的部位特异性递送，所述光敏剂在较长的时间内被相对较低的光通量光激活。本发明可治疗的疾病包括：糖尿病性视网膜病变; 黄斑变性; 和恶性葡萄膜黑素瘤。

39. 发明申请

US20060020804A1 Cross-pollination synchronization of data 有权
公开(公告)号：US20060020804A1
公开(公告)日：2006-01-26
申请号：US11113688
申请日：2005-04-25
申请人： Jason Schleifer , Gary Hall , Garry Tan , James Chen
发明人： Jason Schleifer , Gary Hall , Garry Tan , James Chen
IPC分类号： H04L9/00
CPC分类号： G06F17/30575 , G06F17/30581 , Y10S707/99952 , Y10S707/99953
摘要： A technique and mechanism to effect cross-pollination synchronization of PIM (personal information manager) data to multiple sources. Additionally, a novel feature of the subject invention is the ability to effect cross-pollination synchronization with any number of devices and sources in a network. The invention provides for a user to employ a mobile device or set of devices as a central repository for PIM data (e.g., calendar, contacts and tasks) synchronized from multiple sources (e.g., multiple PC's (personal computers), an exchange server). The invention provides for synchronization of PIM data from multiple types of server sources to multiple devices regardless of the synchronization protocol versions and different schemas.

40. 发明申请

US20050261253A1 Kinase inhibitory phosphonate analogs 失效
标题翻译：激酶抑制性膦酸酯类似物
公开(公告)号：US20050261253A1
公开(公告)日：2005-11-24
申请号：US10832811
申请日：2004-04-26
申请人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Thorsten Kirschberg , Richard Mackman , Sundaramoorthi Swaminathan , William Watkins
发明人： Carina Cannizzaro , James Chen , Xiaowu Chen , Aesop Cho , Lee Chong , Manoj Desai , Maria Fardis , Thorsten Kirschberg , Richard Mackman , Sundaramoorthi Swaminathan , William Watkins
IPC分类号： A61K31/66 , A61K31/662 , A61K47/48 , C07F9/02 , C07F9/58 , C07F9/6561
CPC分类号： A61K31/662 , A61K47/54 , A61K47/548 , C07F9/58 , C07F9/6561
摘要： The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及磷取代的激酶抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

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