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31. 发明授权

US07345058B2 Pyrazoles 失效
标题翻译：吡唑
公开(公告)号：US07345058B2
公开(公告)日：2008-03-18
申请号：US11395763
申请日：2006-03-31
申请人： Paul Gillespie , Robert Alan Goodnow, Jr. , Qiang Zhang
发明人： Paul Gillespie , Robert Alan Goodnow, Jr. , Qiang Zhang
IPC分类号： A61K31/4709 , A61K31/4155 , A61K31/415 , C07D215/08 , C07D231/12
CPC分类号： C07D401/06 , C07D231/14 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D409/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译：本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。

32. 发明申请

US20060199816A1 Aryl sulfonyl piperidines 审中-公开
标题翻译：芳基磺酰基哌啶
公开(公告)号：US20060199816A1
公开(公告)日：2006-09-07
申请号：US11365053
申请日：2006-03-01
申请人： Paul Gillespie , Robert Goodnow , Agnieszka Kowalczyk , Sung-Sau So , Qiang Zhang
发明人： Paul Gillespie , Robert Goodnow , Agnieszka Kowalczyk , Sung-Sau So , Qiang Zhang
IPC分类号： A61K31/538 , A61K31/4709 , A61K31/453 , A61K31/445
CPC分类号： C07D211/96 , A61K31/445 , A61K31/453 , A61K31/4709 , A61K31/538 , C07D401/06 , C07D401/12 , C07D409/12 , C07D409/14 , C07D487/08
摘要： Provided herein are compounds of the formula (1): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译：本文提供了式（1）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。

33. 发明授权

US08188098B2 GPR119 receptor agonists 失效
标题翻译： GPR119受体激动剂
公开(公告)号：US08188098B2
公开(公告)日：2012-05-29
申请号：US12433921
申请日：2009-05-01
申请人： Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
发明人： Shawn David Erickson , Paul Gillespie , Kevin Richard Guertin , Prabha Saba Karnachi , Kyungjin Kim , Chun Ma , Warren William McComas , Sherrie Lynn Pietranico-Cole , Lida Qi , Jefferson Wright Tilley , Qiang Zhang
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译：本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。

34. 发明授权

US07700632B2 Biaryloxymethylarenecarboxylic acids as glycogen synthase activator 失效
标题翻译：作为糖原合酶活化剂的生物芳基氧甲基羧酸
公开(公告)号：US07700632B2
公开(公告)日：2010-04-20
申请号：US11970620
申请日：2008-01-08
申请人： Chang An Chu , Paul Gillespie , Jefferson Wright Tilley
发明人： Chang An Chu , Paul Gillespie , Jefferson Wright Tilley
IPC分类号： A61K31/44 , C07D211/70 , C07D211/78
CPC分类号： C07D213/79 , C07C65/24 , C07D277/56 , C07D307/68 , C07D333/40 , C07D405/06
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
摘要翻译：本发明涉及其中R 1，R 2，R 3，R 4，m，n，p和s如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。该化合物可用于治疗和/或预防与糖原合成酶如糖尿病的活化相关的疾病。

35. 发明申请

US20060027727A1 Concrete slab form system 有权
公开(公告)号：US20060027727A1
公开(公告)日：2006-02-09
申请号：US10495530
申请日：2003-12-17
申请人： Paul Gillespie , Charles Wood
发明人： Paul Gillespie , Charles Wood
IPC分类号： E04G11/00
CPC分类号： E04G11/38 , E04G11/48 , E04G11/486 , E04G17/18 , E04G25/066 , E04G2009/025 , Y10T403/59 , Y10T403/591
摘要： A system of interconnecting structural components for supporting and forming suspended concrete slabs that allow removal of form panels without disturbing the slab support posts (shores). Additional features of the system accommodate changes in suspended slab thickness, horizontal slab dimensions that are not multiples of the basic component dimensions, slab edge cantilevered form panels, attachment to walls and remote manipulation of form panels from the floor below using an erection staff. The primary system components are panels, support posts, telescopic beams, adjustable hanger connections, wall hangers, wall beams, raking shore assemblies and erection/stripping staffs. Form panels are directly supported by the shores without the use of an intermediate member (usually a beam) that is common practice in the concrete forming industry. The system reduces the number of required components that in turn reduces the capital cost to the user and improves his labor efficiency and quality of the concrete surface.

36. 发明授权

US06911389B2 Self aligned vias in dual damascene interconnect, buried mask approach 有权
标题翻译：双镶嵌互连中的自对准通孔，掩埋掩模法
公开(公告)号：US06911389B2
公开(公告)日：2005-06-28
申请号：US10246061
申请日：2002-09-18
申请人： Kenneth D. Brennan , Paul Gillespie
发明人： Kenneth D. Brennan , Paul Gillespie
IPC分类号： H01L21/768 , H01L23/522 , H01L21/44
CPC分类号： H01L21/7681 , H01L23/5226 , H01L2924/0002 , H01L2924/00
摘要： Methods are disclosed for forming vias, trenches, and interconnects through diffusion barrier, etch-stop, and dielectric materials for interconnection of electrical devices in dual damascene structures of a semiconductor device. A buried via mask at the etch-stop level provides openings with two or more adjacent via misalignment error regions merged into rectangular windows aligned orthogonal to a long axis of the underlying conductive features of a first metal level. The rectangular windows used together with openings in a hard mask form via portions, and the openings in the hard mask provide trench portions. Via and trench portions coincide during trench or via etch, as well as during hard mask or etch-stop layer etch together forming an interconnect cavity, which may then be filled with a conductive material to provide a conductive interconnect between the conductive feature of the first metal level and a second metal level.
摘要翻译：公开了用于通过扩散屏障，蚀刻停止和介电材料形成通孔，沟槽和互连的方法，用于半导体器件的双镶嵌结构中的电器件的互连。在蚀刻停止水平处的掩埋通孔掩模提供具有两个或更多个相邻的通孔未对准误差区域的开口，该相邻的通孔未对准误差区域被合并成与第一金属水平的底部导电特征的长轴正交排列的矩形窗口。与通过部分的硬掩模形式的开口一起使用的矩形窗口，并且硬掩模中的开口提供沟槽部分。通孔和沟槽部分在沟槽或通孔蚀刻期间重合，以及在硬掩模或蚀刻停止层蚀刻期间一起形成互连腔，然后可以用导电材料填充以在第一和第二导电特征之间提供导电互连金属水平和第二金属水平。

37. 发明授权

US06515124B2 Dehydroamino acids 失效
标题翻译：脱氢氨基酸
公开(公告)号：US06515124B2
公开(公告)日：2003-02-04
申请号：US09754888
申请日：2001-01-05
申请人： Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
发明人： Nader Fotouhi , Paul Gillespie , Robert William Guthrie , Sherrie Lynn Pietranico-Cole , Weiya Yun
IPC分类号： C07C23584
CPC分类号： C07D249/08 , C07B2200/07 , C07C233/85 , C07C233/87 , C07C311/46 , C07D209/08 , C07D211/34 , C07D213/55 , C07D215/14 , C07D233/26 , C07D235/16 , C07D237/28 , C07D239/52 , C07D249/18 , C07D261/08 , C07D271/12 , C07D277/30 , C07D277/38 , C07D277/62 , C07D277/64 , C07D285/14 , C07D307/16 , C07D317/60 , C07D333/24 , C07D333/60 , C07D401/12 , C07D403/12 , C07D409/04 , C07D417/04 , C07F9/4006 , C07F9/5728 , C07F9/6524 , C07F9/65583
摘要： Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasis.
摘要翻译：公开了作为LFA-1拮抗剂活性的芳族脱氢氨基酸。该活性使得这些化合物能够预防因T细胞活化而引起的炎症，因此减少或消除炎症性皮肤病牛皮癣。

38. 发明授权

US09073881B2 Benzoic acid derivatives 有权
标题翻译：苯甲酸衍生物
公开(公告)号：US09073881B2
公开(公告)日：2015-07-07
申请号：US13603602
申请日：2012-09-05
申请人： Paul Gillespie
发明人： Paul Gillespie
IPC分类号： A61K31/426 , A61K31/496 , A61K31/506 , C07D417/10 , A61K31/4439 , C07D417/04 , C07D277/30 , A61K31/427 , A61K31/5377 , A61K31/454 , C07D277/34 , C07D417/08 , C07D417/12 , C07D277/38
CPC分类号： C07D277/34 , C07D277/38 , C07D417/04 , C07D417/08 , C07D417/12
摘要： There are disclosed are compounds of the formula: wherein R1 and R2 are as disclosed herein, which are eIF4E inhibitors useful in the treatment of cancers. Also disclosed are compositions comprising the compounds, as well as methods of treating cancer using the compounds.
摘要翻译：已经公开了下式的化合物：其中R1和R2如本文所公开的，其是可用于治疗癌症的eIF4E抑制剂。还公开了包含该化合物的组合物，以及使用该化合物治疗癌症的方法。

39. 发明申请

US20070203210A1 Thiazolyl-benzimidazoles 失效
标题翻译：噻唑基 - 苯并咪唑
公开(公告)号：US20070203210A1
公开(公告)日：2007-08-30
申请号：US11703306
申请日：2007-02-07
申请人： John Frederick Boylan , Jianping Cai , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kang Le , Christophe Michoud
发明人： John Frederick Boylan , Jianping Cai , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow , Kang Le , Christophe Michoud
IPC分类号： A61K31/427 , C07D417/04
CPC分类号： C07D417/04
摘要： The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
摘要翻译：本发明涉及式（1）的化合物及其药学上可接受的盐，其制备方法及其使用方法。

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