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31. 发明授权

US06562008B1 Front loading medical injector and syringe for use therewith 失效
标题翻译：前部装载医用注射器和与其一起使用的注射器
公开(公告)号：US06562008B1
公开(公告)日：2003-05-13
申请号：US09440029
申请日：1999-11-12
申请人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
发明人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
IPC分类号： A61M5315
CPC分类号： A61M5/14546 , A61M5/14566 , A61M2005/14553 , A61M2205/581 , A61M2205/582 , A61M2205/583 , Y10S128/01
摘要： A front-loading syringe which comprises a movable plunger for injecting liquid contrast media, is rotatably mountable on a front wall of an injector housing with an interference fit and in sealed relationship with respect thereto, with or without a pressure jacket, by a first-quick release mechanism. At the same time, the plunger is connected to an injector drive mechanism by a second readily releasable mechanism. During the mounting operation, a sensor reads injection information from an indicator device on the syringe and feeds it to an injector control. An audible-and-tactile indicating mechanism also is activated when the syringe is essentially in the desired mounted position. The syringe may include reinforcing ribs which also function as volumetric gradations, and liquid media presence-or-absence indicating dots which appear circular against a liquid media background and oval-shaped against an air background. An injection end of the syringe comprises an injector portion of reduced diameter inside a screw-threaded attachment portion of larger diameter, and may include loop-shaped reinforcing handle portions.
摘要翻译：一种包括用于注射液体造影剂的活动柱塞的前装载注射器，可旋转地安装在喷射器壳体的前壁上，其具有过盈配合并且与其相关的密封关系，具有或不具有压力套，快速释放机制。同时，柱塞通过第二容易释放的机构连接到喷射器驱动机构。在安装操作期间，传感器从注射器上的指示器装置读取注射信息并将其馈送到注射器控制器。当注射器基本上处于所需的安装位置时，也可以触发听觉和触觉指示机构。注射器可以包括还用作体积灰度的加强肋，以及液体介质的存在或不存在，指示针对液体介质背景呈圆形并且与空气背景呈椭圆形的点。注射器的注射端部包括在较大直径的螺纹连接部分内的直径减小的注射器部分，并且可以包括环形加强手柄部分。

32. 发明授权

US06402717B1 Front-loading medical injector and syringe for use therewith 失效
公开(公告)号：US06402717B1
公开(公告)日：2002-06-11
申请号：US09451890
申请日：1999-12-01
申请人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
发明人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
IPC分类号： A61M3100
CPC分类号： A61M5/14546 , A61M5/14566 , A61M2005/14553 , A61M2205/581 , A61M2205/582 , A61M2205/583 , Y10S128/01
摘要： A front-loading syringe which comprises a movable plunger for injecting liquid contrast media, is rotatably mountable on a front wall of an injector housing with an interference fit and in sealed relationship with respect thereto, with or without a pressure jacket, by a first-quick release mechanism. At the same time, the plunger is connected to an injector drive mechanism by a second readily releasable mechanism. During the mounting operation, a sensor reads injection information from an indicator device on the syringe and feeds it to an injector control. An audible-and-tactile indicating mechanism also is activated when the syringe is essentially in the desired mounted position. The syringe may include reinforcing ribs which also function as volumetric gradations, and liquid media presence-or-absence indicating dots which appear circular against a liquid media background and oval-shaped against an air background. An injection end of the syringe comprises an injector portion of reduced diameter inside a screw-threaded attachment portion of larger diameter, and may include loop-shaped reinforcing handle portions.

33. 发明授权

US06189195B1 Manufacture of prefilled syringes 失效
标题翻译：制造预充式注射器
公开(公告)号：US06189195B1
公开(公告)日：2001-02-20
申请号：US08517645
申请日：1995-08-22
申请人： David M. Reilly , Edward J. Rhinehart , Eugene A. Gelblum , Mark W. Hitchins , Michelle Robinson
发明人： David M. Reilly , Edward J. Rhinehart , Eugene A. Gelblum , Mark W. Hitchins , Michelle Robinson
IPC分类号： B23P1500
CPC分类号： B65B3/003 , Y10T29/49808 , Y10T29/4984
摘要： This invention relates to a process for manufacturing prefilled syringes where at least one of the syringe components is manufactured in at least a class 100 environment. The process includes the steps of manufacturing syringe components, such as the barrel and plunger substrate, within at least a class 100 and MCB-3 environment; manufacturing syringe components, such as the plunger cover and tip seal in an environment less clean than a class 100 environment; decontaminating the plunger cover and tip seal; lubricating at least one of the barrel, plunger substrate, plunger cover and tip seal; assembling the barrel and tip seal to form a barrel/tip seal combination; assembling the plunger cover and plunger substrate to form a plunger; filling the barrel/tip seal combination with a predetermined amount of fluid; and final assembling of the prefilled syringe by inserting the plunger into the barrel/tip seal combination. When the syringe components are manufactured at different locations, each component is tripled-bagged to maintain the component substantially free from contaminants, and transported to an assembly site where the components are unpackaged and assembled into the barrel/tip seal combination and plunger. When filling and final assembly of the barrel/tip seal combination takes place at a location separate from its assembly site, the barrel/tip seal combination is tripled-bagged to maintain it substantially free from contaminants, and transported to a filling and final assembling site for filling and final assembling into a prefilled syringe.
摘要翻译：本发明涉及一种用于制造预充式注射器的方法，其中至少一个注射器组件在至少100级环境中制造。该方法包括在至少100级和MCB-3环境中制造注射器部件（例如筒体和柱塞基底）的步骤; 在比100级环境更干净的环境中制造注射器部件，例如柱塞盖和末端密封; 净化柱塞盖和顶端密封; 润滑桶，柱塞基板，柱塞盖和端盖密封件中的至少一个; 组装筒和尖端密封以形成筒/尖端密封组合; 组装柱塞盖和柱塞基板以形成柱塞; 用预定量的流体填充桶/尖端密封组合; 以及通过将柱塞插入筒/尖端密封组合中来预填充注射器的最终组装。当注射器组件在不同位置制造时，每个组件被三倍重装，以保持组件基本上没有污染物，并被运输到组件的未被包装并组装到筒/尖端密封组合和柱塞中的组装位置。当筒/尖端密封组合的填充和最终组装在与其组装位置分离的位置处发生时，筒/尖端密封组合被三倍重装，以使其基本上不含污染物，并被运送到填充和最终组装位置用于填充和最终组装成预充式注射器。

34. 发明授权

US5997502A Front loading medical injector and syringe for use therewith 失效
公开(公告)号：US5997502A
公开(公告)日：1999-12-07
申请号：US901602
申请日：1997-07-28
申请人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
发明人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
IPC分类号： A61M5/145 , A61M31/00
CPC分类号： A61M5/14546 , A61M2005/14553 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M5/14566 , Y10S128/01
摘要： A front-loading syringe which comprises a movable plunger for injecting liquid contrast media, is rotatably mountable on a front wall of an injector housing with an interference fit and in sealed relationship with respect thereto, with or without a pressure jacket, by a first-quick release mechanism. At the same time, the plunger is connected to an injector drive mechanism by a second readily releasable mechanism. During the mounting operation, a sensor reads injection information from an indicator device on the syringe and feeds it to an injector control. An audible-and-tactile indicating mechanism also is activated when the syringe is essentially in the desired mounted position. The syringe may include reinforcing ribs which also function as volumetric gradations, and liquid media presence-or-absence indicating dots which appear circular against a liquid media background and oval-shaped against an air background. An injection end of the syringe comprises an injector portion of reduced diameter inside a screw-threaded attachment portion of larger diameter, and may include loop-shaped reinforcing handle portions.

35. 发明授权

US5383858A Front-loading medical injector and syringe for use therewith 失效
标题翻译：前装医疗注射器和注射器用于此
公开(公告)号：US5383858A
公开(公告)日：1995-01-24
申请号：US929926
申请日：1992-08-17
申请人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
发明人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
IPC分类号： A61M5/145 , A61M1/00
CPC分类号： A61M5/14546 , A61M2005/14553 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M5/14566 , Y10S128/01
摘要： A front-loading syringe which comprises a movable plunger for injecting liquid contrast media, is rotatably mountable on a front wall of an injector housing with an interference fit and in sealed relationship with respect thereto, with or without a pressure jacket, by a first-quick release mechanism. At the same time, the plunger is connected to an injector drive mechanism by a second readily releasable mechanism. During the mounting operation, a sensor reads injection information from an indicator device on the syringe and feeds it to an injector control. An audible-and-tactile indicating mechanism also is activated when the syringe is essentially in the desired mounted position. The syringe may include reinforcing ribs which also function as volumetric gradations, and liquid media presence-or-absence indicating dots which appear circular against a liquid media background and oval-shaped against an air background. An injection end of the syringe comprises an injector portion of reduced diameter inside a screw-threaded attachment portion of larger diameter, and may include,loop-shaped reinforcing handle portions.
摘要翻译：一种包括用于注射液体造影剂的活动柱塞的前装载注射器，可旋转地安装在喷射器壳体的前壁上，其具有过盈配合并且与其相关的密封关系，具有或不具有压力套，快速释放机制。同时，柱塞通过第二容易释放的机构连接到喷射器驱动机构。在安装操作期间，传感器从注射器上的指示器装置读取注射信息并将其馈送到注射器控制器。当注射器基本上处于所需的安装位置时，也可以触发听觉和触觉指示机构。注射器可以包括还用作体积灰度的加强肋，以及液体介质的存在或不存在，指示针对液体介质背景呈圆形并且与空气背景呈椭圆形的点。注射器的注射端包括在较大直径的螺纹连接部分内的直径减小的注射器部分，并且可以包括环形加强手柄部分。

36. 发明授权

US07081105B2 Injector system having a front loading pressure jacket assembly 失效
标题翻译：具有前装载压力套管组件的喷射器系统
公开(公告)号：US07081105B2
公开(公告)日：2006-07-25
申请号：US10911863
申请日：2004-08-05
申请人： David M. Reilly , Eugene A. Gelblum
发明人： David M. Reilly , Eugene A. Gelblum
IPC分类号： A61B6/00
CPC分类号： A61M5/14546 , A61M5/14566 , A61M2005/14553 , A61M2205/581 , A61M2205/582 , A61M2205/583 , Y10S128/01
摘要： An injector system includes an injector and a syringe. The injector includes a housing having a front wall, a drive member moveable through the front wall of the housing, and a pressure jacket assembly for operably associating the syringe with the housing. The pressure jacket assembly includes a rearward end mounted on the front wall of the housing and a forward open end for receiving the syringe therethrough. The syringe includes a body having a main section, a conical section in fluid communication with the main section and a fluid discharge section in fluid communication with the conical section. The syringe further includes a plunger movably disposed in the body. The plunger includes one or more hook members extending rearward from the plunger for connecting the plunger to the drive member of the injector. The syringe also includes a protrusion for facilitating handling of the syringe. Preferably, the protrusion is operably associated with and extends forwardly from the conical section of the body.
摘要翻译：注射器系统包括注射器和注射器。注射器包括壳体，其具有前壁，可移动穿过壳体的前壁的驱动构件和用于将注射器与壳体可操作地相关联的压力套组合件。压力套组件包括安装在壳体的前壁上的后端和用于通过其接纳注射器的前开口端。注射器包括主体，其具有主部分，与主部分流体连通的锥形部分和与锥形部分流体连通的流体排出部分。注射器还包括可移动地设置在主体中的柱塞。柱塞包括从柱塞向后延伸的一个或多个钩构件，用于将柱塞连接到喷射器的驱动构件。注射器还包括用于便于处理注射器的突起。优选地，突出部可操作地与主体的锥形部分相关联并向前延伸。

37. 发明授权

US06808513B2 Front loading medical injector and syringe for use therewith 失效
标题翻译：前部装载医用注射器和与其一起使用的注射器
公开(公告)号：US06808513B2
公开(公告)日：2004-10-26
申请号：US10166848
申请日：2002-06-10
申请人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
发明人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
IPC分类号： A61M5315
CPC分类号： A61M5/14546 , A61M5/14566 , A61M2005/14553 , A61M2205/581 , A61M2205/582 , A61M2205/583 , Y10S128/01
摘要： A front-loading syringe, which comprises a movable plunger for injecting liquid contrast media, is mountable on a front wall of an injector housing having a pressure jacket, by a first quick release mechanism. At the same time, the plunger is connected to an injector drive mechanism by a second readily releasable mechanism. During the mounting operation, a sensor reads injection information from an indicator device on the syringe and feeds it to an injector control. An injection end of the syringe may include loop-shaped reinforcing handle portions.
摘要翻译：包括用于注射液体造影剂的可移动柱塞的前装载注射器可通过第一快速释放机构安装在具有压力套的注射器壳体的前壁上。同时，柱塞通过第二容易释放的机构连接到喷射器驱动机构。在安装操作期间，传感器从注射器上的指示器装置读取注射信息并将其馈送到注射器控制器。注射器的注射端可以包括环形加强手柄部分。

38. 发明授权

US06733478B2 System and method for providing information from a syringe to an injector 失效
标题翻译：用于从注射器向注射器提供信息的系统和方法
公开(公告)号：US06733478B2
公开(公告)日：2004-05-11
申请号：US10287167
申请日：2002-11-04
申请人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
发明人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
IPC分类号： A61M500
CPC分类号： A61M5/14546 , A61M5/14566 , A61M2005/14553 , A61M2205/581 , A61M2205/582 , A61M2205/583 , Y10S128/01
摘要： A front-loading syringe which comprises a movable plunger for injecting liquid contrast media, is rotatably mountable on a front wall of an injector housing with an interference fit and in sealed relationship with respect thereto, with or without a pressure jacket, by a first-quick release mechanism. At the same time, the plunger is connected to an injector drive mechanism by a second readily releasable mechanism. During the mounting operation, a sensor reads injection information from an indicator device on the syringe and feeds it to an injector control. An audible-and-tactile indicating mechanism also is activated when the syringe is essentially in the desired mounted position. The syringe may include reinforcing ribs, which also function as volumetric gradations, and liquid media presence-or-absence indicating dots which appear circular against a liquid media background and oval-shaped against an air background. An injection end of the syringe comprises an injector portion of reduced diameter inside a screw-threaded attachment portion of larger diameter, and may include loop-shaped reinforcing handle portions.
摘要翻译：一种包括用于注射液体造影剂的活动柱塞的前装载注射器，可旋转地安装在喷射器壳体的前壁上，其具有过盈配合并且与其相关的密封关系，具有或不具有压力套，快速释放机制。同时，柱塞通过第二容易释放的机构连接到喷射器驱动机构。在安装操作期间，传感器从注射器上的指示器装置读取注射信息并将其馈送到注射器控制器。当注射器基本上处于所需的安装位置时，也可以触发听觉和触觉指示机构。注射器可以包括也用作体积灰度的加强肋，以及液体介质的存在或不存在，指示针对液体介质背景呈圆形并且与空气背景呈椭圆形的点。注射器的注射端部包括在较大直径的螺纹连接部分内的直径减小的注射器部分，并且可以包括环形加强手柄部分。

39. 发明授权

US5795333A Front-loading medical injector and syringe for use therewith 失效
公开(公告)号：US5795333A
公开(公告)日：1998-08-18
申请号：US375431
申请日：1995-01-19
申请人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
发明人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
IPC分类号： A61M5/145 , A61M37/00
CPC分类号： A61M5/14546 , A61M2005/14553 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M5/14566 , Y10S128/01
摘要： A front-loading syringe which comprises a movable plunger for injecting liquid contrast media, is rotatably mountable on a front wall of an injector housing with an interference fit and in sealed relationship with respect thereto, with or without a pressure jacket, by a first-quick release mechanism. At the same time, the plunger is connected to an injector drive mechanism by a second readily releasable mechanism. During the mounting operation, a sensor reads injection information from an indicator device on the syringe and feeds it to an injector control. An audible-and-tactile indicating mechanism also is activated when the syringe is essentially in the desired mounted position. The syringe may include reinforcing ribs which also function as volumetric gradations, and liquid media presence-or-absence indicating dots which appear circular against a liquid media background and oval-shaped against an air background. An injection end of the syringe comprises an injector portion of reduced diameter inside a screw-threaded attachment portion of larger diameter, and may include loop-shaped reinforcing handle portions.

40. 发明授权

US5741232A Front loading medical injector and syringe for use therewith 失效
公开(公告)号：US5741232A
公开(公告)日：1998-04-21
申请号：US780012
申请日：1996-12-23
申请人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
发明人： David M. Reilly , Joseph B. Havrilla , Eugene A. Gelblum , Daniel Kazousky
IPC分类号： A61M5/145 , A61M37/00
CPC分类号： A61M5/14546 , A61M2005/14553 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M5/14566 , Y10S128/01
摘要： A front-loading syringe which comprises a movable plunger for injecting liquid contrast media, is rotatably mountable on a front wall of an injector housing with an interference fit and in sealed relationship with respect thereto, with or without a pressure jacket, by a first-quick release mechanism. At the same time, the plunger is connected to an injector drive mechanism by a second readily releasable mechanism. During the mounting operation, a sensor reads injection information from an indicator device on the syringe and feeds it to an injector control. An audible-and-tactile indicating mechanism also is activated when the syringe is essentially in the desired mounted position. The syringe may include reinforcing ribs which also function as volumetric gradations, and liquid media presence-or-absence indicating dots which appear circular against a liquid media background and oval-shaped against an air background. An injection end of the syringe comprises an injector portion of reduced diameter inside a screw-threaded attachment portion of larger diameter, and may include loop-shaped reinforcing handle portions.

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