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31. 发明申请

US20100041133A1 Biological targeting compositions and methods of using the same 审中-公开
公开(公告)号：US20100041133A1
公开(公告)日：2010-02-18
申请号：US12228868
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： C12N5/06
CPC分类号： A61K41/0071 , A61K47/6901 , A61K49/0002
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.

32. 发明申请

US20100041014A1 Biological targeting compositions and methods of using the same 失效
标题翻译：生物靶向组合物及其使用方法
公开(公告)号：US20100041014A1
公开(公告)日：2010-02-18
申请号：US12228880
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： C12Q1/70 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/555 , A61K31/00
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.
摘要翻译：描述了改良的红细胞。在一个实施方案中，修饰的红细胞包括靶结合剂。描述了使用修饰的红细胞靶向递送成像剂，药物和肽和蛋白质药物。描述了制备改性红细胞的方法，含有其的药物和诊断组合物以及涉及修饰的红细胞的诊断和治疗方法。

33. 发明申请

US20100040546A1 Biological targeting compositions and methods of using the same 审中-公开
公开(公告)号：US20100040546A1
公开(公告)日：2010-02-18
申请号：US12228892
申请日：2008-08-13
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , William Gates , Alois A. Langer , Eric C. Leuthardt , Royce A. Levien , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61K49/00 , A61K35/12 , C12Q1/02 , A61P33/00 , A61P31/00 , C12Q1/70
CPC分类号： A61K41/0028 , A61K41/0071 , A61K47/6901 , A61K49/0002 , A61K49/0097 , A61K49/0409 , G01N33/542 , G01N33/586 , G01N2458/30 , Y02A50/52 , Y02A50/58
摘要： Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein pharmaceuticals using modified red blood cells are described. Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described.

34. 发明授权

US5014284A Discrete slope delta modulation with recovery means 失效
标题翻译：具有恢复手段的离散斜率delta调制
公开(公告)号：US5014284A
公开(公告)日：1991-05-07
申请号：US373913
申请日：1989-06-30
申请人： Alois A. Langer , Khalil J. Maalouf
发明人： Alois A. Langer , Khalil J. Maalouf
IPC分类号： G06T9/00 , H03M3/02
CPC分类号： G06T9/005 , H03M3/022
摘要： A method and apparatus for processing electrical signals by modifying delta modulation to discrete slope delta modulation includes converting its electrical signals into compressed digital information, and representing this digital information as a sequence of slops or deltas added to the past value of the representation. For each sample period, a slope is chosen from slope tables having multiple entries and each choice is represented by a Huffman code. Signal compression occurs in two steps: first the selection of a small number of possible slopes provides compression and also the most probable slopes are represented by the shortest Huffman codes providing additional compression. Depending on the history of the slope chosen, multiple tables can be accessed with different slop entries. Two check point values are provided which code absolute output levels instead of slopes in order to facilitate recovery of the signal in the event of transmission errors. Initial matching of a specific slope value sought in the same table wherein the next preceding value was found. In one embodiment, at least four slope tables each having at least four values is employed. The apparatus has components for performing the method.
摘要翻译：用于通过将增量调制修改为离散斜率增量调制来处理电信号的方法和装置包括将其电信号转换为压缩数字信息，并将该数字信息表示为添加到表示的过去值的斜率或增量的序列。对于每个采样周期，从具有多个条目的斜率表中选择斜率，并且每个选择由霍夫曼代码表示。信号压缩分为两个步骤：首先选择少量可能的斜率提供压缩，最可能的斜率由提供附加压缩的最短霍夫曼码表示。根据所选斜率的历史，可以使用不同的斜率条目访问多个表。提供了两个检查点值，其编码绝对输出电平而不是斜率，以便在传输错误的情况下促进信号的恢复。在同一表中寻求的具有下一个前一值的特定斜率值的初始匹配。在一个实施例中，采用至少四个具有至少四个值的斜率表。该装置具有用于执行该方法的部件。

35. 发明授权

US4650465A Injectors and injector consoles 失效
标题翻译：注射器和注射器控制台
公开(公告)号：US4650465A
公开(公告)日：1987-03-17
申请号：US670685
申请日：1984-11-13
申请人： Alois A. Langer , Albert W. Rinne
发明人： Alois A. Langer , Albert W. Rinne
IPC分类号： A61M5/00
CPC分类号： A61M5/00 , Y10S128/12 , Y10S128/13
摘要： An angiographic injector having a separable console selecting and displaying injector functions and parameters. Microprocessors provide serial data transmission between console and injector base, and between injector head and injector base. A microprocessor in the base controls the injector.
摘要翻译：具有可分离控制台的血管造影注射器，其选择和显示注射器功能和参数。微处理器在控制台和进样器底座之间以及喷头和喷射器底座之间提供串行数据传输。基座中的微处理器控制喷油器。

36. 发明授权

US4440172A Apparatus for combining pacing and cardioverting functions in a single implanted device 失效
标题翻译：用于在单个植入装置中组合起搏和心律转换功能的装置
公开(公告)号：US4440172A
公开(公告)日：1984-04-03
申请号：US215520
申请日：1980-12-11
申请人： Alois A. Langer
发明人： Alois A. Langer
IPC分类号： A61N1/39 , A61N1/36
CPC分类号： A61N1/3962 , Y10S128/908
摘要： The invention relates to an apparatus for combining pacing and cardioverting functions in a single implanted device, circuitry being provided not only to interface the defibrillator to the ECG amplifier and other elements of the device, but also to provide protection of the ECG amplifier from the defibrillator output pulses, from loading by the defibrillator itself, and from overloading by externally generated defibrillator pulses. A specific embodiment of the invention combines a defibrillator, a pacer and an ECG amplifier in a single implanted device utilizing two terminal-electrode lead combinations for connection to the patient, while further embodiments employ three and four terminal-electrode lead combinations. The invention employs a high-frequency transformer coupling technique for pacing, or, alternatively, high-frequency transformer coupling with modulation-demodulation. Moreover, in accordance with the invention, overloading of the ECG amplifier is prevented by provision of (in one embodiment) series-connected and oppositely oriented zener diodes, and (in a second embodiment) parallel-connected diodes in series with a blocking capacitor for blocking DC voltage.
摘要翻译：本发明涉及一种用于在单个植入装置中组合起搏和心律转换功能的装置，不仅提供将除颤器连接到ECG放大器和装置的其它元件的电路，而且还提供ECG放大器与除颤器的保护输出脉冲，由除颤器本身加载，以及由外部产生的去纤颤器脉冲的过载。本发明的一个具体实施例将单独的植入装置中的除颤器，起搏器和ECG放大器组合在一起，利用用于连接到患者的两个端子 - 电极引线组合，而另外的实施例采用三个和四个端子电极引线组合。本发明采用高频变压器耦合技术进行起搏，或采用调制解调的高频变压器耦合。此外，根据本发明，通过提供（在一个实施例中）串联连接且相反方向的齐纳二极管和（在第二实施例中）并联连接的二极管与阻塞电容器串联来防止ECG放大器的过载，阻断直流电压。

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