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31. 发明授权

US10682330B2 Method for producing liposome encapsulating paclitaxel monoglycoside and/or docetaxel monoglycoside 有权
公开(公告)号：US10682330B2
公开(公告)日：2020-06-16
申请号：US14386855
申请日：2013-03-22
申请人： ENSUIKO SUGAR REFINING CO., LTD. , Hiroki Hamada , Ichiro Fujiwara , NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
发明人： Hiroki Hamada , Ichiro Fujiwara , Masaharu Seno , Tomonari Kasai , Tsukasa Shigehiro , Masaharu Murakami , Katsuhiko Mikuni
IPC分类号： A61K31/337 , A61K47/26 , A61K9/127 , A61K31/7048 , C07K16/32 , A61K47/69 , A61K39/00
摘要： In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level. The present invention provides a method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell, the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water.

32. 发明授权

US06630911B2 Compact antenna and producing method thereof 失效
公开(公告)号：US06630911B2
公开(公告)日：2003-10-07
申请号：US10024085
申请日：2001-12-17
申请人： Yoshikazu Kamei , Takanori Washiro , Hiroki Hamada , Takahiro Ueno , Masayuki Ishiwa
发明人： Yoshikazu Kamei , Takanori Washiro , Hiroki Hamada , Takahiro Ueno , Masayuki Ishiwa
IPC分类号： H01Q140
CPC分类号： H01Q1/40 , B29C33/005 , B29C45/0046 , B29C45/0055 , B29C45/14344 , B29C45/14639 , B29C45/14836 , B29C45/2669 , B29C45/4005 , B29C2045/0027 , B29L2031/3456 , H01Q1/242 , H01Q1/36
摘要： A compact antenna comprises a core which is a hard linear member having a predetermined shape corresponding to resonance characteristic, a conductor film which covers at least a portion of an outer surface of the core and which has higher electric conductivity than that of the core, and a substrate which closely surrounds and holds the outer surface of the core covered with the connection film. A film thickness of the conductor film is equal to a skin depth and thus, it is possible to inexpensively maintain reliability, and to prevent radiation efficiency from being lowered.

33. 发明授权

US06288412B1 Thin film transistors for display devices having two polysilicon active layers of different thicknesses 失效
标题翻译：用于具有不同厚度的两个多晶硅有源层的显示器件的薄膜晶体管
公开(公告)号：US06288412B1
公开(公告)日：2001-09-11
申请号：US08974746
申请日：1997-11-19
申请人： Hiroki Hamada , Kiichi Hirano , Nobuhiro Gouda , Hisashi Abe , Eiji Taguchi , Nobuhiko Oda , Yoshihiro Morimoto
发明人： Hiroki Hamada , Kiichi Hirano , Nobuhiro Gouda , Hisashi Abe , Eiji Taguchi , Nobuhiko Oda , Yoshihiro Morimoto
IPC分类号： H01L2900
CPC分类号： H01L21/02667 , G02F1/13454 , H01L21/02532 , H01L21/2022 , H01L27/12 , H01L29/66757
摘要： A method of manufacturing a polycrystalline silicon film having a particular field effect mobility is disclosed. A first polycrystalline silicon film is formed on a transparent insulation substrate. The surface of the silicon film is oxidized, and an amorphous silicon film is formed on the first polycrystalline silicon film and oxide layer. The amorphous silicon film is subjected to a solid phase growth process to be converted to a second polycrystalline silicon film. The field effect mobility of the second polycrystalline silicon film can be adjusted to a desired value by controlling the relative thicknesses of the first and second polycrystalline silicon films.
摘要翻译：公开了制造具有特定场效应迁移率的多晶硅膜的方法。在透明绝缘基板上形成第一多晶硅膜。硅膜的表面被氧化，在第一多晶硅膜和氧化物层上形成非晶硅膜。将非晶硅膜进行固相生长工艺以转变为第二多晶硅膜。通过控制第一和第二多晶硅膜的相对厚度，可以将第二多晶硅膜的场效应迁移率调整到期望值。

34. 发明授权

US06232622B1 Semiconductor device with high electric field effect mobility 有权
标题翻译：具有高电场效应迁移率的半导体器件
公开(公告)号：US06232622B1
公开(公告)日：2001-05-15
申请号：US09406819
申请日：1999-09-28
申请人： Hiroki Hamada
发明人： Hiroki Hamada
IPC分类号： H01L2976
CPC分类号： H01L29/78696 , G02F1/13454 , H01L29/66757 , H01L29/66765 , H01L29/78621 , H01L29/78675
摘要： A polycrystalline silicon TFT of a top-gate type having a polycrystalline silicon film functioning as an active layer on a transparent insulating substrate. A gate electrode is provided on a channel region of the polycrystalline silicon film via a gate insulating film. On both sides of the channel region, source-drain regions of LDD structure consisting of low impurity concentration regions and high impurity concentration regions are provided. In the channel region of the polycrystalline silicon film, multiple monocrystal regions connecting source-drain regions are provided perpendicular to the transparent insulating substrate. Though electrons cannot smoothly pass through the channel region of the polycrystalline silicon film because of crystal grain boundaries and crystal defects therein, electric field effect mobility can be heightened by providing monocrystal regions, since electrons can smoothly pass through the monocrystal regions.
摘要翻译：一种顶栅型的多晶硅TFT，其具有在透明绝缘基板上用作有源层的多晶硅膜。栅电极通过栅极绝缘膜设置在多晶硅膜的沟道区上。在沟道区域的两侧，设置由低杂质浓度区域和高杂质浓度区域构成的LDD结构的源极 - 漏极区域。在多晶硅膜的沟道区域中，连接源极 - 漏极区的多个单晶区垂直于透明绝缘基片设置。尽管电子由于其晶界和晶体缺陷而不能平滑地通过多晶硅膜的沟道区，但通过提供单晶区，可以提高电场效应迁移率，因为电子可以平滑地通过单晶区。

35. 发明授权

US5684169A Cyclodextrin inclusion complex of taxol, and method for its production and its use 失效
标题翻译：紫杉醇的环糊精包合物及其生产方法及其应用
公开(公告)号：US5684169A
公开(公告)日：1997-11-04
申请号：US470018
申请日：1995-06-06
申请人： Hiroki Hamada , Kyoko Saito , Katsuhiko Mikuni , Nobuhiro Kuwahara , Hideki Takahashi
发明人： Hiroki Hamada , Kyoko Saito , Katsuhiko Mikuni , Nobuhiro Kuwahara , Hideki Takahashi
IPC分类号： A61K31/335 , A61K47/48 , C07D305/14
CPC分类号： B82Y5/00 , A61K31/335 , A61K47/48969
摘要： There is provided an unbranched cyclodextrin or a branched cyclodextrin inclusion complex of taxol. The complex is produced by adding an unbranched cyclodextrin of a branched cyclodextrin to taxol at a molar ratio of 1-20 times with respect to taxol. A method is provided for the improvement of the solubility of taxol in water by adding an unbranched cyclodextrin or a branched cyclodextrin thereto at a molar ratio of 1-20 times with respect to taxol. The solubility of taxol in water is improved by the present invention. A cyclodextrin inclusion complex of taxol according to the present invention serves to make taxol more easily absorbed when administered to a cancer patient, which is beneficial to cancer patients and the physiological effects of taxol may therefore be more effectively induced.
摘要翻译：提供紫杉醇的无支链环糊精或支链环糊精包合物。通过将支链环糊精的无支链环糊精与紫杉醇以相对于紫杉醇为1-20倍的摩尔比添加到紫杉醇中而制备。提供了一种通过以相对于紫杉醇为1-20倍的摩尔比添加无支链环糊精或支链环糊精来提高紫杉醇在水中的溶解度的方法。本发明提高了紫杉醇在水中的溶解度。根据本发明的紫杉醇的环糊精包合物用于在给予癌症患者时更容易地吸收紫杉醇，这有利于癌症患者，因此可以更有效地诱导紫杉醇的生理作用。

36. 发明授权

US5264389A Method of manufacturing a semiconductor laser device 失效
标题翻译：制造半导体激光器件的方法
公开(公告)号：US5264389A
公开(公告)日：1993-11-23
申请号：US896386
申请日：1992-06-10
申请人： Hiroki Hamada , Shoji Honda , Masayuki Shono , Takao Yamaguchi
发明人： Hiroki Hamada , Shoji Honda , Masayuki Shono , Takao Yamaguchi
IPC分类号： H01S5/22 , H01S5/32 , H01S5/323 , H01S5/343 , H01L21/20
CPC分类号： B82Y20/00 , H01S5/32 , H01S5/32325 , H01S2304/04 , H01S5/22 , H01S5/3202 , H01S5/34326 , Y10S148/064 , Y10S148/11 , Y10S438/973
摘要： A semiconductor laser device of an AlGaInP system includes a GaAs substrate and a surface of the substrate is inclined by 5.degree. or more from a {100} plane in a direction.
摘要翻译： AlGaInP系统的半导体激光器件包括GaAs衬底，并且衬底的表面在<011>方向上从{100}面倾斜5°或更多。

37. 发明申请

US20070103069A1 LAMINATED CONFORMAL SEAL FOR ELECTROLUMINESCENT DISPLAYS 有权
标题翻译：用于电致发光显示器的层压合格密封
公开(公告)号：US20070103069A1
公开(公告)日：2007-05-10
申请号：US11554901
申请日：2006-10-31
申请人： Peter Manuela , Joseph Alfred Vincent , Yoshida Isao , Hiroki Hamada , Abe Hisashi
发明人： Peter Manuela , Joseph Alfred Vincent , Yoshida Isao , Hiroki Hamada , Abe Hisashi
IPC分类号： H01J1/62 , H01J63/04
CPC分类号： H05B33/04
摘要： The present invention is an electroluminescent display that incorporates a laminated seal that inhibits exposure of display components to atmospheric contaminants and to a sealing process for fabrication of the same. The sealed electroluminescent display comprises a substrate upon which is constructed a thick dielectric electroluminescent display covered by a laminated seal comprising a lower multi-functional polymer film and an upper inorganic film that provides a barrier layer to inhibit exposure of the electroluminescent display structure to an atmospheric contaminant.
摘要翻译：本发明是一种电致发光显示器，其包含抑制显示组件暴露于大气污染物的层压密封件及其制造的密封工艺。密封电致发光显示器包括基底，其上构成了由层叠密封件覆盖的厚电介质电致发光显示器，该层叠密封件包括下部多功能聚合物膜和上部无机膜，其提供阻挡层以抑制电致发光显示结构暴露于大气污染物。

38. 发明申请

US20070025995A1 Taxoid derivative covalently linked to tumor-specific antibody and a method for preparing the same 审中-公开
标题翻译：与肿瘤特异性抗体共价连接的紫杉烷衍生物及其制备方法
公开(公告)号：US20070025995A1
公开(公告)日：2007-02-01
申请号：US11219686
申请日：2005-09-07
申请人： Hiroki Hamada , Katsuhiko Mikuni , Katsuyoshi Nakanishi , Tadakatsu Mandai
发明人： Hiroki Hamada , Katsuhiko Mikuni , Katsuyoshi Nakanishi , Tadakatsu Mandai
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： A61K47/6851 , A61K47/6809
摘要： To provide a taxoid derivative that has improved solubility in water and acts specifically with respect to tumors, thereby mitigating side effects. The present invention provides an anticancer agent comprises covalent bond compound of an antibody that reacts specifically with respect to cancer cells with a taxoid derivative and a method for preparing the anticancer agent according to claim 1, characterized by reacting, in the presence of reduction agent, an antibody that reacts specifically with respect to cancer cells with a reaction product obtained by allowing periodic acid or periodate to act on a taxoid derivative.
摘要翻译：提供具有改善的在水中的溶解度并且特别针对肿瘤起作用的紫杉烷衍生物，从而减轻副作用。本发明提供一种抗癌剂，其包含与癌细胞特异性反应的抗体的共价键化合物和紫杉烷衍生物，以及权利要求1所述的抗癌剂的制备方法，其特征在于，在还原剂存在下，具有与癌细胞特异性反应的抗体与通过允许高碘酸或高碘酸盐作用于紫杉烷衍生物而获得的反应产物。

39. 发明授权

US06936959B2 Display apparatus 有权
标题翻译：显示装置
公开(公告)号：US06936959B2
公开(公告)日：2005-08-30
申请号：US10338644
申请日：2003-01-09
申请人： Hiroki Hamada , Daisuke Ide , Koji Suzuki
发明人： Hiroki Hamada , Daisuke Ide , Koji Suzuki
IPC分类号： H05B33/26 , G09F9/30 , H01J1/62 , H01J63/04 , H01L27/32 , H01L51/50 , H01L51/52 , H05B33/00 , H05B33/14
CPC分类号： H01L27/3279 , H01L51/529
摘要： A first molybdenum layer made of a molybdenum film, an aluminum conductive layer made of an aluminum-neodymium alloy film, a second molybdenum layer made of a molybdenum film and an insulating film layer made of a silicon dioxide film are stacked, in this order from the bottom to the top, on an insulating substrate made of glass.
摘要翻译：由钼膜制成的第一钼层，由铝 - 钕合金膜制成的铝导电层，由钼膜制成的第二钼层和由二氧化硅膜制成的绝缘膜层以此顺序从在底部到顶部，在由玻璃制成的绝缘基底上。

40. 发明授权

US06905903B2 Display unit and method of fabricating the same 有权
标题翻译：显示单元及其制造方法
公开(公告)号：US06905903B2
公开(公告)日：2005-06-14
申请号：US10634763
申请日：2003-08-06
申请人： Isao Hasegawa , Hiroki Hamada , Daisuke Ide
发明人： Isao Hasegawa , Hiroki Hamada , Daisuke Ide
IPC分类号： G02F1/1333 , G02F1/1343 , G02F1/136 , G02F1/1362 , G02F1/1368 , G09F9/30 , H01L21/316 , H01L21/77 , H01L21/84 , H01L27/12 , H01L21/00 , H01L21/44
CPC分类号： G02F1/136227 , G02F1/13439 , G02F2001/133337 , H01L27/12 , H01L27/124
摘要： A display unit capable of inhibiting moisture and gas from penetrating into a liquid crystal layer and an alignment layer also after formation of a display electrode and suppressing decomposition of a material forming the display electrode is obtained. In this display unit, an impurity-introduced layer containing an impurity element having high electronegativity is formed on the surface of an insulator film and the surface of the display electrode after formation of the display electrode. Thus, the insulator film and the display electrode are improved in effects of preventing transmission of moisture and gas also after formation of the display electrode. The impurity-introduced layer formed on the surface of the display electrode stabilizes the surface of an ITO film forming the display electrode, thereby suppressing decomposition of the ITO film.
摘要翻译：获得能够抑制湿气和气体渗透到液晶层中的显示单元，以及在形成显示电极之后也抑制形成显示电极的材料的分解的取向层。在该显示单元中，在形成显示电极之后，在绝缘体膜的表面和显示电极的表面上形成含有具有高电负性的杂质元素的杂质引入层。因此，在形成显示电极之后，绝缘体膜和显示电极的效果也得到改善，防止湿气和气体的传播。形成在显示电极的表面上的杂质引入层使形成显示电极的ITO膜的表面稳定，从而抑制ITO膜的分解。

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