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31. 发明申请

US20050059622A1 Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression 审中-公开
公开(公告)号：US20050059622A1
公开(公告)日：2005-03-17
申请号：US10863075
申请日：2004-06-07
申请人： William Andrews , Christopher Foster , Stephanie Fraser , Hamid Mohammadpour
发明人： William Andrews , Christopher Foster , Stephanie Fraser , Hamid Mohammadpour
IPC分类号： A61K38/00 , C07K16/00 , C12N9/12 , C12P21/04 , A61K48/00 , A61K38/17
CPC分类号： C12N9/1276 , A61K38/00 , C07K16/00 , C12N2510/04 , G01N2500/10 , G01N2500/20
摘要： Methods and compositions are provided for modulating, and generally upregulating, the expression of telomerase reverse transcriptase (TERT) by blocking repression of TERT transcription, e.g., by inhibiting binding of repressor factor to a Site C repressor binding site located in the TERT minimal promoter. The subject methods and compositions find use in a variety of different applications, including the immortalization of cells, the production of reagents for use in life science research, therapeutic applications; therapeutic agent screening applications; and the like. In further describing the subject invention, the methods and compositions of the invention are described first in greater detail, followed by a review of the various applications in which the subject invention finds use.

32. 发明授权

US08475808B2 Immunogenic reagents from west nile virus 有权
标题翻译：西尼罗病毒的免疫原性试剂
公开(公告)号：US08475808B2
公开(公告)日：2013-07-02
申请号：US10557427
申请日：2004-05-21
申请人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
发明人： William Andrews , David Chien , Qui-Lim Choo , Stephen Coates , Doris Coit , Charles Harrington , Susan Hilt , Michael Houghton , Angelica Medina-Selby , Sergio Pichuantes , Yiu-Lian Fong
IPC分类号： A61K39/12 , C12Q1/70 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K2319/02 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N33/6854 , G01N2333/18 , G01N2469/20 , Y02A50/394
摘要： Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.
摘要翻译：描述了免疫原性西尼罗病毒（WNV）蛋白的重组产生。包含蛋白质的这些蛋白质，其融合物，编码蛋白质的多核苷酸及其组合以及由其产生的抗体可用于预防，治疗和诊断WNV感染的免疫原性组合物中。还描述了用于检测生物样品中WNV存在的高灵敏度ELISA和条带免疫测定方法。

33. 发明申请

US20120311900A1 SCROLL SYSTEM AND METHOD 审中-公开
标题翻译：滚动系统和方法
公开(公告)号：US20120311900A1
公开(公告)日：2012-12-13
申请号：US13157329
申请日：2011-06-10
申请人： William Andrews
发明人： William Andrews
IPC分类号： G09F19/00 , B65H39/00
CPC分类号： G09F11/29 , G09F11/30
摘要： A scroll system and method. The scroll system includes a core that has two end walls that are preferably disc-shaped. A slot that detachably couples a stack of writing material is disposed within the core. The writing materials need not be accessed sequentially but are randomly accessible. The writing materials are also rollable around the core and can be unwound from said core for use.
摘要翻译：滚动系统和方法。涡旋系统包括具有优选为盘状的两个端壁的芯。一个可拆卸地连接一堆书写材料的槽设置在该芯内。写作材料不需要顺序访问，而是随机访问的。书写材料也可围绕芯部滚动，并且可以从所述芯体展开使用。

34. 发明授权

US08324934B1 Programmable buffer 有权
标题翻译：可编程缓冲器
公开(公告)号：US08324934B1
公开(公告)日：2012-12-04
申请号：US13007688
申请日：2011-01-17
申请人： Keith Truong , John Schadt , Ravi Lall , William Andrews
发明人： Keith Truong , John Schadt , Ravi Lall , William Andrews
IPC分类号： H03K19/094
CPC分类号： H03K19/0941 , H03K3/0377
摘要： In one embodiment of the invention, a programmable device, such as an FPGA, has a programmable input buffer with a VCCIO-powered buffer stage for high-voltage signaling and a VCC-powered buffer stage for low-voltage signaling. In addition to a main driver section, the VCCIO-powered buffer stage has a mixed-mode section for handling multiple different over-drive and multiple different under-drive conditions, a hysteresis section for providing multiple different trip-point hysteresis modes of operation, and a level-shifting section with look-ahead circuitry that enables the main driver section to be implemented with low-power, high-threshold devices, while still enabling the VCCIO-powered buffer stage to operate with low skew and high speed.
摘要翻译：在本发明的一个实施例中，诸如FPGA的可编程器件具有可编程输入缓冲器，其具有用于高电压信号的VCCIO供电缓冲级和用于低电压信号的VCC供电缓冲级。除主驱动器部分外，VCCIO供电的缓冲级具有混合模式部分，用于处理多个不同的过驱动和多个不同的驱动下条件，滞后部分用于提供多种不同的跳变点滞后操作模式，以及具有先行电路的电平转换部分，其使得主驱动器部分能够用低功率，高阈值器件实现，同时仍然使得VCCIO供电的缓冲器级以低歪斜和高速度运行。

35. 发明申请

US20100293888A1 VERTICAL DEFLECTION EXTENSION END MEMBER 有权
标题翻译：垂直偏移延伸终端
公开(公告)号：US20100293888A1
公开(公告)日：2010-11-25
申请号：US12468553
申请日：2009-05-19
申请人： William Andrews
发明人： William Andrews
IPC分类号： E04B2/08 , E04C2/38 , E04G25/06
CPC分类号： E04B2/7457 , E04B2/7459 , E04B2/767 , E04B2/789 , E04B2/82
摘要： A wall structure has a telescoping portion and a stationary portion. An overlapping section of the telescoping portion has a recess to allow dry wall to be fastened to the stationary portion at the overlapping section without being attached to the telescoping portion. The fastener pierces through the drywall and a sidewall of the stationary portion. However, a tip of the fastener does not engage a sidewall of the telescoping portion. Rather, the tip of the fastener stops within the recess of the telescoping portion.
摘要翻译：壁结构具有伸缩部分和固定部分。伸缩部分的重叠部分具有凹部，以允许干壁在重叠部分处固定到固定部分而不附接到伸缩部分。紧固件穿过干墙和固定部分的侧壁。然而，紧固件的尖端不接合伸缩部分的侧壁。相反，紧固件的尖端停在伸缩部分的凹部内。

36. 发明授权

US07579779B2 Pivotable magnetic assembly for allowing insertion or removal of a linear beam tube 有权
标题翻译：用于允许插入或移除线性束管的可旋转磁性组件
公开(公告)号：US07579779B2
公开(公告)日：2009-08-25
申请号：US11352404
申请日：2006-02-13
申请人： Stuart William Andrews
发明人： Stuart William Andrews
IPC分类号： H01J23/087 , H01J25/04
CPC分类号： H01J23/087 , H01J23/10 , H01J25/04
摘要： An electron beam tube device has a magnetic frame with the top part being pivotable so as to pivot from a closed position in which the top part, including an electromagnetic coil covers the electron beam tube to an open position in which the electron beam tube is uncovered. This allows electron beam tubes with either large parts or integral parts such as output feeders to be removed from the magnetic frame without complete removal of the top plate.
摘要翻译：电子束管装置具有磁性框架，其顶部可枢转，以便从闭合位置枢转，其中包括电磁线圈的顶部覆盖电子束管至电子束管未被覆盖的打开位置。这允许具有大部件或整体部件（例如输出馈线）的电子束管从磁性框架移除而不完全移除顶板。

37. 发明申请

US20080058277A1 Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression 审中-公开
标题翻译：调节端粒酶逆转录酶（TERT）表达的方法和组合物
公开(公告)号：US20080058277A1
公开(公告)日：2008-03-06
申请号：US11713556
申请日：2007-02-28
申请人： William Andrews , Christopher Foster , Stephanie Fraser , Hamid Mohammadpour
发明人： William Andrews , Christopher Foster , Stephanie Fraser , Hamid Mohammadpour
IPC分类号： A61K48/00 , A61P43/00
CPC分类号： C12N9/1276 , A61K38/00 , C07K16/00 , C12N2510/04 , G01N2500/10 , G01N2500/20
摘要： Methods and compositions are provided for modulating, and generally upregulating, the expression of telomerase reverse transcriptase (TERT) by blocking repression of TERT transcription, e.g., by inhibiting binding of repressor factor to a Site C repressor binding site located in the TERT minimal promoter. The subject methods and compositions find use in a variety of different applications, including the immortalization of cells, the production of reagents for use in life science research, therapeutic applications; therapeutic agent screening applications; and the like. In further describing the subject invention, the methods and compositions of the invention are described first in greater detail, followed by a review of the various applications in which the subject invention finds use.
摘要翻译：提供方法和组合物用于通过阻止TERT转录的抑制来调节和通常上调端粒酶逆转录酶（TERT）的表达，例如通过抑制阻遏物因子与位于TERT最小启动子中的位点C阻遏物结合位点的结合。主题方法和组合物可用于各种不同的应用，包括细胞的永生化，用于生命科学研究的试剂的生产，治疗应用; 治疗剂筛选应用; 等等。在进一步描述本发明时，首先更详细地描述本发明的方法和组合物，随后对本发明所使用的各种应用进行回顾。

38. 发明申请

US20070238639A1 Telomerase expression repressor proteins and methods of using the same 有权
公开(公告)号：US20070238639A1
公开(公告)日：2007-10-11
申请号：US11726388
申请日：2007-03-20
申请人： William Andrews , Christopher Foster , Stephanie Fraser , Hamid Mohammadpour , Laura Briggs
发明人： William Andrews , Christopher Foster , Stephanie Fraser , Hamid Mohammadpour , Laura Briggs
IPC分类号： A61K31/00 , C07K14/47 , C12Q1/68
CPC分类号： C12N15/635 , A61K38/00 , C07K14/4703
摘要： Telomerase repressor proteins and nucleic acid compositions encoding the same are provided. The subject repressor proteins bind to a repressor site in the TERT minimal promoter, e.g., a Site C site, and thereby inhibit TERT expression. Also provided are methods of modulating, e.g., inhibiting or enhancing, TERT expression. The subject invention finds use in a variety of different applications, including therapeutic and therapeutic agent screening applications.

39. 发明申请

US20070164844A1 Temperature-independent, linear on-chip termination resistance 有权
标题翻译：温度独立，线性片上终端电阻
公开(公告)号：US20070164844A1
公开(公告)日：2007-07-19
申请号：US11300886
申请日：2005-12-15
申请人： Mou Lin , William Andrews , John Schadt
发明人： Mou Lin , William Andrews , John Schadt
IPC分类号： H01C7/00
CPC分类号： H04L25/0298 , H01L28/20
摘要： In one embodiment of the invention, an integrated circuit, such as an FPGA, has one or more programmable termination schemes, each having a plurality of resistive termination legs connected in parallel, and a calibration circuit designed to control each termination scheme for process, voltage, and temperature (PVT) variations. The sense element in the calibration circuit and each resistive leg in each termination scheme has a transistor-based transmission gate connected in series with a non-silicided poly (NSP) resistor. The negative temperature coefficient of resistivity of each NSP resistor offsets the positive temperature coefficient of resistivity of the corresponding transmission gate to provide a temperature-independent sense element and temperature-independent termination legs. The temperature-independence and constant IV characteristic of the sense element and termination legs enable a single calibration circuit to simultaneously control multiple termination schemes operating at different termination voltage levels.
摘要翻译：在本发明的一个实施例中，诸如FPGA的集成电路具有一个或多个可编程端接方案，每个可编程端接方案具有并联连接的多个电阻端接支路，以及被设计成控制每个端接方案用于处理电压的校准电路，和温度（PVT）变化。校准电路中的感测元件和每个端接方案中的每个电阻支路具有与非硅化聚（NSP）电阻器串联连接的基于晶体管的传输栅极。每个NSP电阻器的负温度系数抵消相应传输门的电阻率的正温度系数，以提供与温度无关的感测元件和温度独立的端接脚。感测元件和终端支路的温度独立性和恒定IV特性使得单个校准电路能够同时控制在不同终端电压电平下工作的多个终端方案。

40. 发明授权

US07223043B1 Structural members and joining arrangements therefor 有权
标题翻译：结构成员及其配合
公开(公告)号：US07223043B1
公开(公告)日：2007-05-29
申请号：US09979214
申请日：2000-05-22
申请人： William Andrews
发明人： William Andrews
IPC分类号： E04B1/58 , E04B1/24
CPC分类号： E04B2/789 , E04B2/7459 , E04B2/767 , Y10T403/46 , Y10T403/4605 , Y10T403/7043
摘要： A joining arrangement for use in the construction of stud frames and for releasable attachment of a first member to a second structural member forming part of the frame. The first member includes in at least one side wall a female recess which, when the members are joined, engages a corresponding male protrusion in at least one wall of the second member. The respective formations in the first and second members engage such that they are generally in alignment thereby securing the first member to the second member and wherein the first member is a stud and the second member is a plate.
摘要翻译：一种用于构造螺柱架的连接装置和用于将第一构件可释放地附接到形成框架的一部分的第二结构构件。第一构件在至少一个侧壁中包括阴凹部，当凹入部件接合时，凹槽与第二构件的至少一个壁中的对应的阳突起接合。第一和第二构件中的相应结构使得它们大致对准，从而将第一构件固定到第二构件，并且其中第一构件是螺柱，并且第二构件是板。

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