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31. 发明授权

US08914107B2 Ventilation sensor rate response normalization and calculation 有权
标题翻译：通风传感器速率响应规范化和计算
公开(公告)号：US08914107B2
公开(公告)日：2014-12-16
申请号：US12784151
申请日：2010-05-20
申请人： Paul F. Emerson , Gary T. Seim , Michael A. Querimit , Donald L. Hopper , Stephen R. Pitzl , Daniel O'Brien
发明人： Paul F. Emerson , Gary T. Seim , Michael A. Querimit , Donald L. Hopper , Stephen R. Pitzl , Daniel O'Brien
IPC分类号： A61N1/365 , A61N1/362 , A61N1/37
CPC分类号： A61N1/36521 , A61N1/362 , A61N1/365 , A61N1/37
摘要： A cardiac rhythm management (CRM) device can extract ventilation information from thoracic impedance or other information, and adjust a delivery rate of the CRM therapy. A tidal volume of a patient is measured and used to adjust a ventilation rate response factor. The measured tidal volume can optionally be adjusted using a ventilation rate dependent adjustment factor. The ventilation rate response factor can also be adjusted using a maximum voluntary ventilation (MVV), an age predicted maximum heart rate, a resting heart rate, and a resting ventilation determined for the patient. In various examples, a global ventilation sensor rate response factor (for a population) can be programmed into the CRM device, and automatically tailored to be appropriate for a particular patient.
摘要翻译：心脏节律管理（CRM）设备可以从胸部阻抗或其他信息中提取通气信息，并调整CRM治疗的输送速率。测量患者的潮气量并用于调节通气率反应因子。测量的潮气量可以任选地使用通风率依赖调节因子进行调整。通气率反应因子也可以使用最大自主通气（MVV），年龄预测最大心率，静息心率和为患者确定的休息通气进行调整。在各种示例中，可将全球通气传感器速率响应因子（对于群体）编程到CRM设备中，并且被自动调整为适合于特定患者。

32. 发明申请

US20120004695A1 REVERSE PACING-MODE SWITCH 审中-公开
标题翻译：反向开关模式开关
公开(公告)号：US20120004695A1
公开(公告)日：2012-01-05
申请号：US13235008
申请日：2011-09-16
申请人： Gary T. Seim
发明人： Gary T. Seim
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/3688
摘要： A device comprises a cardiac contraction sensing circuit, a timer circuit, an electrical stimulation circuit, and a controller. The timer circuit provides a time duration of an atrial-atrial interval between successive atrial contractions, a ventricular-ventricular interval between successive ventricular contractions, and an atrial-ventricular (A-V) interval between an atrial contraction and a same cardiac cycle ventricular contraction. The controller includes an event detection module and a pacing module. The event detection module is configured for determining whether A-V block events are sustained over multiple cardiac cycles. The pacing module is configured for providing pacing therapy according to a primary pacing mode that includes AAI(R) mode with non-tracking VVI backup mode, and for switching the pacing therapy to a secondary tracking pacing mode if A-V block events are sustained over multiple cardiac cycles.
摘要翻译：一种装置包括心脏收缩感测电路，定时器电路，电刺激电路和控制器。定时器电路提供连续心房收缩之间的心房间隔的持续时间，连续心室收缩之间的心室 - 心室间隔和心房收缩与相同心动周期心室收缩之间的心房 - 心室（A-V）间隔。控制器包括事件检测模块和起搏模块。事件检测模块被配置用于确定A-V块事件是否在多个心动周期上持续。起搏模块被配置为根据主起搏模式提供起搏治疗，该起搏模式包括具有非跟踪VVI备用模式的AAI（R）模式，以及如果AV阻塞事件持续多次，则将起搏治疗切换到辅助跟踪起搏模式心脏周期。

33. 发明授权

US07761152B2 Delay to therapy following controlled atrial shock therapy request 失效
标题翻译：患者受控心房休克治疗后延迟治疗
公开(公告)号：US07761152B2
公开(公告)日：2010-07-20
申请号：US11273980
申请日：2005-11-15
申请人： Victor T. Chen , Gary T. Seim , Carlos Ricci , Michael L. Favet , Hal Propp
发明人： Victor T. Chen , Gary T. Seim , Carlos Ricci , Michael L. Favet , Hal Propp
IPC分类号： A61N1/39
CPC分类号： A61N1/3956
摘要： An implantable cardiac device detects a patient therapy request originating from external to the implantable device. A shock therapy delay period is timed in response to the detection of the patient therapy request. Atrial shock therapy is provided to the patient after expiration of the shock therapy delay period (if the presence of an ongoing atrial arrhythmia is detected). The patient therapy request may be provided by a patient activator including a magnet for operating a reed switch in the implanted device to provide the request. A patient activator including an input and receiver/transmitter circuitry may be employed to request the immediate providing of atrial shock therapy, and/or to set the duration the shock therapy delay period. By allowing specific delays to therapy after a therapy request, a patient can prepare for the requested therapy and thereby mitigate therapy discomfort.
摘要翻译：可植入心脏装置检测源自可植入装置外部的患者治疗请求。响应于患者治疗请求的检测，休克治疗延迟期是定时的。在休克治疗延迟期结束后（如果检测到正在进行的心律失常的存在），向患者提供心房休克疗法。患者治疗请求可以由患者激活器提供，包括用于在植入装置中操作舌簧开关的磁体以提供请求。可以使用包括输入和接收器/发射器电路的患者激活器来请求立即提供心房休克疗法和/或设置休克治疗延迟时期的持续时间。通过在治疗请求后允许特定的延迟治疗，患者可以准备所要求的治疗，从而减轻治疗不适。

34. 发明授权

US07706877B2 Patient controlled atrial shock therapy 有权
标题翻译：患者控制心房休克疗法
公开(公告)号：US07706877B2
公开(公告)日：2010-04-27
申请号：US11264525
申请日：2005-11-01
申请人： Victor T. Chen , Gary T. Seim , Hal Propp , LeAnne Eberle , Lynn TeWinkel
发明人： Victor T. Chen , Gary T. Seim , Hal Propp , LeAnne Eberle , Lynn TeWinkel
IPC分类号： A61N1/00
CPC分类号： A61N1/37252 , A61N1/3956
摘要： An implanted cardiac device detects an atrial arrhythmia and provides periodically updated atrial arrhythmia status as long as the arrhythmia is ongoing. A patient may request an indication of ongoing atrial arrhythmia status from external to the patient using a patient activator. The patient activator may include a magnet for closing a reed switch in the implanted device to provide the request or may provide the request over a telemetry link to the implanted device. The implanted device may provide the requested atrial arrhythmia status and other information in the form of an audible tone produced by the implanted device or as a message telemetered from the implanted device to the patient activator. The patient activator may include a tone detector and display for providing a visual indication of the atrial arrhythmia status indication. The magnet activator may also be employed to request or withhold atrial shock therapy.
摘要翻译：植入式心脏装置检测心房心律失常，并且只要心律失常正在进行，就能提供定期更新的心房心律失常状态。患者可以使用患者激活剂从外部向患者请求持续的心房心律失常状态的指示。患者激活器可以包括用于关闭植入装置中的舌簧开关以提供请求的磁体，或者可以通过到植入装置的遥测链路提供请求。植入装置可以以由植入装置产生的听觉音调的形式或作为从植入装置遥测到患者激活器的消息来提供所请求的心房心律失常状态和其他信息。患者激活器可以包括用于提供心房心律失常状态指示的视觉指示的音调检测器和显示器。磁铁激活剂也可用于要求或禁止心房休克治疗。

35. 发明申请

US20090157128A1 SENSING THRESHOLD CONTROL TO LIMIT AMPLITUDE TRACKING 有权
标题翻译：感应阈值控制限制幅度跟踪
公开(公告)号：US20090157128A1
公开(公告)日：2009-06-18
申请号：US12330857
申请日：2008-12-09
申请人： Gary T. Seim , Ron A. Balczewski
发明人： Gary T. Seim , Ron A. Balczewski
IPC分类号： A61N1/39 , A61N1/37
CPC分类号： A61N1/3621 , A61N1/371
摘要： A depolarization sensing threshold can be determined using an amplitude-limited portion of a cardiac signal received using an implantable medical device. One or more cardiac depolarizations can be detected using the cardiac signal and the depolarization sensing threshold.
摘要翻译：可以使用使用可植入医疗装置接收的心脏信号的限幅部分来确定去极化感测阈值。可以使用心脏信号和去极化感测阈值来检测一个或多个心脏去极化。

36. 发明申请

US20080255628A1 REVERSE PACING-MODE SWITCH 有权
标题翻译：反向开关模式开关
公开(公告)号：US20080255628A1
公开(公告)日：2008-10-16
申请号：US11734120
申请日：2007-04-11
申请人： Gary T. Seim
发明人： Gary T. Seim
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/3688
摘要： A device comprises a cardiac contraction sensing circuit, a timer circuit, an electrical stimulation circuit, and a controller. The timer circuit provides a time duration of an atrial-atrial interval between successive atrial contractions, a ventricular-ventricular interval between successive ventricular contractions, and an atrial-ventricular (A-V) interval between an atrial contraction and a same cardiac cycle ventricular contraction. The controller includes an event detection module and a pacing module. The event detection module is configured for determining whether A-V block events are sustained over multiple cardiac cycles. The pacing module is configured for providing pacing therapy according to a primary pacing mode that includes AAI(R) mode with independent VVI backup mode, and for switching the pacing therapy to a secondary pacing mode if A-V block events are sustained over multiple cardiac cycles. Other devices and methods are described.
摘要翻译：一种装置包括心脏收缩感测电路，定时器电路，电刺激电路和控制器。定时器电路提供连续心房收缩之间的心房间隔的持续时间，连续心室收缩之间的心室 - 心室间隔和心房收缩与相同心动周期心室收缩之间的心房 - 心室（A-V）间隔。控制器包括事件检测模块和起搏模块。事件检测模块被配置用于确定A-V块事件是否在多个心动周期上持续。起搏模块被配置为根据主起搏模式提供起搏治疗，该起搏模式包括具有独立VVI备用模式的AAI（R）模式，并且如果A-V阻塞事件在多个心动周期上持续，则用于将起搏治疗切换到辅助起搏模式。描述其他设备和方法。

37. 发明授权

US07421294B2 System and method for preventing recurrence of atrial tachyarrhythmia 有权
公开(公告)号：US07421294B2
公开(公告)日：2008-09-02
申请号：US10975553
申请日：2004-10-28
申请人： Victor T. Chen , Gary T. Seim , Milton M. Morris
发明人： Victor T. Chen , Gary T. Seim , Milton M. Morris
IPC分类号： A61N1/362
CPC分类号： A61N1/3962 , A61N1/3622
摘要： A system and method for providing pacing pulses after a cardioversion/defibrillation shock, where the pacing pulses have a pacing rate at an initial value. The pacing rate is decreased from the initial value until at least one intrinsic cardiac contraction is detected. In one embodiment, the pacing rate is decreased by a set amount after pacing a set number of cardiac cycles. Providing the set number of pacing pulses and decreasing the pacing rate by the set amount is then repeated until at least one intrinsic cardiac contraction is detected. An intrinsic cardiac rate is then determined from the at least one intrinsic cardiac contraction. The pacing rate is then increased and maintained to be above (i.e., greater than) the intrinsic cardiac rate.

38. 发明授权

US07257442B2 Mode switching algorithm for AV block 失效
标题翻译： AV块的模式切换算法
公开(公告)号：US07257442B2
公开(公告)日：2007-08-14
申请号：US10854736
申请日：2004-05-26
申请人： Andrew P. Kramer , Gary T. Seim
发明人： Andrew P. Kramer , Gary T. Seim
IPC分类号： A61N1/00
CPC分类号： A61N1/368
摘要： An apparatus and method is presented for treating patients with sinus node dysfunction who have apparently normal intrinsic AV conduction and thus do not require ventricular pacing unless there is an unexpected AV conduction failure. In one embodiment, a cardiac device with dual-chamber pacing capability is programmed to operate in a primary DDI (or DDI(R)) mode adjusted to pace only the atria if intrinsic AV conduction is intact and switch to a secondary DDD (or DDD(R)) mode upon detection of AV block.
摘要翻译：提出了一种用于治疗窦房结功能障碍患者的装置和方法，其具有明显正常的内在AV传导，因此除非出现意外的AV传导衰竭，否则不需要心室起搏。在一个实施例中，具有双室起搏能力的心脏装置被编程为在主要DDI（或DDI））模式下操作，其被调整为仅在内部AV传导完整的情况下仅调节心房，并切换到次级DDD（或DDD （R））模式。

39. 发明授权

US07120493B2 Shock lead impedance measurement to ensure safe delivery of shock therapy to maintain circuit integrity 有权
标题翻译：冲击导线阻抗测量，以确保安全交付休克疗法以维持电路完整性
公开(公告)号：US07120493B2
公开(公告)日：2006-10-10
申请号：US10210790
申请日：2002-07-31
申请人： Hal M. Propp , Gary T. Seim , Michael L. Favet
发明人： Hal M. Propp , Gary T. Seim , Michael L. Favet
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/3706 , A61N2001/083
摘要： An apparatus and method of automatically measuring the lead impedance of a high energy shock lead before delivery of high energy therapy used to treat heart arrhythmia. In one example, an impedance measurement circuit measures the impedance between electrodes in a plurality of pairs of electrodes. The measured lead electrode impedance is compared to a predetermined value to detect if the lead is shorted to another lead. If a high-energy shock electrode is shorted to another lead, a shorted lead indicator is set to a fault state. Based on the state of the shorted lead indicator, a processor prevents or allows the delivery of high energy therapy. By checking for a lead short before delivery of the therapy, all of the energy of the therapy is delivered to the patient rather than being bypassed by a shorted lead connection.
摘要翻译：在用于治疗心律失常的高能量治疗之前自动测量高能量冲击引线的引线阻抗的装置和方法。在一个示例中，阻抗测量电路测量多对电极中的电极之间的阻抗。将测量的引线电极阻抗与预定值进行比较，以检测引线是否与另一引线短路。如果高能量的冲击电极短路到另一个引线，则引脚指示器短路设置为故障状态。基于短路引线指示器的状态，处理器防止或允许高能量治疗的传递。通过在治疗之前检查引线短路，治疗的所有能量都被传递给患者，而不是被短路引线连接旁路。

40. 发明授权

US06741890B1 Method and apparatus for detection of premature atrial contractions 有权
标题翻译：用于检测早产性心房收缩的方法和装置
公开(公告)号：US06741890B1
公开(公告)日：2004-05-25
申请号：US09615488
申请日：2000-07-13
申请人： Gary T. Seim , Victor T. Chen
发明人： Gary T. Seim , Victor T. Chen
IPC分类号： A61N1362
CPC分类号： A61N1/3622
摘要： A system and method for detecting premature atrial contractions in which a function of A—A intervals measured between successive atrial senses is computed and compared with a present A—A interval. In accordance with the invention, a premature atrial contraction is detected if the present A—A interval is less than a specified percentage of a moving average of previous A—A intervals and below a specified absolute limit value.
摘要翻译：一种用于检测早期心房收缩的系统和方法，其中计算在连续心房感测之间测量的A-A间隔的功能并与当前的A-A间隔进行比较。根据本发明，如果当前A-A间隔小于先前A-A间隔的移动平均值的指定百分比并且低于指定的绝对极限值，则检测到过早的心房收缩。

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