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31. 发明授权

US06794382B2 Benzimidazole derivatives, preparation and therapeutic use thereof 失效
标题翻译：苯并咪唑衍生物，其制备和治疗用途
公开(公告)号：US06794382B2
公开(公告)日：2004-09-21
申请号：US10343467
申请日：2003-01-30
申请人： Francis Barth , Daniel Bichon , Frank Bolkenius , Viviane Van Dorsselaer
发明人： Francis Barth , Daniel Bichon , Frank Bolkenius , Viviane Van Dorsselaer
IPC分类号： C07D47106
CPC分类号： C07D471/06 , C07D487/06
摘要： The invention relates to benzimidazole derivatives of general formula in which X represents a nitrogen atom or a carbon atom; and when X represents a nitrogen atom: R3 represents a hydrogen atom or a C1-C4 alkyl group, or does not exist, to give the compounds of formula (I) comprising a secondary or tertiary amine; R4 represents a hydrogen atom or a C1-C6 alkyl, C3-C7 cycloalkyl, optionally substituted C3-C7 heterocycloalkyl, —(CH2)p-heteroaryl, heteroaryl-carbonyl, phenylcarbonyl, (C1-C6)alkylcarbonyl, —(CH2)pCOOR, optionally substituted phenylsulphonyl or optionally substituted —(CH2)p-phenyl group, and, when X represents a carbon atom: R3 represents a hydrogen atom or a group —NR5R6, —N(R5)3+, —NHCOR7, —CONHR5, —COR7, —NHCONH2, —OH or —CH2OH, R4 represents a hydrogen atom or an optionally substituted —(CH2)p-phenyl, —(CH2)p-heteroaryl or —(CH2)tNR7R8 group. Preparation process and therapeutic application.
摘要翻译：本发明涉及X表示氮原子或碳原子的一般结构式的苯并咪唑衍生物，当X表示氮原子时：R 3表示氢原子或C 1 -C 4烷基，或不存在，得到式（I）包括仲胺或叔胺; R 4表示氢原子或C 1 -C 6烷基，C 3 -C 7环烷基，任选取代的C 3 -C 7杂环烷基， - （CH 2）p - 杂芳基，杂芳基 - 羰基，苯基羰基，（ C 1 -C 6）烷基羰基， - （CH 2）p COOR，任选取代的苯基磺酰基或任选取代的 - （CH 2）对苯基，并且当X表示碳原子时：R 3表示氢原子或-NR 5 R 6基，-N（ R5）3 +，-NHCOR7，-CONHR5，-COR7，-NHCONH2，-OH或-CH2OH，R4表示氢原子或任选取代的 - （CH 2）p - 苯基， - （CH 2）p - - （CH2）tNR7R8组。制备方法和治疗应用。

32. 发明授权

US06613306B1 Ultrasound contrast agents and methods of making and using them 失效
标题翻译：超声造影剂及其使用方法
公开(公告)号：US06613306B1
公开(公告)日：2003-09-02
申请号：US09401838
申请日：1999-09-22
申请人： Michel Schneider , Feng Yan , Pascal Grenier , Jerome Puginier , Marie-Bernadette Barrau , Philippe Bussat , Eva Hybl , Daniel Bichon
发明人： Michel Schneider , Feng Yan , Pascal Grenier , Jerome Puginier , Marie-Bernadette Barrau , Philippe Bussat , Eva Hybl , Daniel Bichon
IPC分类号： A61B800
CPC分类号： A61K49/223 , Y10S977/929
摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
摘要翻译：在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。它们含有表面活性剂和任选的亲水稳定剂。表面活性剂可以是脂质体的形式。通过在与水相混合之前或之后将表面活性剂暴露于空气或气体中来获得悬浮液。通过使用作为填充气体的填充气体，其在水中的溶解度，以标准条件下以升水表示的水分数除以平方根，可以赋予在超声波回波造影中用作造影剂的这些充气微泡的压力下突出的抵抗压力崩溃的抵抗力的分子量不超过0.003。还公开了具有特定气体混合物的对比剂，其具有有利的性质。

33. 发明授权

US5711933A Method of making polymeric gas or air filled microballoons for ultrasonic echography 失效
标题翻译：制造聚合气体或空气填充的微球用于超声波回波测量的方法
公开(公告)号：US5711933A
公开(公告)日：1998-01-27
申请号：US288550
申请日：1994-08-10
申请人： Daniel Bichon , Philippe Bussat , Michel Schneider
发明人： Daniel Bichon , Philippe Bussat , Michel Schneider
IPC分类号： A61B8/00 , A61B20060101 , A61K20060101 , A61K9/107 , A61K9/127 , A61K9/16 , A61K9/50 , A61K47/30 , A61K49/00 , A61K49/22 , B01J13/02 , B01J13/04 , B01J13/06 , A61K9/14
CPC分类号： A61K49/223
摘要： Method of making gas or air filled microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is deformable and resilient for use in ultrasonic contrast compositions are described.
摘要翻译：描述了一种平均尺寸在0.5至1000微米范围内的气体或空气填充微球的方法，该微球由50至500nm厚的可生物降解的界面沉积的合成聚合物膜界定，其可变形和弹性用于超声对比组合物。

34. 发明授权

US4506672A Sheathed surgical suture filament and method for its preparation 失效
标题翻译：护套外科缝合线及其制备方法
公开(公告)号：US4506672A
公开(公告)日：1985-03-26
申请号：US279972
申请日：1981-06-30
申请人： Daniel Bichon
发明人： Daniel Bichon
IPC分类号： A61L15/00 , A61L17/14 , D06M15/564 , A61L17/00
CPC分类号： A61L17/145 , D06M15/564 , Y10S128/08
摘要： Catgut suturing filament protected by a flexible polymer sheath that is slowly hydrolytically degradable and impervious to body fluid degratative enzymes. The sheath is prepared by coating the catgut filament with an isocyanate capped polyhydroxylated polyester followed by curing.

35. 发明申请

US20060257321A1 Ultrasound contrast agents and methods of making and using them 审中-公开
公开(公告)号：US20060257321A1
公开(公告)日：2006-11-16
申请号：US11444362
申请日：2006-06-01
申请人： Michel Schneider , Feng Yan , Nadine Garcel , Pascal Grenier , Jerome Puginier , Marie-Bernadette Barrau , Philippe Bussat , Eva Hybl , Daniel Bichon
发明人： Michel Schneider , Feng Yan , Nadine Garcel , Pascal Grenier , Jerome Puginier , Marie-Bernadette Barrau , Philippe Bussat , Eva Hybl , Daniel Bichon
IPC分类号： A61K49/00
CPC分类号： A61K49/223
摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.

36. 发明授权

US6123922A Resilient deformable microballoons for echographic imaging 失效
标题翻译：用于回波成像的弹性变形微球
公开(公告)号：US6123922A
公开(公告)日：2000-09-26
申请号：US929274
申请日：1997-09-12
申请人： Daniel Bichon , Philippe Bussat , Michel Schneider
发明人： Daniel Bichon , Philippe Bussat , Michel Schneider
IPC分类号： A61B8/00 , A61B20060101 , A61K20060101 , A61K9/107 , A61K9/127 , A61K9/16 , A61K9/50 , A61K47/30 , A61K49/00 , A61K49/22 , B01J13/02 , B01J13/04 , B01J13/06
CPC分类号： A61K49/223
摘要： Air or gas filled microballoons bounded by an interfacially deposited polymer membrane which can be dispersed in aqueous carrier liquids to be injected into living organisms or administered orally, rectally and urethrally for therapeutic or diagnostic purposes (echography). The properties of the polymeric membrane of the microballoons (elasticity, permeability, biodegradability) can be controlled at will depending on the selected polymer, the interfacial deposition conditions, and the polymer additives.
摘要翻译：由界面沉积的聚合物膜界定的空气或气体填充的微球，其可以分散在水性载体液体中以被注射到活生物体中，或者以口服，直肠和尿道给药以用于治疗或诊断目的（回波图）。根据所选择的聚合物，界面沉积条件和聚合物添加剂，可以随意控制微球聚合物膜的性质（弹性，渗透性，生物降解性）。

37. 发明授权

US6110443A Dry stable formation to produce microbubble suspension for ultrasound 失效
标题翻译：干稳定形成以产生超声波微泡悬浮液
公开(公告)号：US6110443A
公开(公告)日：2000-08-29
申请号：US853936
申请日：1997-05-09
申请人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
发明人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
IPC分类号： A61B8/00 , A61B5/055 , A61K9/10 , A61K9/127 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/34 , A61K47/36 , A61K49/00 , A61K49/22 , A61B8/13
CPC分类号： A61K49/223 , A61K49/227 , Y10S514/975
摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
摘要翻译：在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。它们含有层状表面活性剂和任选的亲水稳定剂。层状表面活性剂可以是脂质体的形式。通过在与水相混合之前或之后将层状表面活性剂暴露于空气或气体中获得悬浮液。

38. 发明授权

US5658551A Stable microbubbles suspensions injectable into living organisms 失效
公开(公告)号：US5658551A
公开(公告)日：1997-08-19
申请号：US456385
申请日：1995-06-01
申请人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
发明人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
IPC分类号： A61B8/00 , A61B5/055 , A61K9/10 , A61K9/127 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/34 , A61K47/36 , A61K49/00 , A61K49/22 , A61B8/13
CPC分类号： A61K49/223 , A61K49/227 , Y10S514/975
摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.

39. 发明授权

US5531980A Stable microbubbles suspensions injectable into living organisms 失效
公开(公告)号：US5531980A
公开(公告)日：1996-07-02
申请号：US315347
申请日：1994-09-30
申请人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
发明人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
IPC分类号： A61B8/00 , A61B5/055 , A61K9/10 , A61K9/127 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/34 , A61K47/36 , A61K49/00 , A61K49/22
CPC分类号： A61K49/223 , A61K49/227 , Y10S514/975
摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.

40. 发明授权

US5271928A Stable microbubbles suspensions injectable into living organisms 失效
标题翻译：稳定的微泡悬浮液可注入生物体
公开(公告)号：US5271928A
公开(公告)日：1993-12-21
申请号：US775989
申请日：1991-11-20
申请人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
发明人： Michel Schneider , Daniel Bichon , Philippe Bussat , Jerome Puginier , Eva Hybl-Sutherland
IPC分类号： A61B8/00 , A61B5/055 , A61K9/10 , A61K9/127 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/34 , A61K47/36 , A61K49/00 , A61K49/22
CPC分类号： A61K49/223 , A61K49/227 , Y10S514/975
摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
摘要翻译： PCT No.PCT / EP91 / 00620 Sec。 371日期1991年11月20日 102（e）1991年11月20日日期PCT 1991年4月2日PCT PCT。出版物WO91 / 15244 日期：1991年10月17日。在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。它们含有层状表面活性剂和任选的亲水稳定剂。层状表面活性剂可以是脂质体的形式。通过在与水相混合之前或之后将层状表面活性剂暴露于空气或气体中获得悬浮液。

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