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31. 发明授权

US06248656B1 Metal-jacketed lead manufacturing process using resist layers 有权
标题翻译：使用抗蚀剂层的金属外壳铅制造工艺
公开(公告)号：US06248656B1
公开(公告)日：2001-06-19
申请号：US09374394
申请日：1999-08-13
申请人： David R. Baker , John Grange , David Light , Hung-Ming Wang
发明人： David R. Baker , John Grange , David Light , Hung-Ming Wang
IPC分类号： H01L2144
CPC分类号： H01L21/4857 , H01L21/486
摘要： Metal leads are formed on a copper conductive layer by applying a first resist and a main resist over the first resist, and forming aligned openings in these resist. A bottom layer of cover metal such as gold is plated onto the copper conductive layer in these openings, followed by a principal metal such as copper. The main resist is then removed so as to expose edges of the principal metal layer. A jacket of cover metal is plated onto the exposed edges and surfaces of the principal metal layer. During this stage, the first resist prevents deposition of the cover metal except on the leads. The jacket merges with the bottom layer of cover material, so as to form a continuous coating extending around the perimeters of the leads. The first resist is removed, and the conductive layer is etched away. The cover metal protects the principal metal during the etching stage.
摘要翻译：通过在第一抗蚀剂上施加第一抗蚀剂和主抗蚀剂，在铜导电层上形成金属引线，并在这些抗蚀剂中形成对准的开口。覆盖金属如金的底层被镀在这些开口中的铜导电层上，随后是诸如铜的主要金属。然后去除主抗蚀剂以暴露主金属层的边缘。将覆盖金属的护套电镀在主金属层的暴露的边缘和表面上。在这个阶段，第一个抗蚀剂防止除了引线之外的覆盖金属的沉积。护套与覆盖材料的底层合并，以形成围绕引线周边延伸的连续涂层。去除第一抗蚀剂，并且蚀刻掉导电层。覆盖金属在蚀刻阶段保护主要金属。

32. 发明授权

US08501185B2 Dimeric molecular complexes 失效
标题翻译：二聚体分子复合物
公开(公告)号：US08501185B2
公开(公告)日：2013-08-06
申请号：US12302283
申请日：2007-05-24
申请人： Tara Renee Heitner Hansen , David Light , Kirk McLean , Renate Parry , Noboru Satozawa , Douglas Schneider , Marian Seto
发明人： Tara Renee Heitner Hansen , David Light , Kirk McLean , Renate Parry , Noboru Satozawa , Douglas Schneider , Marian Seto
IPC分类号： C07K1/32 , C07K16/46 , C07K16/00 , A61K39/00
CPC分类号： C07K16/00 , C07K16/3069 , C07K2317/52 , C07K2317/53 , C07K2317/55 , C07K2317/622 , C07K2319/30
摘要： Dimeric molecular complexes useful for diagnostics and therapeutics.
摘要翻译：用于诊断和治疗的二聚体分子复合物。

33. 发明申请

US20120178693A1 Cofactors for Thrombin Activation of Factor VII and Uses Thereof 审中-公开
标题翻译：凝血酶激活因子Ⅶ的辅因子及其用途
公开(公告)号：US20120178693A1
公开(公告)日：2012-07-12
申请号：US13393157
申请日：2010-08-28
申请人： David Light , Maxine Bauzon , David Kiewlich , Terry Hermiston
发明人： David Light , Maxine Bauzon , David Kiewlich , Terry Hermiston
IPC分类号： A61K38/17 , C12N15/62 , A61P7/04 , C12N5/10 , C12N5/16 , C07K19/00 , C12N15/63
CPC分类号： C07K14/745 , A61K38/00
摘要： The invention relates to fusion proteins that bind the enzyme thrombin and enhance the activation of the substrate Factor VII to the product Factor VIIa. The invention is also directed to polynucleotides, vectors, host cells, pharmaceutical compositions, and methods of treatment.
摘要翻译：本发明涉及结合酶凝血酶并增强底物因子VII对产物因子VIIa的活化的融合蛋白。本发明还涉及多核苷酸，载体，宿主细胞，药物组合物和治疗方法。

34. 发明申请

US20110229476A1 MONOSPECIFIC AND MULTISPECIFIC ANTIBODIES AND METHOD OF USE 有权
标题翻译：单一和多重抗体及其使用方法
公开(公告)号：US20110229476A1
公开(公告)日：2011-09-22
申请号：US12671942
申请日：2008-08-16
申请人： Bing Liu , David Light , Zhuozhi Wang , Douglas Schneider
发明人： Bing Liu , David Light , Zhuozhi Wang , Douglas Schneider
IPC分类号： A61K39/395 , C07K16/44 , G01N33/53 , C12N9/96 , A61P35/00 , A61P35/02 , A61P29/00 , A61P3/10 , A61P25/00 , A61P19/02 , A61P7/06 , A61P17/06 , A61P1/12 , A61P33/06 , A61P31/04 , A61P31/00 , A61P31/18 , A61P31/06 , A61P31/14 , A61P31/20
CPC分类号： C07K16/468 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6821 , A61K47/6827 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K16/3069 , C07K16/3076 , C07K16/36 , C07K2317/31 , C07K2317/56 , C07K2317/64 , Y02A50/412
摘要： This invention relates to monospecific and multispecific antibodies that may be utilized for the diagnosis and treatment of various diseases. In addition, these antibodies may be modified by protease cleavage. Protease control or regulation may be provided by a protease site located in, for example, a linker. These protease-regulated antibodies may also be utilized for the diagnosis and treatment of various diseases.
摘要翻译：本发明涉及可用于诊断和治疗各种疾病的单特异性和多特异性抗体。此外，这些抗体可以通过蛋白酶切割来修饰。蛋白酶控制或调节可以由位于例如接头的蛋白酶位点提供。这些蛋白酶调节的抗体也可用于各种疾病的诊断和治疗。

35. 发明申请

US20110201523A1 Particle Arrays and Methods of Making and Using 审中-公开
标题翻译：粒子阵列及其制作和使用方法
公开(公告)号：US20110201523A1
公开(公告)日：2011-08-18
申请号：US13027336
申请日：2011-02-15
申请人： Wolfgang HINZ , John Leamon , David Light , Jonathan Rothberg
发明人： Wolfgang HINZ , John Leamon , David Light , Jonathan Rothberg
IPC分类号： C40B40/06
CPC分类号： C12N15/1093 , B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00596 , B01J2219/00722 , C12Q1/6874 , C40B40/08 , C40B50/06 , Y10T428/2982
摘要： The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.
摘要翻译：本发明提供了在核酸分析中具有应用的颗粒组合物。本发明的核酸聚合物颗粒允许多核苷酸在其整个体积中被连接，以便比仅通过表面附着可实现的更高的负载能力。在一个方面，本发明的核酸聚合物颗粒包含具有低变异系数的具有均匀尺寸分布的聚丙烯酰胺颗粒，这导致分析测定中颗粒对颗粒的变化减少。这种颗粒组合物用于各种扩增反应以制备来自核酸片段文库的扩增子文库。

36. 发明申请

US20110195252A1 Scaffolded Nucleic Acid Polymer Particles and Methods of Making and Using 审中-公开
标题翻译：脚手架核酸聚合物颗粒及其制备和使用方法
公开(公告)号：US20110195252A1
公开(公告)日：2011-08-11
申请号：US13026707
申请日：2011-02-14
申请人： Wolfgang HINZ , John Leamon , David Light , Jonathan Rothberg
发明人： Wolfgang HINZ , John Leamon , David Light , Jonathan Rothberg
IPC分类号： B32B5/00 , C08F265/10
CPC分类号： C12N15/1093 , B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00596 , B01J2219/00722 , C12Q1/6874 , C40B40/08 , C40B50/06 , Y10T428/2982
摘要： The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.
摘要翻译：本发明提供了在核酸分析中具有应用的颗粒组合物。本发明的核酸聚合物颗粒允许多核苷酸在其整个体积中被连接，以便比仅通过表面附着可实现的更高的负载能力。在一个方面，本发明的核酸聚合物颗粒包含具有低变异系数的具有均匀尺寸分布的聚丙烯酰胺颗粒，这导致分析测定中粒子与粒子变化的减少。这种颗粒组合物用于各种扩增反应以制备来自核酸片段文库的扩增子文库。

37. 发明授权

US07960532B2 Polynucleotides encoding anticoagulant antibodies 失效
标题翻译：编码抗凝血抗体的多核苷酸
公开(公告)号：US07960532B2
公开(公告)日：2011-06-14
申请号：US12503893
申请日：2009-07-16
申请人： David Light , Kirk McLean
发明人： David Light , Kirk McLean
IPC分类号： C07H21/04
CPC分类号： G01N33/86 , A61K2039/505 , C07K16/36 , C07K16/40 , C07K2317/622 , G01N2800/224
摘要： This invention relates to novel antibodies that bind with greater affinity to the factor VIIa/tissue factor (FVIIa/TF) complex than to tissue factor (TF) alone, do not compete for binding to TF with FVII and FX, an inhibit FX activation. The antibodies bind at the site of injury and prevent the initiation of thrombosis. The antibodies can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.
摘要翻译：本发明涉及与单独的组织因子（TF）相比，与因子VIIa /组织因子（FVIIa / TF）复合物具有更高亲和力结合的新型抗体，不竞争与FVII和FX的结合，抑制FX激活。抗体在损伤部位结合并防止血栓形成的发生。抗体可用于治疗各种血栓形成病症，包括但不限于深静脉血栓形成，弥散性血管内凝血和急性冠状动脉综合征。

38. 发明申请

US20110027268A1 ANTI-MESOTHELIN ANTIBODIES AND USES THEREOF 有权
标题翻译：抗丝氨酸抗体及其用途
公开(公告)号：US20110027268A1
公开(公告)日：2011-02-03
申请号：US12744849
申请日：2008-11-19
申请人： Antje Kahnert , David Light , Doug Schneider , Renate Parry , Noboru Satozawa , Tara Heitner , Stefan Steidl , Ulrike Schubert
发明人： Antje Kahnert , David Light , Doug Schneider , Renate Parry , Noboru Satozawa , Tara Heitner , Stefan Steidl , Ulrike Schubert
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/63 , C12N5/10 , C12N1/21 , A61P35/00
CPC分类号： C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/77 , C07K2317/92
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 4O.kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译：本发明提供了重组抗原结合区和含有这样的抗原结合区的抗体和功能片段，所述抗原结合区对于多个肿瘤如胰腺和卵巢肿瘤间皮瘤中过表达的膜锚定的40kDa的间皮素多肽是特异性的和肺癌细胞。因此，这些抗体可用于治疗这些和其他病症和病症。本发明的抗体也可用于诊断领域，以及进一步研究间皮素在与癌症相关疾病进展中的作用。本发明还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。

39. 发明授权

US07696439B2 Layered metal structure for interconnect element 有权
标题翻译：用于互连元件的分层金属结构
公开(公告)号：US07696439B2
公开(公告)日：2010-04-13
申请号：US11801336
申请日：2007-05-09
申请人： David Light
发明人： David Light
IPC分类号： H01B7/18 , H05K1/00
CPC分类号： H05K3/062 , H05K3/202 , H05K2201/0361 , H05K2203/0384 , Y10T29/49224
摘要： A layered metal structure is provided in accordance with an aspect of the invention. The structure can be used, for example, to fabricate a conductive interconnect element for conductively interconnecting one or more microelectronic elements. The layered structure includes first and second metal layers each of which may include one or more of copper or aluminum, for example. An intervening layer, may include for example, chromium between the first and second metal layers, chromium being resistant to an etchant usable to pattern the first and second metal layers selectively to the intervening layer. An etchant such as cupric chloride, ferric chloride (FeCl3), a peroxysulfuric composition, or a persulfate composition may be used to pattern the first and second metal layers in such case.
摘要翻译：根据本发明的一个方面提供了层状金属结构。该结构可以用于例如制造导电互连一个或多个微电子元件的导电互连元件。层状结构包括例如可以包括铜或铝中的一种或多种的第一和第二金属层。中间层可以包括例如在第一和第二金属层之间的铬，铬耐腐蚀剂可以选择性地将第一和第二金属层图案化成中间层。在这种情况下，可以使用诸如氯化铜，氯化铁（FeCl 3），过氧化硫组合物或过硫酸盐组合物的蚀刻剂来图案化第一和第二金属层。

40. 发明申请

US20090317390A1 NOVEL TISSUE FACTOR TARGETED ANTIBODIES AS ANTICOAGULANTS 失效
标题翻译：新型组织因子定向抗体作为抗凝剂
公开(公告)号：US20090317390A1
公开(公告)日：2009-12-24
申请号：US12503893
申请日：2009-07-16
申请人： David Light , Kirk McLean
发明人： David Light , Kirk McLean
IPC分类号： A61K39/395 , C07H21/04
CPC分类号： G01N33/86 , A61K2039/505 , C07K16/36 , C07K16/40 , C07K2317/622 , G01N2800/224
摘要： This invention relates to novel antibodies that bind with greater affinity to the factor VIIa/tissue factor (FVIIa/TF) complex than to tissue factor (TF) alone, do not compete for binding to TF with FVII and FX, and inhibit FX activation. The antibodies bind at the site of injury and prevent the initiation of thrombosis. The antibodies can be used to treat a variety of thrombotic conditions including, but not limited to, deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.
摘要翻译：本发明涉及以与构成因子（FVIIa / TF）复合物相比更高的亲和力结合的单克隆抗体，不与FVII和FX竞争结合TF，并且抑制FX激活。抗体在损伤部位结合并防止血栓形成的发生。抗体可用于治疗各种血栓形成病症，包括但不限于深静脉血栓形成，弥散性血管内凝血和急性冠状动脉综合征。

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