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31. 发明申请

US20100222394A1 METHOD FOR PRODUCING PYRAZOL-3-YL-BENZAMIDE DERIVATIVE 审中-公开
标题翻译：生产吡唑-3-基-L-苯甲酰胺衍生物的方法
公开(公告)号：US20100222394A1
公开(公告)日：2010-09-02
申请号：US12679836
申请日：2008-09-25
申请人： Kenichi Asakawa , Naotaka Sawada , Takayuki Tsuritani , Toshiaki Mase , Keiji Takahashi , Takahiro Itoh , Feng Xu , Naoki Yoshikawa
发明人： Kenichi Asakawa , Naotaka Sawada , Takayuki Tsuritani , Toshiaki Mase , Keiji Takahashi , Takahiro Itoh , Feng Xu , Naoki Yoshikawa
IPC分类号： A61K31/4439 , C07D401/12 , C07D213/71 , A61P3/10 , A61P3/04
CPC分类号： C07D213/71 , C07D401/12 , C07D487/08
摘要： The present invention provides a more efficient industrial method for producing a pyrazol-3-yl-benzamide derivative expressed by a formula useful as medicine: wherein R2, R3 and R4 each independently represent a lower alkyl group.
摘要翻译：本发明提供了用于制备由用作药物的式表示的吡唑-3-基 - 苯甲酰胺衍生物的更有效的工业方法：其中R2，R3和R4各自独立地表示低级烷基。

32. 发明授权

US07749985B2 Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 失效
标题翻译：氨基甲酸氨基甲酸烷基酯前药，合成和使用方法
公开(公告)号：US07749985B2
公开(公告)日：2010-07-06
申请号：US12506961
申请日：2009-07-21
申请人： Mark A. Gallop , Feng Xu , Thu Phan , Usha Dilip , Ge Peng
发明人： Mark A. Gallop , Feng Xu , Thu Phan , Usha Dilip , Ge Peng
IPC分类号： A61K31/66 , C07F9/02
CPC分类号： C07F9/301
摘要： Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.
摘要翻译： 3-氨基丙基次膦酸的氨基甲酸烷基酯氨基甲酸酯前药及其类似物，3-氨基丙基次膦酸及其类似物的制备酰氨基烷基氨基甲酸酯前药的方法及其类似物，使用3-氨基丙基次膦酸及其类似物的酰氨基烷基氨基甲酸酯前药的方法和包含酰氨基烷基氨基甲酸酯前药3 - 氨基丙基次膦酸及其类似物用于治疗疾病或病症如轻度认知障碍，与阿尔茨海默氏病相关的认知障碍阿尔茨海默氏病，抑郁症，焦虑和癫痫。还公开了适用于口服给药和缓释口服剂型的3-氨基丙基次膦酸的氨基氧基烷基氨基甲酸酯前药及其类似物。

33. 发明申请

US20100113497A1 GABA CONJUGATES AND METHODS OF USE THEREOF 有权
标题翻译： GABA结合物及其使用方法
公开(公告)号：US20100113497A1
公开(公告)日：2010-05-06
申请号：US12576136
申请日：2009-10-08
申请人： Feng Xu
发明人： Feng Xu
IPC分类号： A61K31/485 , C07D489/00 , C07C269/00 , A61K31/225
CPC分类号： A61K47/48023 , A61K9/0019 , A61K9/0053 , A61K31/16 , A61K31/19 , A61K31/191 , A61K31/192 , A61K31/195 , A61K31/197 , A61K31/675 , A61K45/06 , A61K47/54 , C07C271/22 , C07C2601/14
摘要： In one aspect, the present invention provides a composition of a covalent conjugate of a GABA analog with a drug. In another aspect, the present invention provides methods for treating pain and neurological disorders using the conjugates of GABA analogs.
摘要翻译：一方面，本发明提供了GABA类似物与药物的共价缀合物的组合物。另一方面，本发明提供使用GABA类似物的缀合物治疗疼痛和神经障碍的方法。

34. 发明申请

US20090286763A1 AMINO ACID DERIVED PRODRUGS OF PROPOFOL, COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：丙烯酸的氨基酸衍生物，组合物及其用途
公开(公告)号：US20090286763A1
公开(公告)日：2009-11-19
申请号：US12467758
申请日：2009-05-18
申请人： Feng Xu , Mark A. Gallop , Vivek Sasikumar
发明人： Feng Xu , Mark A. Gallop , Vivek Sasikumar
IPC分类号： A61K31/56 , A61K31/265 , C07C69/96
CPC分类号： C07C323/60 , A61K38/00 , C07C229/22 , C07C237/12 , C07C237/20 , C07D233/64 , C07K5/06026 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/06095 , C07K5/06113 , C07K5/06147 , C07K5/06165
摘要： The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.
摘要翻译：本发明提供丙泊酚前药，制备异丙酚前药的方法，异丙酚前药的药物组合物和使用异丙酚前药的方法及其药物组合物，用于治疗或预防疾病或病症如偏头痛头痛和化疗后或术后手术恶心和呕吐。

35. 发明授权

US07576127B2 Aromatic prodrugs of propofol, compositions and uses thereof 失效
标题翻译：丙泊酚的芳族前药，其组合物和用途
公开(公告)号：US07576127B2
公开(公告)日：2009-08-18
申请号：US11507968
申请日：2006-08-21
申请人： Mark A. Gallop , Feng Xu
发明人： Mark A. Gallop , Feng Xu
IPC分类号： A61K31/265 , A61K31/235
CPC分类号： C07C271/28
摘要： Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting are disclosed herein.
摘要翻译：丙泊酚的前药，制备丙泊酚前药的方法，丙泊酚前药的药物组合物和使用异丙酚前药的方法及其药物组合物治疗或预防疾病或病症如偏头痛头痛和化疗后或术后手术恶心和呕吐。

36. 发明授权

US07550506B2 Amino acid derived prodrugs of propofol, compositions and uses thereof 失效
标题翻译：丙泊酚的氨基酸衍生前药，其组合物和用途
公开(公告)号：US07550506B2
公开(公告)日：2009-06-23
申请号：US11180064
申请日：2005-07-12
申请人： Feng Xu , Mark A. Gallop , Vivek Sasikumar
发明人： Feng Xu , Mark A. Gallop , Vivek Sasikumar
IPC分类号： A61K31/24 , C07C229/36
CPC分类号： C07C323/60 , A61K38/00 , C07C229/22 , C07C237/12 , C07C237/20 , C07D233/64 , C07K5/06026 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/06095 , C07K5/06113 , C07K5/06147 , C07K5/06165
摘要： The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.
摘要翻译：本发明提供丙泊酚前药，制备异丙酚前药的方法，异丙酚前药的药物组合物和使用异丙酚前药的方法及其药物组合物，用于治疗或预防疾病或病症如偏头痛头痛和化疗后或术后手术恶心和呕吐。

37. 发明授权

US07538064B2 Isomerization catalyst and process 有权
标题翻译：异构化催化剂和工艺
公开(公告)号：US07538064B2
公开(公告)日：2009-05-26
申请号：US12147064
申请日：2008-06-26
申请人： Ralph D. Gillespie , Feng Xu
发明人： Ralph D. Gillespie , Feng Xu
IPC分类号： B01J27/00 , B01J27/185 , B01J23/00 , B01J23/40 , B01J23/42 , B01J23/56 , B01J23/44
CPC分类号： B01J37/28 , B01J21/06 , B01J21/066 , B01J23/6527 , B01J27/1856 , B01J27/188 , B01J37/0205 , B01J37/031 , B01J37/08 , C07C5/2724 , C07C2521/06 , C07C2523/20 , C07C2523/30 , C07C2523/36 , C07C2523/40 , C07C2523/745 , C07C2523/75 , C07C2523/755 , C10G11/02 , C10G11/04 , C10G29/205 , C10G35/085 , C10G45/06 , C10G45/52 , C10G45/60 , C10G45/62 , C10G47/14 , C10G50/00 , C10K3/04
摘要： A catalyst and process is disclosed to selectively upgrade a paraffinic feedstock to obtain an isoparaffin-rich product for blending into gasoline. The catalyst comprises a support of a tungstated oxide or hydroxide of a Group IVB (IUPAC 4) metal, a phosphorus component, and at least one platinum-group metal component which is preferably platinum. The catalyst has a structure other than a hetropoly anion structure.
摘要翻译：公开了一种催化剂和方法，用于选择性地升级链烷烃原料以获得用于混合成汽油的富含异链烷烃的产物。该催化剂包含钨IVB（IUPAC 4）金属，磷成分和至少一种优选为铂的铂族金属成分的钨酸氧化物或氢氧化物的载体。催化剂具有除了全反式阴离子结构以外的结构。

38. 发明申请

US20090130707A1 Methods of reducing the inhibitory effect of a redox active metal ion on the enzymatic hydrolysis of cellulosic material 审中-公开
标题翻译：降低氧化还原活性金属离子对纤维素材料酶水解的抑制作用的方法
公开(公告)号：US20090130707A1
公开(公告)日：2009-05-21
申请号：US12263268
申请日：2008-10-31
申请人： Feng Xu
发明人： Feng Xu
IPC分类号： C12P1/00
CPC分类号： C12P7/10 , C12P19/02 , Y02E50/16
摘要： The present invention relates to methods of producing a cellulosic material reduced in a redox active metal cation having a redox potential (Eo) in the range of about −0.4 to about 1.2 volts, comprising treating the cellulosic material with an effective amount of a chelator to reduce the inhibitory effect of the redox active metal cation on enzymatically degrading or converting the cellulosic material and alternatively also treating the cellulosic material with an effective amount of an oxidant when the redox active metal cation has a low valence state to convert the redox active metal cation to a high valence state to preferentially chelate the redox active metal cation. The present invention also relates to methods for degrading or converting a cellulosic material and to methods of producing a fermentation product.
摘要翻译：本发明涉及减少氧化还原电位（Eo）在约-0.4至约1.2伏范围内的氧化还原活性金属阳离子还原的纤维素材料的方法，包括用有效量的螯合剂处理纤维素材料至降低氧化还原活性金属阳离子对酶促降解或转化纤维素材料的抑制作用，或者当氧化还原活性金属阳离子具有低价态以转化氧化还原活性金属阳离子时，用有效量的氧化剂处理纤维素材料以高价态优先螯合氧化还原活性金属阳离子。本发明还涉及降解或转化纤维素材料的方法以及生产发酵产物的方法。

39. 发明授权

US07414007B2 Isomerization catalyst and process 有权
标题翻译：异构化催化剂和工艺
公开(公告)号：US07414007B2
公开(公告)日：2008-08-19
申请号：US11304521
申请日：2005-12-15
申请人： Ralph D. Gillespie , Feng Xu
发明人： Ralph D. Gillespie , Feng Xu
IPC分类号： B01J27/00 , B01J27/188 , B01J27/185 , B01J23/00
CPC分类号： B01J27/188 , B01J23/6527 , B01J27/1856
摘要： A catalyst and process is disclosed to selectively upgrade a paraffinic feedstock to obtain an isoparaffin-rich product for blending into gasoline. The catalyst comprises a support of a tungstated oxide or hydroxide of a Group IVB (IUPAC 4) metal, a phosphorus component, and at least one platinum-group metal component which is preferably platinum. The catalyst has a structure other than a hetropoly anion structure.
摘要翻译：公开了一种催化剂和方法，用于选择性地升级链烷烃原料以获得用于混合成汽油的富含异链烷烃的产物。该催化剂包含钨IVB（IUPAC 4）金属，磷成分和至少一种优选为铂的铂族金属成分的钨酸氧化物或氢氧化物的载体。催化剂具有除了全反式阴离子结构以外的结构。

40. 发明申请

US20080128327A1 Isomerization Catalyst and Process 有权
标题翻译：异构化催化剂和工艺
公开(公告)号：US20080128327A1
公开(公告)日：2008-06-05
申请号：US12022651
申请日：2008-01-30
申请人： Ralph D. Gillespie , Feng Xu
发明人： Ralph D. Gillespie , Feng Xu
IPC分类号： C10G35/085
CPC分类号： B01J37/28 , B01J21/06 , B01J21/066 , B01J23/6527 , B01J27/1856 , B01J27/188 , B01J37/0205 , B01J37/031 , B01J37/08 , C07C5/2724 , C07C2521/06 , C07C2523/20 , C07C2523/30 , C07C2523/36 , C07C2523/40 , C07C2523/745 , C07C2523/75 , C07C2523/755 , C10G11/02 , C10G11/04 , C10G29/205 , C10G35/085 , C10G45/06 , C10G45/52 , C10G45/60 , C10G45/62 , C10G47/14 , C10G50/00 , C10K3/04
摘要： A catalyst and process is disclosed to selectively upgrade a paraffinic feedstock to obtain an isoparaffin-rich product for blending into gasoline. The catalyst comprises a support of a tungstated oxide or hydroxide of a Group IVB (IUPAC 4) metal, a phosphorus component, and at least one platinum-group metal component which is preferably platinum. The catalyst has a structure other than a heteropoly anion structure.
摘要翻译：公开了一种催化剂和方法，用于选择性地升级链烷烃原料以获得用于混合成汽油的富含异链烷烃的产物。该催化剂包含钨IVB（IUPAC 4）金属，磷成分和至少一种优选为铂的铂族金属成分的钨酸氧化物或氢氧化物的载体。该催化剂具有除杂多阴离子结构以外的结构。

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