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31. 发明申请

US20060204442A1 Magnetically targetable particles comprising magnetic components and biocompatible polymers for site-specific delivery of biologically active agents 审中-公开
标题翻译：包含磁性组分和生物相容性聚合物的可磁性靶向颗粒用于生物活性剂的位点特异性递送
公开(公告)号：US20060204442A1
公开(公告)日：2006-09-14
申请号：US10571210
申请日：2004-09-11
申请人： Gilles Tapolsky , Yuhua Li , Yuyuan Jiao
发明人： Gilles Tapolsky , Yuhua Li , Yuyuan Jiao
IPC分类号： A61K49/10 , A61K9/14
CPC分类号： A61K41/00 , A61K9/5094 , A61K31/282 , A61K31/40 , A61K31/555 , A61K33/26 , A61K45/06 , A61K47/593 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K49/0002 , A61K2300/00
摘要： The invention relates to magnetically targetable particles comprising at least one magnetic component The particles are capable of delivering selectively to a site or organ a biologically active substance for in vivo medical diagnosis and/or treatment. The particles are prepared by many processes such as encapsulation processes. Also described are methods for making the particles, methods for localized in vivo delivery of a biologically active agent utilizing the particles, a kit for the administration of the particles, as well as a method for sterilizing the particles.
摘要翻译：本发明涉及包含至少一种磁性组分的可磁性靶向颗粒。颗粒能够选择性地递送至位点或器官用于体内医学诊断和/或治疗的生物活性物质。颗粒通过许多方法制备，例如封装方法。还描述了制备颗粒的方法，利用颗粒的生物活性剂的局部体内递送方法，用于施用颗粒的试剂盒以及用于对颗粒进行灭菌的方法。

32. 发明申请

US20060034923A1 Pharmaceutical compositions for controlled release delivery of biologically active compounds 有权
标题翻译：用于控释释放生物活性化合物的药物组合物
公开(公告)号：US20060034923A1
公开(公告)日：2006-02-16
申请号：US11201932
申请日：2005-08-11
申请人： Yuhua Li , Benjamin Chien
发明人： Yuhua Li , Benjamin Chien
IPC分类号： A61K31/663 , A61K9/22
CPC分类号： A61K31/663 , A61K9/0024 , A61K9/1647 , A61K9/7007 , A61K31/704 , A61K38/22 , A61K38/26 , A61K38/31 , A61K47/34 , A61K47/541 , A61K47/548
摘要： The present invention provides compositions and methods for the controlled release delivery of one or more biologically active compounds to a subject. Specifically, the invention provides for a pharmaceutical composition for the controlled release delivery of biologically active compounds to a subject comprising: a) a complex of a biologically active compound having at least one basic functional group and a polyanion derived from hexahydroxycyclohexane having at least two negatively charged functional groups; and b) a pharmaceutically acceptable carrier comprising a biodegradable, water-insoluble polymer. By complexing a biologically active compound with a polyanion, the tight, stable complex may be incorporated into a long-acting dosage system having a more desired drug release curve over time than that is found in the prior art. The invention also provides the methods of making such compositions and the methods of use thereof.
摘要翻译：本发明提供了一种或多种生物活性化合物向受试者的控制释放递送的组合物和方法。具体地说，本发明提供了用于向受试者控释生物活性化合物的药物组合物，包括：a）具有至少一个碱性官能团的生物活性化合物和衍生自六羟基环己烷的聚阴离子的复合物，其具有至少两个负面带电功能组; 和b）包含可生物降解的水不溶性聚合物的药学上可接受的载体。通过使生物活性化合物与聚阴离子络合，紧密，稳定的复合物可以掺入长效剂量系统中，其具有比现有技术中发现的更长时间的药物释放曲线。本发明还提供了制备这种组合物的方法及其使用方法。

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