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31. 发明授权

US08357780B2 Polypeptides, antibody variable domains and antagonists methods for 有权
标题翻译：多肽，抗体可变结构域和拮抗剂
公开(公告)号：US08357780B2
公开(公告)日：2013-01-22
申请号：US12663498
申请日：2008-06-03
申请人： Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
发明人： Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
IPC分类号： C07K16/00
CPC分类号： C07K16/2878 , A61K9/007 , A61K9/0078 , A61K9/1623 , A61K9/1641 , A61K39/3955 , A61K2039/544 , A61M11/005 , A61M15/08 , A61M16/14 , C07K16/00 , C07K16/005 , C07K16/22 , C07K16/2866 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The invention relates to anti-IL-1R1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
摘要翻译：本发明涉及抗蛋白酶降解抗体的抗IL-1R1多肽和抗体单可变结构域（dAb），以及包含它们的拮抗剂。多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道，以及用于治疗炎性疾病，例如关节炎或COPD。

32. 发明授权

US08324350B2 Dual-specific IL-1α/IL-1β antibodies 失效
标题翻译：双特异性IL-1α/ IL-1和bgr; 抗体
公开(公告)号：US08324350B2
公开(公告)日：2012-12-04
申请号：US12006068
申请日：2007-12-28
申请人： Chung-ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
发明人： Chung-ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
IPC分类号： C07K16/00
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , C07K16/245 , C07K2317/569 , C07K2317/92
摘要： The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1α and human IL-1β. The dual specific antibodies of the invention also neutralize both human IL-1α and human IL-1β. The invention also provides domain antibodies (dAbs) specific for human IL-1α and human IL-1β.
摘要翻译：本发明提供了对人IL-1α和人IL-1和bgr特异的分离的双重特异性抗体或其抗原结合部分。本发明的双重特异性抗体也中和人IL-1α和人IL-1和bgr两者。本发明还提供对人IL-1α和人IL-1和bgr特异性的结构域抗体（dAb）。

33. 发明申请

US20100291103A1 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS AND ANTAGONISTS 有权
标题翻译：多肽，抗体可变域和拮抗剂
公开(公告)号：US20100291103A1
公开(公告)日：2010-11-18
申请号：US12663505
申请日：2008-06-03
申请人： Micheal Steward , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever , Laurent Jespers , Thil Dinuk Batuwangala
发明人： Micheal Steward , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever , Laurent Jespers , Thil Dinuk Batuwangala
IPC分类号： A61K39/395 , C07K16/22 , A61P35/00 , A61P29/00
CPC分类号： C07K16/2878 , C07K16/22 , C07K16/244 , C07K16/2866 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The invention relates to anti-VEGF polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.
摘要翻译：本发明涉及对蛋白酶降解有抗性的抗VEGF多肽和抗体单可变结构域（dAb）以及包含它们的拮抗剂。多肽，dAb和拮抗剂可用于肺部给药，口服给药，递送至肺部并递送至患者胃肠道，以及治疗癌症和炎性疾病如关节炎。

34. 发明申请

US20060083747A1 Fc fusion 审中-公开
标题翻译： Fc融合
公开(公告)号：US20060083747A1
公开(公告)日：2006-04-20
申请号：US11166496
申请日：2005-06-24
申请人： Gregory Winter , Ian Tomlinson , Olga Ignatovich , Neil Brewis
发明人： Gregory Winter , Ian Tomlinson , Olga Ignatovich , Neil Brewis
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/46
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/241 , C07K16/40 , C07K2317/52 , C07K2317/569 , C07K2317/94 , C07K2319/00
摘要： The present invention relates to a simple method for generating antibody-based structures suitable for in vivo use. In particular, the invention relates to a method for the generation of antibody-based structures suitable for in vivo use comprising the steps of: (a) selecting an antibody single variable domain having an epitope binding specificity; and (b) attaching the single domain of step (a) to an effector group. Uses of molecules generated using the method of the Invention are also described.
摘要翻译：本发明涉及一种生成适用于体内使用的基于抗体的结构的简单方法。特别地，本发明涉及一种生成适合于体内应用的基于抗体的结构的方法，包括以下步骤：（a）选择具有表位结合特异性的抗体单可变结构域; 和（b）将步骤（a）的单一结构域连接到效应子组。还描述了使用本发明的方法生成的分子的用途。

35. 发明申请

US20050261341A1 Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol 审中-公开
标题翻译：制备（R）-α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇的新方法
公开(公告)号：US20050261341A1
公开(公告)日：2005-11-24
申请号：US11114381
申请日：2005-04-26
申请人： Wolfgang Laux , Gerard Guillamot , Frederick Laskovics , Chi-Hsin King , James Hitt , Sandra Stolz-Dunn , Ian Tomlinson , Johannes Koek
发明人： Wolfgang Laux , Gerard Guillamot , Frederick Laskovics , Chi-Hsin King , James Hitt , Sandra Stolz-Dunn , Ian Tomlinson , Johannes Koek
IPC分类号： A61K31/445 , C07D211/20 , C07D211/22
CPC分类号： C07D211/22 , C07D211/32
摘要： The present invention provides various processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme:
摘要翻译：本发明提供制备（R）-α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇的各种方法。这些过程可以通过以下方案来表征：

36. 发明申请

US20050227321A1 Low-cost production of peptides 有权
标题翻译：低成本生产肽
公开(公告)号：US20050227321A1
公开(公告)日：2005-10-13
申请号：US10971444
申请日：2004-10-22
申请人： Joseph Krebs , Paul Zorner , Ian Tomlinson
发明人： Joseph Krebs , Paul Zorner , Ian Tomlinson
IPC分类号： C07H21/04 , C07K5/06 , C07K14/47 , C12N1/21 , C12N9/48 , C12N15/74 , C12P21/04 , C12P21/06
CPC分类号： C07K14/4723 , C07K2319/35 , C07K2319/50
摘要： The subject invention relates to a low cost method of producing peptides, including antimicrobial peptides (AMPs), by using microbes. The subject methods enable greatly improved yields of the peptide/AMP as compared to those heretofore known in the art. The subject methods also surprisingly enable the use of Pseudomonas fluorescens to produce AMPs and other peptides. There are several components of the subject invention, which can be used alone or in combination. The subject invention provides for the production of peptides/AMPs in concatemeric precursors. The subject invention also provides novel methods of assembling monomers into multimers, and of cleaving the multimers to yield active monomers. The subject invention also relates to the use of these multimers fused to carrier peptides to produce fusion proteins. Preferably, both the multimers and the fusion proteins (multimers with the carrier polypeptides) lack charge balancing. It has been surprisingly determined that it is not necessary to offset the positive charges of multiple copies of AMPs in multimeric constructs. Thus, the subject invention enables the use of a wider range of multimers and carrier peptides.
摘要翻译：本发明涉及通过使用微生物生产肽（包括抗微生物肽（AMP））的低成本方法。与本领域已知的方法相比，本发明方法能够大大提高肽/ AMP的产率。本发明的方法也令人惊奇地使得能够使用荧光假单胞菌来产生AMP和其他肽。本发明的几个组分可单独使用或组合使用。本发明提供了在并联前体中生产肽/ AMP。本发明还提供了将单体组装成多聚体的新方法，以及裂解多聚体以产生活性单体。本发明还涉及这些与载体肽融合的多聚体产生融合蛋白的用途。优选地，多聚体和融合蛋白（携带多肽的多聚体）都缺乏电荷平衡。已经令人惊讶地确定，不需要在多聚体构建体中抵消多个拷贝的AMP的正电荷。因此，本发明使得能够使用更宽范围的多聚体和载体肽。

37. 发明申请

US20050192430A1 Linker arms for nanocrystals and compounds thereof 审中-公开
标题翻译：用于纳米晶体的接头臂及其化合物
公开(公告)号：US20050192430A1
公开(公告)日：2005-09-01
申请号：US10977175
申请日：2004-10-29
申请人： Sandra Rosenthal , Ian Tomlinson , Tadd Kippeny
发明人： Sandra Rosenthal , Ian Tomlinson , Tadd Kippeny
IPC分类号： C07C323/12 , C07C323/16 , C07D209/16 , C07D277/24 , C07D277/26 , C07D295/135 , C07D451/02 , C07D451/14 , G01N33/58 , C07K16/00
CPC分类号： C07C323/12 , B82Y15/00 , C07C323/16 , C07D209/16 , C07D277/24 , C07D277/26 , C07D295/135 , C07D451/02 , C07D451/14 , G01N33/588
摘要： A nanocrystal compound comprising: a nanocrystal, and attached thereto a compound of the following formula: n is 0 or an integer from 1 to 48; X and Z are independently O, NH, N—R, S, CH2, CO, COHN, NHCO, SO, SO2NH, NHSO2, carbamate and thio carbamate; R is alkyl or aryl; r is 0 or an integer from 1 to 15; and wherein S is the attachment point to a nanocrystal compound. The nanocrystal compounds of the present invention are useful fluorescent labels.
摘要翻译：一种纳米晶体化合物，包括：纳米晶体，并与其连接，具有下式的化合物：n为0或1至48的整数; X和Z独立地是O，NH，NR，S，CH 2，CO，COHN，NHCO，SO，SO 2 NH，NHSO 2 ，氨基甲酸酯和硫代氨基甲酸酯; R是烷基或芳基; r为0或1〜15的整数; 并且其中S是与纳米晶体化合物的连接点。本发明的纳米晶体化合物是有用的荧光标记。

38. 发明授权

US4038013A Spinneret apparatus with particulate material conveying means 失效
标题翻译：具有颗粒材料输送方式的纺丝装置
公开(公告)号：US4038013A
公开(公告)日：1977-07-26
申请号：US672432
申请日：1976-03-31
申请人： Ian Tomlinson
发明人： Ian Tomlinson
IPC分类号： B29B7/00 , B29C47/00 , B29C47/10 , B29C47/36 , B29C47/38 , B29C47/66 , D01D1/00 , D01D5/02
CPC分类号： B29C47/666 , B29C47/0004 , B29C47/362 , B29C47/38 , B29C47/6043 , D01D1/00 , B29C47/0014
摘要： Apparatus is disclosed for extruding filaments from synthetic polymeric particulate material which is conveyed to the melting area by means including a cylindrical barrel having an internal wall provided with a screw thread, and a rotating member mounted within the barrel being of a polygonal cross-section having a transverse dimension closely approximate to the inner diameter of the screw flights of the screw thread so as to allow movement of the material in a direction of the screw axis but to substantially prevent rotation of the material about the axis relative to the rotating member.

39. 发明申请

US20130171146A1 DUAL-SPECIFIC IL-1A/ IL-1B ANTIBODIES 审中-公开
标题翻译：双特异性IL-1A / IL-1B抗体
公开(公告)号：US20130171146A1
公开(公告)日：2013-07-04
申请号：US13591027
申请日：2012-08-21
申请人： Chung-ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
发明人： Chung-ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
IPC分类号： C07K16/46 , A61K45/06 , C07K16/24 , A61K39/395
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , C07K16/245 , C07K2317/569 , C07K2317/92
摘要： The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1α and human IL-1β. The dual specific antibodies of the invention also neutralize both human IL-1α and human IL-1β. The invention also provides domain antibodies (dAbs) specific for human IL-1α and human IL-1β.
摘要翻译：本发明提供了对人IL-1α和人IL-1β特异的分离的双重特异性抗体或其抗原结合部分。本发明的双重特异性抗体也中和人IL-1α和人IL-1beta。本发明还提供了对人IL-1α和人IL-1β特异性的结构域抗体（dAb）。

40. 发明申请

US20100234570A1 Ligand 审中-公开
标题翻译：配体
公开(公告)号：US20100234570A1
公开(公告)日：2010-09-16
申请号：US11501546
申请日：2006-08-08
申请人： Kevin Moulder , Ian Tomlinson
发明人： Kevin Moulder , Ian Tomlinson
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , C07K16/241 , C07K16/2875 , C07K16/2878 , C07K16/40 , C07K16/42 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/92 , C07K2318/20
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
摘要翻译：本发明提供了包含具有第一结合特异性的第一免疫球蛋白可变结构域和具有第二结合特异性的互补或非互补免疫球蛋白可变结构域的双重特异性配体。

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