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31. 发明申请

US20220033757A1 OPEN-TOP MICROFLUIDIC DEVICE WITH STRUCTURAL ANCHORS 有权
公开(公告)号：US20220033757A1
公开(公告)日：2022-02-03
申请号：US17494221
申请日：2021-10-05
申请人： EMULATE, INC.
发明人： Daniel Levner , Christopher David Hinojosa , Norman Wen , Antonio Varone , Justin Nguyen , Lina Williamson , S. Jordan Kerns , Catherine Karalis , Geraldine Hamilton , Carol Lucchesi
IPC分类号： C12M1/42 , C12M3/06 , C12M1/12 , G01N33/50 , G01N33/543 , C12M1/00 , C12N5/0793 , C12N5/079 , C12N5/071 , C12N5/077
摘要： A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.

32. 发明申请

US20210062129A1 STEM CELL-BASED LUNG-ON-CHIP MODELS 有权
公开(公告)号：US20210062129A1
公开(公告)日：2021-03-04
申请号：US16983850
申请日：2020-08-03
申请人： EMULATE, INC.
发明人： Janna Nawroth , Riccardo Barrile , David Conegliano , Remi Villenave , Carolina Carolina , Justin Nguyen , Antonio Varone , Catherine Karalis , Geraldine Hamilton
IPC分类号： C12M3/06 , C12N5/071 , C12N5/074
摘要： An in vitro microfluidic “organ-on-chip” device is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a stem cell-based Lung-on-Chip is described. This in vitro microfluidic system can be used for modeling differentiation of cells on-chip into lung cells, e.g., a lung (Lung-On-Chip), bronchial (Airway-On-Chip; small-Airway-On-Chip), alveolar sac (Alveolar-On-Chip), etc., for use in modeling disease states of derived tissue, i.e. as healthy, pre-disease and diseased tissues. Additionally, stem cells under differentiation protocols for deriving (producing) differentiated lung cells off-chips may be seeded onto microfluidic devices at any desired point during the in vitro differentiation pathway for further differentiation on-chip or placed on-chip before, during or after terminal differentiation. Additionally, these microfluidic “stem cell-based Lung-on-Chip” allow identification of cells and cellular derived factors driving disease states in addition to drug testing for diseases, infections and for reducing inflammation effecting lung alveolar and/or epithelial regions. Further, fluidic devices are provided seeded with primary alveolar cells for use in providing a functional Type II and Type I cell layer, wherein Type II cells express and secrete surfactants, such as Surfactant B (Surf B; SP-B) and Surfactant C (Surf C; SP-C), which were detectable at the protein level by antibody staining in Type II cells. A number of uses are contemplated for the devices and cells, including but not limited to, for use under inflammatory conditions, in drug development and testing, and for individualized (personalized) medicine. Moreover, an ALI-M was developed for supporting multiple cell types in co-cultures with functional Type II and Type I cells.

33. 发明申请

US20200378956A1 HUMAN MICROPHYSIOLOGICAL CELL SYSTEM FOR LIVER DISEASE CONVERSTION PROV 1-18585 AND PROV 2-19154 审中-公开
公开(公告)号：US20200378956A1
公开(公告)日：2020-12-03
申请号：US16995405
申请日：2020-08-17
申请人： EMULATE, INC.
发明人： Catherine Karalis , Deborah Barrillos Petropolis
IPC分类号： G01N33/50 , C12M3/06 , C12M1/12 , G01N33/92
摘要： The present invention is related to the field of liver disease. Solid substrates comprising microfluidic channels (e.g., microchips) are configured to support growing and differentiating hepatocytes and are contemplated to provide a suitable environment for the development of fully functional liver tissue. These solid substrates can be used to induce various toxicity conditions in the liver tissue subsequent to the exposure to various chemicals. For example, chronic exposure to ethanol induces a clinical state of alcoholic liver disease in the liver tissue. Alternatively, certain disease states can result in the development of non-alcoholic liver diseases (e.g., non- alcoholic steatohepatitis; NASH).

34. 发明申请

US20200087628A1 ADVANCED PULMONARY MODELS 审中-公开
公开(公告)号：US20200087628A1
公开(公告)日：2020-03-19
申请号：US16692383
申请日：2019-11-22
申请人： EMULATE, INC.
发明人： Remi Villenave , Carolina Lucchesi , Justin Nguyen , Catherine Karalis , Geraldine Hamilton
IPC分类号： C12N5/071 , B01L3/00 , C12N1/20
摘要： The present invention relates to microfluidic fluidic systems and methods for the in vitro modeling diseases of the lung and small airway. In one embodiment, the invention relates to a system for testing responses of a microfluidic Small Airway-on-Chip infected with one or more infectious agents (e.g. respiratory viruses) as a model of respiratory disease exacerbation (e.g. asthma exacerbation). In one embodiment, this disease model on a microfluidic chip allows for a) the testing of anti-inflammatory and/or anti-viral compounds introduced into the system, as well as b) the monitoring of the participation, recruitment and/or movement of immune cells, including the transmigration of cells. In particular, this system provides, in one embodiment, an in-vitro platform for modeling severe asthma as “Severe Asthma-on-Chip.” In some embodiments, this invention provides a model of viral-induced asthma in humans for use in identifying potentially effective treatments.

35. 发明申请

US20190119618A1 DEVICES, SYSTEMS AND METHODS FOR INHIBITING INVASION AND METASASES OF CANCER 审中-公开
公开(公告)号：US20190119618A1
公开(公告)日：2019-04-25
申请号：US16089220
申请日：2017-03-30
申请人： EMULATE, INC.
发明人： Geraldine Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
IPC分类号： C12M3/06 , C12M1/12 , G01N33/50 , C12N5/09
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.

36. 发明申请

US20180185844A1 IN VITRO EPITHELIAL MODELS COMPRISING LAMINA PROPRIA-DERIVED CELLS 审中-公开
公开(公告)号：US20180185844A1
公开(公告)日：2018-07-05
申请号：US15819435
申请日：2017-11-21
申请人： EMULATE, Inc.
发明人： S. Jordan Kerns , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Daniel Levner , Carolina Lucchesi , Antonio Varone , Remi Villenave
IPC分类号： B01L3/00 , G01N33/50
摘要： An in vitro microfluidic “organ-on-chip” is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and the associated tissue specific epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory tissue, e.g., autoimmune disorders involving epithelia and diseases involving epithelial layers. These multicellular, layered microfluidic “organ-on-chip”, e.g. “epithelia-on-chip” further allow for comparisons between types of epithelia tissues, e.g., lung (Lung-On-Chip), bronchial (Airway-On-Chip), skin (Skin-On-Chip), cervix (Cervix-On-Chip), blood brain barrier (BBB-On-Chip), etc., in additional to neurovascular tissue, (Brain-On-Chip), and between different disease states of tissue, i.e. healthy, pre-disease and diseased areas. Additionally, these microfluidic “organ-on-chips” allow identification of cells and cellular derived factors driving disease states in addition to drug testing for reducing inflammation effecting epithelial regions.

37. 发明公开

US20240344005A1 DEVICES, SYSTEMS AND METHODS FOR INHIBITING INVASION AND METASTASES OF CANCER 审中-公开
公开(公告)号：US20240344005A1
公开(公告)日：2024-10-17
申请号：US18631480
申请日：2024-04-10
申请人： EMULATE, Inc.
发明人： Geraldine A. Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
IPC分类号： C12M3/06 , C12M1/12 , C12N5/09 , G01N33/50
CPC分类号： C12M23/16 , C12M25/02 , C12N5/0693 , G01N33/5011 , G01N33/5017
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.

38. 发明授权

US12098352B2 Stem cell-based lung-on-chip models 有权
公开(公告)号：US12098352B2
公开(公告)日：2024-09-24
申请号：US16983850
申请日：2020-08-03
申请人： EMULATE, INC.
发明人： Janna Nawroth , Riccardo Barrile , David Conegliano , Remi Villenave , Carolina Lucchesi , Justin Nguyen , Antonio Varone , Catherine Karalis , Geraldine Hamilton
IPC分类号： C12M3/06 , B01L3/00 , C12N5/071 , C12N5/074
CPC分类号： C12M23/16 , B01L3/5027 , C12N5/0688 , C12N5/0696 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/155 , C12N2501/41 , C12N2502/1323 , C12N2502/27 , C12N2503/04 , C12N2506/02 , C12N2513/00 , G01N2800/12
摘要： An in vitro microfluidic “organ-on-chip” device is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a stem cell-based Lung-on-Chip is described. This in vitro microfluidic system can be used for modeling differentiation of cells on-chip into lung cells, e.g., a lung (Lung-On-Chip), bronchial (Airway-On-Chip; small-Airway-On-Chip), alveolar sac (Alveolar-On-Chip), etc., for use in modeling disease states of derived tissue, i.e. as healthy, pre-disease and diseased tissues. Additionally, stem cells under differentiation protocols for deriving (producing) differentiated lung cells off-chips may be seeded onto microfluidic devices at any desired point during the in vitro differentiation pathway for further differentiation on-chip or placed on-chip before, during or after terminal differentiation.

39. 发明公开

US20240299932A1 ORGANS-ON-CHIPS AS A PLATFORM FOR EPIGENETICS DISCOVERY 审中-公开
公开(公告)号：US20240299932A1
公开(公告)日：2024-09-12
申请号：US18659536
申请日：2024-05-09
申请人： EMULATE, INC.
发明人： Catherine Karalis , Ville Kujala
IPC分类号： B01L3/00 , C12M1/12 , C12M3/06 , C12Q1/6809 , G01N33/50
CPC分类号： B01L3/5027 , C12M23/16 , C12Q1/6809 , G01N33/5023 , G01N33/5064 , G01N33/5091 , B01L2300/0819 , B01L2400/0487 , C12M25/02
摘要： The present invention relates to microfluidic fluidic devices, methods and systems for use in identifying epigenetic signatures in a range of sample types, e.g., cells established on a “chip” (including but not limited to single cell samples, cell populations, cell layers and whole tissues, such as a biopsy), immune cells, cfDNA, exosomes, and the like. More specifically, in some embodiments, a microfluidic chip containing a sample is contacted with a test compound (e.g. DNA altering test compound, an RNA expression altering test compound, etc.) for use in providing a diagnostic epigenetic signature for that type of sample (or cell type) exposed to that specific test compound. In some embodiments, after contact with a test compound, effluent fluids (e.g. fluids exiting the “chip” that contacted the cells) are derived for testing as a “virtual blood draw.” In some embodiments, epigenetic signatures include (but are not limited to) identifying specific combinations of modifications of chromosomes and specific modifications of DNA.

40. 发明授权

US11970680B2 Devices, systems and methods for inhibiting invasion and metasases of cancer 有权
公开(公告)号：US11970680B2
公开(公告)日：2024-04-30
申请号：US16089220
申请日：2017-03-30
申请人： EMULATE, INC.
发明人： Geraldine A. Hamilton , Norman Wen , Catherine Karalis , Antonio Varone , Daniel Levner , Riccardo Barrile
IPC分类号： G01N31/00 , C12M1/12 , C12M3/06 , C12N5/09 , G01N33/50 , G01N33/53
CPC分类号： C12M23/16 , C12M25/02 , C12N5/0693 , G01N33/5011 , G01N33/5017
摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and understanding cancer, and, more specifically, for understanding the factors that contribute to cancer invading tissues and causing metastases. Tumor cells are grown on microfluidic devices with other non-cancerous tissues under conditions that simulate tumor invasion. The interaction with immune cells can be tested to inhibit this activity by linking a cancer chip to a lymph chip.

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