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    • 38. 发明申请
    • NEUROSTIMULATION SYSTEM AND METHOD FOR PROVIDING THERAPY TO PATIENT WITH MINIMAL SIDE EFFECTS
    • 用于向患者提供最小化副作用的神经细胞治疗系统和方法
    • US20120089200A1
    • 2012-04-12
    • US13253735
    • 2011-10-05
    • Emarit A.S. RanuBradley L. HersheyKerry Bradley
    • Emarit A.S. RanuBradley L. HersheyKerry Bradley
    • A61N1/36
    • A61N1/36071A61N1/0553A61N1/36171A61N1/36182
    • A method comprises conveying a pulsed waveform between an electrode and a stimulation site of a spinal cord, thereby evoking the antidromic propagation of action potentials along a first sensory neural fiber creating a therapeutic effect in the tissue region, evoking the orthodromic propagation of action potentials along the first sensory neural fiber potentially creating paresthesia corresponding to the tissue region, and evoking the antidromic propagation of action potentials along a second sensory neural fiber potentially creating a side-effect in another tissue region. The method further comprises conveying electrical energy between an electrode and a blocking site rostral to the stimulation site, thereby blocking the action potentials propagated along the first sensory neural fiber and reducing the paresthesia, and conveying electrical energy between an electrode and a blocking site caudal to the stimulation site, thereby blocking the action potentials propagated along the second sensory neural fiber and reducing the side-effect.
    • 一种方法包括在电极和脊髓的刺激部位之间传送脉冲波形,从而引起沿着第一感觉神经纤维的动作电位的反向扩散,从而在组织区域产生治疗效果,引起动作电位的正常传播 第一感觉神经纤维潜在地产生对应于组织区域的感觉异常,并且引起沿着潜在地在另一组织区域中产生副作用的第二感觉神经纤维的动作电位的反向扩散。 该方法还包括将电极和阻塞位点之间的电能传递到刺激部位,从而阻止沿着第一感觉神经纤维传播的动作电位并减少感觉异常,并将电极和阻塞部位尾部之间的电能传递到 刺激部位,从而阻止沿着第二感觉神经纤维传播的动作电位并降低副作用。
    • 40. 发明授权
    • Method for optimizing search for spinal cord stimulation parameter setting
    • 优化脊髓刺激参数设置搜索的方法
    • US08065013B2
    • 2011-11-22
    • US11746405
    • 2007-05-09
    • Kerry BradleyJames R. ThackerCarla M. WoodsJohn D. King
    • Kerry BradleyJames R. ThackerCarla M. WoodsJohn D. King
    • A61N1/34
    • A61N1/36071A61N1/0551Y10S128/92
    • A method of transitioning stimulation energy (e.g., electrical stimulation pulses) between a plurality of electrodes implanted within a patient is provided. The method comprises selecting a plurality of stimulation output values (e.g., electrical current amplitude values) for each of the electrodes. The method further comprises selecting a plurality of different modification values for at least one of the electrodes, respectively multiplying the stimulation output values and the modification values to determine modified stimulation output values for the electrode(s), which may optionally be stored in a steering table, and incrementally transitioning the stimulation energy to or from the electrode(s) in accordance with the modified stimulation output values. The modified stimulation output values are stored in a steering table. The modification values may be selected in a manner that maintains paresthesia when transitioning the stimulation energy between the electrodes.
    • 提供了在植入患者体内的多个电极之间转换刺激能量(例如,电刺激脉冲)的方法。 该方法包括为每个电极选择多个刺激输出值(例如,电流振幅值)。 该方法还包括为至少一个电极选择多个不同的修改值,分别乘以刺激输出值和修改值,以确定电极的修改的刺激输出值,其可以可选地存储在转向 表,并且根据修改的刺激输出值逐渐地将刺激能量转移到电极或从电极移动。 经修改的刺激输出值存储在转向表中。 可以以在电极之间转换刺激能量时保持感觉异常的方式来选择修饰值。