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31. 发明授权

US08785487B2 Hepatitis C virus inhibitors 有权
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：US08785487B2
公开(公告)日：2014-07-22
申请号：US13013212
申请日：2011-01-25
申请人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
发明人： Yao-Ling Qiu , Ce Wang , Xiaowen Peng , Lu Ying , Hui Cao , Yat Sun Or
IPC分类号： C07D207/16 , C07D209/44 , A61K38/00 , A61P31/14
CPC分类号： C07D498/18 , C07D519/00 , C07F9/6561
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: Q-G-A-L-B—W (I), which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式（I）的化合物及其药学上可接受的盐，酯或前药：抑制含RNA病毒，特别是丙型肝炎病毒（HCV）的Q-G-A-L-B-W（I）因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

32. 发明授权

US08306318B2 Image processing apparatus, image processing method, and computer readable storage medium 有权
标题翻译：图像处理装置，图像处理方法和计算机可读存储介质
公开(公告)号：US08306318B2
公开(公告)日：2012-11-06
申请号：US12858705
申请日：2010-08-18
申请人： Hui Cao , Takashi Naito
发明人： Hui Cao , Takashi Naito
IPC分类号： G06K9/00
CPC分类号： G06K9/4642 , G06K9/6857 , G06T7/44 , G06T2207/20016 , G06T2207/20021 , G06T2207/30196
摘要： A feature vector computation section 24 of an image processing apparatus computes a feature vector expressing gradient histograms for each of plural child regions that have been further partitioned from plural parent regions partitioned from a discrimination-subject image. A feature relative vector computation section 26 of the image processing apparatus computes for each parent region a feature relative vector expressing relative values computed from respective combinations of the same or different elements across feature vectors computed for each child region, and relative values computed from respective combinations of the same or different elements within one of the feature vectors. A discrimination section 30 of the image processing apparatus, based on the feature relative vector computed for each parent region, discriminates whether or not the image subject to processing is an image in which a processing target object appears.
摘要翻译：图像处理装置的特征矢量计算部分24计算对于从分辨对象图像分割的多个母区域进一步分割的多个子区域中的每一个的表达梯度直方图的特征向量。图像处理装置的特征相对矢量计算部分26针对每个父区域计算表示从针对每个子区域计算的特征向量的相同或不同元素的相应组合计算的相对值的特征相对向量，以及根据各个组合计算的相对值在特征向量之一内的相同或不同的元素。图像处理装置的识别部分30基于针对每个父区域计算的特征相对向量，判别出处理对象的图像是否是处理目标对象出现的图像。

33. 发明申请

US20120150518A1 Method and System For Coupling Reservoir and Surface Facility Simulations 有权
标题翻译：耦合水库和地面设施模拟的方法和系统
公开(公告)号：US20120150518A1
公开(公告)日：2012-06-14
申请号：US13293660
申请日：2011-11-10
申请人： Baris Güyagüler , Vito J. Zapata , Hui Cao , Hernan F. Stamati , Jonathan A. Holmes
发明人： Baris Güyagüler , Vito J. Zapata , Hui Cao , Hernan F. Stamati , Jonathan A. Holmes
IPC分类号： G06G7/50
CPC分类号： E21B41/00
摘要： A method, system and apparatus are disclosed for coupling independent reservoir and surface facility network simulators. A reservoir simulator is configured to simulate fluid flow in subterranean reservoirs and a surface facility network simulator is configured to simulate fluid flow in production equipment. Simulation of fluid flow in a subterranean reservoir is initiated using the reservoir simulator. Simulation of fluid flow in production equipment is initiated using the surface facility network simulator. The simulated fluid flow in the production equipment includes fluids produced from the subterranean reservoir. The simulation of fluid, flow in the subterranean reservoir is coupled with the simulation of fluid flow in the production equipment using, a sub-domain inflow performance relationship.
摘要翻译：公开了用于耦合独立的储层和地面设施网络模拟器的方法，系统和装置。油藏模拟器被配置为模拟地下储层中的流体流动，并且地面设施网络模拟器被配置为模拟生产设备中的流体流动。使用储层模拟器启动地下储层中的流体流动的模拟。使用地面设施网络模拟器启动生产设备中流体流动的模拟。生产设备中的模拟流体流动包括从地下储层产生的流体。地下储层中的流体，流动的模拟与使用子域流入性能关系的生产设备中的流体流动的模拟相结合。

34. 发明授权

US07516056B2 Apparatus, method and system for improved reservoir simulation using a multiplicative overlapping Schwarz preconditioning for adaptive implicit linear systems 有权
标题翻译：用于利用适应性隐性线性系统的乘法重叠Schwarz预处理改进储层模拟的装置，方法和系统
公开(公告)号：US07516056B2
公开(公告)日：2009-04-07
申请号：US11410622
申请日：2006-04-25
申请人： John Wallis , Hamdi A. Tchelepi , Hui Cao
发明人： John Wallis , Hamdi A. Tchelepi , Hui Cao
IPC分类号： G06F9/455
CPC分类号： G06F17/5018 , G06F2217/16
摘要： A method, system and apparatus are disclosed for conducting a reservoir simulation, using a reservoir model of a gridded region of interest. The grid of the region of interest includes one or more types of cells, the type of cell being distinguished by the number of unknown variables representing properties of the cells. The cells share a common variable as an unknown variable. The method includes the steps of identifying different cell types for the grid; constructing an overall matrix for the reservoir model based on the different cell types; at least partially decoupling the common variable from the other unknown variables in the matrix by using a reduction process to yield a reduced matrix; mathematically breaking up the variables in the reduced matrix into k subsets by cell types; applying an overlapping multiplicative Schwartz procedure to the reduced matrix to obtain a preconditioner and using the preconditioner to solve for the unknown variables.
摘要翻译：公开了一种使用感兴趣的网格区域的储层模型进行油藏模拟的方法，系统和装置。感兴趣区域的网格包括一个或多个类型的单元格，通过表示单元格属性的未知变量的数量区分单元格的类型。单元格共享一个公共变量作为未知变量。该方法包括识别网格的不同小区类型的步骤; 基于不同的细胞类型构建储层模型的总体矩阵; 通过使用缩减过程来至少部分地将公共变量与矩阵中的其他未知变量解耦，以产生简化的矩阵; 通过细胞类型数学地将简化矩阵中的变量分解成k个子集; 将重叠乘法Schwartz过程应用于简化矩阵以获得预处理器，并使用预处理器来解决未知变量。

35. 发明申请

US20070275449A1 Method for Large-Scale Production, Isolation, Purification and the Uses of Multi-Type Recombinant Adeno-Associated Virus Vectors 审中-公开
标题翻译：大规模生产，分离，纯化及多重型重组腺相关病毒载体的应用方法
公开(公告)号：US20070275449A1
公开(公告)日：2007-11-29
申请号：US10576000
申请日：2003-10-15
申请人： Xiaobing Wu , Hui Cao , Xiaoyan Dong
发明人： Xiaobing Wu , Hui Cao , Xiaoyan Dong
IPC分类号： C12N7/02 , C12N15/63 , C12N7/01
CPC分类号： C12N7/00 , C12N15/86 , C12N2710/16643 , C12N2710/16644 , C12N2750/14143 , C12N2750/14151
摘要： The present invention relates to the method for production, isolation, purification and the uses of recombinant herpes simplex virus vectors loaded with five sero-type adeno-associated virus AAV1, 3, 4, 5 and 6 respectively. The above five sero-type recombinant herpes simplex viruses are HSV-r2c1, HSR-r2c3, HSV-r2c4, HSV-r2c6 respectively. The 1, 3, 4, 5 and 6 sero-type recombinant adeno-associated viruses vectors could be produced by infecting the cells with the recombinant herpes simplex virus vectors.
摘要翻译：本发明涉及分别装载有五种血清型腺相关病毒AAV1,3,4,5和6的重组单纯疱疹病毒载体的生产，分离，纯化和用途的方法。上述五种血清型重组单纯疱疹病毒分别为HSV-r2c1，HSR-r2c3，HSV-r2c4，HSV-r2c6。可以通过用重组单纯疱疹病毒载体感染细胞来产生1,2,3,4,5和6型血清型重组腺相关病毒载体。

36. 发明申请

US20060265204A1 Apparatus, method and system for improved reservoir simulation using a multiplicative overlapping Schwarz preconditioning for adaptive implicit linear systems 有权
公开(公告)号：US20060265204A1
公开(公告)日：2006-11-23
申请号：US11410622
申请日：2006-04-25
申请人： John Wallis , Hamdi Tchelepi , Hui Cao
发明人： John Wallis , Hamdi Tchelepi , Hui Cao
IPC分类号： G06G7/48
CPC分类号： G06F17/5018 , G06F2217/16
摘要： A method, system and apparatus are disclosed for conducting a reservoir simulation, using a reservoir model of a gridded region of interest. The grid of the region of interest includes one or more types of cells, the type of cell being distinguished by the number of unknown variables representing properties of the cells. The cells share a common variable as an unknown variable. The method includes the steps of identifying different cell types for the grid; constructing an overall matrix for the reservoir model based on the different cell types; at least partially decoupling the common variable from the other unknown variables in the matrix by using a reduction process to yield a reduced matrix; mathematically breaking up the variables in the reduced matrix into k subsets by cell types; applying an overlapping multiplicative Schwartz procedure to the reduced matrix to obtain a preconditioner and using the preconditioner to solve for the unknown variables.

37. 发明授权

US5877509A Quantum well exciton-polariton light emitting diode 失效
标题翻译：量子阱激子 - 极化子发光二极管
公开(公告)号：US5877509A
公开(公告)日：1999-03-02
申请号：US970948
申请日：1997-11-14
申请人： Stanley Pau , Hui Cao , Yoshihisa Yamamoto
发明人： Stanley Pau , Hui Cao , Yoshihisa Yamamoto
IPC分类号： H01L33/06 , H01L33/10 , H01L29/06
CPC分类号： H01L33/06 , B82Y10/00 , H01L33/105
摘要： A light emitting device made of semiconducting materials. The device has an optical microcavity which supports a resonant mode of predetermined photon energy. Within the cavity is a quantum well of predetermined thickness and energy depth. The quantum well is designed such that it forms bound electron, exciton, lower polariton, and hole energy states of predetermined energy. The energy of an exciton state is set to equal the predetermined photon energy of the microcavity mode such that polariton states are created. A means is provided for resonantly tunneling electrons into a quantum well energy state. In a first embodiment, electrons resonantly tunnel into an electron energy state. In a second embodiment, electrons resonantly tunnel into an exciton energy state, during which tunneling the electrons simultaneously fuse with holes to form excitons. In the first embodiment, the electron state to lower polariton state transition energy is made equal to the energy of a longitudinal optical (LO) phonon of the quantum well material. This energy equivalence facilitates the rapid thermalization of resonantly tunneled electrons to combine with holes and form polaritons resonant with the cavity mode. Thermalization is rapid because it only requires the scattering of a single LO phonon. The photon component of the polariton is then emitted through the leaky cavity reflector. The second embodiment sets the exciton to polariton transition energy equal to the LO phonon energy to facilitate rapid thermalization to the polariton state. Photons are then emitted through the leaky Bragg reflector in the same manner as the first embodiment.
摘要翻译：由半导体材料制成的发光器件。该器件具有支持预定光子能量的共振模式的光学微腔。在腔内是一个预定厚度和能量深度的量子阱。量子阱被设计成使其形成结合的电子，激子，低极化子和预定能量的空穴能态。将激子状态的能量设定为等于微腔模式的预定光子能量，从而产生极化子态。提供了一种用于将电子谐振地隧穿到量子阱能量状态的装置。在第一实施例中，电子谐振地隧穿成电子能态。在第二个实施例中，电子谐振地隧道入激子能态，在此期间，电子同时与空穴一起熔化以形成激子。在第一实施例中，将使极性较小的跃迁能量降低的电子状态等于量子阱材料的纵向光学（LO）声子的能量。这种能量等价有助于谐振隧穿电子的快速热化与空穴结合并形成与腔模共振的极化子。热化是快速的，因为它只需要单个LO声子的散射。然后通过泄漏腔反射器发射极化子的光子分量。第二实施例将激子设置为等于LO声子能量的极化子跃迁能量，以促进快速热化至极化子态。然后以与第一实施例相同的方式通过漏布拉格反射器发射光子。

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