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31. 发明申请

US20110142952A1 Pharmaceutical Compositions 审中-公开
标题翻译：药物组合物
公开(公告)号：US20110142952A1
公开(公告)日：2011-06-16
申请号：US13000114
申请日：2009-06-17
申请人： David J. Harris , Stephen Randall Holmes-Farley , Steven C. Polomoscanlk , Adnan Salameh , Bruce Shutts , Richard Silva
发明人： David J. Harris , Stephen Randall Holmes-Farley , Steven C. Polomoscanlk , Adnan Salameh , Bruce Shutts , Richard Silva
IPC分类号： A61K9/16 , A61K31/785 , A61K31/132 , C08G73/02 , C07C217/42 , B32B5/16
CPC分类号： A61K9/1641 , Y10T428/2982
摘要： This invention relates to crosslinked amine-containing polymers for binding compounds or ions, and more specifically relates to pharmaceutically acceptable compositions for binding compounds or ions that include crosslinked amine-containing polymers. The pharmaceutically acceptable composition includes, for example, crosslinked polyamine particles, or pharmaceutically acceptable salts thereof, having a particle size distribution wherein greater than 10 vol. % of the particles have a particle size greater than 500 μm.
摘要翻译：本发明涉及用于结合化合物或离子的交联的含胺聚合物，更具体地涉及用于结合包含交联的含胺聚合物的化合物或离子的药学上可接受的组合物。药学上可接受的组合物包括例如交联的多胺颗粒或其药学上可接受的盐，其具有大于10体积％颗粒的％具有大于500μm的粒度。

32. 发明授权

US08377428B2 Low salt forms of polyallylamine 有权
公开(公告)号：US08377428B2
公开(公告)日：2013-02-19
申请号：US12427127
申请日：2009-04-21
申请人： John S. Petersen , Steven K. Burke , Stephen Randall Holmes-Farley
发明人： John S. Petersen , Steven K. Burke , Stephen Randall Holmes-Farley
IPC分类号： A61K31/74
CPC分类号： A61K31/765 , A61K31/785
摘要： Disclosed is a pharmaceutical composition comprising a stable polyallylamine hydrochloride polymer in which between about 4% to about 12% by weight of the polymer is a chloride anion and a pharmaceutically acceptable carrier or diluent.

33. 发明申请

US20100068167A1 Low Salt Forms of Polyallylamine 有权
标题翻译：低盐形式的聚烯丙胺
公开(公告)号：US20100068167A1
公开(公告)日：2010-03-18
申请号：US12427127
申请日：2009-04-21
申请人： John S. Petersen , Steven K. Burke , Stephen Randall Holmes-Farley
发明人： John S. Petersen , Steven K. Burke , Stephen Randall Holmes-Farley
IPC分类号： A61K31/74
CPC分类号： A61K31/765 , A61K31/785
摘要： Disclosed is a pharmaceutical composition comprising a stable polyallylamine hydrochloride polymer in which between about 4% to about 12% by weight of the polymer is a chloride anion and a pharmaceutically acceptable carrier or diluent.
摘要翻译：公开了包含稳定的聚烯丙胺盐酸盐聚合物的药物组合物，其中约4％至约12％重量的聚合物是氯化物阴离子和药学上可接受的载体或稀释剂。

34. 发明授权

US07541024B2 Low salt forms of polyallylamine 有权
公开(公告)号：US07541024B2
公开(公告)日：2009-06-02
申请号：US10125684
申请日：2002-04-17
申请人： John S. Petersen , Steven K. Burke , Stephen Randall Holmes-Farley
发明人： John S. Petersen , Steven K. Burke , Stephen Randall Holmes-Farley
IPC分类号： A61K31/74
CPC分类号： A61K31/765 , A61K31/785
摘要： Disclosed is a pharmaceutical composition comprising a stable polyallylamine hydrochloride polymer in which between about 4% to about 12% by weight of the polymer is a chloride anion and a pharmaceutically acceptable carrier or diluent.

35. 发明授权

US07119120B2 Phosphate transport inhibitors 有权
标题翻译：磷酸盐转运抑制剂
公开(公告)号：US07119120B2
公开(公告)日：2006-10-10
申请号：US10327627
申请日：2002-12-20
申请人： Thomas H. Jozefiak , Cecilia M. Bastos , Andrew T. Papoulis , Stephen Randall Holmes-Farley
发明人： Thomas H. Jozefiak , Cecilia M. Bastos , Andrew T. Papoulis , Stephen Randall Holmes-Farley
IPC分类号： A61K31/18 , A61K31/16 , A61K37/18
CPC分类号： A61K45/06 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/415 , A61K31/63 , A61K33/38 , A61K2300/00
摘要： Disclosed are compounds which have been identified as inhibitors of phosphate transport. Many of the compounds are represented by Structural Formula (I): Ar1—W—X—Y—Ar2; or a pharmaceutically acceptable salt thereof. Ar1 and Ar2 are independently a substituted or unsubstituted aryl group or an optionally substituted five membered or six membered non-aromatic heterocylic group fused to an optionally substituted monocylic aryl group. W and Y are independently a covalent bond or a C1–C3 substituted or unsubstituted alkylene group. X is a heteroatom-containing functional group, an aromatic heterocyclic group, substituted aromatic heterocyclic group, non-aromatic heterocyclic group, substituted non-aromatic heterocyclic group, an olefin group or a substituted olefin group. Also disclosed are methods of treating a subject with a disease associated with hyperphosphatemia, as well as a disease mediated by phosphate-transport function. The methods comprise the step of administering an effective amount of the one of the compounds described above.
摘要翻译：公开了已被鉴定为磷酸盐转运抑制剂的化合物。许多化合物由结构式（I）表示：<？in-line-formula description =“In-line Formulas”end =“lead”？> Ar -WXY-Ar _{2 <？in-line-formula description =“In-line Formulas”end =“tail”？>或其药学上可接受的盐。 Ar 1和Ar 2独立地是与任选取代的单环芳基稠合的取代或未取代的芳基或任选取代的五元或六元非芳族杂环基。 W和Y独立地是共价键或C1-C3取代或未取代的亚烷基。 X为含杂原子的官能团，芳香族杂环基，取代芳香族杂环基，非芳香族杂环基，取代非芳香族杂环基，烯基或取代烯基。还公开了治疗患有与高磷酸盐血症相关的疾病的受试者以及由磷酸盐转运功能介导的疾病的方法。所述方法包括施用有效量的上述一种化合物的步骤。}

36. 发明授权

US07049345B2 Fat-binding polymers 有权
公开(公告)号：US07049345B2
公开(公告)日：2006-05-23
申请号：US10187315
申请日：2002-06-27
申请人： Stephen Randall Holmes-Farley
发明人： Stephen Randall Holmes-Farley
IPC分类号： A61K47/30
CPC分类号： A61K31/785 , A61K31/74
摘要： The present invention provides fat-binding polymers, which comprise dialkanolamine, dialkanolammonium, aminoalkylpolyol, and ammoniumalkylpolyol pendant groups for subjects in need of fat removal from the gastrointestinal tract, particularly subjects suffering from steatorrhea and/or experiencing side effects from lipase inhibitors. Patients being administered with lipase inhibitors are typically being treated for Type II Diabetes, streatorrhea, and hypertriglyceridemia. The fat binding polymers of this invention are also suitable for use with obese subjects.

37. 发明授权

US06281252B1 Method for reducing oxalate 有权
标题翻译：降低草酸盐的方法
公开(公告)号：US06281252B1
公开(公告)日：2001-08-28
申请号：US09668874
申请日：2000-09-25
申请人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III
发明人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III
IPC分类号： A61K4700
CPC分类号： A61K45/06 , A61K31/785 , A61K31/787 , A61K38/44 , A61K38/51 , C12Y102/03004 , C12Y401/01002 , A61K2300/00
摘要： A method for reducing oxalate levels in a patient that includes administering to the patient a therapeutically effective amount of non-absorbable amine polymers such as a polymer characterized by a repeat unit having the formula: and salts and copolymers thereof, where n is a positive integer and x is zero or an integer between 1 and about 4.
摘要翻译：一种用于降低患者中草酸盐含量的方法，包括向患者施用治疗有效量的不可吸收的胺聚合物，例如聚合物，其特征在于具有下式的重复单元：及其盐和共聚物，其中n为正整数 x为0或1至4之间的整数。

38. 发明授权

US6034129A Ionic polymers as anti-infective agents 失效
公开(公告)号：US6034129A
公开(公告)日：2000-03-07
申请号：US670764
申请日：1996-06-24
申请人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Thomas X. Neenan , Stephen Randall Holmes-Farley
IPC分类号： A61K31/785 , A61P31/04 , A61P31/10 , A61P33/00 , A61P33/04 , A61K31/14 , A61K31/16 , A61K31/74
CPC分类号： A61K31/785
摘要： A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.

39. 发明授权

US5981693A Process for removing bile salts from a patient and alkylated compositions therefor 有权
公开(公告)号：US5981693A
公开(公告)日：1999-11-09
申请号：US288357
申请日：1999-04-08
申请人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley
IPC分类号： A01N33/18 , A61K20060101 , A61K31/04 , A61K31/785 , A61K31/787 , A61P1/16 , A61P3/06 , C08F8/00 , C08F8/02 , C08F8/44 , C08F16/00 , C08F18/22 , C08F26/02 , C08F116/00 , C08F220/34 , C08F220/60 , C08F283/00 , C08G69/26 , C08G73/00 , C08G73/02 , C08G81/00
CPC分类号： C08F220/60 , A61K31/785 , A61K31/787 , C08F220/34 , C08F26/00 , C08F8/00 , C08F8/02 , C08F8/44 , C08L39/02
摘要： The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer comprises the reaction product of polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent and a crosslinking agent.

40. 发明授权

US5917007A Process for removing bile salts from a patient and alkylated compositions therefor 有权
公开(公告)号：US5917007A
公开(公告)日：1999-06-29
申请号：US129286
申请日：1998-08-05
申请人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley
发明人： W. Harry Mandeville, III , Stephen Randall Holmes-Farley
IPC分类号： A01N33/18 , A61K20060101 , A61K31/04 , A61K31/785 , A61K31/787 , A61P1/16 , A61P3/06 , C08F8/00 , C08F8/02 , C08F8/44 , C08F16/00 , C08F18/22 , C08F26/02 , C08F116/00 , C08F220/34 , C08F220/60 , C08F283/00 , C08G69/26 , C08G73/00 , C08G73/02 , C08G81/00 , C08G65/04
CPC分类号： C08F220/60 , A61K31/785 , A61K31/787 , C08F220/34 , C08F26/00 , C08F8/00 , C08F8/02 , C08F8/44 , C08L39/02
摘要： The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer comprises the reaction product of polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent and a crosslinking agent.

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