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    • 38. 发明授权
    • Thiazolidinedione derivative and its use as antidiabetic
    • 噻唑烷二酮衍生物及其用作抗糖尿病药
    • US07358366B2
    • 2008-04-15
    • US11458471
    • 2006-07-19
    • Paul David James BlacklerRobert Gordon GilesStephen MooreMichael John Sasse
    • Paul David James BlacklerRobert Gordon GilesStephen MooreMichael John Sasse
    • C07D417/12
    • C07D417/12
    • A polymorphic form of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, maleic acid salt (the “Polymorph”) characterised in that it provides: (i) an infra red spectrum containing peaks at 1752, 1546, 1154, 621, and 602 cm−1; and/or (ii) a Raman spectrum containing peaks at 1751, 1243 and 602 cm−1; and/or (iii) a solid-state nuclear magnetic resonance spectrum containing peaks at 111.9, 114.8, 119.6, 129.2, 134.0, 138.0, 144.7, 153.2, 157.1, 170.7, 172.0, and 175.0 ppm; and/or (iv) an X-ray powder diffraction (XRPD) pattern which gives calculated lattice spacings of 6.46, 5.39, 4.83, 4.68, 3.71, 3.63, 3.58, and 3.48 Angstroms; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.
    • 5- [4- [2-(N-甲基-N-(2-吡啶基)氨基)乙氧基]苄基]噻唑烷-2,4-二酮,马来酸盐(“多晶型”)的多晶形式,其特征在于 它提供:(i)在1752,1546,1154,621和602cm -1处含有峰的红外光谱; 和/或(ii)在1751,1243和602cm -1处含有峰的拉曼光谱; 和/或(iii)在111.9,114.8,119.6,129.2,134.0,138.0,144.7,153.2,157.1,170.7,172.0和175.0ppm处含有峰的固态核磁共振光谱; 和/或(iv)X射线粉末衍射(XRPD)图案,其给出计算的晶格间距为6.46,5.39,4.83,4.68,3.73,3.63,3.58和3.48埃; 制备这种化合物的方法,含有这种化合物的药物组合物和这种化合物在医药中的用途。