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31. 发明申请

US20050059800A1 Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl 失效
标题翻译：制备（1R，2S，5S）-3-氮杂双环[3,1,0]己烷-2-甲酰胺，N- [3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3 - [（2S）-2 - [[[1,1-二甲基乙基]氨基]羰基氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基
公开(公告)号：US20050059800A1
公开(公告)日：2005-03-17
申请号：US10867600
申请日：2004-06-15
申请人： Anantha Sudhakar , Vilas Dahanukar , Ilia Zavialov , Cecilia Orr , Hoa Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael Green , George Wong , Jeonghan Park , Tetsuo Iwama
发明人： Anantha Sudhakar , Vilas Dahanukar , Ilia Zavialov , Cecilia Orr , Hoa Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael Green , George Wong , Jeonghan Park , Tetsuo Iwama
IPC分类号： C07C271/22 , C07K5/02 , C07K5/06
CPC分类号： C07K5/0202 , C07C271/22 , C07C2601/04
摘要： In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译：在一个实施方案中，本申请涉及制备式I化合物的方法以及在制备式I化合物的方法中制备的某些中间体化合物。

32. 发明授权

US09395562B1 Method and apparatus for eye and eyewear characteristics measurement 有权
标题翻译：眼睛和眼镜特征测量的方法和装置
公开(公告)号：US09395562B1
公开(公告)日：2016-07-19
申请号：US14680871
申请日：2015-04-07
申请人： Hoa Nguyen , Sameer Cholayil , Phuong Pham , Cuong Manh Nguyen
发明人： Hoa Nguyen , Sameer Cholayil , Phuong Pham , Cuong Manh Nguyen
IPC分类号： A61B3/10 , G02C13/00 , A61B3/00 , A61B3/14
CPC分类号： G02C13/005 , A61B3/0025 , A61B3/111 , A61B3/14
摘要： A method and apparatus for contactless measurement of the characteristics of patients' eyes and eyewear without using any reference device for scaling measurements. The non-contact system comprises of a measurement device having an array of proximity sensors for contactless distance measurement, which is embracing a mobile device having a digital camera, a processor, gyroscope or 3-axis accelerometer sensors, and wireless transceivers. The wireless transceivers support fast and real-time communication between the mobile device and the measurement device. The mobile device is configured to obtain information of distance between the patient face the measurement device at the same time as the digital camera is capturing images of the patient. Such distances assist the processor of the mobile device to re-construct actual eye and eyewear characteristics from the captured image of the digital camera. The built-in gyroscope sensors may be used to correct errors caused by inadequate orientation of the patient's face and/or the mobile device. The method thus enables fast, accurate and reference less measurement, and reduces the responsibilities of users.
摘要翻译：一种用于非接触式测量患者眼睛和眼镜的特征的方法和装置，而不使用任何参考装置进行缩放测量。非接触式系统包括具有用于非接触式距离测量的接近传感器阵列的测量装置，其包括具有数字照相机，处理器，陀螺仪或3轴加速度计传感器的移动装置以及无线收发器。无线收发器支持移动设备和测量设备之间的快速和实时通信。移动装置被配置为在数字照相机正在拍摄患者的图像的同时获得面对测量装置的患者之间的距离的信息。这样的距离有助于移动设备的处理器从数字照相机的拍摄图像重构实际的眼睛和眼镜特征。内置的陀螺仪传感器可用于校正由患者脸部和/或移动装置的不适当取向引起的错误。因此，该方法能够快速，准确和参考较少的测量，并减少用户的责任。

33. 发明申请

US20140178371A1 ANTI-ANGIOGENESIS THERAPY FOR THE TREATMENT OF OVARIAN CANCER 审中-公开
标题翻译：用于治疗OVARIAN癌症的抗血栓形成治疗
公开(公告)号：US20140178371A1
公开(公告)日：2014-06-26
申请号：US14157351
申请日：2014-01-16
申请人： Jakob Dupont , Cornelia Irl , Amreen Husain , Mika A. Sovak , Jing Yi , Hoa Nguyen
发明人： Jakob Dupont , Cornelia Irl , Amreen Husain , Mika A. Sovak , Jing Yi , Hoa Nguyen
IPC分类号： C07K16/22 , A61K31/7068 , A61K31/282 , A61K39/395 , A61K31/337
摘要： This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer using an anti-VEGF antibody, preferably in combination with one or more additional anti-tumor therapeutic agents for the treatment of ovarian cancer.
摘要翻译：本发明涉及一般用抗VEGF抗体治疗疾病和病理状况。更具体地，本发明涉及使用抗VEGF抗体治疗易患或诊断为癌症的患者，优选与一种或多种另外的抗肿瘤治疗剂组合用于治疗卵巢癌。

34. 发明授权

US07749770B2 Mechanical device for mixing a fluid sample with a treatment solution 有权
标题翻译：用于将流体样品与处理溶液混合的机械装置
公开(公告)号：US07749770B2
公开(公告)日：2010-07-06
申请号：US12462810
申请日：2009-08-10
申请人： Hoa Nguyen , Urs A. Ramel , Jeffrey A. Pierce
发明人： Hoa Nguyen , Urs A. Ramel , Jeffrey A. Pierce
IPC分类号： G01N1/10 , G01N33/48
CPC分类号： G01N1/38 , A61B5/14532 , A61B5/150022 , A61B5/150213 , A61B5/150343 , A61B5/150755 , A61B5/157 , B01F5/0646 , B01F5/0655 , B01F11/0005 , B01F15/00512 , B01F15/0205 , B01F15/0206 , B01F15/0212 , Y10T436/25 , Y10T436/25625
摘要： A method of preparing a fluid sample for use in a fluid analyte monitor, the method including drawing a fluid sample into a capillary channel in a body having a septum piercing projection; piercing a first septum covering a treatment solution chamber with the septum piercing projection, thereby exposing the fluid sample in the capillary channel to the contents of the treatment solution chamber; mixing the fluid sample with the contents of the treatment solution chamber; and piercing a second septum covering the treatment solution channel such that the mixed fluid and treatment solution chamber contents are received into a fluid analyte meter. The method may also include shaking the treatment solution chamber with the capillary channel therein, thereby mixing the fluid sample with the contents of the treatment solution chamber.
摘要翻译：一种制备用于流体分析物监测器的流体样品的方法，所述方法包括将流体样品拉入具有隔膜穿孔突起的体内的毛细通道中; 用隔垫穿刺突起刺穿覆盖处理溶液室的第一隔膜，从而将毛细管通道中的流体样品暴露于处理溶液室的内容物; 将流体样品与处理溶液室的内容物混合; 并刺穿覆盖处理溶液通道的第二隔膜，使得混合流体和处理溶液室内容物被接收到流体分析物仪表中。该方法还可以包括用其中的毛细通道摇晃处理溶液室，从而将流体样品与处理溶液室的内容物混合。

35. 发明授权

US07296069B2 Method and system for network fault monitoring with linux 有权
标题翻译：使用linux进行网络故障监控的方法和系统
公开(公告)号：US07296069B2
公开(公告)日：2007-11-13
申请号：US10140214
申请日：2002-05-08
申请人： Hoa Nguyen
发明人： Hoa Nguyen
IPC分类号： G06F15/173
CPC分类号： G06F11/328
摘要： A method and system for monitoring faults in network interface cards on networked computer systems or devices. The system includes a means for establishing an electrical connection to a computer network; a means for controlling data sent across the establishing means; a means for directly querying the status of the establishing means; and a means for tracking the status of the establishing means. The method includes steps for initializing data structures for tracking the status of one or more network interface cards to be monitored; initiating monitoring of the one or more network interface cards; ascertaining a configurable polling interval; determining if a shutdown condition has occurred; monitoring the status of the one or more network interface cards when a shutdown condition has not occurred; and clearing all resources when a shutdown condition has occurred.
摘要翻译：一种用于监控网络计算机系统或设备上网络接口卡故障的方法和系统。该系统包括用于建立到计算机网络的电连接的装置; 用于控制通过建立装置发送的数据的手段; 直接查询建立手段状况的手段; 以及跟踪建立手段状态的手段。该方法包括用于初始化用于跟踪待监视的一个或多个网络接口卡的状态的数据结构的步骤; 启动对所述一个或多个网络接口卡的监视; 确定可配置轮询间隔; 确定是否发生关闭条件; 当没有发生停机条件时监视一个或多个网络接口卡的状态; 并在发生关闭条件时清除所有资源。

36. 发明申请

US20070010024A1 Method of analysis of amine by mass spectrometry 审中-公开
公开(公告)号：US20070010024A1
公开(公告)日：2007-01-11
申请号：US11486416
申请日：2006-07-12
申请人： Hoa Nguyen , Trinh Nguyen , Duc Nguyen
发明人： Hoa Nguyen , Trinh Nguyen , Duc Nguyen
IPC分类号： G01N33/00
CPC分类号： G01N33/6848 , H01J49/00 , Y10T436/17 , Y10T436/173845
摘要： Method of identification and quantitative analysis of primary and/or secondary amine(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said amine with a stable isotope labeled reagent, and is added to a sample containing said amine. Said amine in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said amine are made from a plot of ion ratio of said converted amine to said internal standard versus amine concentration.

37. 发明申请

US20060258863A1 Synthesis of CCR5 antagonists 失效
标题翻译： CCR5拮抗剂的合成
公开(公告)号：US20060258863A1
公开(公告)日：2006-11-16
申请号：US11326154
申请日：2006-01-05
申请人： Xiongwei Shi , Man Zhu , William Leong , Vilas Dahanukar , Ilia Zavialov , Cecilia Proletei , Shannon Zhao , Hong-Chang Lee , Yi Liu , Hoa Nguyen , Wenxue Wu , Bosco D'Sa , Feng Liang , Loc Tran
发明人： Xiongwei Shi , Man Zhu , William Leong , Vilas Dahanukar , Ilia Zavialov , Cecilia Proletei , Shannon Zhao , Hong-Chang Lee , Yi Liu , Hoa Nguyen , Wenxue Wu , Bosco D'Sa , Feng Liang , Loc Tran
IPC分类号： C07D403/14
CPC分类号： C07D211/96 , C07D211/26 , C07D401/14
摘要： The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
摘要翻译：本发明涉及4- [4 - [（R） - [1- [环丙基磺酰基] -4-哌啶基]（3-氟苯基）甲基] -3（S） - 甲基-1-哌嗪基] 1 - [（4,6-二甲基-5-嘧啶基）羰基] -4-甲基哌啶]，以及通过新途径从容易获得的起始原料中间产物。

38. 发明申请

US20060036877A1 Method and system for managing peripheral connection wakeup in a processing system supporting multiple virtual machines 有权
标题翻译：在支持多个虚拟机的处理系统中管理外围连接唤醒的方法和系统
公开(公告)号：US20060036877A1
公开(公告)日：2006-02-16
申请号：US10916974
申请日：2004-08-12
申请人： Gary Anderson , Hoa Nguyen , Thoi Nguyen
发明人： Gary Anderson , Hoa Nguyen , Thoi Nguyen
IPC分类号： G06F1/26
CPC分类号： G06F1/3209
摘要： A method and system for managing peripheral connection wakeup signaling in a processing system supporting multiple virtual machines provides a mechanism by which ownership of a peripheral having system wakeup capability is transferred between virtual machines. The power management event signal is connected to a service processor input that in turn signals a hypervisor to direct the wakeup activity to a particular logical partition in which the virtual machine was last executing. The hypervisor can then determine whether or not to wake up the entire system, or portions thereof and can direct the power management event to the appropriate virtual machine. In particular the peripheral may be an Ethernet adapter supporting Wake-On-LAN capability. State initialization, which is typically ensured by system power cycling is provided instead by controlling power to the standby power source or in some instances by forcing an indication of a disconnect/reconnect of the wakeup signaling connection.
摘要翻译：用于在支持多个虚拟机的处理系统中管理外围连接唤醒信令的方法和系统提供了一种机制，通过该机制，具有系统唤醒能力的外围设备的所有权在虚拟机之间传送。电源管理事件信号连接到服务处理器输入，该服务处理器输入又传送信号管理程序以将唤醒活动引导到虚拟机最后执行的特定逻辑分区。管理程序然后可以确定是否唤醒整个系统或其部分，并且可以将电源管理事件引导到适当的虚拟机。特别地，外设可以是支持Wake-On-LAN功能的以太网适配器。通过系统功率循环确保的状态初始化是通过控制待机电源的电源，或者在某些情况下通过强制唤醒信令连接的断开/重新连接的指示来提供的。

39. 发明申请

US20050070022A1 Method of analysis of aldehyde and ketone by mass spectrometry 失效
标题翻译：通过质谱分析醛和酮的方法
公开(公告)号：US20050070022A1
公开(公告)日：2005-03-31
申请号：US10675763
申请日：2003-09-30
申请人： Hoa Nguyen , Trinh Nguyen , Duc Nguyen
发明人： Hoa Nguyen , Trinh Nguyen , Duc Nguyen
IPC分类号： G01N33/00
CPC分类号： H01J49/0009 , C10L1/1857 , Y10T436/13 , Y10T436/173845 , Y10T436/200833 , Y10T436/24 , Y10T436/25125
摘要： Method of identification and quantitative analysis of aldehyde(s) and/or ketone(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said aldehyde(s) and/or ketone(s) with a stable isotope labeled reagent, and is added to a sample containing said aldehyde(s) and/or ketone(s). Said aldehyde(s) and/or ketone(s) in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said aldehyde(s) and/or ketone(s) are made from a plot of ion ratio of said converted aldehyde and/or ketone to said internal standard versus aldehyde and/or ketone concentration.
摘要翻译：提供了使用稳定同位素标记的内标通过质谱鉴定和定量分析样品中的醛和/或酮的方法。所述内标是通过将所述醛和/或酮的真实样品与稳定同位素标记的试剂反应制备的，并加入到含有所述醛和/或酮的样品中，。然后使用非标记试剂将所述样品中的所述醛和/或酮定量地转化为具有相同结构的化合物，除了稳定的同位素原子，如所述内标的那样。然后提取所述样品，并通过质谱法分析提取物。所述醛和/或酮的鉴定和定量由所述转化的醛和/或酮与所述内标的离子比对醛和/或酮浓度的曲线图来制备。

40. 发明申请

US20050014279A1 Method of analysis of amine by mass spectrometry 审中-公开
标题翻译：通过质谱法分析胺的方法
公开(公告)号：US20050014279A1
公开(公告)日：2005-01-20
申请号：US10619709
申请日：2003-07-14
申请人： Hoa Nguyen , Trinh Nguyen , Duc Nguyen
发明人： Hoa Nguyen , Trinh Nguyen , Duc Nguyen
IPC分类号： A61M36/14 , G01N33/00 , G01N33/487
CPC分类号： G01N33/6848 , H01J49/00 , Y10T436/17 , Y10T436/173845
摘要： Method of identification and quantitative analysis of primary and/or secondary amine(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said amine with a stable isotope labeled reagent, and is added to a sample containing said amine. Said amine in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said amine are made from a plot of ion ratio of said converted amine to said internal standard versus amine concentration.
摘要翻译：提供了使用稳定同位素标记的内标通过质谱鉴定和定量分析样品中的一级或二级胺的方法。所述内标是通过将所述胺的真实样品与稳定同位素标记的试剂反应制备的，并加入含有所述胺的样品中。然后使用非标记试剂将所述样品中的所述胺定量转化为具有相同结构的化合物，除了稳定的同位素原子，如所述内标的那样。然后提取所述样品，并通过质谱法分析提取物。所述胺的鉴定和定量由所述转化的胺与所述内标的离子比对胺浓度的曲线图来制备。

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