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31. 发明申请

US20110237999A1 SYSTEMS AND METHODS FOR APPLYING AND MONITORING EYE THERAPY 审中-公开
标题翻译：用于应用和监测眼睛治疗的系统和方法
公开(公告)号：US20110237999A1
公开(公告)日：2011-09-29
申请号：US13051699
申请日：2011-03-18
申请人： David Muller , John Marshall , Marc D. Friedman , Stephen Blinn , Ronald Scharf , Pavel Kamaev , Radha Pertaub
发明人： David Muller , John Marshall , Marc D. Friedman , Stephen Blinn , Ronald Scharf , Pavel Kamaev , Radha Pertaub
IPC分类号： A61F9/007 , A61B3/10
摘要： Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.
摘要翻译：用于激活角膜组织内的交联以在眼睛治疗治疗之后稳定和加强角膜组织的装置和方法。提供反馈系统以获取测量并将反馈信息传递给控制器。反馈系统可以包括干涉仪系统，角膜偏振仪系统或用于监测角膜内的交联活动的其它构型。该控制器适用于分析反馈信息，并根据信息调整眼睛治疗。还提供反馈系统的方面来监测和诊断眼睛的特征1.还提供了根据由反馈系统提供的信息激活交联以提高交联疗法的准确性和安全性的方法。

32. 发明申请

US20100256701A1 Determining Site-To-Site Pacing Delay For Multi-Site Anti-Tachycardia Pacing 有权
标题翻译：确定多站点抗心动过速起搏的站点到站点起搏延迟
公开(公告)号：US20100256701A1
公开(公告)日：2010-10-07
申请号：US12416778
申请日：2009-04-01
申请人： David Muller
发明人： David Muller
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61B5/0452 , A61N1/3682 , A61N1/3684
摘要： An exemplary method includes delivering a pace using an electrode positioned on the lateral wall of the left ventricle of a heart, sensing the pace using an electrode positioned in the right ventricle of the heart, determining a left to right directional conduction time (TLR), delivering a pace using an electrode positioned in the right ventricle of the heart, sensing the pace using an electrode positioned on the lateral wall of the left ventricle of the heart, determining a right to left directional conduction time (TRL), calculating a site-to-site offset (VVATP) for multi-site anti-tachycardia pacing based on the left to right directional conduction time and the right to left directional conduction time and instructing an implantable device to deliver multi-site anti-tachycardia pacing using the site-to-site offset (VVATP). Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括使用位于心脏左心室侧壁上的电极来传送步速，使用位于心脏右心室的电极来感测步速，确定从左到右的方向传导时间（TLR），使用位于心脏右心室中的电极进行步调，使用位于心脏左心室侧壁上的电极感测步速，确定右向左方向传导时间（TRL），计算位置 - 基于从左到右定向导通时间和从右到左定向传导时间的多位点抗心动过速起搏的现场偏移（VVATP），并且指示植入装置使用位置偏移起搏来提供多部位抗心动过速起搏，站点偏移（VVATP）。还公开了其它示例性方法，装置，系统等。

33. 发明申请

US20100185192A1 EYE THERAPY SYSTEM 有权
标题翻译：眼睛治疗系统
公开(公告)号：US20100185192A1
公开(公告)日：2010-07-22
申请号：US12617554
申请日：2009-11-12
申请人： David Muller , Radha Pertaub , Steven Meyers , Russ Dresher , Thomas Ryan , Ronald Scharf
发明人： David Muller , Radha Pertaub , Steven Meyers , Russ Dresher , Thomas Ryan , Ronald Scharf
IPC分类号： A61B18/08
CPC分类号： A61B18/18 , A61B18/1815 , A61B2090/065 , A61F9/0079
摘要： Systems and methods improve operation of an applicator that delivers heat-generating energy to an eye as a part of an eye therapy. For example, reflected power may be measured to determine whether sufficient contact has been established between the applicator and the eye for accurate and precise delivery of energy to the eye. In addition, at least one of forward and reflected power may be measured to monitor the application of coolant pulses that control the generation of heat in the eye when the applicator delivers energy to the eye. Further, the forward and reflected power may be measured to determine an efficiency of energy transfer or an impedance mismatch. Based on the efficiency of energy transfer or the impedance mismatch, an adjustable parameter of a tuning element may be modified.
摘要翻译：系统和方法改善了作为眼部治疗的一部分将发热能量提供给眼睛的施用器的操作。例如，可以测量反射功率以确定施用器和眼睛之间是否已经建立足够的接触，以准确和精确地将能量递送到眼睛。此外，可以测量正向和反射功率中的至少一个以监测当施用器向眼睛递送能量时控制眼睛中的热量产生的冷却剂脉冲的应用。此外，可以测量正向和反射功率以确定能量传递的效率或阻抗失配。基于能量传递的效率或阻抗失配，可以修改调谐元件的可调参数。

34. 发明申请

US20090209954A1 SYSTEM AND METHOD FOR RESHAPING AN EYE FEATURE 失效
标题翻译：用于修复眼睛特征的系统和方法
公开(公告)号：US20090209954A1
公开(公告)日：2009-08-20
申请号：US12209123
申请日：2008-09-11
申请人： David Muller , Ronald Scharf , Thomas Ryan , Neal Marshall , Artie Wu
发明人： David Muller , Ronald Scharf , Thomas Ryan , Neal Marshall , Artie Wu
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/14 , A61B18/18 , A61B18/22 , A61B34/76 , A61B2018/00029 , A61B2018/00083 , A61B2018/1405 , A61B2018/1807 , A61B2090/065 , A61F9/0079 , A61F9/009 , A61F2009/00853 , A61F2009/00872
摘要： A system for applying therapy to an eye includes an applicator having a conducting element configured to direct energy from an energy source to an application end of the conducting element, where the application end has at least one eye contact portion. A positioning system positions the at least one eye contact portion in stable engagement with the eye surface. The conducting element is disposed within a housing for the applicator and at least one adjustment system is employed to move the conducting element relative to the housing. The at least one adjustment system enables controlled movement of the conducting element and the at least one eye contact portion against the corneal surface. In particular embodiments, sufficient contact between the applicator and the cornea is determined by causing applanation of the cornea. In other embodiments, at least one measurement device is employed to determine when sufficient contact has been established.
摘要翻译：用于向眼睛施加治疗的系统包括具有导电元件的施用器，该导电元件被配置为将能量从能量源引导到导电元件的施加端，其中施加端具有至少一个眼睛接触部分。定位系统将至少一个眼睛接触部分定位成与眼睛表面稳定接合。导电元件设置在用于施用器的壳体内，并且使用至少一个调节系统来相对于壳体移动导电元件。所述至少一个调节系统使得所述导电元件和所述至少一个眼睛接触部分能够受控地移动抵靠角膜表面。在特定实施例中，施加器和角膜之间的充分接触是通过引起角膜的扁平化来确定的。在其他实施例中，采用至少一个测量装置来确定何时建立了足够的接触。

35. 发明申请

US20090187178A1 SYSTEM AND METHOD FOR POSITIONING AN EYE THERAPY DEVICE 失效
标题翻译：用于定位眼睛治疗装置的系统和方法
公开(公告)号：US20090187178A1
公开(公告)日：2009-07-23
申请号：US12018450
申请日：2008-01-23
申请人： David Muller , Vance Thompson
发明人： David Muller , Vance Thompson
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B90/11 , A61B2017/306 , A61F9/0079 , A61F9/008 , A61F9/009 , A61F9/013 , A61F2009/00853 , A61F2009/00872
摘要： A system for aligning an eye therapy instrument over a selected area or feature of an eye provides an attachment element that is removably attached to a surface of an eye. A receiving element is coupled to the attachment element and movable relative to the attachment element. The receiving element includes a coupling element configured to operably couple an eye therapy instrument to the receiving element and adjustably move the eye therapy instrument into a selected position with respect to the attachment element. The system makes adjustments to ensure accurate delivery of treatment from the eye therapy device to areas of the eye. In one embodiment, the receiving element allows lateral adjustments to be made along one or more axes. Additionally or alternatively, the receiving element allows angular or rotational adjustments to be made about one or more axes.
摘要翻译：用于将眼部治疗仪器对准眼睛的选定区域或特征的系统提供可拆卸地附接到眼睛表面的附接元件。接收元件联接到附接元件并且可相对于附接元件移动。接收元件包括耦合元件，其被配置为可操作地将眼部治疗器械耦合到接收元件并且可调节地将眼部治疗仪器相对于附接元件移动到选定位置。系统进行调整，以确保从眼部治疗装置到眼睛区域的准确传送。在一个实施例中，接收元件允许沿着一个或多个轴进行横向调整。附加地或替代地，接收元件允许围绕一个或多个轴进行角度或旋转调节。

36. 发明授权

US10092393B2 Corneal implant systems and methods 有权
公开(公告)号：US10092393B2
公开(公告)日：2018-10-09
申请号：US14152425
申请日：2014-01-10
申请人： David Muller
发明人： David Muller
IPC分类号： A61F9/00 , A61F2/14 , A61F9/008
摘要： According to one aspect of the present disclosure, an implant for correcting vision impairment is disclosed. The implant is made from a donor corneal tissue sized and shaped to provide a predetermined refractive correction and reshaping of a cornea. The donor corneal tissue includes a posterior surface and an anterior surface. The posterior surface has a surface profile that is configured to generally correspond to a shape of an implantation site of the cornea.

37. 发明申请

US20170319329A1 Corneal Implant Systems and Methods 审中-公开
公开(公告)号：US20170319329A1
公开(公告)日：2017-11-09
申请号：US15588249
申请日：2017-05-05
申请人： David Muller , Michael Mrochen , Jennifer Stone
发明人： David Muller , Michael Mrochen , Jennifer Stone
IPC分类号： A61F2/14
CPC分类号： A61F2/142 , A61F2/145 , A61F9/0081 , A61F9/00812 , A61F9/00831 , A61F9/00834 , A61F9/00836 , A61F2009/00844 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2240/002
摘要： A system for forming corneal implants includes a first cutting apparatus configured to cut a donor cornea and form a portion of corneal tissue. The donor cornea includes an anterior surface and a posterior surface. The first cutting apparatus is configured to cut the donor cornea along an axis extending between the anterior surface and the posterior surface. The system also includes a second cutting apparatus configured to form a plurality of lenticules from the portion of corneal tissue by making, to the portion of corneal tissue, a series of cuts transverse to the axis. Corneal tissue between consecutive cuts by the second cutting apparatus provides a corresponding lenticule to be shaped for a corneal implant. A distance between the consecutive cuts defines a thickness for the corresponding lenticule.

38. 发明授权

US09020580B2 Systems and methods for monitoring time based photo active agent delivery or photo active marker presence 有权
标题翻译：用于监测基于时间的光活性剂递送或光活性标记存在的系统和方法
公开(公告)号：US09020580B2
公开(公告)日：2015-04-28
申请号：US13488097
申请日：2012-06-04
申请人： Marc D. Friedman , Pavel Kamaev , David Muller , Radha Pertaub , Ronald Scharf , Evan Sherr , David Usher
发明人： Marc D. Friedman , Pavel Kamaev , David Muller , Radha Pertaub , Ronald Scharf , Evan Sherr , David Usher
IPC分类号： A61B3/10 , A61N5/06 , A61B3/107 , A61B3/135 , A61F9/007 , A61K49/00 , A61F9/008 , A61N5/067 , A61M37/00
CPC分类号： A61M5/007 , A61B3/10 , A61B3/107 , A61B3/135 , A61B3/145 , A61B5/0066 , A61B5/0071 , A61F9/0079 , A61F9/008 , A61F2009/00851 , A61F2009/00872 , A61F2009/00893 , A61K49/006 , A61M37/0092 , A61N5/062 , A61N2005/0626 , A61N2005/0661 , A61N2005/067
摘要： Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.
摘要翻译：用于监测基于时间的光活性剂递送或光活性标记物在眼睛中的存在的装置和方法。提供一种监测系统，用于通过照亮眼睛来测量光活性标记物的存在，以激发光活性标记，然后观察来自光活性标记的特征发射。示例系统包括Scheimpflug光学系统或裂隙灯光学系统，以观察眼睛的横截面图像以监测施加到眼睛上的光活性剂的瞬时分布，扩散模式和摄取速率。系统和方法还允许利用受监控的眼睛中的光活性剂的分布作为交联系统的反馈。

39. 发明授权

US08992516B2 Eye therapy system 有权
公开(公告)号：US08992516B2
公开(公告)日：2015-03-31
申请号：US11898189
申请日：2007-09-10
申请人： David Muller
发明人： David Muller
IPC分类号： A61B18/18 , A61B18/14 , A61F9/007 , A61B18/00 , A61B18/22 , A61F9/009 , A61F9/008 , A61N1/36 , A61N1/40
CPC分类号： A61B18/14 , A61B18/1477 , A61B18/18 , A61B18/22 , A61B2018/00005 , A61B2018/00023 , A61B2018/00029 , A61B2018/00702 , A61B2018/00791 , A61B2018/1425 , A61B2018/1807 , A61F9/0079 , A61F9/009 , A61F2009/00853 , A61F2009/00872 , A61N1/36046 , A61N1/403
摘要： A system for applying therapy to an eye selectively applies coolant to the corneal surface to minimize heat-related damage to the corneal surface during thermokeratoplasty. Embodiments may include an energy source, a conducting element, a coolant supply, and at least one coolant delivery element. The conducting element is operably connected to the energy source and extends from a proximal end to a distal end. The conducting element directs energy from the energy source to the distal end, which is positionable at the eye. The coolant delivery elements are in communication with the coolant supply and are operable to deliver a micro-controlled pulse of coolant to the distal end.

40. 发明授权

US08583234B1 System and method for left atrial pacing in patients with diastolic heart failure 有权
标题翻译：舒张性心力衰竭患者左心房起搏的系统和方法
公开(公告)号：US08583234B1
公开(公告)日：2013-11-12
申请号：US13571235
申请日：2012-08-09
申请人： David Muller
发明人： David Muller
IPC分类号： A61N1/00
CPC分类号： A61N1/365 , A61N1/3622 , A61N1/36564 , A61N1/368
摘要： Techniques are provided for use with an implantable medical device for delivering left atrial (LA) pacing to address Diastolic Heart Failure, also referred to as Heart Failure with Preserved Ejection Fraction. In one example, pulse delivery times are selected for delivery of LA pacing pulses sufficient so that activation of the LA occurs when LA pressure (LAP) is lower than would occur in the absence of LA pacing. The pulse delivery times and also set so that subsequent activation of the right ventricle (RV) occurs when LAP is lower than would occur in the absence of LA pacing. LA pacing then is delivered by the implanted device at the selected pulse delivery times to mitigate Diastolic Heart Failure or to address other conditions.
摘要翻译：提供技术用于可植入医疗装置，用于输送左心房（LA）起搏以解决舒张性心力衰竭，也称为具有保留的喷射分数的心力衰竭。在一个示例中，选择脉冲递送时间用于输送足够的LA起搏脉冲，使得当LA压力（LAP）低于在不存在LA起搏时发生时LA的激活。脉冲输送时间也设定为当LAP低于不存在LA起搏时发生的右心室（RV）的随后激活。 LA起搏然后由植入装置以选定的脉搏递送时间递送，以缓解舒张性心力衰竭或解决其他情况。

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