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31. 发明申请

US20100168246A1 AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE 审中-公开
标题翻译：胺化合物和抑制神经递质反应
公开(公告)号：US20100168246A1
公开(公告)日：2010-07-01
申请号：US12722342
申请日：2010-03-11
申请人： Elliott Richelson , Paul R. Carlier
发明人： Elliott Richelson , Paul R. Carlier
IPC分类号： A61K31/135 , C07C215/30 , A61P25/00
CPC分类号： C07C215/28 , A61K31/137 , A61K31/138 , A61K45/06 , C07C215/30 , A61K2300/00
摘要： The invention relates to amine compounds as well as methods and materials involved in modulating neurotransmitter reuptake. Specifically, the invention provides amine compounds, methods for synthesizing amine compounds, and methods for inhibiting neurotransmitter reuptake.
摘要翻译：本发明涉及胺化合物以及涉及调节神经递质再摄取的方法和材料。具体地说，本发明提供胺化合物，合成胺化合物的方法和抑制神经递质再摄取的方法。

32. 发明申请

US20080275272A1 AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE 审中-公开
标题翻译：胺化合物和抑制神经递质反应
公开(公告)号：US20080275272A1
公开(公告)日：2008-11-06
申请号：US12171990
申请日：2008-07-11
申请人： Elliott Richelson , Paul R. Carlier
发明人： Elliott Richelson , Paul R. Carlier
IPC分类号： C07C215/28
CPC分类号： C07C215/28 , A61K31/137 , A61K31/138 , A61K45/06 , C07C215/30 , A61K2300/00
摘要： The invention relates to amine compounds as well as methods and materials involved in modulating neurotransmitter reuptake. Specifically, the invention provides amine compounds, methods for synthesizing amine compounds, and methods for inhibiting neurotransmitter reuptake.
摘要翻译：本发明涉及胺化合物以及涉及调节神经递质再摄取的方法和材料。具体地说，本发明提供胺化合物，合成胺化合物的方法和抑制神经递质再摄取的方法。

33. 发明申请

US20070173458A1 Neo-tryptophan 失效
标题翻译：新色氨酸
公开(公告)号：US20070173458A1
公开(公告)日：2007-07-26
申请号：US11452616
申请日：2006-06-14
申请人： Elliott Richelson , Bernadette Cusack , Yuan-Ping Pang , Daniel McCormick , Abdul Fauq , Beth Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Cusack , Yuan-Ping Pang , Daniel McCormick , Abdul Fauq , Beth Tyler , Mona Boules
IPC分类号： C07K7/06 , A61K38/08
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.
摘要翻译：本发明提供了新的氨基酸，新色氨酸，以及含有这种新型氨基酸的多肽，如神经降压素类似物。此外，本发明提供新色氨酸衍生物，5-羟色胺样新色氨酸衍生物和含有这些衍生物的多肽。本发明还提供了制备新色氨酸，新色氨酸衍生物，血清素样新色氨酸衍生物和含有这些化合物的组合物的方法。此外，本发明提供了在哺乳动物中诱导神经降压素反应的方法以及用于治疗具有5-羟色胺识别分子的哺乳动物的方法。

34. 发明授权

US07098307B2 Neo-tryptophan 有权
公开(公告)号：US07098307B2
公开(公告)日：2006-08-29
申请号：US11178269
申请日：2005-07-08
申请人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
IPC分类号： C07K1/06 , C07K7/06
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.

35. 发明申请

US20060189536A1 Treating the effects of nicotine 审中-公开
标题翻译：治疗尼古丁的作用
公开(公告)号：US20060189536A1
公开(公告)日：2006-08-24
申请号：US11415570
申请日：2006-05-02
申请人： Elliott Richelson , Paul Fredrickson , Mona Boules
发明人： Elliott Richelson , Paul Fredrickson , Mona Boules
IPC分类号： A61K38/17 , A61K31/195
CPC分类号： A61K38/10 , A61K31/137 , Y10S514/813 , A61K2300/00
摘要： The invention provides methods and materials for treating the effects of nicotine. In particular, the invention provides methods that involve administering a neurotensin receptor (NTR) agonist to a mammal that has been exposed to nicotine. The NTR agonist typically is administered in an amount effective to diminish or abolish the effects that nicotine has on the treated mammal. NTR agonists that can be used in methods of the invention include neurotensin (NT) polypeptide analogs such as NT69L. The invention also provides compositions containing an NTR agonist in combination with other agents used to help overcome nicotine effects such as sensitization and dependence. The compositions provided herein can be used to treat the effects of nicotine, including hyperactivity, hypothermia, respiratory distress, and hypertension.
摘要翻译：本发明提供了治疗尼古丁作用的方法和材料。特别地，本发明提供了涉及向暴露于尼古丁的哺乳动物施用神经降压素受体（NTR）激动剂的方法。 NTR激动剂通常以有效减少或消除尼古丁对治疗的哺乳动物的作用的量施用。可用于本发明方法的NTR激动剂包括神经丝氨酸（NT）多肽类似物，如NT69L。本发明还提供含有NTR激动剂与用于帮助克服尼古丁效应如致敏和依赖性的其它试剂组合的组合物。本文提供的组合物可用于治疗尼古丁的作用，包括多动症，低体温，呼吸窘迫和高血压。

36. 发明授权

US06989270B1 Using polyamide nucleic acid oligomers to engender a biological response 失效
标题翻译：使用聚酰胺核酸低聚物产生生物反应
公开(公告)号：US06989270B1
公开(公告)日：2006-01-24
申请号：US09168714
申请日：1998-10-08
申请人： Elliott Richelson , Beth Marie Tyler , Bernadette Marie Cusack , Christopher Lee Douglas , Karen Jansen
发明人： Elliott Richelson , Beth Marie Tyler , Bernadette Marie Cusack , Christopher Lee Douglas , Karen Jansen
IPC分类号： C07H21/04 , C12N15/00 , A61K48/00
CPC分类号： C07K14/003 , A61K38/00 , A61K2123/00 , C12N15/1138 , C12N2310/3181
摘要： The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. The invention also provides sense and antisense PNA oligomers that modulate transcription and translation, respectively. The invention also provides mismatch PNA oligomers that modulate the degree of an engendered biological response. In addition, the invention provides methods and materials for detecting PNA oligomers within a biological sample collected from an animal. Further, the invention provides methods and materials for screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, the invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.
摘要翻译：本发明涉及用于细胞外活细胞的PNA寡聚体的方法和材料。具体地，本发明提供了用PNA寡聚体处理活细胞的方法和材料，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。此外，本发明提供了用于向动物口服PNA寡聚体的方法和材料，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。本发明还提供分别调节转录和翻译的有义和反义PNA寡聚体。本发明还提供了调节产生的生物反应程度的错配PNA寡聚体。此外，本发明提供了用于检测从动物收集的生物样品中的PNA寡聚体的方法和材料。此外，本发明提供了用于筛选潜在的PNA寡聚体以产生序列特异性生物反应的能力的方法和材料。此外，本发明提供鉴定多肽的功能和确定功能性多肽的相对周转率的方法。

37. 发明授权

US06914080B2 Amine compounds and inhibiting neurotransmitter reuptake 失效
公开(公告)号：US06914080B2
公开(公告)日：2005-07-05
申请号：US10755893
申请日：2004-01-12
申请人： Elliott Richelson , Paul R. Carlier
发明人： Elliott Richelson , Paul R. Carlier
IPC分类号： A61K31/137 , A61K31/138 , A61K45/06 , C07C215/28 , A61K31/135
CPC分类号： C07C215/28 , A61K31/137 , A61K31/138 , A61K45/06 , C07C215/30 , A61K2300/00
摘要： The invention relates to amine compounds as well as methods and materials involved in modulating neurotransmitter reuptake. Specifically, the invention provides amine compounds, methods for synthesizing amine compounds, and methods for inhibiting neurotransmitter reuptake.

38. 发明授权

US06743627B1 Using polyamide nucleic acid oligomers to engender a biological response 失效
标题翻译：使用聚酰胺核酸低聚物产生生物反应
公开(公告)号：US06743627B1
公开(公告)日：2004-06-01
申请号：US09016685
申请日：1998-01-30
申请人： Elliott Richelson , Beth Marie Tyler , Daniel J. McCormick , Bernadette Marie Cusack , Clark V. Hoshall , Christopher Lee Douglas , Karen Jansen
发明人： Elliott Richelson , Beth Marie Tyler , Daniel J. McCormick , Bernadette Marie Cusack , Clark V. Hoshall , Christopher Lee Douglas , Karen Jansen
IPC分类号： C07K2104
CPC分类号： C12N15/1138 , A61K38/00 , A61K2123/00 , C07K14/003 , C12N2310/3181
摘要： The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. This invention also provides methods of screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, this invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.
摘要翻译：本发明涉及用于细胞外活细胞的PNA寡聚体的方法和材料。具体地，本发明提供了用PNA寡聚体处理活细胞的方法，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。此外，本发明提供了用于向动物口服PNA寡聚体的方法和材料，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。本发明还提供了筛选潜在的PNA寡聚体以产生序列特异性生物反应的能力的方法。此外，本发明提供鉴定多肽的功能和确定功能性多肽的相对周转率的方法。

39. 发明授权

US06472209B1 Using polyamide nucleic acid oligomers to engender a biological response 失效
标题翻译：使用聚酰胺核酸低聚物产生生物反应
公开(公告)号：US06472209B1
公开(公告)日：2002-10-29
申请号：US08953269
申请日：1997-10-17
申请人： Elliott Richelson , Beth Marie Tyler , Daniel J. McCormick , Bernadette Marie Cusack , Clark V. Hoshall , Christopher Lee Douglas , Karen Jansen
发明人： Elliott Richelson , Beth Marie Tyler , Daniel J. McCormick , Bernadette Marie Cusack , Clark V. Hoshall , Christopher Lee Douglas , Karen Jansen
IPC分类号： C07H2104
CPC分类号： C12N15/1138 , A61K38/00 , A61K2123/00 , C07K14/003 , C12N2310/3181
摘要： The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. This invention also provides methods of screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, this invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.
摘要翻译：本发明涉及用于细胞外活细胞的PNA寡聚体的方法和材料。具体地，本发明提供了用PNA寡聚体处理活细胞的方法，使得寡聚物交叉生物屏障并以序列特异性方式产生生物反应。本发明还提供了筛选潜在的PNA寡聚体以产生序列特异性生物反应的能力的方法。此外，本发明提供鉴定多肽的功能和确定功能性多肽的相对周转率的方法。

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