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31. 发明申请

US20150148647A1 Adjustment of Sensor Sensitivity by Controlling Copolymer Film Thickness Through a Controlled Drying Step 有权
标题翻译：通过控制干燥步骤控制共聚物膜厚度来调节传感器灵敏度
公开(公告)号：US20150148647A1
公开(公告)日：2015-05-28
申请号：US14092655
申请日：2013-11-27
申请人： Google Inc.
发明人： Zenghe Liu , Huanfen Yao
IPC分类号： H01M4/04 , A61B5/145
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/6821 , C12Q1/001 , C12Q1/002 , C12Q1/005 , G01N27/3271 , G02C7/04
摘要： An analyte sensor and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode, and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer. The method of making the analyte sensor includes depositing a precursor mixture containing monomers and an analyte sensing component onto an electrode, exposing the deposited precursor mixture to a controlled environment for a specified period of time, and photopolymerizing the deposited exposed precursor mixture into a copolymer layer in contact with a surface of the electrode. Exposing the deposited precursor mixture to a controlled environment can increase the sensitivity of the sensor by reducing the thickness of the copolymer layer and/or by causing the analyte sensitive component within the copolymer layer to have a non-uniform concentration within the layer.
摘要翻译：公开了分析物传感器和用于制造分析物传感器的方法。一方面，分析物传感器包括与电极表面接触的交联的亲水共聚物和嵌入交联的亲水共聚物内的分析物感测组分。制备分析物传感器的方法包括将含有单体和分析物感测组分的前体混合物沉积到电极上，将沉积的前体混合物暴露于受控环境达指定的时间段，并将沉积的暴露的前体混合物光聚合成共聚物层与电极的表面接触。将沉积的前体混合物暴露于受控环境可以通过减小共聚物层的厚度和/或通过使共聚物层内的分析物敏感组分在层内具有不均匀的浓度来增加传感器的灵敏度。

32. 发明授权

US08965478B2 Microelectrodes in an ophthalmic electrochemical sensor 有权
公开(公告)号：US08965478B2
公开(公告)日：2015-02-24
申请号：US13650418
申请日：2012-10-12
申请人： Google Inc.
发明人： Zenghe Liu
IPC分类号： A61B5/05 , G01N33/50 , C12N9/00 , G01N27/26 , A61B5/1473 , A61B5/145 , A61B5/00 , A61B5/1486 , G01N27/327
CPC分类号： A61B5/1468 , A61B5/0002 , A61B5/0004 , A61B5/14507 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/6821 , A61B5/6867 , G01N27/3271 , G02C7/04
摘要： An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have at least one dimension less than 25 micrometers. The reference electrode can have an area at least five times greater than an area of the working electrode. A portion of the polymeric material can surround the working electrode and the reference electrode such that an electrical current conveyed between the working electrode and the reference electrode is passed through the at least partially surrounding portion of the transparent polymeric material.

33. 发明申请

US20150005602A1 Methods for Adhering a Substrate to a Polymer Layer 有权
标题翻译：将基材粘合到聚合物层上的方法
公开(公告)号：US20150005602A1
公开(公告)日：2015-01-01
申请号：US13930687
申请日：2013-06-28
申请人： Google Inc
发明人： Jeffrey George Linhardt , Zenghe Liu
IPC分类号： A61B3/10
CPC分类号： A61B3/101 , B29C65/522 , B29D11/00048 , B29D11/00817 , B32B37/185 , B32B2551/00 , G02C7/04 , G02C7/049 , G02C2202/16
摘要： The present disclosure provides a method including forming a polymer layer defining a side of an eye-mountable device. The method may also include providing an adhesive in a ring-shaped pattern on a ring-shaped substrate or on the first polymer layer. The method may also include providing the ring-shaped substrate on the first polymer layer in a predetermined rotational orientation. The method may also include applying a force to one or more of the ring-shaped substrate and the polymer layer to adhere the first polymer layer to the ring-shaped substrate. The method may also include curing the ring-shaped substrate and the first polymer layer.
摘要翻译：本公开提供了一种方法，包括形成限定眼睛安装装置的侧面的聚合物层。该方法还可以包括在环形基底上或在第一聚合物层上提供呈环状图案的粘合剂。该方法还可以包括以预定的旋转方向在第一聚合物层上提供环形基材。该方法还可以包括向一个或多个环形基底和聚合物层施加力以将第一聚合物层粘附到环形基底上。该方法还可以包括固化环形基底和第一聚合物层。

34. 发明申请

US20150001073A1 Porous Polymeric Formulation Prepared Using Monomer 有权
标题翻译：使用单体制备的多孔聚合物配方
公开(公告)号：US20150001073A1
公开(公告)日：2015-01-01
申请号：US13930858
申请日：2013-06-28
申请人： Google Inc.
发明人： Zenghe Liu , Jeffrey George Linhardt
IPC分类号： C12Q1/00
CPC分类号： C12Q1/003
摘要： An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode, and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer. The crosslinked, hydrophilic copolymer has methacrylate-derived backbone chains of first methacrylate-derived units, second methacrylate-derived units and third methacrylate-derived units. The first and second methacrylate-derived units have side chains that can be the same or different, and the third methacrylate-derived units in different backbone chains are connected by hydrophilic crosslinks.
摘要翻译：公开了用于连续或半连续监测生理参数的分析物传感器和用于制备分析物传感器的方法。一方面，分析物传感器包括与电极表面接触的交联的亲水共聚物和嵌入交联的亲水共聚物内的分析物感测组分。交联的亲水共聚物具有衍生自第一甲基丙烯酸酯单元，第二甲基丙烯酸酯衍生单元和第三甲基丙烯酸酯衍生单元的甲基丙烯酸酯衍生的主链。第一和第二甲基丙烯酸酯衍生单元具有可以相同或不同的侧链，并且不同主链中的第三甲基丙烯酸酯衍生单元通过亲水性交联连接。

35. 发明申请

US20150001072A1 Chemically Reactive Enzyme Immobilization 有权
标题翻译：化学活性酶固定化
公开(公告)号：US20150001072A1
公开(公告)日：2015-01-01
申请号：US13930821
申请日：2013-06-28
申请人： Google Inc.
发明人： Zenghe Liu , Jeffrey George Linhardt
IPC分类号： G01N27/327 , B05D5/12
CPC分类号： G01N27/327 , A61B5/1486 , A61B5/6821 , C12Q1/006 , G01N27/3271
摘要： An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked, hydrophilic copolymer sensing layer in contact with a surface of an electrode, where the sensing layer includes methacrylate-derived backbone chains having covalent bonds to an analyte sensing component. The method includes combining the precursor components of the sensing layer, depositing the combined mixture on a surface of an electrode, and curing the deposited mixture.
摘要翻译：公开了用于连续或半连续监测生理参数的分析物传感器和用于制备分析物传感器的方法。分析物传感器包括与电极表面接触的交联的亲水共聚物感测层，其中感测层包括具有与分析物感测组分共价键的甲基丙烯酸酯衍生的骨架链。该方法包括组合感测层的前体组分，将组合的混合物沉积在电极的表面上，并固化沉积的混合物。

36. 发明申请

US20140329303A1 In-vitro contact lens testing 审中-公开
标题翻译：体外隐形眼镜测试
公开(公告)号：US20140329303A1
公开(公告)日：2014-11-06
申请号：US14338429
申请日：2014-07-23
申请人： Google Inc.
发明人： Zenghe Liu , James Etzkorn
IPC分类号： G01N33/52 , G01N33/53 , G01N33/543 , G01N21/64
CPC分类号： G01N33/528 , B01J2219/00612 , B01J2219/00621 , G01N21/6486 , G01N21/75 , G01N33/5304 , G01N33/54366 , G01N33/54386 , G01N33/62 , G01N33/66 , G01N33/92 , G01N33/98 , G01N2333/46 , Y10T436/144444
摘要： Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.
摘要翻译：介绍了用于测试分析物的隐形眼镜的隐形眼镜测试仪器和方法。一方面，提供了一种装置，其包括构造成保持一个或多个隐形眼镜的壳体，以及设置在壳体内并包括试剂的测试室，所述试剂被配置为响应于存在预定的放置在测试室中的隐形眼镜上或其内的生物标志物，其中化学反应产生与生成生物标志物的个体的状态信息相关的已知结果。

37. 发明授权

US08880139B1 Symmetrically arranged sensor electrodes in an ophthalmic electrochemical sensor 有权
标题翻译：眼科电化学传感器中对称布置的传感器电极
公开(公告)号：US08880139B1
公开(公告)日：2014-11-04
申请号：US14034323
申请日：2013-09-23
申请人： Google Inc.
发明人： James Etzkorn , Zenghe Liu
IPC分类号： A61B5/05 , G01N33/50 , G01N27/26 , C12N9/00 , A61B5/1486 , A61B5/00 , A61B5/1477 , A61B5/145 , G01N27/327
CPC分类号： A61B5/1486 , A61B3/101 , A61B5/0002 , A61B5/0004 , A61B5/002 , A61B5/14507 , A61B5/14532 , A61B5/14546 , A61B5/1477 , A61B5/6821 , A61B5/7264 , A61B2560/0214 , G01N27/30 , G01N27/3271 , G01N27/4166 , G02C7/04
摘要： An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode.
摘要翻译：一种可眼睛安装的装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。电化学传感器包括工作电极，参比电极和选择性地与分析物反应以产生与可眼睛安装的装置暴露于的流体中的分析物的浓度相关的传感器测量的试剂。工作电极可以具有第一侧边缘和第二侧边缘。参考电极可以被定位成使得工作电极的第一和第二侧边缘的至少一部分与参考电极的相应部分相邻。

38. 发明授权

US08821811B2 In-vitro contact lens testing 有权
公开(公告)号：US08821811B2
公开(公告)日：2014-09-02
申请号：US13627727
申请日：2012-09-26
申请人： Google Inc.
发明人： Zenghe Liu , James Etzkorn
IPC分类号： G01N21/75 , C12M1/34 , C12M3/00
CPC分类号： G01N33/528 , B01J2219/00612 , B01J2219/00621 , G01N21/6486 , G01N21/75 , G01N33/5304 , G01N33/54366 , G01N33/54386 , G01N33/62 , G01N33/66 , G01N33/92 , G01N33/98 , G01N2333/46 , Y10T436/144444
摘要： Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.

39. 发明申请

US20140194713A1 CONTACT LENSES HAVING TWO-ELECTRODE ELECTROCHEMICAL SENSORS 审中-公开
公开(公告)号：US20140194713A1
公开(公告)日：2014-07-10
申请号：US14029281
申请日：2013-09-17
申请人： GOOGLE INC.
发明人： Zenghe Liu
IPC分类号： A61B5/1486 , A61B5/00 , A61B5/145
CPC分类号： A61B5/1486 , A61B5/0004 , A61B5/002 , A61B5/14507 , A61B5/14532 , A61B5/14546 , A61B5/1495 , A61B5/6821
摘要： Apparatus, systems and methods employing contact lenses with two-electrode electrochemical sensors are provided. In some aspects, the contact lens includes: a substrate that forms at least part of a body of the contact lens; and a circuit, disposed on or within the substrate, and including a two-electrode electrochemical sensor. The two-electrode electrochemical sensor can include: a working electrode; and a combination reference-counter electrode. The electrochemical sensor can be an amperometric sensor that senses a biological feature of a wearer of the contact lens. The working electrode can generate a signal indicative of the sensed analyte, and the combination reference-counter electrode can pass the signal generated from the working electrode. The signal can be employed to determine the analyte concentration of a solution in contact with the contact lens.

40. 发明申请

US20140087452A1 IN-VITRO CONTACT LENS TESTING 有权
标题翻译： IN-VITRO接触式镜头测试
公开(公告)号：US20140087452A1
公开(公告)日：2014-03-27
申请号：US13627727
申请日：2012-09-26
申请人： Google Inc.
发明人： Zenghe Liu , James Etzkorn
IPC分类号： C12M1/34 , G01N33/53
CPC分类号： G01N33/528 , B01J2219/00612 , B01J2219/00621 , G01N21/6486 , G01N21/75 , G01N33/5304 , G01N33/54366 , G01N33/54386 , G01N33/62 , G01N33/66 , G01N33/92 , G01N33/98 , G01N2333/46 , Y10T436/144444
摘要： Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.
摘要翻译：介绍了用于测试分析物的隐形眼镜的隐形眼镜测试仪器和方法。一方面，提供了一种装置，其包括构造成保持一个或多个隐形眼镜的壳体，以及设置在壳体内并包括试剂的测试室，所述试剂被配置为响应于存在预定的放置在测试室中的隐形眼镜上或其内的生物标志物，其中化学反应产生与生成生物标志物的个体的状态信息相关的已知结果。

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