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31. 发明申请

US20110135632A1 METHODS FOR THE MODULATION OF ANGIOGENESIS 有权
标题翻译：血管生成调节方法
公开(公告)号：US20110135632A1
公开(公告)日：2011-06-09
申请号：US12999746
申请日：2009-06-19
申请人： Donald E. Ingber , Akiko Mammoto
发明人： Donald E. Ingber , Akiko Mammoto
IPC分类号： A61K39/395 , A61K31/7088 , A61K38/00 , A61P35/00 , A61P3/10 , A61P27/02 , A61P19/02 , A61P25/28 , A61P3/04 , A61P17/06 , A61P9/00 , A61P17/02
CPC分类号： C12N15/113 , A61K31/7088 , A61K45/06 , C12N2310/14
摘要： The present invention relates to methods and compositions of promoting or inhibiting capillary endothelial (CE) cell migration, promoting or inhibiting the formation of CE networks and promoting or inhibiting angiogenesis, and uses thereof. In particular, the present invention relates to methods and compositions for promoting capillary endothelial (CE) cell migration, promoting the formation of CE networks and promoting angiogenesis, and uses thereof for the purposes of treating angiogenesis-related disorders characterized by loss or decreased angiogenesis, such as ischemic injury and the like. One aspect of the invention related to use of at least one pro-angiogenic agent selected from at least one of an p190RhoGAP inhibitor, a TFII-I inhibitor or a GATA-2 activator for promoting the formation of CE networks and promoting angiogenesis, and uses thereof for the purposes of treating angiogenesis-related disorders characterized by loss or decreased angiogenesis. Another aspect of the invention related to use of at least one anti-angiogenic agent selected from at least one of an p190RhoGAP activator, a TFII-I activator or a GATA-2 inhibitor for inhibiting the formation of CE networks and inhibiting angiogenesis, and uses thereof for the purposes of treating angiogenesis-related disorders characterized by uncontrolled or elevated angiogenesis.
摘要翻译：本发明涉及促进或抑制毛细血管内皮细胞迁移，促进或抑制CE网络形成和促进或抑制血管发生的方法和组合物及其用途。特别地，本发明涉及用于促进毛细血管内皮细胞迁移，促进CE网络的形成和促进血管发生的方法和组合物及其用于治疗以血管生成减少或减少为特征的血管生成相关病症的用途，例如缺血性损伤等。本发明的一个方面涉及使用选自p190RhoGAP抑制剂，TFII-1抑制剂或GATA-2激活剂中的至少一种的至少一种促血管生成剂来促进CE网络的形成和促进血管生成，以及使用其用于治疗以血管生成丧失或减少为特征的血管生成相关病症的目的。本发明的另一方面涉及使用选自p190RhoGAP激活剂，TFII-1激活剂或GATA-2抑制剂中的至少一种的至少一种抗血管生成剂来抑制CE网络的形成和抑制血管生成，以及使用以治疗以不受控制或升高的血管发生为特征的血管发生相关疾病的目的。

32. 发明申请

US20090078614A1 METHOD AND APPARATUS FOR SEPARATING PARTICLES, CELLS, MOLECULES AND PARTICULATES 有权
标题翻译：分离颗粒，细胞，分子和颗粒的方法和装置
公开(公告)号：US20090078614A1
公开(公告)日：2009-03-26
申请号：US12105805
申请日：2008-04-18
申请人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
发明人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
IPC分类号： B07C5/344
CPC分类号： B03C1/0332 , B03C2201/18 , B03C2201/26 , Y10T436/2575
摘要： A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.
摘要翻译：一种用于连续分离或浓缩颗粒的方法和装置，其包括使层流中的两种流体流过导致目标颗粒迁移到废液流的磁场梯度，以及在流过磁场梯度之后收集每个流体流。

33. 发明申请

US20090011493A1 DEVICE CONTAINING CYTOPHILIC ISLANDS THAT ADHERE CELLS SEPARATED BY CYTOPHOBIC REGIONS 失效
标题翻译：含有CYPOPHOBIC区域分离细胞的胞质岛的装置
公开(公告)号：US20090011493A1
公开(公告)日：2009-01-08
申请号：US12166287
申请日：2008-07-01
申请人： Rahul Singhvi , Amit Kumar , George M. Whitesides , Donald E. Ingber , Gabriel P. Lopez , Daniel I. C. Wang , Gregory N. Stephanopoulos
发明人： Rahul Singhvi , Amit Kumar , George M. Whitesides , Donald E. Ingber , Gabriel P. Lopez , Daniel I. C. Wang , Gregory N. Stephanopoulos
IPC分类号： C12M1/00
CPC分类号： C12N1/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00385 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B81B2201/0214 , B81C1/00206 , B81C2201/034 , B82Y5/00 , B82Y30/00 , C12N5/0068 , C12N5/067 , C12N2535/10 , C12Q1/02 , C40B60/14
摘要： The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).
摘要翻译：本发明提供一种用于将细胞粘附在特定和预定位置的装置以及相关方法。该装置包括限定表面的板和多个细胞亲和岛，其附着细胞，由细胞不粘附的细胞渗透区隔离，与细胞色素岛邻接。岛或区域或两者可以由自组装单层（SAM）形成。

34. 发明申请

US20080145908A1 Selective deposition of materials on contoured surfaces 审中-公开
公开(公告)号：US20080145908A1
公开(公告)日：2008-06-19
申请号：US11901277
申请日：2007-09-14
申请人： Emanuele Ostuni , Christopher S. Chen , Donald E. Ingber , George M. Whitesides
发明人： Emanuele Ostuni , Christopher S. Chen , Donald E. Ingber , George M. Whitesides
IPC分类号： C12N11/08
CPC分类号： B01L3/5085 , B01J2219/00317 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00637 , B01J2219/00659 , B01J2219/00743 , B01L3/5088 , C12N11/08 , Y10S530/812 , Y10S530/815
摘要： The present invention is directed to a method of patterning materials, such as proteins, on a contoured surface by depositing them onto protrusions on the surface and to a cell containment device that may be constructed by this method. In one embodiment, the present invention is directed to a method of selectively depositing a material on a substrate including a contoured surface including a protrusion and a recess. The method includes applying a first fluid to the contoured surface of the substrate and allowing the first fluid to distribute across a portion of the contoured surface such that the first fluid contacts the protrusion and not the recess. The method also includes allowing a first material to deposit on the substrate where the substrate is in contact with the first fluid. Optionally, this method may further include applying a second fluid to the contoured surface of the substrate, allowing the second fluid to distribute across a portion of the contoured surface such that the second fluid contacts the recess, and allowing a second material to deposit on the substrate where the substrate is in contact with the second fluid. Optionally, the method may still further include applying a third fluid to the contoured surface of the substrate, allowing the third fluid to distribute across a portion of the contoured surface, and allowing a third material with an affinity for one of the first material and the second material to deposit on the substrate only where the one of the first material and the second material is deposited. In one embodiment of this method the first material is a cytophobic material, the second material is a cytophilic material and the third material is a cell.In another embodiment, the present invention is directed to a cell containment device, including a substrate having a contoured surface, a recess in the surface of the substrate, a cytophobic material connected to the surface of the substrate outside the recess and a cytophilic material connected to the recess.

35. 发明授权

US06653089B2 Differential treatment of selected parts of a single cell with different fluid components 有权
公开(公告)号：US06653089B2
公开(公告)日：2003-11-25
申请号：US09954978
申请日：2001-09-18
申请人： Shuichi Takayama , Emanuele Ostuni , Philip LeDuc , Keiji Naruse , Donald E. Ingber , George M. Whitesides
发明人： Shuichi Takayama , Emanuele Ostuni , Philip LeDuc , Keiji Naruse , Donald E. Ingber , George M. Whitesides
IPC分类号： G01N3353
CPC分类号： G01N33/5011 , A61K35/12 , C12N5/00 , C12N5/069 , C12N2501/48 , C12N2501/58 , C12N2503/00 , C12N2503/02 , C12N2510/00 , G01N33/5008 , G01N33/502 , G01N33/5035 , G01N33/5076 , G01N33/5079 , G01N33/528 , G01N2800/52
摘要： The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a single cell, and able, in certain embodiments, to establish long-term gradients of active substances within subcellular regions of a single cell. The present invention provides, in some embodiments, techniques for selectively contacting a portion of the surface of a biological cell with a fluid or fluid component carrying a particular potential for a biophysical or biochemical interaction with the cell, and simultaneously contacting a different portion of the surface of the cell with another fluid or fluid component having a different potential for the biophysical or biochemical interaction with the cell.

36. 发明授权

US10655098B2 Cell culture system 有权
公开(公告)号：US10655098B2
公开(公告)日：2020-05-19
申请号：US14001838
申请日：2012-02-28
申请人： Donald E. Ingber , Hyun Jung Kim
发明人： Donald E. Ingber , Hyun Jung Kim
IPC分类号： C12M3/00 , C12M1/00 , C12M1/12 , C12M1/34 , C12M1/24 , C12M1/06
摘要： The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora.

37. 发明授权

US08722638B2 Methods for the modulation of angiogenesis 有权
标题翻译：调节血管发生的方法
公开(公告)号：US08722638B2
公开(公告)日：2014-05-13
申请号：US12999746
申请日：2009-06-19
申请人： Donald E. Ingber , Akiko Mammoto
发明人： Donald E. Ingber , Akiko Mammoto
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/113 , A61K31/7088 , A61K45/06 , C12N2310/14
摘要： The present invention relates to methods and compositions for promoting or inhibiting capillary endothelial (CE) cell migration, promoting or inhibiting the formation of CE networks and promoting or inhibiting angiogenesis. Some embodiments relate to methods and compositions for treating angiogenesis-related disorders characterized by loss or decreased angiogenesis. One aspect relates to the use of at least one pro-angiogenic agent selected from at least one of an p190RhoGAP inhibitor, a TFII-I inhibitor or a GATA-2 activator for promoting the formation of CE networks and angiogenesis, and methods for treating angiogenesis-related disorders characterized by loss or decreased angiogenesis. Another aspect of the invention related to use of at least one anti-angiogenic agent selected from at least one of an p190RhoGAP activator, a TFII-I activator or a GATA-2 inhibitor for inhibiting the formation of CE networks and inhibiting angiogenesis, and methods for treating angiogenesis-related disorders characterized by uncontrolled or elevated angiogenesis.
摘要翻译：本发明涉及用于促进或抑制毛细血管内皮细胞迁移，促进或抑制CE网络形成和促进或抑制血管发生的方法和组合物。一些实施方案涉及用于治疗以血管生成减少或减少为特征的血管生成相关病症的方法和组合物。一方面涉及使用至少一种选自p190RhoGAP抑制剂，TFII-1抑制剂或GATA-2激活剂中的至少一种的促血管生成剂来促进CE网络和血管生成的形成，以及用于治疗血管发生的方法以血管生成减少或减少为特征的相关疾病。本发明的另一方面涉及使用选自p190RhoGAP激活剂，TFII-1激活剂或GATA-2抑制剂中的至少一种的至少一种抗血管生成剂来抑制CE网络的形成和抑制血管生成，以及方法用于治疗以不受控制或升高的血管发生为特征的血管发生相关疾病。

38. 发明授权

US08647861B2 Organ mimic device with microchannels and methods of use and manufacturing thereof 有权
标题翻译：具有微通道的器官模拟装置及其使用和制造方法
公开(公告)号：US08647861B2
公开(公告)日：2014-02-11
申请号：US13054095
申请日：2009-07-16
申请人： Donald E. Ingber , Dongeun Huh
发明人： Donald E. Ingber , Dongeun Huh
IPC分类号： C12M1/00
CPC分类号： C12M23/16 , B01L3/5027 , B01L3/50273 , B01L2200/0663 , B01L2300/0854 , B01L2300/0877 , B01L2300/0887 , B01L2300/163 , B01L2400/0472 , B01L2400/0481 , B01L2400/0487 , C12M21/08 , C12M23/58 , C12M25/02 , C12M29/10 , C12N5/0606 , C12N5/061 , C12N5/0623 , C12N5/0647 , C12N5/0654 , C12N5/0662 , C12N5/0671 , C12N5/0688 , C12N5/0696 , C12N5/0697 , G01N33/5005 , G01N33/5088 , G01N33/5091
摘要： System and method includes a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more parallel central microchannels, wherein one or more first fluids are applied through the first central microchannel and one or more second fluids are applied through the second or more central microchannels. The surfaces of each porous membrane can be coated with cell adhesive molecules to support the attachment of cells and promote their organization into tissues on the upper and lower surface of the membrane. The pores may be large enough to only permit exchange of gases and small chemicals, or to permit migration and transchannel passage of large proteins and whole living cells. Fluid pressure, flow and channel geometry also may be varied to apply a desired mechanical force to one or both tissue layers.
摘要翻译：系统和方法包括具有由一个或多个多孔膜分离的中心微通道的主体。膜构造成将中心微通道分成两个或更多个平行的中央微通道，其中一个或多个第一流体通过第一中心微通道施加，并且一个或多个第二流体通过第二或更多个中心微通道施加。每个多孔膜的表面可以涂覆有细胞粘附分子以支持细胞的附着并促进它们组织在膜的上表面和下表面上的组织中。毛孔可能足够大，仅允许气体和小化学物质的交换，或允许大蛋白质和整个活细胞的迁移和经通道通过。流体压力，流动和通道几何形状也可以变化，以将所需的机械力施加到一个或两个组织层。

39. 发明申请

US20130295012A1 SHEAR CONTROLLED RELEASE FOR STENOTIC LESIONS AND THROMBOLYTIC THERAPIES 审中-公开
标题翻译：剪切控制释放用于椎间盘突出症和血栓治疗
公开(公告)号：US20130295012A1
公开(公告)日：2013-11-07
申请号：US13816763
申请日：2011-08-30
申请人： Donald E. Ingber , Netanel Korin , Mathumai Kanapathipillai
发明人： Donald E. Ingber , Netanel Korin , Mathumai Kanapathipillai
IPC分类号： A61K38/02 , A61K31/721
CPC分类号： A61K38/02 , A61K9/1617 , A61K9/5153 , A61K31/721 , A61K38/49 , Y02A50/411
摘要： The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.
摘要翻译：本发明提供了用于治疗或成像狭窄，狭窄病变，闭塞腔，栓塞现象或血栓形成障碍的组合物和方法。本发明还提供了治疗内部出血的组合物和方法。

40. 发明申请

US20130287836A1 HIGH STRENGTH CHITIN COMPOSITE MATERIAL AND METHOD OF MAKING 有权
标题翻译：高强度复合材料及其制备方法
公开(公告)号：US20130287836A1
公开(公告)日：2013-10-31
申请号：US13819391
申请日：2011-08-30
申请人： Donald E. Ingber , Javier Gomez Fernandez
发明人： Donald E. Ingber , Javier Gomez Fernandez
IPC分类号： A61L15/22 , B05D3/10
CPC分类号： A61L27/24 , A61L15/225 , A61L15/28 , A61L15/325 , A61L15/38 , A61L15/425 , A61L15/44 , A61L15/52 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/48 , A61L27/54 , A61L27/56 , B05D3/104 , C08L1/02 , C08L3/02 , C08L5/00 , C08L5/08 , C08L5/10 , C08L89/00
摘要： The present invention is directed to a composite laminar material with high mechanical strength and methods of fabricating the material. The invention also provides a method of attaching a medical implant device to tissue.
摘要翻译：本发明涉及一种具有高机械强度的复合层状材料及其制造方法。本发明还提供了将医疗植入装置附接到组织的方法。

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