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31. 发明申请

US20160256255A9 DESIGN AND METHODS FOR A DEVICE WITH BLOOD FLOW RESTRICTION FEATURE FOR EMBOLUS REMOVAL IN HUMAN VASCULATURE 审中-公开
标题翻译：具有血液流量限制特征的装置的设计和方法，用于人体血管中的移除
公开(公告)号：US20160256255A9
公开(公告)日：2016-09-08
申请号：US14082019
申请日：2013-11-15
申请人： Jianlu Ma
发明人： Jianlu Ma
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61B17/12031 , A61B17/12036 , A61B17/1204 , A61B17/12177 , A61B17/221 , A61B2017/1205 , A61B2017/2212 , A61B2017/2215 , A61F2/013 , A61F2002/015 , A61F2002/018 , A61F2230/0067 , A61F2230/0071
摘要： A mechanical thrombectomy device system is disclosed that is made from a single piece of biocompatible material, including a proximal flow block portion/feature, and/or, a flow block feature in the device body portion, a guidewire like delivery portion and an expandable, treatment portion. The construction of the device from a single piece allows for a seamless transition from the delivery portion to the treatment portion, thus removing any joints or bonding of the two portions together as separate pieces. This improves the strength of the system as a whole and greatly reduces the possibility of the two parts unintentionally detaching from each other. Likewise, the distal treatment portion is cut from a piece of material the same size as the proximal delivery portion, allowing the device to be compacted to a similar size profile giving it delivery advantages including a lower delivery force required and requiring small access systems, and the treatment portion's surface can be altered to enhance embolus affinity by either coating with a substance or changing the texture by mechanical or chemical means.
摘要翻译：公开了一种机械性血栓切除装置系统，其由单件生物相容性材料制成，包括近端流动块部分/特征，和/或装置主体部分中的流动块特征，导丝状输送部分和可扩张的，治疗部分。从单件构造装置允许从输送部分到处理部分的无缝过渡，从而将两个部分的任何接合部或接合部分一起分离成一体。这提高了整个系统的强度，并且大大降低了两个部件无意中彼此分离的可能性。同样地，远端处理部分是从与近端传送部分相同尺寸的一块材料上切割出来的，允许该装置被压实成类似的尺寸轮廓，从而赋予其传送优点，包括所需的较低传送力并且需要小的接入系统，以及治疗部分的表面可以改变以通过用物质涂覆或通过机械或化学方式改变质地来增强栓塞亲和力。

32. 发明申请

US20150196390A1 Device and Method for Mitral Valve Regurgitation Treatment 有权
标题翻译：二尖瓣反流治疗装置及方法
公开(公告)号：US20150196390A1
公开(公告)日：2015-07-16
申请号：US14279511
申请日：2014-05-16
申请人： Jianlu Ma , Yong Huo
发明人： Jianlu Ma , Yong Huo
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2220/0008 , A61F2220/005
摘要： A mitral valve replacement device is adapted to be deployed at a mitral valve position in a human heart. The device has an atrial flange defining an atrial end of the device, a valve body defining a ventricular end of the device, and an annulus support that connects the atrial flange and the valve body, the annulus support including a ring of tabs extending radially therefrom and adapted to engage the native mitral annulus and/or the native leaflet(s) of the human heart. The atrial flange can be seated in the atrium above the native mitral valve annulus in a human heart, and the ring of tabs can engage the native mitral annulus in a manner where the atrial flange and tabs provide a clipping effect to secure the mitral valve replacement device at the native mitral valve position
摘要翻译：二尖瓣置换装置适于部署在人心脏的二尖瓣位置。该装置具有限定装置的心房端的心房凸缘，限定该装置的心室端的阀体以及连接心房凸缘和阀体的环形支撑件，该环形支撑件包括从其径向延伸的突出环并且适于接合人心脏的天然二尖瓣环和/或天然小叶。心房法兰可以位于人心脏上的原生二尖瓣环上方的心房中，并且突出环可以以这样的方式与天然二尖瓣环接合，其中心房法兰和翼片提供夹紧效果以确保二尖瓣置换装置在二尖瓣的位置

33. 发明授权

US09028540B2 Vascular stent with improved vessel wall apposition 有权
标题翻译：血管支架具有改善的血管壁并置
公开(公告)号：US09028540B2
公开(公告)日：2015-05-12
申请号：US13428822
申请日：2012-03-23
申请人： John Wainwright , Jianlu Ma , Michael Louis Losordo
发明人： John Wainwright , Jianlu Ma , Michael Louis Losordo
IPC分类号： A61F2/82 , A61F2/95 , A61F2/915 , A61F2/92
CPC分类号： A61F2/915 , A61B17/12031 , A61B17/12118 , A61B17/1214 , A61F2/848 , A61F2/92 , A61F2/95 , A61F2002/823 , A61F2002/9155 , A61F2002/91575 , A61F2002/9505 , A61F2002/9511 , A61F2002/9528 , A61F2002/9534 , A61F2230/0054 , A61F2250/0036
摘要： A medical device is provided. The medical device includes a vessel-engaging member attached to a distal end of a delivery wire via a connection mechanism. The vessel-engaging member includes a plurality of rows and a plurality of bridges positioned between each adjacent row, each of the bridges connecting a vertex of a first row with a corresponding vertex of a second row. The vessel-engaging member further includes first and second tapered sections coupled to the connection mechanism, each of the tapered sections projecting from a proximal row and tapering in a direction from the proximal row toward the connection mechanism, each of the tapered sections having a length measured along a longitudinal axis, wherein the length of the first tapered section is less than the length of the second tapered section.
摘要翻译：提供医疗设备。医疗装置包括通过连接机构附接到输送线的远端的容器接合构件。容器接合构件包括多个行和位于每个相邻行之间的多个桥，每个桥将第一行的顶点与第二行的对应顶点相连接。容器接合构件还包括联接到连接机构的第一和第二锥形部分，每个锥形部分从近侧排突出，并且在从近侧列朝向连接机构的方向上逐渐变细，每个锥形部分具有长度沿着纵向轴线测量，其中第一锥形部分的长度小于第二锥形部分的长度。

34. 发明申请

US20120296361A1 VASCULAR REMODELING DEVICE 有权
标题翻译：血管再造装置
公开(公告)号：US20120296361A1
公开(公告)日：2012-11-22
申请号：US13473832
申请日：2012-05-17
申请人： Anh CAM , Michael Louis Losordo , Jianlu Ma , Victoria Schuman , Xiaoling Zhao
发明人： Anh CAM , Michael Louis Losordo , Jianlu Ma , Victoria Schuman , Xiaoling Zhao
IPC分类号： A61M29/00 , A61F2/82
CPC分类号： A61B17/1214 , A61B17/12118 , A61F2/852 , A61F2/856 , A61F2/954 , A61F2002/823 , A61F2002/826 , A61F2230/005 , A61F2230/0067 , A61F2230/0097 , A61F2250/0023
摘要： A vascular remodeling device and methods for its use are provided. The device can be positionable at a junction of a bifurcation having an aneurysm and that defines afferent and efferent vessels. Ends of the device can be at least partially inserted into the aneurysm or can anchor the device by being at least partially inserted into efferent vessels. The device can act as a scaffolding to inhibit dislodging of objects out of the aneurysm. The device can permit perfusion to the efferent vessels. Embolic material can be inserted in the aneurysm before, during, and/or after positioning the device.
摘要翻译：提供血管重塑装置及其使用方法。该装置可以定位在具有动脉瘤的分叉的交界处并且定义传入和传出血管。装置的端部可以至少部分地插入动脉瘤中，或者可以通过至少部分地插入到传出血管中来锚定装置。该装置可以作为脚手架来抑制物体从动脉瘤的移动。该装置可以允许对输出血管灌注。栓塞材料可以在设备定位之前，期间和/或之后插入动脉瘤中。

35. 发明申请

US20120290067A1 VASCULAR REMODELING DEVICE 有权
标题翻译：血管再造装置
公开(公告)号：US20120290067A1
公开(公告)日：2012-11-15
申请号：US13469214
申请日：2012-05-11
申请人： Anh Cam , Michael Louis Losordo , Jianlu Ma , Xiaoling Zhao
发明人： Anh Cam , Michael Louis Losordo , Jianlu Ma , Xiaoling Zhao
IPC分类号： A61F2/94 , B23P17/00 , A61F2/84
CPC分类号： A61B17/12118 , A61B17/12031 , A61B17/1214 , A61B17/12172 , A61F2/07 , A61F2/844 , A61F2/86 , A61F2/90 , A61F2/915 , A61F2/95 , A61F2/954 , A61F2/966 , A61F2002/077 , A61F2002/821 , A61F2002/823 , A61F2230/0076 , A61F2240/001 , A61F2250/0039 , Y10T29/4998
摘要： Described herein are flexible implantable devices or stents that can conform to the shape of vessels of the neurovasculature. In some embodiments, the devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. In some embodiments, a vascular remodeling device includes a first section and a protruding section. During deployment, the device expands from a compressed configuration to an expanded configuration. The first section anchors the device in an afferent vessel and/or in an efferent vessel of a bifurcation and the protruding section is positioned in the junction of the bifurcation having an aneurysm and across the neck of the aneurysm or at least partially within the aneurysm.
摘要翻译：这里描述的是可以符合神经血管系统血管形状的柔性可植入装置或支架。在一些实施例中，装置可引导血管内的血流远离动脉瘤或限制血液流动到动脉瘤。在一些实施方案中，血管重建装置包括第一部分和突出部分。在部署期间，设备将从压缩配置扩展到扩展配置。第一部分将装置固定在传入血管和/或分叉的输出容器中，并且突出部分位于具有动脉瘤并且跨越动脉瘤颈部或至少部分在动脉瘤内的分叉的交界处。

36. 发明申请

US20070293930A1 IMPLANT AND DELIVERY SYSTEM WITH MULTIPLE MARKER INTERLOCKS 有权
标题翻译：具有多个标记交错的植入和传送系统
公开(公告)号：US20070293930A1
公开(公告)日：2007-12-20
申请号：US11748235
申请日：2007-05-14
申请人： Lixiao Wang , Jianlu Ma , Joe Tatalovich , Peggy Waltz , Keith Smythe , Rich Kusleika
发明人： Lixiao Wang , Jianlu Ma , Joe Tatalovich , Peggy Waltz , Keith Smythe , Rich Kusleika
IPC分类号： A61F2/06
CPC分类号： A61F2/962 , A61F2/91 , A61F2/915 , A61F2/95 , A61F2002/91541 , A61F2002/91558 , A61F2002/91591 , A61F2002/9522 , A61F2002/9665 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2250/0098
摘要： An implant delivery system has one or more interlock assemblies which connect the implant delivery catheter to the implant, an improved inner tubular member and an outer tubular member. The interlock assemblies, improved inner tubular member and outer tubular member cooperate to place the implant in tension during deployment, thereby reducing implant deployment force.
摘要翻译：植入物递送系统具有将植入物输送导管连接到植入物的一个或多个互锁组件，改进的内部管状构件和外部管状构件。联锁组件，改进的内部管状构件和外部管状构件协调以在展开期间使植入物处于张力状态，从而减少植入物展开力。

37. 发明申请

US20070289677A1 IMPLANT HAVING HIGH FATIGUE RESISTANCE, DELIVERY SYSTEM, AND METHOD OF USE 有权
标题翻译：具有高耐疲劳性，输送系统和使用方法的植入物
公开(公告)号：US20070289677A1
公开(公告)日：2007-12-20
申请号：US11764336
申请日：2007-06-18
申请人： Jianlu Ma , Joe Tatalovich , Lixiao Wang , Xiaoling Zhao , Dan Ranum
发明人： Jianlu Ma , Joe Tatalovich , Lixiao Wang , Xiaoling Zhao , Dan Ranum
IPC分类号： A61F2/92 , A61F2/90 , A61F2/82 , C22F1/10
CPC分类号： A61F2/86 , A61F2/89 , A61F2/91 , A61F2/966 , A61F2210/0004 , A61F2220/0041 , A61F2250/0071 , A61L31/022 , C21D1/00 , C22C19/03 , C22F1/10
摘要： According to one aspect of the present invention, a fatigue resistant stent comprises a flexible tubular structure having an inside diameter, an outside diameter, and a sidewall therebetween and having apertures extending through the sidewall. According to other aspects of the invention, processes for making a fatigue resistant stent are disclosed. According to further aspects of the invention, delivery systems for a fatigue resistant stent and methods of use are provided.
摘要翻译：根据本发明的一个方面，耐疲劳支架包括具有内径，外径和侧壁的柔性管状结构，并且具有延伸穿过侧壁的孔。根据本发明的其它方面，公开了制造耐疲劳支架的方法。根据本发明的另一方面，提供了一种用于耐疲劳支架的输送系统和使用方法。

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