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31. 发明申请

US20080051542A1 Medical devices having polymeric regions with improved adhesion 有权
标题翻译：具有改善粘附性的聚合物区域的医疗装置
公开(公告)号：US20080051542A1
公开(公告)日：2008-02-28
申请号：US11809484
申请日：2007-06-01
申请人： Frederick H. Strickler
发明人： Frederick H. Strickler
IPC分类号： C08F212/08 , C08G77/04
CPC分类号： A61L31/041 , A61L31/14 , C08L53/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain at least one polymeric region in contact with a metallic region. The polymeric region contains at least one block copolymer that contains at least one low Tg block and at least one high Tg block. The polymeric region contains at least one polymer that contains at least one adhesion promoting group selected from one or more of halo-silane, alkoxy-silane, epoxy, anhydride, phenoxy, hydroxyl, amino, sulfonate and carboxyl groups, which at least one polymer may correspond to the block copolymer, a supplemental polymer, or both.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含与金属区域接触的至少一个聚合物区域。聚合物区域含有至少一种包含至少一个低Tg嵌段和至少一个高Tg嵌段的嵌段共聚物。聚合物区域含有至少一种含有至少一种选自卤代硅烷，烷氧基 - 硅烷，环氧，酸酐，苯氧基，羟基，氨基，磺酸酯和羧基中的一种或多种粘附促进基团的聚合物，该至少一种聚合物可以对应于嵌段共聚物，补充聚合物，或两者。

32. 发明授权

US08535702B2 Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权
标题翻译：具有用于受控药物递送和调节的生物相容性的多孔聚合物区域的医疗装置
公开(公告)号：US08535702B2
公开(公告)日：2013-09-17
申请号：US11048616
申请日：2005-02-01
申请人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
发明人： Robert E. Richard , Frederick H. Strickler , Marlene C. Schwarz , Rudolf Faust , Shrirang V. Ranade , Michael N. Helmus
IPC分类号： A61F2/00
CPC分类号： A61L31/129 , A61L27/48 , A61N1/05
摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.
摘要翻译：本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸并且经历生物整合的生物分解聚合物相，并且经历相分离的聚合物区域在体内成为纳米孔聚合物区域。本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。这些方法包括（a）提供包含稳定聚合物相和纳米尺度的可分解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗在植入或插入医疗装置时在体内释放的药剂。

33. 发明申请

US20110150972A1 MEDICAL DEVICES HAVING IMPROVED PERFORMANCE 有权
标题翻译：具有改进性能的医疗器械
公开(公告)号：US20110150972A1
公开(公告)日：2011-06-23
申请号：US13036777
申请日：2011-02-28
申请人： Frederick H. Strickler , Shrirang V. Ranade
发明人： Frederick H. Strickler , Shrirang V. Ranade
IPC分类号： A61K47/32 , A61K9/70 , A61P31/00 , A61P29/00 , A61P35/00 , A61P7/02
CPC分类号： A61L29/041 , A61L27/16 , A61L29/16 , A61L31/048 , A61L31/16 , A61L2300/00 , C08L53/005
摘要： According to an aspect of the present invention, medical devices are provided that contain at least one polymeric region which contains (a) at least one block copolymer that contains at least at least three polymer blocks that differ from one another and (b) at least one therapeutic agent.
摘要翻译：根据本发明的一个方面，提供了包含至少一个聚合物区域的医疗装置，该聚合物区域含有（a）至少含有至少三个彼此不同的聚合物嵌段的嵌段共聚物，和（b）至少一种治疗剂。

34. 发明授权

US07914807B2 Medical devices having improved performance 有权
标题翻译：具有改进性能的医疗设备
公开(公告)号：US07914807B2
公开(公告)日：2011-03-29
申请号：US11714029
申请日：2007-03-05
申请人： Shaina Brito , Frederick H. Strickler
发明人： Shaina Brito , Frederick H. Strickler
IPC分类号： C08L53/00 , A61L31/00 , A61L27/00 , A61L29/00
CPC分类号： A61L31/048 , A61L27/16 , A61L29/041 , C08F293/00 , C08L53/02
摘要： In accordance with various aspects of the invention, implantable and insertable medical devices are provided, which contain one or more polymeric regions. In one aspect, the polymeric regions comprise (a) a block copolymer that comprises a polyaromatic block and a polyalkene block admixed with (b) a sulfonated high Tg polymer. In another aspect, the polymeric regions comprise a block copolymer that comprises (a) a sulfonated polymer block and (b) fluorinated polymer block.
摘要翻译：根据本发明的各个方面，提供了可植入和可插入的医疗装置，其包含一个或多个聚合物区域。在一个方面，聚合物区域包含（a）嵌段共聚物，其包含与（b）磺化的高Tg聚合物混合的多芳族嵌段和聚烯烃嵌段。另一方面，聚合物区域包含嵌段共聚物，其包含（a）磺化聚合物嵌段和（b）氟化聚合物嵌段。

35. 发明授权

US07713539B2 Medical devices containing radiation resistant block copolymer 有权
标题翻译：含抗辐射嵌段共聚物的医疗器械
公开(公告)号：US07713539B2
公开(公告)日：2010-05-11
申请号：US10894400
申请日：2004-07-19
申请人： Frederick H. Strickler , Robert E. Richard
发明人： Frederick H. Strickler , Robert E. Richard
IPC分类号： A61L31/04 , A61L31/16 , A61L29/04 , A61L29/16
CPC分类号： A61L29/041 , A61L29/16 , A61L31/048 , A61L31/16 , A61L2300/00
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant block copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprise (a) a release region and (b) at least one therapeutic agent and the release region comprises a radiation resistant copolymer that includes (i) a low Tg hydrocarbon polymer block and (ii) one or more high Tg polymer blocks.
摘要翻译：本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。本发明还涉及用于与可插入或可植入的医疗装置结合使用的耐辐射嵌段共聚物材料。放射线灭菌的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含抗辐射共聚物，其包括（i）低Tg烃聚合物嵌段和（ii）一种或多种高 Tg聚合物嵌段。

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