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31. 发明授权

US07893065B2 Heterocyclic inhibitors of MEK and methods of use thereof 有权
标题翻译： MEK的杂环抑制剂及其使用方法
公开(公告)号：US07893065B2
公开(公告)日：2011-02-22
申请号：US12186202
申请日：2008-08-05
申请人： Allison L. Marlow , Eli M. Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
发明人： Allison L. Marlow , Eli M. Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
IPC分类号： C07D237/20 , A61K31/50 , A61P29/00 , A61P35/00
CPC分类号： C07D213/80 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/50 , A61K31/501 , A61K31/5025 , A61K31/5377 , A61K45/06 , C07D209/46 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , A61K2300/00
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, and W are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, and inflammatory conditions in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative and inflammatory diseases in mammals and pharmaceutical compositions containing such compounds.
摘要翻译：公开了式I化合物及其药学上可接受的盐和前药，其中R1，R2，R7，R8，R9和W如说明书中所定义。这些化合物是MEK抑制剂，并且可用于治疗过度增殖性疾病，例如癌症和炎症，以及哺乳动物中的炎性病症。还公开了使用这些化合物治疗哺乳动物中过度增生和炎性疾病的方法和含有这些化合物的药物组合物。

32. 发明申请

US20100063053A1 HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF 有权
标题翻译： MEK的杂环抑制剂及其使用方法
公开(公告)号：US20100063053A1
公开(公告)日：2010-03-11
申请号：US12577312
申请日：2009-10-12
申请人： Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
发明人： Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
IPC分类号： A61K31/50 , C07D213/72 , A61K31/44 , C07D237/02 , A61P35/00 , A61P29/00
CPC分类号： C07D213/78 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formulas I and V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要翻译：公开了式I和V的化合物及其药学上可接受的盐和前药，其中R1，R2，R7，R8和R9，W，X和Y如说明书中所定义。这些化合物是MEK抑制剂，可用于治疗哺乳动物和炎性病症中的过度增殖性疾病，例如癌症和炎症。还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。

33. 发明授权

US07598383B2 Heterocyclic inhibitors of MEK and methods of use thereof 有权
标题翻译： MEK的杂环抑制剂及其使用方法
公开(公告)号：US07598383B2
公开(公告)日：2009-10-06
申请号：US10992612
申请日：2004-11-18
申请人： Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
发明人： Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
IPC分类号： C07D487/04 , A61K31/44
CPC分类号： C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specifications. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要翻译：公开了式I化合物及其药学上可接受的盐和前药，其中R1，R2，R7，R8和R9，W，X和Y如说明书中所定义。这些化合物是MEK抑制剂，可用于治疗哺乳动物和炎性病症中的过度增殖性疾病，例如癌症和炎症。还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。

34. 发明授权

US07592570B2 Oven with convection air current and energy savings features 有权
标题翻译：烤箱具有对流气流和节能功能
公开(公告)号：US07592570B2
公开(公告)日：2009-09-22
申请号：US11901129
申请日：2007-09-14
申请人： Duane Yoder , James Blake , Roberto Nevarez
发明人： Duane Yoder , James Blake , Roberto Nevarez
IPC分类号： A21B1/14 , A21B1/26 , F27B9/32 , F27B9/36 , F27D1/02 , F27D7/04 , F27D23/00
CPC分类号： A21B1/26 , A21B1/48 , A47J37/044 , Y02P60/83
摘要： An oven for heating, cooking, or toasting a food product. The oven can comprise a conveyor for conveying the food product, and a parabolically shaped top surface with a plurality of reflectors connected thereto, to direct heat back toward the conveyor. The oven can also comprise a fan for circulating air within the oven cavity. The oven can also comprise a controller that can place the oven in an energy savings mode, when it detects that the oven is not in use. The controller can place the oven in energy savings mode by adjusting the speed of, or shutting off the conveyor, or by adjusting the amount of energy supplied to heating elements disposed within the oven.
摘要翻译：用于加热，烹饪或烘烤食品的烤箱。烤箱可以包括用于输送食品的输送机和具有与其连接的多个反射器的抛物线形的顶表面，以将热量引导回输送机。烘箱还可以包括用于在烤箱腔内循环空气的风扇。烤箱还可以包括一个控制器，当控制器检测到烤箱不使用时，可以将烤箱置于节能模式。控制器可以通过调节输送机的速度或切断输送机，或者调节供应给设在烘箱内的加热元件的能量的量来将烘箱置于节能模式。

35. 发明申请

US20090215834A1 HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF 有权
标题翻译： MEK的杂环抑制剂及其使用方法
公开(公告)号：US20090215834A1
公开(公告)日：2009-08-27
申请号：US12186273
申请日：2008-08-05
申请人： Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
发明人： Allison L. Marlow , Eli Wallace , Jeongbeob Seo , Joseph P. Lyssikatos , Hong Woon Yang , James Blake
IPC分类号： A61K31/4412 , C07D213/78 , A61P29/00 , A61P35/04
CPC分类号： C07D213/80 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/50 , A61K31/501 , A61K31/5025 , A61K31/5377 , A61K45/06 , C07D209/46 , C07D213/82 , C07D215/48 , C07D231/56 , C07D237/24 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , A61K2300/00
摘要： Disclosed are compounds of the Formula V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, and inflammatory conditions in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases and inflammatory conditions in mammals and pharmaceutical compositions containing such compounds.
摘要翻译：公开了式V的化合物及其药学上可接受的盐和前药，其中R1，R2，R7，R8和R9以及W如说明书中所定义。这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，如癌症和炎症以及炎性病症。还公开了使用这些化合物治疗哺乳动物的过度增殖性疾病和炎性病症的方法以及含有这些化合物的药物组合物。

36. 发明授权

US07511058B2 Heterocyclic inhibitors of MEK and methods of use thereof 失效
标题翻译： MEK的杂环抑制剂及其使用方法
公开(公告)号：US07511058B2
公开(公告)日：2009-03-31
申请号：US11410336
申请日：2006-04-24
申请人： T. Brian Hurley , Eli M. Wallace , Joseph P. Lyssikatos , James Blake
发明人： T. Brian Hurley , Eli M. Wallace , Joseph P. Lyssikatos , James Blake
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： C07D471/04 , C07D261/20
摘要： Disclosed are compounds of the Formula III and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 R10, and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要翻译：公开了式III的化合物及其药学上可接受的盐和前药，其中R 1，R 2，R 7，R 8，R 9 R 10和W如说明书中所定义。这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，例如癌症和炎症。还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。

37. 发明授权

US07271178B2 Heterocyclic inhibitors of MEK and methods of use thereof 失效
标题翻译： MEK的杂环抑制剂及其使用方法
公开(公告)号：US07271178B2
公开(公告)日：2007-09-18
申请号：US11410343
申请日：2006-04-24
申请人： Eli M. Wallace , James Blake
发明人： Eli M. Wallace , James Blake
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07D261/20
摘要： Disclosed are compounds of the Formula V and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, R10, R11 and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
摘要翻译：公开了式V的化合物及其药学上可接受的盐和前药，其中R 1，R 2，R 7，R 4， 8，R 9，R 10，R 11和W如说明书中所定义。这些化合物是MEK抑制剂，可用于治疗哺乳动物中的过度增生性疾病，例如癌症和炎症。还公开了使用这些化合物治疗哺乳动物中过度增殖性疾病的方法和含有这些化合物的药物组合物。

38. 发明申请

US20070197537A1 Heterobicyclic thiophene compounds and methods of use 有权
标题翻译：异双环噻吩化合物及其使用方法
公开(公告)号：US20070197537A1
公开(公告)日：2007-08-23
申请号：US11699830
申请日：2007-01-30
申请人： James Blake , Steven Boyd , Jason De Meese , John Gaudino , Allison Marlow , Jeongbeob Seo , Allen Thomas , Hongqi Tian
发明人： James Blake , Steven Boyd , Jason De Meese , John Gaudino , Allison Marlow , Jeongbeob Seo , Allen Thomas , Hongqi Tian
IPC分类号： A61K31/503 , A61K31/519 , A61K31/4743 , C07D498/02
CPC分类号： C07D495/04 , C07D519/00
摘要： Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译：式I化合物及其药学上可接受的盐可用于抑制受体酪氨酸激酶和用于治疗由此介导的病症。公开了使用式I化合物及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

39. 发明申请

US20060030610A1 Method of treating inflammatory diseases 失效
公开(公告)号：US20060030610A1
公开(公告)日：2006-02-09
申请号：US11208442
申请日：2005-08-19
申请人： Kevin Koch , T. Hurley , Hong Yang , Joseph Lyssikatos , James Blake , Allison Marlow , Eli Wallace
发明人： Kevin Koch , T. Hurley , Hong Yang , Joseph Lyssikatos , James Blake , Allison Marlow , Eli Wallace
IPC分类号： A61K31/42 , C07D261/20
CPC分类号： C07D261/20 , A61K31/42 , C07D417/06 , C07D471/04
摘要： Disclosed are methods of treating inflammatory diseases and disorders, such as arthritis and inflammatory bowel disease, in mammals.

40. 发明申请

US20050284084A1 Shear wall aspect ratio reducing frame (ARRF) 审中-公开
标题翻译：剪切墙纵横比缩小框架（ARRF）
公开(公告)号：US20050284084A1
公开(公告)日：2005-12-29
申请号：US10861676
申请日：2004-06-04
申请人： James Blake
发明人： James Blake
IPC分类号： E04B1/26 , E04C3/30
CPC分类号： E04B1/26 , E04B2001/268 , E04B2001/2696
摘要： My invention, the Shear Wall Aspect Ratio Reducing Frame is a simple, economical, efficient, easy to install device that allows greater oppotunity and flexibility in the size and location of openings in the walls of wood frame constructed buildings particularly houses. The ARRF would replace the commercial, pre-fabricated systems now in use which are costly and inefficient labor-intensive shear wall devices. The ARRF achieves its goal by reducing the moment arm in the overturning equations that are used to determine the uplift forces in a shear wall. The ARRF reduces forces in walls rather than increase their bulk which is the strategic concept now in use throughout the design professions and the construction industry to solve the aspect ratio problem.
摘要翻译：我的发明，剪切墙纵横比减速框架是一种简单，经济，高效，易于安装的设备，可以在木框架建筑物，特别是房屋的墙壁上的开口尺寸和位置上实现更大的对抗性和灵活性。 ARRF将取代现在使用的商业，预制的系统，这些系统是昂贵且无效的劳动密集型剪力墙装置。 ARRF通过减少用于确定剪力墙隆起力的倾覆方程中的力矩臂来实现其目标。 ARRF减少墙壁的力量，而不是增加其体积，这是现在在整个设计行业和建筑行业使用的战略概念来解决纵横比问题。

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