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31. 发明授权

US5800512A PTFE vascular graft 失效
标题翻译： PTFE血管移植
公开(公告)号：US5800512A
公开(公告)日：1998-09-01
申请号：US588052
申请日：1996-01-22
申请人： David J. Lentz , Jamie Henderson , Edward J. Dormier , Richard J. Zdrahala
发明人： David J. Lentz , Jamie Henderson , Edward J. Dormier , Richard J. Zdrahala
IPC分类号： A61L27/00 , A61F2/06 , A61F2/88 , A61L27/16 , A61L27/50 , A61L27/56 , A61F2/04
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/507 , A61F2002/0086 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.
摘要翻译：可植入的微孔ePTFE管状血管移植物显示出长期通畅性，优异的径向拉伸强度和缝合孔伸长抗性。移植物包括第一ePTFE管和周向设置在第一管上的第二ePTFE管。第一个ePTFE管表现出足以促进细胞内皮细胞向内生长和愈合的孔隙度。第二ePTFE管表现出超过第一管的径向拉伸强度的增强的径向强度。

32. 发明授权

US4654031A Flash chamber 失效
标题翻译：闪光室
公开(公告)号：US4654031A
公开(公告)日：1987-03-31
申请号：US723247
申请日：1985-04-15
申请人： David J. Lentz
发明人： David J. Lentz
IPC分类号： A61M25/00 , A61M25/06 , A61M5/14
CPC分类号： A61M25/0693
摘要： A flash chamber formed of two molded components being a cap which fits over a hollow hub and conjugates therewith to form a tortuous path through the hub and then between the outside of the hub and the inside of the cap.
摘要翻译：由两个模制部件形成的闪光室是一个盖子，该盖子装配在中空的轮毂上并与其共轭以形成通过轮毂的曲折路径，然后在轮毂的外侧和盖的内部之间。

33. 发明申请

US20100100073A1 CATHETER ARTICULATION SEGMENT WITH ALTERNATING CUTS 失效
标题翻译：具有替代品的导管结构部分
公开(公告)号：US20100100073A1
公开(公告)日：2010-04-22
申请号：US12642362
申请日：2009-12-18
申请人： David J. Lentz , Richard J. Koerner
发明人： David J. Lentz , Richard J. Koerner
IPC分类号： A61M25/00
CPC分类号： A61M25/0013 , A61M25/0054 , A61M25/0138
摘要： An articulation segment for a catheter includes a tube formed with a first plurality of axially aligned slits that are respectively oriented in planes perpendicular to the axis, with each slit extending azimuthally in an arc partway around the axis. The tube is also formed with a second plurality of similarly formed slits that are axially offset and diametrically opposed relative to the slits of the first plurality to allow for a bending of the catheter in a plurality of different planes. In a particular embodiment, the slits are arranged to allow the articulation segment to be reconfigured from a straight, substantially cylindrically shaped tube to a configuration in which a portion of the articulation segment is formed in the shape of a ring.
摘要翻译：用于导管的关节节段包括形成有第一多个轴向对准的狭缝的管，其分别定向在垂直于轴线的平面中，每个狭缝围绕轴线在一半弧中方位延伸。管还形成有第二多个类似形成的狭缝，其相对于第一多个的狭缝轴向地偏置并沿直径相对，以允许导管在多个不同平面中弯曲。在特定实施例中，狭缝被布置成允许关节运动部分从直的基本上圆柱形的管重新配置到其中关节节段的一部分形成为环形的构造。

34. 发明授权

US07637903B2 Catheter articulation segment with alternating cuts 有权
标题翻译：导管交叉节段交替切割
公开(公告)号：US07637903B2
公开(公告)日：2009-12-29
申请号：US10872612
申请日：2004-06-21
申请人： David J. Lentz , Richard J. Koerner
发明人： David J. Lentz , Richard J. Koerner
IPC分类号： A61M25/00
CPC分类号： A61M25/0013 , A61M25/0054 , A61M25/0138
摘要： An articulation segment for a catheter includes a tube formed with a first plurality of axially aligned slits that are respectively oriented in planes perpendicular to the axis, with each slit extending azimuthally in an arc partway around the axis. The tube is also formed with a second plurality of similarly formed slits that are axially offset and diametrically opposed relative to the slits of the first plurality to allow for a bending of the catheter in a plurality of different planes. In a particular embodiment, the slits are arranged to allow the articulation segment to be reconfigured from a straight, substantially cylindrically shaped tube to a configuration in which a portion of the articulation segment is formed in the shape of a ring.
摘要翻译：用于导管的关节节段包括形成有第一多个轴向对准的狭缝的管，其分别定向在垂直于轴线的平面中，每个狭缝围绕轴线在一半弧中方位延伸。管还形成有第二多个类似形成的狭缝，其相对于第一多个的狭缝轴向地偏置并沿直径相对，以允许导管在多个不同平面中弯曲。在特定实施例中，狭缝被布置成允许关节运动部分从直的基本上圆柱形的管重新配置到其中关节节段的一部分形成为环形的构造。

35. 再颁专利

USRE40868E1 Refrigeration source for a cryoblation catheter 失效
标题翻译：冷冻导管的制冷源
公开(公告)号：USRE40868E1
公开(公告)日：2009-08-11
申请号：US11865686
申请日：2007-10-01
申请人： Eric Ryba , David J. Lentz , Ravikumar Kudaravalli , Hong Li
发明人： Eric Ryba , David J. Lentz , Ravikumar Kudaravalli , Hong Li
IPC分类号： A61B18/18
CPC分类号： F25D3/10 , A61B18/02 , A61B2017/00199 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , F25B9/02 , F25B2700/13 , F25D16/00 , F25D2400/36
摘要： A catheter-based system for performing a cryoablation procedure uses a precooler to lower the temperature of a fluid refrigerant to a sub-cool temperature (−40° C.) at a working pressure (400 psi). The sub-cooled fluid is then introduced into a supply line of the catheter. Upon outflow of the primary fluid from the supply line, and into a tip section of the catheter, the fluid refrigerant boils at an outflow pressure of approximately one atmosphere, at a temperature of about −88° C. In operation, the working pressure is computer controlled to obtain an appropriate outflow pressure for the coldest possible temperature in the tip section.
摘要翻译：用于执行冷冻消融程序的基于导管的系统使用预冷器来在工作压力（400psi）下将流体制冷剂的温度降低到亚冷温度（-40℃）。然后将次冷流体引入导管的供应管线。在主要流体从供应管路流出并进入导管的尖端部分时，流体制冷剂在大约一个大气压的流出压力下沸腾，温度约为-88℃。在操作中，工作压力为计算机控制以获得适当的流出压力，用于在尖端部分中最冷的温度。

36. 发明申请

US20090053535A1 Reduced Residual Formation in Etched Multi-Layer Stacks 审中-公开
标题翻译：蚀刻多层堆叠中残留形成的减少
公开(公告)号：US20090053535A1
公开(公告)日：2009-02-26
申请号：US12196959
申请日：2008-08-22
申请人： Frank Y. Xu , Weijun Liu , Cynthia B. Brooks , Dwayne L. LaBrake , David J. Lentz
发明人： Frank Y. Xu , Weijun Liu , Cynthia B. Brooks , Dwayne L. LaBrake , David J. Lentz
IPC分类号： B32B27/00 , C08F2/46 , B05D3/00 , B44C1/22
CPC分类号： G03F7/027 , B82Y10/00 , B82Y40/00 , G03F7/0002 , Y10T428/24612
摘要： A multi-layer stack for imprint lithography is formed by applying a first polymerizable composition to a substrate, polymerizing the first polymerizable composition to form a first polymerized layer, applying a second polymerizable composition to the first polymerized layer, and polymerizing the second polymerizable composition to form a second polymerized layer on the first polymerized layer. The first polymerizable composition includes a polymerizable component with a glass transition temperature less than about 25° C., and the first polymerized layer is substantially impermeable to the second polymerizable composition.
摘要翻译：通过将第一可聚合组合物施加到基底上，聚合第一可聚合组合物以形成第一聚合层，向第一聚合层施加第二可聚合组合物，并将第二可聚合组合物聚合成在第一聚合层上形成第二聚合层。第一可聚合组合物包括玻璃化转变温度低于约25℃的可聚合组分，并且第一聚合层对于第二可聚合组合物基本上是不可渗透的。

37. 发明授权

US07285108B2 Active system for deflecting a distal portion of a catheter into a hoop configuration 有权
标题翻译：用于将导管的远端部分偏转成环形构造的主动系统
公开(公告)号：US07285108B2
公开(公告)日：2007-10-23
申请号：US10876312
申请日：2004-06-24
申请人： Richard J. Koerner , David J. Lentz , Joseph A. O'Donnell , Alvin B. Salinas
发明人： Richard J. Koerner , David J. Lentz , Joseph A. O'Donnell , Alvin B. Salinas
IPC分类号： A61M31/00 , A61B1/00
CPC分类号： A61M25/0147 , A61B2017/003 , A61B2018/0212 , A61B2018/0231 , A61B2018/0262 , A61M25/0136 , A61M2025/0161
摘要： An active system for deflecting a distal portion of a catheter into a hoop configuration includes an elongated catheter body having a proximal portion and a distal portion that is formed with a lumen. A thin-walled tube, which is typically made of a metallic material, is positioned in the lumen. The tube includes a cylindrical wall and includes a plurality of lateral slits that are typically formed in the tube wall and arranged such that the tube can be transformed between a relaxed, cylindrical configuration and a deflected configuration wherein the tube is substantially hoop shaped. One end of a deflection wire is attached to the tube and the other wire end is attached to a reel that is rotationally mounted onto a catheter handle housing. In use, the reel is rotated to axially retract the wire and transform the tube into a hoop configuration.
摘要翻译：用于将导管的远侧部分偏转成环形构造的主动系统包括具有近端部分和形成有内腔的远侧部分的细长导管主体。通常由金属材料制成的薄壁管被定位在内腔中。管包括圆柱形壁并且包括多个横向狭缝，其通常形成在管壁中并且布置成使得管可以在松弛的圆柱形构造和偏转构造之间变形，其中管基本上是环形的。偏转线的一端附接到管，另一个线端附接到旋转地安装到导管手柄壳体上的卷轴上。在使用中，卷轴旋转以轴线缩回线，并将管转变成环箍构型。

38. 发明授权

US07004936B2 Refrigeration source for a cryoablation catheter 失效
公开(公告)号：US07004936B2
公开(公告)日：2006-02-28
申请号：US10243997
申请日：2002-09-12
申请人： Eric Ryba , David J. Lentz , Ravikumar Kudaravalli
发明人： Eric Ryba , David J. Lentz , Ravikumar Kudaravalli
IPC分类号： A61B18/18
CPC分类号： F25D3/10 , A61B18/02 , A61B2017/00199 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , F25B9/02 , F25B2700/13 , F25D16/00 , F25D2400/36
摘要： A catheter-based system for performing a cryoablation procedure uses a precooler to lower the temperature of a fluid refrigerant to a sub-cool temperature (−40° C.) at a working pressure (400 psi). The sub-cooled fluid is then introduced into a supply line of the catheter. Upon outflow of the primary fluid from the supply line, and into a tip section of the catheter, the fluid refrigerant boils at an outflow pressure of approximately one atmosphere, at a temperature of about −88° C. In operation, the working pressure is computer controlled to obtain an appropriate outflow pressure for the coldest possible temperature in the tip section.

39. 发明授权

US06824543B2 Guidance system for a cryocatheter 有权
公开(公告)号：US06824543B2
公开(公告)日：2004-11-30
申请号：US10317842
申请日：2002-12-11
申请人： David J. Lentz
发明人： David J. Lentz
IPC分类号： A61B1818
CPC分类号： A61M25/01 , A61B18/02 , A61B2017/22038 , A61B2017/22051 , A61B2018/0212 , A61M2025/0177
摘要： A system for guiding a cryocatheter through the vasculature of a patient includes a guidewire positioned in the vasculature across a predetermined site. A connector is attached to the distal end of the cryocatheter and is configured to receive the guidewire. The connector is then placed over the guidewire to guide the cryocatheter through the vasculature along the guidewire to the predetermined site. The tip of the cryocatheter can then be used at the predetermined site to cryoablate the tissue or otherwise remove heat from the predetermined site.

40. 发明授权

US06803069B2 Method for imparting a bio-active coating 失效
标题翻译：赋予生物活性涂层的方法
公开(公告)号：US06803069B2
公开(公告)日：2004-10-12
申请号：US09885361
申请日：2001-06-20
申请人： Birendra K. Patnaik , Horng-Ban Lin , David J. Lentz , Richard J. Zdrahala
发明人： Birendra K. Patnaik , Horng-Ban Lin , David J. Lentz , Richard J. Zdrahala
IPC分类号： B05D300
CPC分类号： A61L27/34 , A61L27/507 , A61L33/0029 , A61L33/0047 , A61L33/0094
摘要： Disclosed are implantable medical devices with enhanced patency. Expanded polytetrafluoroethylene small caliber vascular grafts coated with polymer bound bio-active agents that exhibit enhanced patency are disclosed. The polymer bound bio-active agents can include anti-thrombogenic agents, antibiotics, antibacterial agents and antiviral agents. Methods of preparing same are also provided.
摘要翻译：公开了具有增强的通畅的可植入医疗装置。公开了扩张聚四氟乙烯小口径血管移植物，其涂覆有聚合物结合的生物活性剂，其显示增强的通畅。聚合物结合的生物活性剂可以包括抗血栓形成剂，抗生素，抗菌剂和抗病毒剂。还提供了制备方法。

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