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31. 发明授权

US07329402B2 Methods of imaging and treatment 失效
标题翻译：成像和治疗方法
公开(公告)号：US07329402B2
公开(公告)日：2008-02-12
申请号：US10341167
申请日：2003-01-13
申请人： Evan C. Unger , Yunqiu Wu
发明人： Evan C. Unger , Yunqiu Wu
IPC分类号： A61B8/00 , A61R9/127 , A61R38/00 , A61R38/04
CPC分类号： A61K49/225 , A61K49/223 , A61K49/227 , A61K49/228 , B82Y5/00
摘要： Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus, low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.
摘要翻译：新型超声方法包括向患者施用靶向囊泡组合物，其包含包含脂质，蛋白质或聚合物的囊泡，包封气体，与靶向配体组合，以及使用超声波扫描患者。扫描可以包括将患者暴露于第一类型的超声能量，然后使用第二类型的超声能量询问患者。靶向配体优选靶向组织，细胞或受体，包括心肌细胞，内皮细胞，上皮细胞，肿瘤细胞和糖蛋白GPIIbIIIa受体。该方法可用于检测血栓，老化或回声血栓的增强，靶向组织，细胞或受体的低浓度囊泡和囊泡。

32. 发明授权

US06416740B1 Acoustically active drug delivery systems 失效
标题翻译：声学活性药物输送系统
公开(公告)号：US06416740B1
公开(公告)日：2002-07-09
申请号：US09075343
申请日：1998-05-11
申请人： Evan C. Unger
发明人： Evan C. Unger
IPC分类号： A61B800
CPC分类号： A61K9/5123 , A61K9/0009 , A61K9/1075 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/145 , A61K9/146 , A61K41/0028 , A61K47/62 , A61K47/6925 , A61K49/223 , B82Y5/00
摘要： The present invention is directed to targeted therapeutic delivery systems comprising a gas or gaseous precursor filled microsphere wherein said gas or gaseous precursor filled microsphere comprises an oil, a surfactant, and a therapeutic compound. Methods of preparing the targeted therapeutic delivery systems are also embodied by the present invention which comprise processing a solution comprising an oil and a surfactant in the presence of a gaseous precursor, at a temperature below the gel to liquid crystalline phase transition temperature of the surfactant to form gas or gaseous precursor filled microsphere, and adding to said microspheres a therapeutic compound resulting in a targeted therapeutic delivery system, wherein said processing is selected from the group consisting of controlled agitation, controlled drying, and a combination thereof.
摘要翻译：本发明涉及包含气体或气体前体填充的微球体的靶向治疗递送系统，其中所述气体或气体前体填充的微球体包含油，表面活性剂和治疗化合物。制备靶向治疗递送系统的方法也由本发明体现，其包括在气态前体存在下，在低于表面活性剂的凝胶至液晶相转变温度的温度下处理包含油和表面活性剂的溶液，形成气体或气体前体填充微球体，并向所述微球体加入导致靶向治疗递送系统的治疗化合物，其中所述加工选自受控搅拌，受控干燥及其组合。

33. 发明授权

US06403056B1 Method for delivering bioactive agents using cochleates 有权
标题翻译：使用耳蜗递送生物活性剂的方法
公开(公告)号：US06403056B1
公开(公告)日：2002-06-11
申请号：US09540448
申请日：2000-03-31
申请人： Evan C. Unger
发明人： Evan C. Unger
IPC分类号： A61B800
CPC分类号： A61K49/223 , A61K9/1271 , A61K41/0028 , A61K47/544 , Y10T428/2984
摘要： The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and diagnostic imaging, as well as their use as contrast agents.
摘要翻译：本发明涉及带电荷的脂质，包含带电脂质的组合物，以及这些组合物在药物递送，靶向药物递送，治疗成像和诊断成像中的用途，以及它们作为造影剂的用途。

34. 发明授权

US6090800A Lipid soluble steroid prodrugs 失效
标题翻译：脂溶性类固醇前药
公开(公告)号：US6090800A
公开(公告)日：2000-07-18
申请号：US851780
申请日：1997-05-06
申请人： Evan C. Unger , DeKang Shen
发明人： Evan C. Unger , DeKang Shen
IPC分类号： A61K9/127 , A61K41/00 , A61K49/22 , A61K31/56 , C07J5/00
CPC分类号： A61K41/0028 , A61K47/48053 , A61K49/223 , A61K9/1271
摘要： The present invention is directed to novel lipid soluble steroid prodrugs compositions comprising steroid prodrugs, and uses of the same.
摘要翻译：本发明涉及包含类固醇前药的新型脂溶性类固醇前药组合物及其用途。

35. 发明授权

US5997898A Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery 失效
标题翻译：用于治疗性递送方法的氟化两亲物的稳定组合物
公开(公告)号：US5997898A
公开(公告)日：1999-12-07
申请号：US465868
申请日：1995-06-06
申请人： Evan C. Unger
发明人： Evan C. Unger
IPC分类号： A61K47/24 , A61K9/127 , A61K49/00 , A61K49/18 , A61K49/22 , A61K9/50 , A61K49/04
CPC分类号： A61K49/1806 , A61K49/223 , A61K49/227 , Y10S514/962 , Y10S514/963
摘要： Stabilized compositions comprising, in combination with a gas, a fluorinated amphiphilic compound. The compositions are particularly suitable for use in diagnostic applications, including ultrasound. The compositions can take the form of vesicular compositions, such as micelles and liposomes.
摘要翻译：包含与气体组合的含氟两亲化合物的稳定组合物。该组合物特别适用于诊断应用，包括超声波。组合物可以采取水泡组合物的形式，例如胶束和脂质体。

36. 发明授权

US5948387A Contrast media for ultrasonic imaging 失效
公开(公告)号：US5948387A
公开(公告)日：1999-09-07
申请号：US853509
申请日：1997-05-09
申请人： Evan C. Unger , Guanli Wu
发明人： Evan C. Unger , Guanli Wu
IPC分类号： A61K49/22 , A61K49/00 , C08K9/06
CPC分类号： A61K49/226 , A61K49/223
摘要： Novel contrast media for use in ultrasonic imaging are described. Such contrast media may be comprised of an aqueous solution of one or more biocompatible polymers, wherein said biocompatible polymers are coated with and/or in admixture with at least one silicon containing compound. Alternatively, the contrast media may be comprised of an aqueous solution of one or more biocompatible synthetic polymers, or an aqueous solution of cellulose. The contrast media may be employed, if desired, with anti-gas agents and/or suspending agents.

37. 发明授权

US5770222A Therapeutic drug delivery systems 失效
公开(公告)号：US5770222A
公开(公告)日：1998-06-23
申请号：US472305
申请日：1995-06-07
申请人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
发明人： Evan C. Unger , Thomas A. Fritz , Terry Matsunaga , VaradaRajan Ramaswami , David Yellowhair , Guanli Wu
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K31/70 , A61K39/395 , A61K41/00 , A61K47/48 , A61K49/18 , A61K49/22 , A61M5/31 , A61Q19/00
CPC分类号： A61K49/22 , A61K41/0028 , A61K41/0052 , A61K47/48869 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61M5/3145 , Y10S436/829 , Y10S977/801 , Y10S977/907 , Y10S977/915
摘要： Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.

38. 发明授权

US5762910A Liposoluble compounds useful as magnetic resonance imaging agents 失效
公开(公告)号：US5762910A
公开(公告)日：1998-06-09
申请号：US762367
申请日：1996-12-09
申请人： Evan C. Unger , DeKang Shen
发明人： Evan C. Unger , DeKang Shen
IPC分类号： A61K49/00 , A61K49/06 , A61K49/18 , C07C237/12 , C07F5/00 , C07F13/00 , C07F15/02 , G01R33/28 , A61B5/055
CPC分类号： G01R33/5601 , A61K49/06 , A61K49/1806 , A61K49/1812 , Y10S514/836 , Y10T436/24
摘要： Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other additives. The lipids may be in the form of liposomes, micelles or lipid emulsions. The contrast agents of the invention have particular use in magnetic resonance imaging of the liver, blood pool and reticuloendothelial system.

39. 发明授权

US5624662A Liposoluble heterocyclic compounds useful as magnetic resonance imaging agents 失效
标题翻译：用作磁共振成像剂的脂溶性杂环化合物
公开(公告)号：US5624662A
公开(公告)日：1997-04-29
申请号：US487287
申请日：1995-06-07
申请人： Evan C. Unger , DeKang Shen
发明人： Evan C. Unger , DeKang Shen
IPC分类号： A61K49/00 , A61K49/06 , A61K49/18 , C07C237/12 , C07F5/00 , C07F13/00 , C07F15/02 , G01R33/28 , A61B5/055
CPC分类号： G01R33/5601 , A61K49/06 , A61K49/1806 , A61K49/1812 , Y10S514/836 , Y10T436/24
摘要： Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other additives. The lipids may be in the form of liposomes, micelles or lipid emulsions. The contrast agents of the invention have particular use in magnetic resonance imaging of the liver, blood pool and reticuloendothelial system.
摘要翻译：已经合成了具有长酰基链的顺磁性离子和化合物的新颖复合物作为磁共振成像造影剂。这些新型脂溶性造影剂可以单独施用，或与脂质，悬浮剂或其它添加剂一起施用。脂质可以是脂质体，胶束或脂质乳剂的形式。本发明的造影剂特别用于肝脏，血液池和网状内皮系统的磁共振成像。

40. 发明授权

US5571497A Liposomes as contrast agents for ultrasonic imaging and apparatus and methods for preparing the same 失效
标题翻译：作为超声成像造影剂的脂质体及其制备方法
公开(公告)号：US5571497A
公开(公告)日：1996-11-05
申请号：US468056
申请日：1995-06-06
申请人： Evan C. Unger
发明人： Evan C. Unger
IPC分类号： A61B8/00 , A61K8/14 , A61K9/127 , A61K41/00 , A61K47/48 , A61K49/04 , A61K49/18 , A61K49/22 , A61Q19/00 , B01J13/00 , B32B5/16 , A61K49/00
CPC分类号： A61K9/127 , A61K41/0028 , A61K41/0052 , A61K47/48815 , A61K47/4893 , A61K49/1815 , A61K49/223 , A61K49/227 , A61K9/1277 , A61K9/1278
摘要： Liposomes suitable as ultrasound contrast agents which contain media of various types including gases, gaseous precursors activated by pH, temperature or pressure, as well as other solid or liquid contrast enhancing agents, are described. Methods of using the same as ultrasound contrast agents are also disclosed. The present invention also comprises novel methods for synthesizing liposomes having encapsulated therein gases.
摘要翻译：适合作为超声造影剂的脂质体，其包含各种类型的介质，包括气体，通过pH，温度或压力激活的气态前体，以及其它固体或液体对比度增强剂。还公开了使用其作为超声造影剂的方法。本发明还包括合成已封装有气体的脂质体的新方法。

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