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31. 发明授权

US07121531B1 Gate with lock housing 有权
标题翻译：带锁壳的门
公开(公告)号：US07121531B1
公开(公告)日：2006-10-17
申请号：US11015637
申请日：2004-12-20
申请人： Jesus Gonzalez
发明人： Jesus Gonzalez
IPC分类号： E04H17/16
CPC分类号： E05B65/0007 , E05B17/2084 , E06B11/02 , Y10T70/7915 , Y10T70/7921
摘要： A gate assembly with moving gate members with one pivoting end and a moving end. This moving end includes upper and lower tubular members that receive the ends of a protruding reinforcement member mounted to a housing for the locking hardware. The ends of the protruding reinforcement member extend internally a sufficient distance to enhance the structural integrity of the moving end. The reinforcement member readily aligns the housing with the tubular members of the moving end and provides a sturdy structure that is tamper proof. Through openings in the walls of the housing cooperate to permit the operation of the locking hardware.
摘要翻译：具有移动门构件的门组件，具有一个枢转端和移动端。该移动端包括上和下管状构件，其接收安装到用于锁定硬件的壳体的突出加强构件的端部。突出的加强构件的端部在内部延伸足够的距离以增强移动端的结构完整性。加强构件容易地将壳体与移动端的管状构件对准并且提供防篡改的坚固结构。通过壳体的壁中的开口协作以允许锁定硬件的操作。

32. 外观设计

USD420624S Wheeled trainer for skating 失效
公开(公告)号：USD420624S
公开(公告)日：2000-02-15
申请号：US100150
申请日：1999-02-05
申请人： Jesus Gonzalez
设计人： Jesus Gonzalez

33. 发明授权

US09278144B2 Selective delivery molecules and methods of use 有权
标题翻译：选择性递送分子和使用方法
公开(公告)号：US09278144B2
公开(公告)日：2016-03-08
申请号：US14235522
申请日：2012-07-27
申请人： Junjie Liu , Jesus Gonzalez
发明人： Junjie Liu , Jesus Gonzalez
IPC分类号： A61K38/00 , A61K49/00 , C07K7/08
CPC分类号： C07K7/08 , A61K38/00 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0054 , A61K49/0056 , C07K14/435 , G01N21/6428 , G01N33/574 , G01N33/582 , G01N2021/6432 , G01N2021/6439
摘要： Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
摘要翻译：本文公开了一种选择性递送分子，其包含：（a）有效抑制或阻止摄入细胞或组织滞留的酸性序列（部分A），（b）分子转运或保留序列（部分B）和（ c）部分A和部分B之间的接头，和（d）至少一个货物部分。

34. 发明授权

US08505656B1 Automotive hauling system 有权
标题翻译：汽车拖运系统
公开(公告)号：US08505656B1
公开(公告)日：2013-08-13
申请号：US13776955
申请日：2013-02-26
申请人： Jesus Gonzalez
发明人： Jesus Gonzalez
IPC分类号： B62D61/10
CPC分类号： B62D7/144
摘要： The present invention features an automobile hauling system for improved maneuverability and hauling capacity for a tractor and trailer combination used to transport automobiles. The system features a cab-over automobile hauling tractor having an extended wheelbase frame with first and second side notches. The tractor features a first steering axle assembly, a second steering axle assembly, and an h-link. A pitman arm first end is located on a steering box and a pitman arm second end is pivotally located on a first drag link. The tractor features a supplemental axle assembly and a drive axle assembly located on the frame bottom. The system features an automobile hauling trailer pivotally located on the frame top side.
摘要翻译：本发明的特征在于一种用于提高用于运输汽车的拖拉机和拖车组合的机动性和牵引能力的汽车牵引系统。该系统具有驾驶室牵引拖拉机，其具有带有第一和第二侧槽口的延长的轴距框架。拖拉机具有第一转向轴组件，第二转向轴组件和h型连杆。一个坑手臂的第一端位于一个转向箱上，一个坑手臂的第二端枢转地位于一个第一拖链上。拖拉机具有补充轴组件和位于框架底部的驱动桥组件。该系统具有枢转地位于框架顶侧的汽车牵引拖车。

35. 发明授权

US07201902B2 Production of recombinant protein pap 31 for the diagnosis and prevention of Bartonella bacilliformis infection 有权
标题翻译：生产重组蛋白pap 31用于诊断和预防杆菌B型杆菌感染
公开(公告)号：US07201902B2
公开(公告)日：2007-04-10
申请号：US11239444
申请日：2005-09-23
申请人： Wei-Mei Ching , Laura Hendrix , Jesus Gonzalez
发明人： Wei-Mei Ching , Laura Hendrix , Jesus Gonzalez
IPC分类号： A61K39/12
CPC分类号： G01N33/56911 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K14/195 , C12N2795/10022 , G01N2469/20
摘要： The invention relates to a recombinant DNA and polypeptide sequence of an immuno-dominant phage particle associated protein from Bartonella bacilliformis. The recombinant protein is easily produced permitting the conduct of more accurate and rapid diagnositic assays for the detection of B. bacilliformis infection with reduced reagent and equipment requirements over that required by currently available methods of diagnosis. The DNA and polypeptide sequence is also useful in vaccine preparations against B. bacilliformis.
摘要翻译：本发明涉及来自巴氏杆菌的免疫显性噬菌体颗粒相关蛋白的重组DNA和多肽序列。重组蛋白质容易生产，允许进行更精确和快速的诊断测定用于检测杆菌感染，其具有比当前可用的诊断方法所需的试剂和设备要求更低的试剂和设备要求。 DNA和多肽序列也可用于针对杆菌杆菌的疫苗制剂。

36. 发明申请

US20070026384A1 Detection of transmembrane potentials by optical methods 有权
标题翻译：通过光学方法检测跨膜电位
公开(公告)号：US20070026384A1
公开(公告)日：2007-02-01
申请号：US11529838
申请日：2006-09-29
申请人： Roger Tsien , Jesus Gonzalez
发明人： Roger Tsien , Jesus Gonzalez
IPC分类号： C12Q1/00 , G01N33/53 , C07K14/47 , C07K16/46 , C07D403/02
CPC分类号： G01N33/502 , C07D209/08 , C07D239/60 , C07D239/62 , C07D239/66 , C07D311/16 , C07F5/003 , C07F5/02 , C07F5/027 , C07F9/10 , C07F9/5728 , C09B23/02 , G01N33/5005 , G01N33/5008 , G01N33/5044 , G01N33/5058 , G01N33/5076 , G01N33/52 , G01N33/542 , G01N33/582 , G01N33/6872 , G01N2500/10 , Y10S436/80
摘要： Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: (a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first face of the membrane to a second face of the membrane in response to changes in the potential of the membrane, as described by the Nernst equation, (b) introducing a second reagent which labels the first face or the second face of the membrane, which second reagent comprises a chromophore capable of undergoing energy transfer by either (i) donating excited state energy to the fluorescent ion, or (ii) accepting excited state energy from the fluorescent ion, (c) exposing the membrane to radiation; (d) measuring energy transfer between the fluorescent ion and the second reagent, and (e) relating the energy transfer to the membrane potential. Energy transfer is typically measured by fluorescence resonance energy transfer. In some embodiments the first and second reagents are bound together by a suitable linker. In one aspect the method is used to identify compounds which modulate membrane potentials in biological membranes.
摘要翻译：提供了用于确定膜的电位的方法和组合物。一方面，该方法包括：（a）如所描述的那样，引入包含能够从膜的第一面重新分布到膜的第二面的疏水性荧光离子的第一试剂，以响应膜的电位变化通过能斯特方程，（b）引入标记膜的第一面或第二面的第二试剂，该第二试剂包含能够通过（i）向荧光离子提供激发态能而进行能量转移的发色团，或（ii）从荧光离子接受激发态能量，（c）将膜暴露于辐射; （d）测量荧光离子和第二试剂之间的能量转移，和（e）将能量转移与膜电位相关联。能量转移通常通过荧光共振能量转移来测量。在一些实施方案中，第一和第二试剂通过合适的接头结合在一起。在一个方面，该方法用于鉴定调节生物膜中膜电位的化合物。

37. 发明申请

US20060281069A1 Ion channel assay methods 有权
公开(公告)号：US20060281069A1
公开(公告)日：2006-12-14
申请号：US11444214
申请日：2006-05-31
申请人： Michael Maher , Jesus Gonzalez
发明人： Michael Maher , Jesus Gonzalez
IPC分类号： C12Q1/00 , G01N33/567 , G01N33/53
CPC分类号： G01N33/5038 , G01N33/48728 , G01N33/5008 , G01N33/5076 , G01N33/5088 , G01N33/542 , G01N33/6872
摘要： A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.

38. 发明申请

US20060216689A1 Ion channel assay methods 有权
公开(公告)号：US20060216689A1
公开(公告)日：2006-09-28
申请号：US11443721
申请日：2006-05-31
申请人： Michael Maher , Jesus Gonzalez
发明人： Michael Maher , Jesus Gonzalez
IPC分类号： C12Q1/00
CPC分类号： G01N33/542 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5058 , G01N33/5061 , G01N33/5076 , G01N33/5088 , G01N33/6872
摘要： A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.

39. 发明申请

US20060067945A1 Production of recombinant protein pap 31 for the diagnosis and prevention of Bartonella bacilliformis infection 有权
标题翻译：生产重组蛋白pap 31用于诊断和预防杆菌B型杆菌感染
公开(公告)号：US20060067945A1
公开(公告)日：2006-03-30
申请号：US11239444
申请日：2005-09-23
申请人： Wei-Mei Ching , Laura Hendrix , Jesus Gonzalez
发明人： Wei-Mei Ching , Laura Hendrix , Jesus Gonzalez
IPC分类号： A61K39/02 , G01N33/554 , C07H21/04 , C12N15/74 , G01N33/569 , C07K14/195 , C07K14/005
CPC分类号： G01N33/56911 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K14/195 , C12N2795/10022 , G01N2469/20
摘要： The invention relates to a recombinant DNA and polypeptide sequence of an immuno-dominant phage particle associated protein from Bartonella bacilliformis. The recombinant protein is easily produced permitting the conduct of more accurate and rapid diagnositic assays for the detection of B. bacilliformis infection with reduced reagent and equipment requirements over that required by currently available methods of diagnosis. The DNA and polypeptide sequence is also useful in vaccine preparations against B. bacilliformis.
摘要翻译：本发明涉及来自巴氏杆菌的免疫显性噬菌体颗粒相关蛋白的重组DNA和多肽序列。重组蛋白质容易生产，允许进行更精确和快速的诊断测定用于检测杆菌感染，其具有比当前可用的诊断方法所需的试剂和设备要求更低的试剂和设备要求。 DNA和多肽序列也可用于针对杆菌杆菌的疫苗制剂。

40. 发明授权

US06907210B2 Remanufactured toner cartridge having modified roller section 失效
标题翻译：具有改性滚筒部分的再制造墨粉盒
公开(公告)号：US06907210B2
公开(公告)日：2005-06-14
申请号：US10660918
申请日：2003-09-13
申请人： Yoel Wazana , Jesus Gonzalez
发明人： Yoel Wazana , Jesus Gonzalez
IPC分类号： G03G20060101 , G03G11/00 , G03G15/00 , G03G15/08 , G03G21/00
CPC分类号： G03G15/0894 , G03G15/0812 , G03G2215/0634
摘要： A remanufactured laser printer toner cartridge incorporates a used doctor blade and/or a used wiper blade. The used doctor blade has been adapted and oriented to make contact with a developer roller or a magnetic roller along a previously unused portion of the doctor blade's metering surface to utilize a new fresh metering surface. The used wiper blade has been adapted and oriented to make contact with a photoconductive drum along a previously unused portion of the wiper blade's wiping surface to utilize a new fresh wiping surface. The invention extends the effective life of doctor blades and wiper blades by utilizing previously unused working surfaces.It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not to be used to interpret or limit the scope or meaning of the claims.
摘要翻译：再制造的激光打印机墨粉盒包括用过的刮刀和/或用过的刮片。所使用的刮刀已经被适配和定向成沿着刮刀的计量表面的先前未使用的部分与显影辊或磁性辊接触，以利用新的新的计量表面。所使用的刮水片已经被适配和定向成沿着刮水片的擦拭表面的先前未使用的部分与感光鼓接触以利用新的新的擦拭表面。本发明通过利用以前未使用的工作表面来延长刮刀和刮水片的寿命。要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。提交它的理解是，它不会被用于解释或限制权利要求的范围或含义。

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