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31. 发明申请

US20070092864A1 Treatment planning methods, devices and systems 审中-公开
标题翻译：治疗计划方法，设备和系统
公开(公告)号：US20070092864A1
公开(公告)日：2007-04-26
申请号：US11542016
申请日：2006-10-02
申请人： Joseph Reinhardt , John Garber , Juerg Tschirren , Milan Sonka , Geoffrey McLennan , Eric Hoffman
发明人： Joseph Reinhardt , John Garber , Juerg Tschirren , Milan Sonka , Geoffrey McLennan , Eric Hoffman
IPC分类号： C12Q1/00 , G06F19/00 , A61B5/00
CPC分类号： A61B90/36 , A61B34/10 , A61B2017/00809 , A61N2005/1074 , G06T7/0012 , G06T7/11 , G06T7/155 , G06T7/174 , G06T2200/24 , G06T2207/10081 , G06T2207/20156 , G06T2207/30061 , G06T2207/30101
摘要： Treatment planning methods, devices and systems. One of the treatment planning methods includes displaying at least a portion of a set of lungs and one or more potential treatment regions; receiving a selection of a target treatment region from among the one or more potential treatment regions; and displaying one or more locations within the portion that are therapeutically linked to the target treatment region. Other treatment planning methods, devices and systems are included.
摘要翻译：治疗计划方法，设备和系统。治疗计划方法之一包括显示一组肺的至少一部分和一个或多个潜在治疗区域; 从所述一个或多个潜在治疗区域中接收目标治疗区域的选择; 以及显示所述部分内与目标治疗区域治疗连接的一个或多个位置。包括其他治疗计划方法，设备和系统。

32. 发明授权

US07141964B2 Adaptive integrated circuit for magnetoresistive sensors 失效
标题翻译：用于磁阻传感器的自适应集成电路
公开(公告)号：US07141964B2
公开(公告)日：2006-11-28
申请号：US10753233
申请日：2004-01-06
申请人： Eric Hoffman , Nicholas F. Busch
发明人： Eric Hoffman , Nicholas F. Busch
IPC分类号： G01B7/00 , H03K3/59
CPC分类号： G01D5/2448
摘要： A device, system and method for adaptively tracking amplitude boundary values of a real time sensor output signal. In accordance with the method of the present invention, an amplitude boundary value, which may be a peak or min amplitude value, representing the current amplitude boundary of the sensor output signal is stored within a digital counter. A two-tap DAC is utilized to convert the digitally stored amplitude boundary value into a reference signal level corresponding in amplitude to the amplitude boundary value. The DAC also converts the amplitude boundary value into an offset reference signal level corresponding in amplitude to the amplitude boundary value offset by a specified multiple of the DAC resolution. The reference signal level and offset reference signal are compared with the real time sensor signal and the digitally stored amplitude boundary value is adjusted in accordance with which reference signal level exceeds the real time sensor signal.
摘要翻译：一种用于自适应跟踪实时传感器输出信号的幅度边界值的装置，系统和方法。根据本发明的方法，将表示传感器输出信号的当前幅度边界的峰值或最小振幅值的振幅边界值存储在数字计数器内。利用二抽头DAC将数字存储的幅度边界值转换成与幅度边界值对应的参考信号电平。 DAC还将幅度边界值转换为与振幅边界值偏移相对应的振幅边界值偏移指定倍数的DAC分辨率的偏移参考信号电平。将参考信号电平和偏移参考信号与实时传感器信号进行比较，并且根据哪个参考信号电平超过实时传感器信号来调整数字存储的幅度边界值。

33. 发明申请

US20060204969A1 Genetic variations (SNPs) adjacent to the AKT1 gene locus, and diagnostic and prognostic uses thereof 审中-公开
标题翻译：与AKT1基因座相邻的遗传变异（SNPs）及其诊断和预后用途
公开(公告)号：US20060204969A1
公开(公告)日：2006-09-14
申请号：US11035377
申请日：2005-01-14
申请人： Eric Hoffman , Joseph Devaney
发明人： Eric Hoffman , Joseph Devaney
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6888 , C12Q2600/124 , C12Q2600/156
摘要： We have identified and isolated a 12 kb region immediately upstream of the AKT1 gene containing eight single nucleotide polymorphic polynucleotides (SNPs) in 4 haplotype regions that show strong association with body composition, Basal Mass Index, and AKT1 expression enhancement in human males. A four-locus haplotype (Haplotype 2) was defined where residues within highly conserved regulatory regions were altered. This haplotype explained up to 26% of population variation in bone cortical volume, 12% of subcutaneous fat volume, and 9% of strength variation, resulting in a body build with large bones, strong muscles, and low subcutaneous fat. Other SNPs detect, presymptomatically, the potential for increased amounts of subcutaneous fat and Type II diabetes. The detection of these SNPs by the techniques described herein forms the foundation for genotype-specific clinical interventions designed to slow the rapid population increases in obesity and Type II diabetes.
摘要翻译：我们已经鉴定并分离了4个单倍型区域中包含八个单核苷酸多态性多核苷酸（SNPs）的AKT1基因上游的12 kb区域，与人体组成，基础质量指数和AKT1表达增强在人类雄性中有很强的相关性。定义了四基因座单倍型（单倍型2），其中高度保守的调控区域内的残基被改变。这种单倍型解释了骨皮层体积，皮下脂肪体积的12％和强度变化的9％的群体变化的26％，导致身体建立与大骨骼，强壮的肌肉和低皮下脂肪。其他SNP检测，在症状前，可能增加皮下脂肪和II型糖尿病。通过本文描述的技术检测这些SNP形成了旨在减缓肥胖和II型糖尿病快速增长的基因型特异性临床干预的基础。

34. 发明申请

US20050190384A1 Method and apparatus for creating a registration network of a scene 失效
标题翻译：用于创建场景的注册网络的方法和装置
公开(公告)号：US20050190384A1
公开(公告)日：2005-09-01
申请号：US11065745
申请日：2005-02-25
申请人： Fred Persi , Eric Hoffman
发明人： Fred Persi , Eric Hoffman
IPC分类号： B41B1/00 , G06F15/00 , G06T7/00
CPC分类号： G06T7/33 , G06T2200/04
摘要： An apparatus for creating a registration network of a scene includes a laser scanner for scanning the scene and obtaining data of the scene. The apparatus includes a plurality of targets placed in the scene. The apparatus includes a mechanism for forming a registration network using only the laser scanner data. A method for creating a registration network of the scene.
摘要翻译：用于创建场景的注册网络的装置包括用于扫描场景并获得场景的数据的激光扫描仪。该装置包括放置在场景中的多个目标。该装置包括仅使用激光扫描器数据形成注册网络的机构。一种用于创建场景的注册网络的方法。

35. 发明申请

US20050146322A1 Adaptive integrated circuit for magnetoresistive sensors 失效
标题翻译：用于磁阻传感器的自适应集成电路
公开(公告)号：US20050146322A1
公开(公告)日：2005-07-07
申请号：US10753233
申请日：2004-01-06
申请人： Eric Hoffman , Nicholas Busch
发明人： Eric Hoffman , Nicholas Busch
IPC分类号： G01D5/244 , G01B7/30 , G01B7/14 , G01R33/025
CPC分类号： G01D5/2448
摘要： A device, system and method for adaptively tracking amplitude boundary values of a real time sensor output signal. In accordance with the method of the present invention, an amplitude boundary value, which may be a peak or min amplitude value, representing the current amplitude boundary of the sensor output signal is stored within a digital counter. A two-tap DAC is utilized to convert the digitally stored amplitude boundary value into a reference signal level corresponding in amplitude to the amplitude boundary value. The DAC also converts the amplitude boundary value into an offset reference signal level corresponding in amplitude to the amplitude boundary value offset by a specified multiple of the DAC resolution. The reference signal level and offset reference signal are compared with the real time sensor signal and the digitally stored amplitude boundary value is adjusted in accordance with which reference signal level exceeds the real time sensor signal.
摘要翻译：一种用于自适应跟踪实时传感器输出信号的幅度边界值的装置，系统和方法。根据本发明的方法，将表示传感器输出信号的当前幅度边界的峰值或最小振幅值的振幅边界值存储在数字计数器内。利用二抽头DAC将数字存储的幅度边界值转换成与幅度边界值对应的参考信号电平。 DAC还将幅度边界值转换为与振幅边界值偏移相对应的振幅边界值偏移指定倍数的DAC分辨率的偏移参考信号电平。将参考信号电平和偏移参考信号与实时传感器信号进行比较，并且根据哪个参考信号电平超过实时传感器信号来调整数字存储的幅度边界值。

36. 发明申请

US20050036668A1 Methods and devices useful for analyzing color medical images 有权
标题翻译：用于分析彩色医学图像的方法和设备
公开(公告)号：US20050036668A1
公开(公告)日：2005-02-17
申请号：US10777764
申请日：2004-02-12
申请人： Geoffrey McLennan , Martin Donnelley , Deepa Gopalakrishnan , Eric Hoffman , Joseph Reinhardt , Melissa Suter
发明人： Geoffrey McLennan , Martin Donnelley , Deepa Gopalakrishnan , Eric Hoffman , Joseph Reinhardt , Melissa Suter
IPC分类号： G06K9/00 , G06K9/46 , G06T7/00 , G06T7/40
CPC分类号： G06K9/4652 , G06T7/0012 , G06T7/90 , G06T2200/24 , G06T2207/10016 , G06T2207/30004
摘要： In one embodiment, a method that includes comparing a subject color medical image to normal color medical image data; and identifying abnormal pixels from the subject color medical image. Another embodiment includes a computer readable medium comprising machine readable instructions for implementing one or more steps of that method. Another embodiment includes a device that has a field programmable gate array configured to perform one or more of the steps of that method. Another embodiment includes a device that has an application specific integrated circuit configured to perform one or more of the steps of that method.
摘要翻译：在一个实施例中，一种方法，其包括将主题彩色医学图像与正常彩色医学图像数据进行比较; 以及从所述被摄体彩色医学图像识别异常像素。另一实施例包括计算机可读介质，其包括用于实现该方法的一个或多个步骤的机器可读指令。另一个实施例包括具有被配置为执行该方法的一个或多个步骤的现场可编程门阵列的设备。另一实施例包括具有被配置为执行该方法的一个或多个步骤的专用集成电路的设备。

37. 发明授权

US06446030B1 Method and apparatus for establishing the layout of a building 失效
标题翻译：建立建筑物布局的方法和装置
公开(公告)号：US06446030B1
公开(公告)日：2002-09-03
申请号：US09012937
申请日：1998-01-24
申请人： Eric Hoffman , Darin Ingimarson
发明人： Eric Hoffman , Darin Ingimarson
IPC分类号： G06F1750
CPC分类号： G01C15/002
摘要： An apparatus for establishing a layout of a building. The apparatus includes a mechanism for scanning a first room of the building to obtain room data. The apparatus also includes a scanner for forming a representation of a layout of the first room from the first room data. The forming mechanism is connected to the scanner. A method for establishing the layout of a building. The method includes the steps of placing a scanner in a first room of the building. Then there is the step of scanning the first room with the scanner to obtain first room data. Then there is the step of forming a representation of the layout of the first room from the first room data.
摘要翻译：一种用于建立建筑物布局的装置。该装置包括用于扫描建筑物的第一房间以获得房间数据的机构。该装置还包括扫描器，用于从第一房间数据形成第一房间的布局的表示。成形机构连接到扫描仪。建立建筑物布局的方法。该方法包括将扫描仪放置在建筑物的第一房间中的步骤。然后，用扫描仪扫描第一个房间以获得第一个房间数据的步骤。然后是从第一个房间数据形成第一个房间的布局的表示的步骤。

38. 发明授权

US6034803A Method and apparatus for directing energy based range detection sensor 失效
标题翻译：用于引导基于能量的距离检测传感器的方法和装置
公开(公告)号：US6034803A
公开(公告)日：2000-03-07
申请号：US846317
申请日：1997-04-30
申请人： Ryan M. Sullivan , Eric Hoffman , William Darin Ingimarson
发明人： Ryan M. Sullivan , Eric Hoffman , William Darin Ingimarson
IPC分类号： G01S7/48 , G01S7/481 , G01S7/484 , G01S7/486 , G01S17/08 , G01S17/42 , G02B26/08
CPC分类号： G01S7/4817 , G01S17/42 , G01S7/4811 , G01S7/4813 , G01S7/484 , G01S7/486 , Y10S359/90
摘要： A directing apparatus includes a mechanism for producing steerable energy. The directing apparatus also includes a mechanism for steering energy from the producing mechanism. The steering mechanism is in communication with the producing mechanism.
摘要翻译：引导装置包括用于产生可转向能量的机构。引导装置还包括用于从生产机构转向能量的机构。转向机构与生产机构相连通。

39. 发明授权

US5920705A Method and apparatus for dynamically shifting between routing and switching packets in a transmission network 失效
标题翻译：用于在传输网络中的路由和交换分组之间动态转换的方法和装置
公开(公告)号：US5920705A
公开(公告)日：1999-07-06
申请号：US792183
申请日：1997-01-30
申请人： Thomas Lyon , Peter Newman , Greg Minshall , Robert Hinden , Fong Ching Liaw , Eric Hoffman , Lawrence B. Huston , William A. Roberson
发明人： Thomas Lyon , Peter Newman , Greg Minshall , Robert Hinden , Fong Ching Liaw , Eric Hoffman , Lawrence B. Huston , William A. Roberson
IPC分类号： G06F13/14 , H04L12/46 , H04L12/56 , H04L12/66 , H04L29/06 , H04Q11/04 , G06F15/16
CPC分类号： H04L12/5601 , H04L12/4608 , H04L29/06 , H04L49/602 , H04L69/16 , H04L69/161 , H04Q11/0478 , H04L49/201 , H04L49/205 , H04L49/351
摘要： A method and apparatus for dynamically shifting between switching and routing packets efficiently to provide high packet throughput. The present invention provides a method for transmitting packets between an upstream node and a downstream node in a network that utilizes flow classification and labelling to redirect flows. The method includes the steps of establishing default virtual channels between the upstream node and the downstream node, receiving a packet at the downstream node, performing a flow classification at the downstream node on the packet to determine whether the packet belongs to a specified flow that should be redirected in the upstream node, selecting a free label at the downstream node, and informing the upstream node that future packets belonging to the specified flow should be sent with the selected free label attached. Other embodiments of the present invention include a basic switching unit, a switch gateway unit, and a switching agent for use in a system for transmitting packets in a network. Another embodiment includes system software, fixed on tangible media, that performs flow classification of packets to enable flow labelling and redirection to dynamically shift between Layer 3 IP packet routing and Layer 2 switching to optimize packet traffic throughput. A further embodiment provides a method for switching a flow at a first node in a network.
摘要翻译：一种用于有效地在交换和路由分组之间动态地转换以提供高分组吞吐量的方法和装置。本发明提供了一种在网络中的上游节点和下游节点之间传输分组的方法，该方法利用流分类和标记来重定向流。该方法包括在上游节点与下游节点之间建立默认虚拟通道，在下游节点接收分组，在分组下游节点执行流分类，确定分组是否属于指定流在上游节点重定向，在下游节点选择一个自由标签，并通知上游节点，属于指定流的未来数据包应以附加的所选择的自由标签发送。本发明的其他实施例包括基站交换单元，交换网关单元和用于在网络中传送分组的系统中使用的交换代理。另一个实施例包括固定在有形介质上的系统软件，其执行分组的流分类，以使流标签和重定向在第3层IP分组路由和第2层交换之间动态地转换以优化分组业务吞吐量。另一实施例提供了一种用于切换网络中的第一节点处的流的方法。

40. 发明授权

US09637738B2 Methods and agents to increase therapeutic dystrophin expression in muscle 有权
公开(公告)号：US09637738B2
公开(公告)日：2017-05-02
申请号：US14249748
申请日：2014-04-10
申请人： Eric Hoffman , Alyson Fiorillo
发明人： Eric Hoffman , Alyson Fiorillo
IPC分类号： C12N15/11 , C12N15/113 , A61K31/573 , A61K31/7088 , A61K45/06
CPC分类号： C12N15/113 , A61K31/573 , A61K31/7088 , A61K45/06 , C12N15/111 , C12N2310/113 , C12N2310/141 , C12N2320/30
摘要： Agents and methods for increasing dystrophin protein expression in muscle through blocking of specific microRNAs and microRNA binding sites on the dystrophin 3′ untranslated region (miR-146a, miRNA-146b, miR-223, miR-320a, miR374a, and miR-382). Methods for increasing the amount of dystrophin useful for effective therapeutic intervention for Becker muscular dystrophy, Duchenne muscular dystrophy, and other disorders where loss of dystrophin from muscle causes pathology.

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